KEGG   PATHWAY: ncar04062
Entry
ncar04062                   Pathway                                
Name
Chemokine signaling pathway - Sciurus carolinensis (gray squirrel)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
ncar04062  Chemokine signaling pathway
ncar04062

Other DBs
GO: 0070098
Organism
Sciurus carolinensis (gray squirrel) [GN:ncar]
Gene
124994036  growth-regulated protein homolog gamma-like [KO:K05505]
124994608  growth-regulated protein homolog gamma-like [KO:K05505]
124994642  alveolar macrophage chemotactic factor [KO:K05506]
124994640  platelet basic protein-like [KO:K10029]
124994380  C-X-C motif chemokine 15-like [KO:K10030]
124994632  interleukin-8 [KO:K10030]
124994671  C-X-C motif chemokine 9-like isoform X1 [KO:K05416]
124994809  C-X-C motif chemokine 10-like [KO:K12671]
124994953  C-X-C motif chemokine 11-like [KO:K12672]
124994976  C-X-C motif chemokine 13-like [KO:K10032]
124981239  C-X-C motif chemokine 16-like isoform X1 [KO:K10035]
124995014  platelet factor 4-like [KO:K05407]
124987531  C-X-C motif chemokine 14 [KO:K10033]
124962072  lymphotactin-like [KO:K05507]
124966827  fractalkine-like [KO:K05508]
124978984  C-C motif chemokine 1-like [KO:K05514]
124980085  C-C motif chemokine 2-like [KO:K14624]
124980086  C-C motif chemokine 2-like [KO:K14624]
124980480  C-C motif chemokine 3-like 1 [KO:K05408]
124980670  C-C motif chemokine 3-like [KO:K05408]
124980411  C-C motif chemokine 4 [KO:K12964]
124980286  C-C motif chemokine 5 [KO:K12499]
124980613  C-C motif chemokine 8-like [KO:K16596]
124980487  eotaxin-like [KO:K16597]
124980096  C-C motif chemokine 14-like [KO:K21092]
124980095  C-C motif chemokine 15-like isoform X1 [KO:K05511]
124981025  C-C motif chemokine 15-like [KO:K05511]
124980493  C-C motif chemokine 16-like [KO:K21093]
124967616  C-C motif chemokine 17-like [KO:K21083]
124964734  C-C motif chemokine 19 [KO:K05512]
124980663  C-C motif chemokine 20-like isoform X1 [KO:K14625]
124964623  C-C motif chemokine 21-like [KO:K16062]
124967260  C-C motif chemokine 22-like [KO:K21095]
124970542  C-C motif chemokine 24-like [KO:K21097]
124970791  C-C motif chemokine 26-like [KO:K21096]
124964014  C-C motif chemokine 27-like [KO:K16598]
124987149  C-C motif chemokine 28-like [KO:K05513]
124980526  C-X-C chemokine receptor type 2-like [KO:K05050]
124980660  C-X-C chemokine receptor type 1-like [KO:K04175]
124972346  C-X-C chemokine receptor type 3 [KO:K04188]
124980050  C-X-C chemokine receptor type 4 [KO:K04189]
124959663  C-X-C chemokine receptor type 5 [KO:K04190]
124969486  C-X-C chemokine receptor type 6-like [KO:K04191]
124968939  chemokine XC receptor 1-like [KO:K04193]
124968753  CX3C chemokine receptor 1 [KO:K04192]
124969328  C-C chemokine receptor type 8-like [KO:K04183]
124988916  C-C chemokine receptor type 6-like [KO:K04181]
124969141  C-C chemokine receptor type 9 [KO:K04184]
124968909  C-C chemokine receptor type 4 [KO:K04179]
124981199  C-C chemokine receptor type 7 isoform X1 [KO:K04182]
124968379  C-C chemokine receptor type 2-like [KO:K04177]
124968378  C-C chemokine receptor type 5 isoform X1 [KO:K04180]
124968711  C-C chemokine receptor type 1-like [KO:K04176]
124967857  probable C-C chemokine receptor type 3 [KO:K04178]
124979152  LOW QUALITY PROTEIN: C-C chemokine receptor type 10-like [KO:K04185]
124964444  LOW QUALITY PROTEIN: tyrosine-protein kinase JAK2-like [KO:K04447] [EC:2.7.10.2]
124968673  LOW QUALITY PROTEIN: tyrosine-protein kinase JAK3-like [KO:K11218] [EC:2.7.10.2]
124979200  signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
124983364  signal transducer and activator of transcription 2-like isoform X1 [KO:K11221]
124978933  signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
124979870  signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
124992673  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
124988012  guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
124991078  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
124990345  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
124987010  adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
124962927  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
124978229  LOW QUALITY PROTEIN: adenylate cyclase type 4-like [KO:K08044] [EC:4.6.1.1]
124992559  adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
124983776  adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
124966834  adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
124965096  adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
124970113  LOW QUALITY PROTEIN: adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
124985819  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
124969119  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
124985502  tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
124977986  tyrosine-protein kinase HCK isoform X1 [KO:K08893] [EC:2.7.10.2]
124959355  tyrosine-protein kinase Fgr [KO:K08891] [EC:2.7.10.2]
124977049  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
124982298  SHC-transforming protein 1 isoform X1 [KO:K06279]
124975378  SHC-transforming protein 2-like [KO:K17447]
124965516  SHC-transforming protein 3 isoform X1 [KO:K17448]
124978227  SHC-transforming protein 4 [KO:K17449]
124980188  growth factor receptor-bound protein 2 [KO:K04364]
124977045  son of sevenless homolog 2 [KO:K03099]
124963384  son of sevenless homolog 1 isoform X1 [KO:K03099]
124974041  LOW QUALITY PROTEIN: son of sevenless homolog 2-like [KO:K03099]
124958599  GTPase HRas isoform X1 [KO:K02833]
124991017  GTPase KRas-like [KO:K07827]
124982118  GTPase KRas isoform X1 [KO:K07827]
124962389  GTPase NRas [KO:K07828]
124971006  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
124990234  LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf-like [KO:K04365] [EC:2.7.11.1]
124977990  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
124990635  LOW QUALITY PROTEIN: mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
124970294  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
124993166  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
124993330  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
124963509  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
124986648  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
124968815  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
124991973  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
124980224  phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
124981277  phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
124983581  protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
124962260  LOW QUALITY PROTEIN: RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
124976076  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124966582  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124989730  forkhead box protein O3 [KO:K09408]
124985256  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
124983354  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
124971778  NF-kappa-B essential modulator isoform X1 [KO:K07210]
124978214  NF-kappa-B inhibitor alpha [KO:K04734]
124966815  NF-kappa-B inhibitor beta [KO:K02581]
124994613  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
124960546  transcription factor p65 [KO:K04735]
124958534  bcl2-associated agonist of cell death-like [KO:K02158]
124966844  LOW QUALITY PROTEIN: glycogen synthase kinase-3 alpha-like [KO:K08822] [EC:2.7.11.26]
124967375  glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
124992642  LOW QUALITY PROTEIN: glycogen synthase kinase-3 beta-like [KO:K03083] [EC:2.7.11.26]
124987174  tyrosine-protein kinase ITK/TSK isoform X1 [KO:K07363] [EC:2.7.10.2]
124969345  LOW QUALITY PROTEIN: proto-oncogene vav-like [KO:K05730]
124980429  guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
124964423  guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
124970154  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
124971456  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
124982630  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
124980331  ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
124958584  serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
124993558  cell division control protein 42 homolog [KO:K04393]
124990642  cell division control protein 42 homolog [KO:K04393]
124980858  cell division control protein 42 homolog isoform X1 [KO:K04393]
124971986  wiskott-Aldrich syndrome protein [KO:K05747]
124993416  transforming protein RhoA [KO:K04513]
124989136  transforming protein RhoA-like isoform X1 [KO:K04513]
124976920  transforming protein RhoA-like [KO:K04513]
124965296  rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
124962770  rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
124976089  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
124969987  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
124993231  guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
124978030  guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
124960444  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
124961969  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
124978139  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
124961463  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
124961876  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
124965653  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
124968657  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
124967414  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
124970655  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
124964520  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
124975713  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
124991054  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
124993726  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
124969192  putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
124990131  guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
124980134  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X1 [KO:K04549]
124976812  phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
124973929  LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein-like [KO:K12365]
124975789  LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein-like [KO:K12365]
124990290  engulfment and cell motility protein 1 isoform X1 [KO:K12366]
124986938  dedicator of cytokinesis protein 2 [KO:K12367]
124964882  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
124990910  paxillin isoform X1 [KO:K05760]
124967218  breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
124991190  crk-like protein [KO:K04438]
124980118  adapter molecule crk isoform X1 [KO:K04438]
124982353  protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
124964255  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
124976705  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
124959812  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
124977474  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
124972679  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
124977089  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
124966613  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
124958788  RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
124978224  ras-related protein Rap-1A [KO:K04353]
124982482  ras-related protein Rap-1b [KO:K07836]
124962289  partitioning defective 3 homolog isoform X1 [KO:K04237]
124992547  rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
124970211  LOW QUALITY PROTEIN: protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
124968791  protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
124970474  neutrophil cytosol factor 1 [KO:K08011]
124985824  rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
124993483  rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
124990808  beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
124960255  beta-adrenergic receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
124986734  G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
124994901  G protein-coupled receptor kinase 4-like isoform X1 [KO:K08291] [EC:2.7.11.16]
124984553  G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
124958432  beta-arrestin-1 isoform X1 [KO:K04439]
124979615  beta-arrestin-2 isoform X1 [KO:K04439]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
ncar04010  MAPK signaling pathway
ncar04060  Cytokine-cytokine receptor interaction
ncar04120  Ubiquitin mediated proteolysis
ncar04630  JAK-STAT signaling pathway
ncar04670  Leukocyte transendothelial migration
ncar04810  Regulation of actin cytoskeleton
KO pathway
ko04062   
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