KEGG   PATHWAY: morg05165
Entry
morg05165                   Pathway                                
Name
Human papillomavirus infection - Microtus oregoni (creeping vole)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
morg05165  Human papillomavirus infection
morg05165

Organism
Microtus oregoni (creeping vole) [GN:morg]
Gene
121441513  Wnt1; proto-oncogene Wnt-1 [KO:K03209]
121463415  Wnt2; protein Wnt-2 [KO:K00182]
121437971  Wnt2b; protein Wnt-2b [KO:K00182]
121457172  Wnt3a; protein Wnt-3a [KO:K00312]
121436221  Wnt3; proto-oncogene Wnt-3 [KO:K00312]
121448785  Wnt4; protein Wnt-4 [KO:K00408]
121455289  Wnt5a; protein Wnt-5a isoform X1 [KO:K00444]
121435324  Wnt5b; protein Wnt-5b [KO:K00444]
121447393  Wnt6; protein Wnt-6 isoform X1 [KO:K00445]
121461270  Wnt7b; protein Wnt-7b isoform X1 [KO:K00572]
121465932  Wnt7a; protein Wnt-7a isoform X1 [KO:K00572]
121454090  Wnt8b; protein Wnt-8b [KO:K00714]
121453656  protein Wnt-8a [KO:K00714]
121442954  protein Wnt-8a-like [KO:K00714]
121456099  Wnt9a; protein Wnt-9a [KO:K01064]
121436027  Wnt9b; protein Wnt-9b [KO:K01064]
121447471  Wnt10a; protein Wnt-10a [KO:K01357]
121441477  Wnt10b; protein Wnt-10b [KO:K01357]
121459039  protein Wnt-11 isoform X1 [KO:K01384]
121450881  protein Wnt-11 isoform X1 [KO:K01384]
121463445  Wnt16; protein Wnt-16 [KO:K01558]
121458637  frizzled-7 [KO:K02432]
121458999  frizzled-1 [KO:K02432]
121445141  frizzled-7 [KO:K02432]
121434768  frizzled-1 [KO:K02432]
121436322  Fzd2; frizzled-2 [KO:K02235]
121458839  Fzd3; frizzled-3 isoform X1 [KO:K02329]
121446844  Fzd4; frizzled-4 [KO:K02354]
121447041  Fzd8; frizzled-8 [KO:K02375]
121433430  Fzd5; frizzled-5 [KO:K02375]
121437706  Fzd6; frizzled-6 [KO:K02376]
121446230  Fzd9; frizzled-9 [KO:K02842]
121446467  Fzd10; frizzled-10 [KO:K02842]
121456540  Dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
121464917  Dvl3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
121448306  segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
121443553  segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
121461919  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
121463835  Axin1; axin-1 isoform X1 [KO:K02157]
121436256  Axin2; axin-2 isoform X1 [KO:K04385]
121459412  Apc2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
121453526  adenomatous polyposis coli protein isoform X1 [KO:K02085]
121443013  adenomatous polyposis coli protein-like isoform X1 [KO:K02085]
121464283  Ctnnb1; catenin beta-1 [KO:K02105]
121445287  casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
121440580  Csnk1a1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
121463282  LOW QUALITY PROTEIN: telomerase reverse transcriptase-like [KO:K11126] [EC:2.7.7.49]
121433658  Tert; telomerase reverse transcriptase isoform X1 [KO:K11126] [EC:2.7.7.49]
121456269  Tcf7; transcription factor 7 isoform X1 [KO:K02620]
121437942  Tcf7l1; transcription factor 7-like 1 isoform X1 [KO:K04490]
121453859  Tcf7l2; transcription factor 7-like 2 isoform X1 [KO:K04491]
121453370  Ube3a; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
121433854  Tlr3; toll-like receptor 3 [KO:K05401]
121459211  Ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
121434311  Traf3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
121446542  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
121461912  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
121451666  Irf3; interferon regulatory factor 3 [KO:K05411]
121447990  Ifnb1; interferon beta [KO:K05415]
121461086  histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
121463856  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
121464786  transcriptional adapter 3-like [KO:K11315]
121433068  Tada3; transcriptional adapter 3 [KO:K11315]
121456449  Tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
121438038  Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
121454138  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
121446866  Pard3; partitioning defective 3 homolog isoform X1 [KO:K04237]
121460470  Pard6b; partitioning defective 6 homolog beta [KO:K06093]
121440114  Pard6g; partitioning defective 6 homolog gamma [KO:K06093]
121447227  Pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
121452820  Prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
121448043  protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
121443525  protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
121448012  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
121461215  Scrib; protein scribble homolog isoform X1 [KO:K16175]
121461810  Dlg1; disks large homolog 1 isoform X1 [KO:K12076]
121440973  Dlg2; disks large homolog 2 isoform X1 [KO:K12075]
121444944  disks large homolog 3 isoform X1 [KO:K21098]
121443291  disks large homolog 3-like isoform X1 [KO:K21098]
121457164  Llgl1; lethal(2) giant larvae protein homolog 1 [KO:K06094]
121436215  Llgl2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
121459317  Crb3; protein crumbs homolog 3 [KO:K06090]
121447988  Patj; inaD-like protein isoform X1 [KO:K06092]
121452254  Pals1; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
121440884  Vwf; von Willebrand factor [KO:K03900]
121465637  Thbs1; thrombospondin-1 [KO:K16857]
121455743  Thbs4; thrombospondin-4 [KO:K04659]
121462777  cartilage oligomeric matrix protein [KO:K04659]
121466624  Thbs2; thrombospondin-2 [KO:K04659]
121450897  Thbs3; thrombospondin-3 [KO:K04659]
121433346  Fn1; fibronectin isoform X1 [KO:K05717]
121456450  Col1a1; collagen alpha-1(I) chain [KO:K06236]
121463383  Col1a2; collagen alpha-2(I) chain [KO:K06236]
121441438  Col2a1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
121462265  Col4a2; collagen alpha-2(IV) chain [KO:K06237]
121462266  Col4a1; collagen alpha-1(IV) chain [KO:K06237]
121436876  Col4a5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
121436956  collagen alpha-6(IV) chain-like [KO:K06237]
121437118  LOW QUALITY PROTEIN: collagen alpha-6(IV) chain-like [KO:K06237]
121437119  LOW QUALITY PROTEIN: collagen alpha-5(IV) chain-like [KO:K06237]
121446838  Col4a4; collagen alpha-4(IV) chain [KO:K06237]
121446839  Col4a3; collagen alpha-3(IV) chain [KO:K06237]
121464154  Col6a6; collagen alpha-6(VI) chain [KO:K06238]
121464389  collagen alpha-4(VI) chain-like [KO:K06238]
121464401  Col6a5; collagen alpha-5(VI) chain [KO:K06238]
121447015  Col6a3; collagen alpha-3(VI) chain [KO:K06238]
121435515  Col6a2; collagen alpha-2(VI) chain [KO:K06238]
121435588  Col6a1; collagen alpha-1(VI) chain [KO:K06238]
121450869  Col9a1; collagen alpha-1(IX) chain [KO:K08131]
121440803  Col9a3; collagen alpha-3(IX) chain [KO:K08131]
121448750  Col9a2; collagen alpha-2(IX) chain [KO:K08131]
121458908  laminin subunit alpha-1 [KO:K05637]
121442781  laminin subunit alpha-1-like [KO:K05637]
121449461  Lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
121453302  Lama3; laminin subunit alpha-3 isoform X1 [KO:K06240]
121445218  laminin subunit alpha-3 isoform X1 [KO:K06240]
121440792  Lama5; laminin subunit alpha-5 [KO:K06240]
121449623  Lama4; laminin subunit alpha-4 isoform X1 [KO:K06241]
121452417  Lamb1; laminin subunit beta-1 isoform X1 [KO:K05636]
121464439  Lamb2; laminin subunit beta-2 [KO:K06243]
121435831  Lamb3; laminin subunit beta-3 [KO:K06244]
121455022  Lamc1; laminin subunit gamma-1 [KO:K05635]
121455243  Lamc2; laminin subunit gamma-2 [KO:K06246]
121463159  Lamc3; laminin subunit gamma-3 isoform X1 [KO:K06247]
121456435  Chad; chondroadherin [KO:K06248]
121458765  Reln; reelin [KO:K06249] [EC:3.4.21.-]
121434713  reelin-like [KO:K06249] [EC:3.4.21.-]
121440975  Spp1; osteopontin [KO:K06250]
121456233  Vtn; vitronectin [KO:K06251]
121454939  Tnr; tenascin-R isoform X1 [KO:K06252]
121455220  Tnn; tenascin-N [KO:K06252]
121433818  Tnc; LOW QUALITY PROTEIN: tenascin [KO:K06252]
121435215  Tnxb; tenascin-X isoform X1 [KO:K06252]
121440996  bone sialoprotein 2 isoform X1 [KO:K06253]
121455632  Itga1; integrin alpha-1 [KO:K06480]
121455957  Itga2; integrin alpha-2 [KO:K06481]
121436258  Itga2b; integrin alpha-IIb [KO:K06476]
121456530  Itga3; integrin alpha-3 isoform X1 [KO:K06482]
121439315  Itga4; integrin alpha-4 [KO:K06483]
121459683  Itga5; integrin alpha-5 isoform X1 [KO:K06484]
121439279  integrin alpha-6 isoform X1 [KO:K06485]
121433233  Itga6; integrin alpha-6 isoform X1 [KO:K06485]
121458703  Itga7; integrin alpha-7 isoform X1 [KO:K06583]
121432633  Itga8; integrin alpha-8 [KO:K06584]
121464384  Itga9; integrin alpha-9 isoform X1 [KO:K06585]
121437996  Itga10; integrin alpha-10 [KO:K06586]
121466152  Itga11; integrin alpha-11 [KO:K06587]
121439259  Itgav; integrin alpha-V isoform X1 [KO:K06487]
121446963  Itgb1; integrin beta-1 isoform X1 [KO:K05719]
121436323  Itgb3; integrin beta-3 [KO:K06493]
121436074  Itgb4; integrin beta-4 [KO:K06525]
121461917  Itgb5; integrin beta-5 [KO:K06588]
121433208  Itgb6; integrin beta-6 [KO:K06589]
121459676  integrin beta-7-like [KO:K06590]
121444246  Itgb7; integrin beta-7 [KO:K06590]
121438607  Itgb8; integrin beta-8 isoform X1 [KO:K06591]
121461246  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
121445985  Pxn; paxillin isoform X1 [KO:K05760]
121435312  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
121435813  Tnfrsf1a; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A [KO:K03158]
121447075  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
121455415  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
121454281  Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
121457709  Fadd; FAS-associated death domain protein [KO:K02373]
121458619  caspase-8-like [KO:K04398] [EC:3.4.22.61]
121444834  caspase-8-like [KO:K04398] [EC:3.4.22.61]
121433874  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
121436273  Slc9a3r1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
121462294  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
121457153  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
121438281  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
121449197  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
121457440  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
121457507  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
121458392  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform-like [KO:K04354]
121453633  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
121436473  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
121442259  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
121455096  Ppp2r3b; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
121464273  Ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
121452278  Ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
121454177  Ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
121452145  Ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
121450864  Ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
121434405  Ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
121435833  Ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
121462616  Tsc1; hamartin isoform X1 [KO:K07206]
121463682  Tsc2; tuberin isoform X1 [KO:K07207]
121439898  Rheb; GTP-binding protein Rheb [KO:K07208]
121448014  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
121441746  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
121462285  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
121454174  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
121457121  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
121435620  Bak1; bcl-2 homologous antagonist/killer [KO:K14021]
121454562  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
121445248  platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
121440622  Pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
121464321  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121453059  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
121448116  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121441780  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
121455952  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121462841  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
121448002  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
121434429  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121449224  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121435875  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121452809  Foxo1; forkhead box protein O1 [KO:K07201]
121441659  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
121435589  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
121454505  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
121457865  G1/S-specific cyclin-D1 [KO:K04503]
121435389  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
121450483  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
121461982  cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
121463961  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
121463532  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
121451458  Ccne2; G1/S-specific cyclin-E2 [KO:K06626]
121443216  Ccne1; G1/S-specific cyclin-E1 [KO:K06626]
121464192  Cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
121459112  Rb1; retinoblastoma-associated protein [KO:K06618]
121460185  Rbl1; retinoblastoma-like protein 1 [KO:K04681]
121447599  Rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
121439032  26S proteasome regulatory subunit 4 [KO:K03062]
121434480  Psmc1; 26S proteasome regulatory subunit 4 [KO:K03062]
121460216  E2f1; transcription factor E2F1 [KO:K17454]
121452823  Ccna2; cyclin-A2 [KO:K06627]
121452921  Ccna1; cyclin-A1 [KO:K06627]
121464308  Atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
121450557  Vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
121454691  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
121462326  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
121437198  NF-kappa-B essential modulator-like isoform X1 [KO:K07210]
121440264  NF-kappa-B essential modulator isoform X1 [KO:K07210]
121450269  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
121454688  Rela; transcription factor p65 isoform X1 [KO:K04735]
121460179  Mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
121458325  Nfx1; transcriptional repressor NF-X1 isoform X1 [KO:K12236]
121438918  LOW QUALITY PROTEIN: histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
121448269  Hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
121449324  Hdac2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
121443315  LOW QUALITY PROTEIN: histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
121443415  LOW QUALITY PROTEIN: histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
121433321  Chd4; chromodomain-helicase-DNA-binding protein 4 isoform X1 [KO:K11643] [EC:5.6.2.-]
121456494  Irf1; interferon regulatory factor 1 [KO:K09444]
121462906  Tbpl2; TATA box-binding protein-like 2 [KO:K03120]
121466523  TATA-box-binding protein isoform X1 [KO:K03120]
121449284  Tbpl1; TATA box-binding protein-like 1 [KO:K03120]
121435269  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435270  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435271  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435272  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435273  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435274  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435275  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435277  RT1 class I histocompatibility antigen, AA alpha chain-like isoform X1 [KO:K06751]
121435283  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435313  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
121435364  class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like isoform X1 [KO:K06751]
121435376  class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like isoform X1 [KO:K06751]
121435377  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121435378  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
121435379  H-2 class I histocompatibility antigen, D-37 alpha chain-like [KO:K06751]
121435380  H-2 class I histocompatibility antigen, L-D alpha chain-like [KO:K06751]
121435381  H-2 class I histocompatibility antigen, L-D alpha chain-like isoform X1 [KO:K06751]
121435382  H-2 class I histocompatibility antigen, D-37 alpha chain-like isoform X1 [KO:K06751]
121435464  class I histocompatibility antigen, B alpha chain-like [KO:K06751]
121435500  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
121435594  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
121435668  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
121435669  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
121435693  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
121435695  putative HLA class I histocompatibility antigen, alpha chain H [KO:K06751]
121435698  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
121462586  B-cell receptor-associated protein 31-like [KO:K14009]
121437163  B-cell receptor-associated protein 31 [KO:K14009]
121440279  B-cell receptor-associated protein 31 [KO:K14009]
121461735  Atp6v1a; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
121463025  Atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
121437613  Atp6v1b1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
121437629  Atp6v1c1; V-type proton ATPase subunit C 1 [KO:K02148]
121438877  V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
121432453  V-type proton ATPase subunit C 2-like isoform X1 [KO:K02148]
121452271  Atp6v1d; V-type proton ATPase subunit D [KO:K02149]
121433102  Atp6v1e2; V-type proton ATPase subunit E 2 [KO:K02150]
121441885  Atp6v1e1; V-type proton ATPase subunit E 1 [KO:K02150]
121462527  V-type proton ATPase subunit F-like [KO:K02151]
121463218  Atp6v1f; V-type proton ATPase subunit F [KO:K02151]
121466308  V-type proton ATPase subunit F-like [KO:K02151]
121446616  Atp6v1g3; V-type proton ATPase subunit G 3 [KO:K02152]
121433871  Atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
121435331  Atp6v1g2; V-type proton ATPase subunit G 2 [KO:K02152]
121451932  Atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
121453994  Tcirg1; V-type proton ATPase 116 kDa subunit a3 isoform X1 [KO:K02154]
121463344  Atp6v0a4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
121445860  Atp6v0a2; V-type proton ATPase 116 kDa subunit a2 [KO:K02154]
121442434  Atp6v0a1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154]
121451903  Atp6v0d2; V-type proton ATPase subunit d 2 [KO:K02146]
121447285  Atp6v0d1; V-type proton ATPase subunit d 1 [KO:K02146]
121464043  Atp6v0e1; V-type proton ATPase subunit e 1 [KO:K02153]
121439903  Atp6v0e2; V-type proton ATPase subunit e 2 [KO:K02153]
121463567  Atp6v0c; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
121448334  Atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
121437018  V-type proton ATPase subunit S1-like [KO:K03662]
121440273  V-type proton ATPase subunit S1 [KO:K03662]
121466544  Egf; pro-epidermal growth factor [KO:K04357]
121459895  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
121463365  growth factor receptor-bound protein 2-like [KO:K04364]
121436142  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
121452307  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
121432861  Sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
121458090  Hras; GTPase HRas [KO:K02833]
121466497  Kras; GTPase KRas isoform X1 [KO:K07827]
121437938  Nras; GTPase NRas [KO:K07828]
121443425  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
121466018  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
121459389  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
121458143  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
121464725  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121455411  Ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
121433098  Ptger4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
121440831  neuroendocrine secretory protein 55-like [KO:K04632]
121440830  Gnas; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
121455756  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
121451033  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
121449799  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
121433487  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
121463404  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
121458259  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
121459918  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
121450873  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
121437635  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
121439698  Creb5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
121448791  Ubr4; E3 ubiquitin-protein ligase UBR4 isoform X1 [KO:K10691] [EC:2.3.2.27]
121442410  tubulin gamma-2 chain isoform X1 [KO:K10389]
121442423  Tubg1; tubulin gamma-1 chain [KO:K10389]
121442441  tubulin gamma-1 chain-like [KO:K10389]
121466038  Pkm; pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
121446439  pyruvate kinase PKM-like [KO:K00873] [EC:2.7.1.40]
121448125  interferon alpha-12-like [KO:K05414]
121448126  interferon alpha-12-like [KO:K05414]
121448127  interferon alpha-1-like [KO:K05414]
121448197  interferon alpha-12-like [KO:K05414]
121448198  interferon alpha-12-like [KO:K05414]
121448492  interferon alpha-12-like [KO:K05414]
121448496  interferon alpha-12-like [KO:K05414]
121448498  interferon alpha-12-like [KO:K05414]
121448501  interferon alpha-12-like [KO:K05414]
121448502  interferon alpha-12-like [KO:K05414]
121448504  interferon alpha-12 [KO:K05414]
121448505  interferon alpha-12-like [KO:K05414]
121448506  interferon alpha-12-like [KO:K05414]
121448508  interferon alpha-12-like [KO:K05414]
121448509  interferon alpha-12-like [KO:K05414]
121448510  interferon alpha-12-like [KO:K05414]
121448511  interferon alpha-12-like [KO:K05414]
121448512  interferon alpha-12-like [KO:K05414]
121448518  interferon alpha-12-like [KO:K05414]
121448524  interferon alpha-12-like [KO:K05414]
121448832  interferon alpha-1-like [KO:K05414]
121461778  Ifnar1; interferon alpha/beta receptor 1 [KO:K05130]
121461923  Ifnar2; interferon alpha/beta receptor 2 [KO:K05131]
121448662  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
121451603  Tyk2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
121458866  signal transducer and activator of transcription 1 [KO:K11220]
121442179  signal transducer and activator of transcription 1-like [KO:K11220]
121462696  Stat2; signal transducer and activator of transcription 2 [KO:K11221]
121434950  Irf9; interferon regulatory factor 9 isoform X1 [KO:K04693]
121432938  interferon-induced, double-stranded RNA-activated protein kinase-like [KO:K16195] [EC:2.7.11.1]
121433086  interferon-induced, double-stranded RNA-activated protein kinase-like isoform X1 [KO:K16195] [EC:2.7.11.1]
121444628  Oasl; 2'-5'-oligoadenylate synthase-like protein isoform X1 [KO:K14608]
121444647  2'-5'-oligoadenylate synthase-like protein 2 [KO:K14608]
121461816  interferon-induced GTP-binding protein Mx1-like [KO:K14754]
121461821  Mx1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
121443608  ubiquitin-like protein ISG15 [KO:K12159]
121448909  ubiquitin-like protein ISG15 [KO:K12159]
121460325  Jag1; protein jagged-1 [KO:K06052]
121462673  Notch1; neurogenic locus notch homolog protein 1 [KO:K02599]
121437905  Notch2; neurogenic locus notch homolog protein 2 [KO:K20994]
121432424  Notch3; neurogenic locus notch homolog protein 3 [KO:K20995]
121435218  Notch4; neurogenic locus notch homolog protein 4 [KO:K20996]
121452267  Psen1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
121461287  Mfng; beta-1,3-N-acetylglucosaminyltransferase manic fringe [KO:K05948] [EC:2.4.1.222]
121464623  beta-1,3-N-acetylglucosaminyltransferase lunatic fringe isoform X1 [KO:K05948] [EC:2.4.1.222]
121444099  beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]
121444594  beta-1,3-N-acetylglucosaminyltransferase radical fringe isoform X1 [KO:K05948] [EC:2.4.1.222]
121446582  beta-1,3-N-acetylglucosaminyltransferase lunatic fringe isoform X1 [KO:K05948] [EC:2.4.1.222]
121456667  Maml1; mastermind-like protein 1 [KO:K06061]
121452813  Maml3; mastermind-like protein 3 [KO:K06061]
121451640  Maml2; mastermind-like protein 2 [KO:K06061]
121460739  Rbpj; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
121460095  Rbpjl; recombining binding protein suppressor of hairless-like protein [KO:K06053]
121441557  recombining binding protein suppressor of hairless-like isoform X1 [KO:K06053]
121441558  recombining binding protein suppressor of hairless-like isoform X1 [KO:K06053]
121445176  Hes1; transcription factor HES-1 [KO:K06054]
121456342  Hes7; transcription factor HES-7 [KO:K09087]
121447142  Hes6; transcription cofactor HES-6 isoform X1 [KO:K09087]
121448577  Hes2; transcription factor HES-2 [KO:K09087]
121448703  Hes3; transcription factor HES-3 isoform X1 [KO:K09088]
121443593  transcription factor HES-5 [KO:K06055]
121448633  transcription factor HES-5 [KO:K06055]
121458205  Hey1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
121466688  hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
121448617  Heyl; hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091]
121449520  Hey2; hairy/enhancer-of-split related with YRPW motif protein 2 isoform X1 [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:20592731
  Authors
Moody CA, Laimins LA
  Title
Human papillomavirus oncoproteins: pathways to transformation.
  Journal
Nat Rev Cancer 10:550-60 (2010)
DOI:10.1038/nrc2886
Reference
PMID:25752815
  Authors
Chen J
  Title
Signaling pathways in HPV-associated cancers and therapeutic implications.
  Journal
Rev Med Virol 25 Suppl 1:24-53 (2015)
DOI:10.1002/rmv.1823
Reference
PMID:26008697
  Authors
Tummers B, Burg SH
  Title
High-risk human papillomavirus targets crossroads in immune signaling.
  Journal
Viruses 7:2485-506 (2015)
DOI:10.3390/v7052485
Reference
PMID:19684440
  Authors
Lehoux M, D'Abramo CM, Archambault J
  Title
Molecular mechanisms of human papillomavirus-induced carcinogenesis.
  Journal
Public Health Genomics 12:268-80 (2009)
DOI:10.1159/000214918
Reference
PMID:23164805
  Authors
Pang CL, Thierry F
  Title
Human papillomavirus proteins as prospective therapeutic targets.
  Journal
Microb Pathog 58:55-65 (2013)
DOI:10.1016/j.micpath.2012.11.002
Reference
PMID:19156753
  Authors
Yugawa T, Kiyono T
  Title
Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins.
  Journal
Rev Med Virol 19:97-113 (2009)
DOI:10.1002/rmv.605
Reference
PMID:17645777
  Authors
Narisawa-Saito M, Kiyono T
  Title
Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins.
  Journal
Cancer Sci 98:1505-11 (2007)
DOI:10.1111/j.1349-7006.2007.00546.x
Reference
PMID:11486705
  Authors
Wolf JK, Ramirez PT.
  Title
The molecular biology of cervical cancer.
  Journal
Cancer Invest 19:621-9 (2001)
DOI:10.1081/CNV-100104290
Reference
PMID:10793105
  Authors
zur Hausen H
  Title
Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis.
  Journal
J Natl Cancer Inst 92:690-8 (2000)
DOI:10.1093/jnci/92.9.690
Reference
PMID:16259056
  Authors
Kim YT, Zhao M
  Title
Aberrant cell cycle regulation in cervical carcinoma.
  Journal
Yonsei Med J 46:597-613 (2005)
DOI:10.3349/ymj.2005.46.5.597
Reference
PMID:15956361
  Authors
McCance DJ
  Title
Human papillomaviruses and cell signaling.
  Journal
Sci STKE 2005:pe29 (2005)
DOI:10.1126/stke.2882005pe29
Reference
PMID:15342967
  Authors
Motoyama S, Ladines-Llave CA, Luis Villanueva S, Maruo T
  Title
The role of human papilloma virus in the molecular biology of cervical carcinogenesis.
  Journal
Kobe J Med Sci 50:9-19 (2004)
Reference
PMID:24316445
  Authors
Tommasino M
  Title
The human papillomavirus family and its role in carcinogenesis.
  Journal
Semin Cancer Biol 26:13-21 (2014)
DOI:10.1016/j.semcancer.2013.11.002
Reference
PMID:26295406
  Authors
Bello JO, Nieva LO, Paredes AC, Gonzalez AM, Zavaleta LR, Lizano M
  Title
Regulation of the Wnt/beta-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins.
  Journal
Viruses 7:4734-55 (2015)
DOI:10.3390/v7082842
Reference
PMID:26289783
  Authors
Shah M, Anwar MA, Park S, Jafri SS, Choi S
  Title
In silico mechanistic analysis of IRF3 inactivation and high-risk HPV E6 species-dependent drug response.
  Journal
Sci Rep 5:13446 (2015)
DOI:10.1038/srep13446
Reference
PMID:26797638
  Authors
James CD, Roberts S
  Title
Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
  Journal
Pathogens 5:E8 (2016)
DOI:10.3390/pathogens5010008
Reference
PMID:26147797
  Authors
Ganti K, Broniarczyk J, Manoubi W, Massimi P, Mittal S, Pim D, Szalmas A, Thatte J, Thomas M, Tomaic V, Banks L
  Title
The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy.
  Journal
Viruses 7:3530-51 (2015)
DOI:10.3390/v7072785
Reference
PMID:21954943
  Authors
Subbaiah VK, Kranjec C, Thomas M, Banks L
  Title
PDZ domains: the building blocks regulating tumorigenesis.
  Journal
Biochem J 439:195-205 (2011)
DOI:10.1042/BJ20110903
Reference
PMID:23175122
  Authors
Banks L, Pim D, Thomas M
  Title
Human tumour viruses and the deregulation of cell polarity in cancer.
  Journal
Nat Rev Cancer 12:877-86 (2012)
DOI:10.1038/nrc3400
Reference
PMID:19029942
  Authors
Thomas M, Narayan N, Pim D, Tomaic V, Massimi P, Nagasaka K, Kranjec C, Gammoh N, Banks L
  Title
Human papillomaviruses, cervical cancer and cell polarity.
  Journal
Oncogene 27:7018-30 (2008)
DOI:10.1038/onc.2008.351
Reference
PMID:19901438
  Authors
Jayshree RS, Sreenivas A, Tessy M, Krishna S
  Title
Cell intrinsic & extrinsic factors in cervical carcinogenesis.
  Journal
Indian J Med Res 130:286-95 (2009)
Reference
PMID:16862386
  Authors
Garnett TO, Duerksen-Hughes PJ
  Title
Modulation of apoptosis by human papillomavirus (HPV) oncoproteins.
  Journal
Arch Virol 151:2321-35 (2006)
DOI:10.1007/s00705-006-0821-0
Reference
PMID:26022660
  Authors
Zhang L, Wu J, Ling MT, Zhao L, Zhao KN
  Title
The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses.
  Journal
Mol Cancer 14:87 (2015)
DOI:10.1186/s12943-015-0361-x
Reference
PMID:22078316
  Authors
Venuti A, Paolini F, Nasir L, Corteggio A, Roperto S, Campo MS, Borzacchiello G
  Title
Papillomavirus E5: the smallest oncoprotein with many functions.
  Journal
Mol Cancer 10:140 (2011)
DOI:10.1186/1476-4598-10-140
Reference
PMID:11753669
  Authors
DiMaio D, Mattoon D
  Title
Mechanisms of cell transformation by papillomavirus E5 proteins.
  Journal
Oncogene 20:7866-73 (2001)
DOI:10.1038/sj.onc.1204915
Reference
PMID:22262402
  Authors
Ganguly N
  Title
Human papillomavirus-16 E5 protein: oncogenic role and therapeutic value.
  Journal
Cell Oncol (Dordr) 35:67-76 (2012)
DOI:10.1007/s13402-011-0069-x
Reference
PMID:23731971
  Authors
DiMaio D, Petti LM
  Title
The E5 proteins.
  Journal
Virology 445:99-114 (2013)
DOI:10.1016/j.virol.2013.05.006
Reference
PMID:23403708
  Authors
De Marco F
  Title
Oxidative stress and HPV carcinogenesis.
  Journal
Viruses 5:708-31 (2013)
DOI:10.3390/v5020708
Reference
PMID:26643553
  Authors
Wieringa HW, van der Zee AG, de Vries EG, van Vugt MA
  Title
Breaking the DNA damage response to improve cervical cancer treatment.
  Journal
Cancer Treat Rev 42:30-40 (2016)
DOI:10.1016/j.ctrv.2015.11.008
Reference
PMID:19861444
  Authors
Chung CH, Gillison ML
  Title
Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications.
  Journal
Clin Cancer Res 15:6758-62 (2009)
DOI:10.1158/1078-0432.CCR-09-0784
Reference
PMID:11325599
  Authors
Koromilas AE, Li S, Matlashewski G
  Title
Control of interferon signaling in human papillomavirus infection.
  Journal
Cytokine Growth Factor Rev 12:157-70 (2001)
DOI:10.1016/S1359-6101(00)00023-X
Reference
PMID:10702232
  Authors
Park JS, Kim EJ, Kwon HJ, Hwang ES, Namkoong SE, Um SJ
  Title
Inactivation of interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein. Implication for the E7-mediated immune evasion mechanism in cervical carcinogenesis.
  Journal
J Biol Chem 275:6764-9 (2000)
DOI:10.1074/jbc.275.10.6764
Reference
PMID:22499770
  Authors
Sandberg A, Lindell G, Kallstrom BN, Branca RM, Danielsson KG, Dahlberg M, Larson B, Forshed J, Lehtio J
  Title
Tumor proteomics by multivariate analysis on individual pathway data for characterization of vulvar cancer phenotypes.
  Journal
Mol Cell Proteomics 11:M112.016998 (2012)
DOI:10.1074/mcp.M112.016998
Reference
PMID:9990017
  Authors
Zwerschke W, Mazurek S, Massimi P, Banks L, Eigenbrodt E, Jansen-Durr P
  Title
Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
  Journal
Proc Natl Acad Sci U S A 96:1291-6 (1999)
DOI:10.1073/pnas.96.4.1291
Reference
PMID:15175323
  Authors
Lu Z, Hu X, Li Y, Zheng L, Zhou Y, Jiang H, Ning T, Basang Z, Zhang C, Ke Y
  Title
Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
  Journal
J Biol Chem 279:35664-70 (2004)
DOI:10.1074/jbc.M403385200
Reference
PMID:18505829
  Authors
Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA
  Title
NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
  Journal
Mol Cell Biol 28:4819-28 (2008)
DOI:10.1128/MCB.01969-07
Reference
PMID:23536685
  Authors
Raff AB, Woodham AW, Raff LM, Skeate JG, Yan L, Da Silva DM, Schelhaas M, Kast WM
  Title
The evolving field of human papillomavirus receptor research: a review of binding and entry.
  Journal
J Virol 87:6062-72 (2013)
DOI:10.1128/JVI.00330-13
Related
pathway
morg04064  NF-kappa B signaling pathway
morg04110  Cell cycle
morg04115  p53 signaling pathway
morg04150  mTOR signaling pathway
morg04151  PI3K-Akt signaling pathway
morg04210  Apoptosis
morg04310  Wnt signaling pathway
morg04330  Notch signaling pathway
morg04510  Focal adhesion
morg04520  Adherens junction
morg04530  Tight junction
morg04612  Antigen processing and presentation
morg04620  Toll-like receptor signaling pathway
morg04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

DBGET integrated database retrieval system