Entry
Name
Epstein-Barr virus infection - Myotis myotis (greater mouse-eared bat)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases. EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
BRITE hierarchy
Pathway map
Ortholog table
Organism
Myotis myotis (greater mouse-eared bat) [GN:
mmyo ]
Gene
118679500 H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752 ]
118679523 RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752 ]
118679525 HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752 ]
118679591 LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
118679613 HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752 ]
118679614 HLA class II histocompatibility antigen, DQ alpha 2 chain-like isoform X1 [KO:K06752 ]
118679619 HLA class II histocompatibility antigen, DR alpha chain [KO:K06752 ]
118679624 SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like isoform X1 [KO:K06752 ]
118679625 boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752 ]
118679626 SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like isoform X1 [KO:K06752 ]
118679627 SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752 ]
118679628 boLa class II histocompatibility antigen, DQB*0101 beta chain-like isoform X1 [KO:K06752 ]
118679633 HLA class II histocompatibility antigen, DM beta chain [KO:K06752 ]
118679640 HLA class II histocompatibility antigen, DM alpha chain [KO:K06752 ]
118660487 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
118668344 MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729 ]
118650066 TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403 ]
118659738 TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404 ]
118671867 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
118661220 STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220 ]
118651142 STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221 ]
118669989 FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390 ]
118650180 APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084 ]
118664241 CD3E; T-cell surface glycoprotein CD3 epsilon chain isoform X1 [KO:K06451 ]
118673501 CD247; T-cell surface glycoprotein CD3 zeta chain isoform X1 [KO:K06453 ]
118655396 PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064 ]
118671610 PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066 ]
118676255 PSMD2; 26S proteasome non-ATPase regulatory subunit 2 isoform X1 [KO:K03028 ]
118662263 PSMD1; 26S proteasome non-ATPase regulatory subunit 1 isoform X1 [KO:K03032 ]
118671666 PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033 ]
118649948 LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 12-like [KO:K03035 ]
118671823 PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035 ]
118671770 PSMD11; 26S proteasome non-ATPase regulatory subunit 11 isoform X1 [KO:K03036 ]
118667921 PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037 ]
118674324 PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038 ]
118656347 LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 7-like [KO:K03038 ]
118648967 PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039 ]
118673745 PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029 ]
118662250 PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X1 [KO:K03030 ]
118674093 PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031 ]
118663710 ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691 ]
118665674 SEM1; LOW QUALITY PROTEIN: 26S proteasome complex subunit SEM1 [KO:K10881 ]
118658369 BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751 ]
118679578 patr class I histocompatibility antigen, B-1 alpha chain-like isoform X1 [KO:K06751 ]
118652788 saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751 ]
118659954 patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751 ]
118659955 patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751 ]
118659956 patr class I histocompatibility antigen, A-2 alpha chain-like isoform X1 [KO:K06751 ]
118659957 patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751 ]
118662409 patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751 ]
118655123 saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751 ]
118655161 class I histocompatibility antigen, Gogo-B*0102 alpha chain-like isoform X1 [KO:K06751 ]
118655171 class I histocompatibility antigen, Gogo-C*0203 alpha chain-like [KO:K06751 ]
118676090 SIN3A; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644 ]
118658119 SAP30L; histone deacetylase complex subunit SAP30L isoform X1 [KO:K19202 ]
118658920 SAP30; histone deacetylase complex subunit SAP30 isoform X1 [KO:K19202 ]
118667398 RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053 ]
118663233 RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053 ]
118658600 FCER2; low affinity immunoglobulin epsilon Fc receptor [KO:K06468 ]
118676760 RUNX3; runt-related transcription factor 3 isoform X1 [KO:K09279 ]
118658909 GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402 ]
118652529 GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma isoform X1 [KO:K04402 ]
118676452 GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402 ]
118677590 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
118668125 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
118675045 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
118675217 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
118656203 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
118657573 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649 ]
118669805 NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469 ]
118674287 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171 ]
118663560 CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160 ]
118672973 CD58; lymphocyte function-associated antigen 3 isoform X1 [KO:K06492 ]
118671501 STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692 ]
118657696 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
118674206 PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859 ] [EC:3.1.4.11 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Young LS, Rickinson AB.
Title
Epstein-Barr virus: 40 years on.
Journal
Reference
Authors
Saha A, Robertson ES
Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
Journal
Reference
Authors
Ning S
Title
Innate immune modulation in EBV infection.
Journal
Reference
Authors
Stanfield BA, Luftig MA
Title
Recent advances in understanding Epstein-Barr virus.
Journal
Reference
Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
Journal
Reference
Authors
Rajsbaum R, Garcia-Sastre A
Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
Journal
Reference
Authors
Hoffmann HH, Schneider WM, Rice CM
Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
Journal
Reference
Authors
Spender LC, Inman GJ
Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
Journal
Reference
Authors
Fu Q, He C, Mao ZR
Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
Journal
Reference
Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
Journal
Reference
Authors
Melchjorsen J
Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
Journal
Reference
Authors
Hansen TH, Bouvier M
Title
MHC class I antigen presentation: learning from viral evasion strategies.
Journal
Reference
Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
Journal
Reference
Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
Journal
Reference
Authors
Ghosh Roy S, Robertson ES, Saha A
Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
Journal
Reference
Authors
Dawson CW, Port RJ, Young LS
Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
Journal
Reference
Authors
Cai Q, Chen K, Young KH
Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
Journal
Reference
Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
Authors
Ersing I, Bernhardt K, Gewurz BE
Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
Journal
Reference
Authors
Wang LW, Jiang S, Gewurz BE
Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
Journal
Reference
Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
Journal
Reference
Authors
Edwards RH, Marquitz AR, Raab-Traub N
Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
Journal
Reference
Authors
Thorley-Lawson DA
Title
Epstein-Barr virus: exploiting the immune system.
Journal
Reference
Authors
Eliopoulos AG, Young LS
Title
LMP1 structure and signal transduction.
Journal
Reference
Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
Journal
Reference
Authors
Kang H, Kiess A, Chung CH
Title
Emerging biomarkers in head and neck cancer in the era of genomics.
Journal
Reference
Authors
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
Title
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
Journal
Reference
Authors
Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
Title
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
Journal
Reference
Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
Journal
Reference
Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
Title
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
Journal
Reference
Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
Journal
Reference
Authors
Longnecker R
Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
Journal
Reference
Authors
El-Sharkawy A, Al Zaidan L, Malki A
Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
Journal
Reference
Authors
Dolcetti R, Masucci MG
Title
Epstein-Barr virus: induction and control of cell transformation.
Journal
Reference
Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
Journal
Related pathway
mmyo04612 Antigen processing and presentation
mmyo04620 Toll-like receptor signaling pathway
mmyo04622 RIG-I-like receptor signaling pathway
KO pathway
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