KEGG   PATHWAY: mmyo05010
Entry
mmyo05010                   Pathway                                
Name
Alzheimer disease - Myotis myotis (greater mouse-eared bat)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
mmyo05010  Alzheimer disease
mmyo05010

Organism
Myotis myotis (greater mouse-eared bat) [GN:mmyo]
Gene
118652779  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 isoform X1 [KO:K06704] [EC:3.4.24.81]
118669297  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
118677629  amyloid-beta precursor protein isoform X1 [KO:K04520]
118674429  NAE1; NEDD8-activating enzyme E1 regulatory subunit [KO:K04532]
118664755  APBB1; amyloid-beta A4 precursor protein-binding family B member 1 isoform X1 [KO:K04529]
118649503  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
118662819  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
118663422  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
118664264  BACE1; beta-secretase 1 [KO:K04521] [EC:3.4.23.46]
118676055  BACE2; beta-secretase 2 isoform X1 [KO:K07747] [EC:3.4.23.45]
118665386  RTN3; reticulon-3 isoform X1 [KO:K20723]
118669000  RTN4; reticulon-4 isoform X1 [KO:K20720]
118674722  PSENEN; gamma-secretase subunit PEN-2 [KO:K06170]
118657710  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
118678803  PSEN2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
118672706  NCSTN; nicastrin isoform X1 [KO:K06171]
118653288  APH1B; gamma-secretase subunit APH-1B isoform X1 [KO:K06172]
118672735  APH1A; gamma-secretase subunit APH-1A [KO:K06172]
118669958  IDE; insulin-degrading enzyme isoform X1 [KO:K01408] [EC:3.4.24.56]
118676435  MME; neprilysin [KO:K01389] [EC:3.4.24.11]
118671627  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
26889517  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
26889520  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
26889529  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
26889508  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
26889530  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
26889533  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
26889510  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
118665210  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
118663528  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
118676864  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
118658680  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
118653714  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
118653841  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
118659276  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
118651524  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
118666177  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
118659978  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
118666453  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
118674353  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6-like [KO:K03950]
118651854  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
118659198  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
118667132  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X1 [KO:K03952]
118650282  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial isoform X1 [KO:K03953]
118677633  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial-like [KO:K03953]
118661392  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
118656414  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
118658957  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
118651305  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
118658191  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
118659585  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
118666341  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
118661238  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
118676920  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
118676944  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
118667403  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
118652705  NDUFB7; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
118669847  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
118670981  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
118656353  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
118653795  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
118661169  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
118672885  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
118665049  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial isoform X1 [KO:K03936] [EC:7.1.1.2]
118656177  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
118656173  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
118658662  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
118665205  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
118659095  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
118664595  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
118655921  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
118670565  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial-like [KO:K00235] [EC:1.3.5.1]
118676311  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
118672944  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
118664349  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
118674548  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
26889534  CYTB; cytochrome b [KO:K00412]
118658381  cytochrome c1, heme protein, mitochondrial-like [KO:K00413]
118653082  cytochrome c1, heme protein, mitochondrial [KO:K00413]
118676147  cytochrome c1, heme protein, mitochondrial-like [KO:K00413]
118668510  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
118656194  cytochrome b-c1 complex subunit 2, mitochondrial isoform X1 [KO:K00415]
118677282  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
118658665  cytochrome b-c1 complex subunit 7-like [KO:K00417]
118670644  cytochrome b-c1 complex subunit 7 isoform X1 [KO:K00417]
118658647  cytochrome b-c1 complex subunit 8 [KO:K00418]
118678367  cytochrome b-c1 complex subunit 9 [KO:K00419]
118678145  cytochrome b-c1 complex subunit 10-like [KO:K00420]
118658907  cytochrome b-c1 complex subunit 10 [KO:K00420]
26889505  COX3; cytochrome c oxidase subunit III [KO:K02262]
26889525  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
26889527  COX2; cytochrome c oxidase subunit II [KO:K02261]
118674112  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
118663651  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
118675843  cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
118676017  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
118652480  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
118678114  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
118656385  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
118657409  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
118666421  cytochrome c oxidase subunit 6B1-like [KO:K02267]
118669352  cytochrome c oxidase subunit 6B1-like [KO:K02267]
118655199  cytochrome c oxidase subunit 6B2 [KO:K02267]
118674654  cytochrome c oxidase subunit 6B1 [KO:K02267]
118670671  cytochrome c oxidase subunit 6C [KO:K02268]
118671315  cytochrome c oxidase subunit 6C-like [KO:K02268]
118674194  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
118660137  cytochrome c oxidase subunit 7A2, mitochondrial isoform X1 [KO:K02270]
118669062  uncharacterized protein LOC118669062 isoform X1 [KO:K02270]
118651610  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
118654460  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
118656735  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
118665381  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
118662999  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
118650906  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
118672118  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
118649386  ATP synthase subunit delta, mitochondrial-like [KO:K02134]
118659348  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
118662963  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
118672074  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
26889504  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
118672708  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
118651236  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
118657855  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
118661898  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
118663441  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
118670790  ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
118671931  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial isoform X1 [KO:K02128]
118665670  ATP synthase subunit d, mitochondrial-like [KO:K02138]
118671446  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
118676997  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
118655681  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
118675387  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
26889528  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
118659315  3-hydroxyacyl-CoA dehydrogenase type-2-like [KO:K08683] [EC:1.1.1.35 1.1.1.178]
118653717  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 isoform X1 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
118657806  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
118658112  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
118670177  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
118650915  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
118650249  ADP/ATP translocase 2-like [KO:K05863]
118651243  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
118665676  ADP/ATP translocase 3-like [KO:K05863]
118659237  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
118652084  ADP/ATP translocase 2-like [KO:K05863]
118654152  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
118657293  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
118670193  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
118658325  LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
118674271  APOE; apolipoprotein E [KO:K04524]
118649984  LRP1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
118669989  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
118649937  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
118665178  FADD; FAS-associated death domain protein [KO:K02373]
118661495  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
118652071  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
118665751  calmodulin-alpha-like isoform X1 [KO:K02183]
118677428  calmodulin-like [KO:K02183]
118658241  neo-calmodulin-like [KO:K02183]
118659208  CALM1; calmodulin-1 [KO:K02183]
118652797  CALM3; calmodulin-3 [KO:K02183]
118669030  CALM2; calmodulin-2 [KO:K02183]
118654466  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
118655601  CALML6; calmodulin-like protein 6 [KO:K02183]
118664770  calmodulin-like protein 5 [KO:K02183]
118672571  LOW QUALITY PROTEIN: calmodulin-like protein 3 [KO:K02183]
118658346  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118670147  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118671846  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118667234  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
118668920  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
118665363  BAD; bcl2-associated agonist of cell death [KO:K02158]
118666111  cytochrome c [KO:K08738]
118679308  cytochrome c-like [KO:K08738]
118654943  cytochrome c-like [KO:K08738]
118650180  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
118677148  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
118650210  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
118649078  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
118678958  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
118649380  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
118664538  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
118667437  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
118649794  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
118663015  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
118663147  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
118665361  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
118655320  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
118656558  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
118652139  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
118672228  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
118657505  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
118652154  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
118667975  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
118654729  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
118678862  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
118679245  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
118670134  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
118678650  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
118656605  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
118674511  RYR3; ryanodine receptor 3 [KO:K04963]
118668410  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
118652119  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
118679657  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
118678179  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
118652876  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
118672007  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
118672678  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
118678214  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
118649620  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
118671592  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
118675238  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
118655263  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
118659758  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
118659182  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
118657754  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
118652068  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
118679322  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118670993  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
118656765  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 isoform X1 [KO:K03237]
118649462  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
118666845  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
118677907  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
118667652  proteasome subunit alpha type-6-like [KO:K02730] [EC:3.4.25.1]
118665958  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
118674683  proteasome subunit alpha type-2-like [KO:K02726] [EC:3.4.25.1]
118679096  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
118663715  PSMA7; proteasome subunit alpha type-7 isoform X1 [KO:K02731] [EC:3.4.25.1]
118663798  PSMA8; proteasome subunit alpha-type 8 isoform X1 [KO:K02731] [EC:3.4.25.1]
118672988  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
118676281  LOW QUALITY PROTEIN: proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
118664860  PSMA1; proteasome subunit alpha type-1 isoform X1 [KO:K02725] [EC:3.4.25.1]
118656008  PSMA3; proteasome subunit alpha type-3 isoform X1 [KO:K02727] [EC:3.4.25.1]
118672366  PSMB6; proteasome subunit beta type-6 isoform X1 [KO:K02738] [EC:3.4.25.1]
118677495  proteasome subunit beta type-7-like [KO:K02739] [EC:3.4.25.1]
118667070  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
118672116  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
118675960  PSMB2; proteasome subunit beta type-2 isoform X1 [KO:K02734] [EC:3.4.25.1]
118679231  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
118659722  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
118673515  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
118666031  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
118659186  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
118674451  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
118655396  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
118665053  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
118671610  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
118676255  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 isoform X1 [KO:K03028]
118662263  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 isoform X1 [KO:K03032]
118671666  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
118678430  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
118649948  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 12-like [KO:K03035]
118671823  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
118671770  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 isoform X1 [KO:K03036]
118667921  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
118674324  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
118656347  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 7-like [KO:K03038]
118648967  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
118673745  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
118662250  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X1 [KO:K03030]
118674093  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
118663710  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
118665674  SEM1; LOW QUALITY PROTEIN: 26S proteasome complex subunit SEM1 [KO:K10881]
118664384  caspase-12-like isoform X1 [KO:K04741] [EC:3.4.22.-]
118678505  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
118665322  CAPN1; calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
118678942  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
118671771  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
118649054  SLC39A2; zinc transporter ZIP2 isoform X1 [KO:K14709]
118672874  SLC39A1; zinc transporter ZIP1 [KO:K14709]
118658329  SLC39A3; zinc transporter ZIP3 [KO:K14709]
118663751  zinc transporter ZIP2-like [KO:K14709]
118653165  SLC39A4; zinc transporter ZIP4 [KO:K14710]
118651080  SLC39A5; zinc transporter ZIP5 [KO:K14711]
118662674  SLC39A6; zinc transporter ZIP6 isoform X1 [KO:K14712]
118679519  SLC39A7; zinc transporter SLC39A7 [KO:K14713]
118671864  SLC39A8; metal cation symporter ZIP8 [KO:K14714]
118657226  SLC39A9; zinc transporter ZIP9 isoform X1 [KO:K14715]
118661239  SLC39A10; zinc transporter ZIP10 isoform X1 [KO:K14716]
118671725  SLC39A11; zinc transporter ZIP11 isoform X1 [KO:K14717]
118674225  SLC39A12; zinc transporter ZIP12 isoform X1 [KO:K14718]
118665054  SLC39A13; zinc transporter ZIP13 isoform X1 [KO:K14719]
118658000  SLC39A14; metal cation symporter ZIP14 [KO:K14720]
118649602  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
118679406  CDK5; cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
118675932  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
118669734  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
118673324  DKK2; dickkopf-related protein 2 [KO:K02165]
118670014  DKK1; dickkopf-related protein 1 [KO:K02165]
118650977  WNT1; proto-oncogene Wnt-1 [KO:K03209]
118672911  WNT2B; protein Wnt-2b [KO:K00182]
118666478  WNT2; protein Wnt-2 [KO:K00182]
118658755  WNT3A; protein Wnt-3a isoform X1 [KO:K00312]
118672219  WNT3; proto-oncogene Wnt-3 isoform X1 [KO:K00312]
118676694  WNT4; protein Wnt-4 [KO:K00408]
118650248  WNT5B; protein Wnt-5b [KO:K00444]
118667971  WNT5A; protein Wnt-5a [KO:K00444]
118662211  WNT6; protein Wnt-6 [KO:K00445]
118650243  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
118677354  WNT7A; protein Wnt-7a [KO:K00572]
118658912  WNT8A; protein Wnt-8a [KO:K00714]
118669850  WNT8B; protein Wnt-8b [KO:K00714]
118658374  WNT9A; protein Wnt-9a [KO:K01064]
118671436  WNT9B; protein Wnt-9b [KO:K01064]
118651671  WNT10B; protein Wnt-10b [KO:K01357]
118661959  WNT10A; protein Wnt-10a isoform X1 [KO:K01357]
118664619  WNT11; protein Wnt-11 [KO:K01384]
118666468  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
118666245  FZD1; frizzled-1 [KO:K02432]
118661773  FZD7; frizzled-7 [KO:K02432]
118672294  FZD2; frizzled-2 [KO:K02235]
118658774  FZD3; frizzled-3 isoform X1 [KO:K02329]
118664546  FZD4; frizzled-4 [KO:K02354]
118661425  FZD5; frizzled-5 [KO:K02375]
118676314  FZD8; frizzled-8 [KO:K02375]
118670703  FZD6; frizzled-6 [KO:K02376]
118653033  FZD10; LOW QUALITY PROTEIN: frizzled-10 [KO:K02842]
118656623  FZD9; frizzled-9 [KO:K02842]
118649950  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
118665196  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
118650242  casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
118677642  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
118655561  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
118672041  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
118669908  FRAT1; proto-oncogene FRAT1 [KO:K03069]
118669907  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
118674082  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
118663040  CSNK2A1; casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
118676987  casein kinase II subunit alpha'-like [KO:K03097] [EC:2.7.11.1]
118679647  CSNK2B; casein kinase II subunit beta [KO:K03115]
118652848  AXIN1; axin-1 isoform X1 [KO:K02157]
118654322  LOW QUALITY PROTEIN: axin-1-like [KO:K02157]
118671617  AXIN2; axin-2 isoform X1 [KO:K04385]
118658707  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
118655759  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
118668371  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
118657973  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
118665504  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
118653594  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
118654184  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
118662055  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
118650010  KIF5A; kinesin heavy chain [KO:K10396]
118661865  KIF5C; kinesin heavy chain isoform X1 [KO:K10396]
118676723  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
118674327  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
118660065  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
118655023  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
118665266  KLC2; kinesin light chain 2 [KO:K10407]
118650258  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
118650856  tubulin alpha-1B chain-like [KO:K07374]
118666216  tubulin alpha-1C chain-like [KO:K07374]
118673521  tubulin alpha-1B chain-like [KO:K07374]
118678375  LOW QUALITY PROTEIN: putative tubulin-like protein alpha-4B [KO:K07374]
118678448  LOW QUALITY PROTEIN: tubulin alpha-3 chain-like [KO:K07374]
118652035  tubulin alpha-1A chain [KO:K07374]
118661080  TUBA4A; tubulin alpha-4A chain [KO:K07374]
118661627  tubulin alpha-1D chain isoform X1 [KO:K07374]
118672614  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
118658764  TUBB4A; tubulin beta-4A chain isoform X1 [KO:K07375]
118679650  TUBB; tubulin beta chain [KO:K07375]
118652991  TUBB3; tubulin beta-3 chain [KO:K07375]
118655285  TUBB4B; tubulin beta-4B chain [KO:K07375]
118662962  TUBB1; tubulin beta-1 chain [KO:K07375]
118663023  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
118675862  tubulin beta-2B chain isoform X1 [KO:K07375]
118676275  TUBB2B; tubulin beta-2B chain [KO:K07375]
118679606  AGER; advanced glycosylation end product-specific receptor [KO:K19722]
118648965  HRAS; GTPase HRas isoform X1 [KO:K02833]
118649554  KRAS; GTPase KRas isoform X1 [KO:K07827]
118672986  NRAS; GTPase NRas [KO:K07828]
118653778  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
118666337  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
118668076  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
118654213  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
118657986  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
118653425  NOX1; NADPH oxidase 1 [KO:K08008]
118653335  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
118664537  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
118665292  RELA; transcription factor p65 [KO:K04735]
118671867  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
118672123  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
118673371  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
118679652  tumor necrosis factor-like isoform X1 [KO:K03156]
118666134  IL6; interleukin-6 [KO:K05405]
118657543  IL1A; interleukin-1 alpha isoform X1 [KO:K04383]
118657544  IL1B; interleukin-1 beta [KO:K04519]
118672850  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
118671448  SNCA; alpha-synuclein isoform X1 [KO:K04528]
118669450  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
118669852  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
118650776  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
118653690  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118659596  insulin-like [KO:K04526]
118659608  insulin-like [KO:K04526]
118659612  insulin-like [KO:K04526]
118659286  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
118661524  IRS1; insulin receptor substrate 1 [KO:K16172]
118651692  IRS2; insulin receptor substrate 2 isoform X1 [KO:K07187]
118654640  IRS4; insulin receptor substrate 4 [KO:K17446]
118675217  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
118656203  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118657573  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
118677590  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118668125  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118675045  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118678909  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118655031  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118674834  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118675322  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
118653012  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
118649389  serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
118651135  ATG101; autophagy-related protein 101 isoform X1 [KO:K19730]
118665077  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
118670959  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
118665082  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
118678960  beclin-2-like [KO:K08334]
118671466  BECN1; beclin-1 isoform X1 [KO:K08334]
118676302  beclin-2-like [KO:K08334]
118668185  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [KO:K08333] [EC:2.7.11.1]
118655744  ATG14; beclin 1-associated autophagy-related key regulator isoform X1 [KO:K17889]
118670051  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
118662908  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
118660375  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
118665340  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
118657857  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
118667386  LOW QUALITY PROTEIN: WD repeat domain phosphoinositide-interacting protein 2-like [KO:K17908]
118671561  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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Dickson DW
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Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?
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J Clin Invest 114:23-7 (2004)
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Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer's disease.
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Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease.
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Trends Neurosci 31:454-63 (2008)
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Neurochem Int 52:621-33 (2008)
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Calcium channel blockers and Alzheimer's disease.
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Alzheimer's disease and Abeta toxicity: from top to bottom.
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Alzheimer's disease pathogenesis and therapeutic interventions.
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J Clin Neurosci 11:456-67 (2004)
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Presenilin-mediated signal transduction.
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Physiol Behav 92:93-7 (2007)
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Presenilins: role in calcium homeostasis.
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Int J Biochem Cell Biol 44:1983-6 (2012)
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Supnet C, Bezprozvanny I
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Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.
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Cell Calcium 50:303-9 (2011)
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Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease.
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APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain.
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J Cell Biol 163:27-33 (2003)
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March separate, strike together--role of phosphorylated TAU in mitochondrial dysfunction in Alzheimer's disease.
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Biochim Biophys Acta 1842:1258-66 (2014)
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Neurobiol Dis 6:440-9 (1999)
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pathway
mmyo00190  Oxidative phosphorylation
mmyo03050  Proteasome
mmyo04020  Calcium signaling pathway
mmyo04140  Autophagy - animal
mmyo04141  Protein processing in endoplasmic reticulum
mmyo04210  Apoptosis
mmyo04310  Wnt signaling pathway
mmyo04910  Insulin signaling pathway
mmyo04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   
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