KEGG   PATHWAY: oor05160
Entry
oor05160                    Pathway                                
Name
Hepatitis C - Orcinus orca (killer whale)
Description
Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
Pathway map
oor05160  Hepatitis C
oor05160

Organism
Orcinus orca (killer whale) [GN:oor]
Gene
101283356  LDLR; low-density lipoprotein receptor isoform X1 [KO:K12473]
101286813  SCARB1; scavenger receptor class B member 1 isoform X2 [KO:K13885]
101277772  CD81; CD81 antigen [KO:K06508]
101273755  CLDN19; claudin-19 [KO:K06087]
101285481  CLDN2; claudin-2 [KO:K06087]
101273517  CLDN7; claudin-7 [KO:K06087]
101270743  CLDN24; putative claudin-24 [KO:K06087]
101270062  CLDN23; claudin-23 [KO:K06087]
101279242  CLDN18; claudin-18 isoform X1 [KO:K06087]
101269602  CLDN14; claudin-14 [KO:K06087]
101287472  CLDN25; LOW QUALITY PROTEIN: putative claudin-25 [KO:K06087]
101288986  CLDN6; claudin-6 [KO:K06087]
101289236  CLDN9; claudin-9 [KO:K06087]
101278208  CLDN17; claudin-17 [KO:K06087]
101278450  CLDN8; claudin-8 [KO:K06087]
101276142  CLDN20; claudin-20 [KO:K06087]
101284769  CLDN1; claudin-1 [KO:K06087]
101285286  CLDN16; claudin-16 [KO:K06087]
101285278  CLDN5; claudin-5 [KO:K06087]
101280298  CLDN4; claudin-4 [KO:K06087]
101280563  CLDN3; claudin-3 [KO:K06087]
101272173  CLDN15; claudin-15 [KO:K06087]
101287132  CLDN11; claudin-11 [KO:K06087]
101271775  CLDN10; claudin-10 isoform X1 [KO:K06087]
101276911  CLDN12; claudin-12 [KO:K06087]
101289239  OCLN; occludin isoform X1 [KO:K06088]
101289192  2'-5'-oligoadenylate synthase 1 isoform X2 [KO:K14216] [EC:2.7.7.84]
101277868  OAS2; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
101286130  RNASEL; 2-5A-dependent ribonuclease isoform X2 [KO:K01165]
101277446  RIGI; LOW QUALITY PROTEIN: antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
101284556  MAVS; mitochondrial antiviral-signaling protein isoform X4 [KO:K12648]
101288184  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
101290315  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101273673  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X4 [KO:K07211] [EC:2.7.11.10]
101272168  IRF3; interferon regulatory factor 3 [KO:K05411]
101277458  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
101274041  interferon alpha-1-like [KO:K05414]
101275016  interferon alpha-1-like [KO:K05414]
101275275  interferon alpha-1-like [KO:K05414]
101287367  interferon alpha-3-like [KO:K05414]
125964698  interferon alpha-1-like [KO:K05414]
125964699  interferon alpha-1-like [KO:K05414]
125964701  interferon alpha-3-like [KO:K05414]
125964702  interferon alpha-3-like [KO:K05414]
125964703  interferon alpha-3-like [KO:K05414]
101289058  IFNB1; interferon beta [KO:K05415]
101282933  IFNG; interferon gamma [KO:K04687]
101278583  TLR3; toll-like receptor 3 [KO:K05401]
101271374  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
101277553  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
101289751  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X2 [KO:K02861] [EC:2.7.11.1]
101281072  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101285763  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101272428  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101289477  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101279857  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101270342  RELA; transcription factor p65 isoform X1 [KO:K04735]
101269870  TNF; tumor necrosis factor [KO:K03156]
101289273  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
101272505  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X3 [KO:K16194] [EC:2.7.11.1]
101270256  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
101282451  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
101288996  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
101284527  interferon-induced protein with tetratricopeptide repeats 1 isoform X1 [KO:K14217]
101278855  EIF3E; eukaryotic translation initiation factor 3 subunit E [KO:K03250]
101281288  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
101281369  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
101284843  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
101284215  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
101283958  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
101275383  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
101278346  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X2 [KO:K11219] [EC:2.7.10.2]
101272458  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
101281591  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
101272815  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
101282947  MX1; LOW QUALITY PROTEIN: interferon-induced GTP-binding protein Mx1 [KO:K14754]
101282697  LOW QUALITY PROTEIN: interferon-induced GTP-binding protein Mx2 [KO:K14754]
101274848  RSAD2; radical S-adenosyl methionine domain-containing protein 2 [KO:K15045]
101274740  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
101275690  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
101279135  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
101287295  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
101279750  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X2 [KO:K04354]
101281621  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
101289109  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
101286814  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
101282700  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101290150  PIAS1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706] [EC:2.3.2.-]
101283152  EGF; pro-epidermal growth factor [KO:K04357]
101275398  EGFR; epidermal growth factor receptor isoform X2 [KO:K04361] [EC:2.7.10.1]
101271441  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
101286587  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
105748221  LOW QUALITY PROTEIN: son of sevenless homolog 2-like [KO:K03099]
101284580  SOS2; son of sevenless homolog 2 isoform X2 [KO:K03099]
101271947  GTPase HRas-like isoform X4 [KO:K02833]
101286301  HRAS; GTPase HRas isoform X2 [KO:K02833]
101281897  KRAS; GTPase KRas isoform X2 [KO:K07827]
101276138  NRAS; GTPase NRas [KO:K07828]
101277195  BRAF; serine/threonine-protein kinase B-raf isoform X4 [KO:K04365] [EC:2.7.11.1]
101272984  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101271966  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
101275276  YWHAZ; 14-3-3 protein zeta/delta isoform X2 [KO:K16197]
101272111  YWHAQ; 14-3-3 protein theta isoform X1 [KO:K16197]
101269225  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
101271921  14-3-3 protein zeta/delta-like [KO:K16197]
101288060  14-3-3 protein theta-like [KO:K16197]
101284483  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
101289864  YWHAH; 14-3-3 protein eta [KO:K16198]
101278999  14-3-3 protein gamma-like isoform X1 [KO:K16198]
101288309  YWHAG; 14-3-3 protein gamma [KO:K16198]
101286388  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101287162  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101273287  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
101289394  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101277568  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101285437  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101281352  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649]
101278075  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101278974  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
101283011  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101272095  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101288103  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101273316  AKT1; RAC-alpha serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101283259  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101289583  CTNNB1; catenin beta-1 [KO:K02105]
101274967  BAD; bcl2-associated agonist of cell death [KO:K02158]
101288384  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
101285670  TP53; cellular tumor antigen p53 isoform X2 [KO:K04451]
101289729  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
101283760  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
101271733  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
101272870  RB1; retinoblastoma-associated protein isoform X2 [KO:K06618]
101275686  E2F1; transcription factor E2F1 isoform X1 [KO:K17454]
101286856  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
101269392  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
101282502  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101271709  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
101281303  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101272436  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101284022  FAS; tumor necrosis factor receptor superfamily member 6 isoform X5 [KO:K04390]
101272962  FADD; FAS-associated death domain protein isoform X1 [KO:K02373]
101281780  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
101289847  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
101282267  CFLAR; CASP8 and FADD-like apoptosis regulator isoform X2 [KO:K04724]
101277745  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
101285349  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
101281395  BAK1; bcl-2 homologous antagonist/killer isoform X2 [KO:K14021]
105747906  cytochrome c-like [KO:K08738]
101283052  cytochrome c [KO:K08738]
101275631  cytochrome c-like [KO:K08738]
105747703  cytochrome c 2 [KO:K08738]
101272869  cytochrome c-like [KO:K08738]
117203203  LOW QUALITY PROTEIN: cytochrome c-like [KO:K08738]
101280303  APAF1; apoptotic protease-activating factor 1 isoform X4 [KO:K02084]
101271677  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
101287944  PSME3; proteasome activator complex subunit 3 isoform X1 [KO:K06698]
101270600  RXRA; retinoic acid receptor RXR-alpha isoform X4 [KO:K08524]
101283267  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
101270749  NR1H3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
101273294  CCND1; G1/S-specific cyclin-D1 isoform X2 [KO:K04503]
101274490  MYC; myc proto-oncogene protein [KO:K04377]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20935  2-5A
Reference
PMID:24520529
  Authors
Hassan M, Selimovic D, El-Khattouti A, Ghozlan H, Haikel Y, Abdelkader O
  Title
Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies.
  Journal
World J Exp Med 2:7-25 (2012)
DOI:10.5493/wjem.v2.i2.7
Reference
PMID:23641066
  Authors
Yamauchi Y, Helenius A
  Title
Virus entry at a glance.
  Journal
J Cell Sci 126:1289-95 (2013)
DOI:10.1242/jcs.119685
Reference
PMID:24509809
  Authors
Feneant L, Levy S, Cocquerel L
  Title
CD81 and hepatitis C virus (HCV) infection.
  Journal
Viruses 6:535-72 (2014)
DOI:10.3390/v6020535
Reference
PMID:18081727
  Authors
Dubuisson J, Helle F, Cocquerel L
  Title
Early steps of the hepatitis C virus life cycle.
  Journal
Cell Microbiol 10:821-7 (2008)
DOI:10.1111/j.1462-5822.2007.01107.x
Reference
PMID:23675659
  Authors
Liang TJ, Ghany MG
  Title
Current and future therapies for hepatitis C virus infection.
  Journal
N Engl J Med 368:1907-17 (2013)
DOI:10.1056/NEJMra1213651
Reference
PMID:23836234
  Authors
Scheel TK, Rice CM
  Title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
  Journal
Nat Med 19:837-49 (2013)
DOI:10.1038/nm.3248
Reference
PMID:26586968
  Authors
Holmes JA, Thompson AJ
  Title
Interferon-free combination therapies for the treatment of hepatitis C: current insights.
  Journal
Hepat Med 7:51-70 (2015)
DOI:10.2147/HMER.S55864
Reference
PMID:15039538
  Authors
Taguchi T, Nagano-Fujii M, Akutsu M, Kadoya H, Ohgimoto S, Ishido S, Hotta H
  Title
Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner.
  Journal
J Gen Virol 85:959-69 (2004)
DOI:10.1099/vir.0.19513-0
Reference
PMID:19708811
  Authors
Horner SM, Gale M Jr
  Title
Intracellular innate immune cascades and interferon defenses that control hepatitis C virus.
  Journal
J Interferon Cytokine Res 29:489-98 (2009)
DOI:10.1089/jir.2009.0063
Reference
PMID:20457596
  Authors
Lemon SM
  Title
Induction and evasion of innate antiviral responses by hepatitis C virus.
  Journal
J Biol Chem 285:22741-7 (2010)
DOI:10.1074/jbc.R109.099556
Reference
PMID:23836238
  Authors
Horner SM, Gale M Jr
  Title
Regulation of hepatic innate immunity by hepatitis C virus.
  Journal
Nat Med 19:879-88 (2013)
DOI:10.1038/nm.3253
Reference
PMID:28862649
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:E24 (2017)
DOI:10.3390/vaccines5030024
Reference
PMID:25852264
  Authors
Yang DR, Zhu HZ
  Title
Hepatitis C virus and antiviral innate immunity: who wins at tug-of-war?
  Journal
World J Gastroenterol 21:3786-800 (2015)
DOI:10.3748/wjg.v21.i13.3786
Reference
PMID:16107833
  Authors
Gale M Jr, Foy EM
  Title
Evasion of intracellular host defence by hepatitis C virus.
  Journal
Nature 436:939-45 (2005)
DOI:10.1038/nature04078
Reference
PMID:17467654
  Authors
Bode JG, Brenndorfer ED, Haussinger D
  Title
Subversion of innate host antiviral strategies by the hepatitis C virus.
  Journal
Arch Biochem Biophys 462:254-65 (2007)
DOI:10.1016/j.abb.2007.03.033
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:16239065
  Authors
Pang R, Tse E, Poon RT
  Title
Molecular pathways in hepatocellular carcinoma.
  Journal
Cancer Lett 240:157-69 (2006)
DOI:10.1016/j.canlet.2005.08.031
Reference
PMID:15302943
  Authors
Macdonald A, Harris M
  Title
Hepatitis C virus NS5A: tales of a promiscuous protein.
  Journal
J Gen Virol 85:2485-502 (2004)
DOI:10.1099/vir.0.80204-0
Reference
PMID:21250384
  Authors
He Y, Staschke KA, Tan SL
  Title
HCV NS5A: A Multifunctional Regulator of Cellular Pathways and Virus Replication
  Journal
Hepatitis C Viruses: Genomes and Molecular Biology (2006)
Reference
PMID:12101418
  Authors
Lan KH, Sheu ML, Hwang SJ, Yen SH, Chen SY, Wu JC, Wang YJ, Kato N, Omata M, Chang FY, Lee SD
  Title
HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis.
  Journal
Oncogene 21:4801-11 (2002)
DOI:10.1038/sj.onc.1205589
Reference
PMID:11886269
  Authors
Majumder M, Ghosh AK, Steele R, Zhou XY, Phillips NJ, Ray R, Ray RB
  Title
Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice.
  Journal
Virology 294:94-105 (2002)
DOI:10.1006/viro.2001.1309
Reference
PMID:15381253
  Authors
Hassan M, Ghozlan H, Abdel-Kader O
  Title
Activation of RB/E2F signaling pathway is required for the modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells.
  Journal
Cell Signal 16:1375-85 (2004)
DOI:10.1016/j.cellsig.2004.04.005
Reference
PMID:11514734
  Authors
Kwun HJ, Jung EY, Ahn JY, Lee MN, Jang KL
  Title
p53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3.
  Journal
J Gen Virol 82:2235-41 (2001)
DOI:10.1099/0022-1317-82-9-2235
Reference
PMID:12056797
  Authors
Yamanaka T, Uchida M, Doi T
  Title
Innate form of HCV core protein plays an important role in the localization and the function of HCV core protein.
  Journal
Biochem Biophys Res Commun 294:521-7 (2002)
DOI:10.1016/S0006-291X(02)00507-7
Reference
PMID:22611309
  Authors
Lim EJ, Chin R, Angus PW, Torresi J
  Title
Enhanced apoptosis in post-liver transplant hepatitis C: effects of virus and immunosuppressants.
  Journal
World J Gastroenterol 18:2172-9 (2012)
DOI:10.3748/wjg.v18.i18.2172
Reference
PMID:17828818
  Authors
Fischer R, Baumert T, Blum HE
  Title
Hepatitis C virus infection and apoptosis.
  Journal
World J Gastroenterol 13:4865-72 (2007)
DOI:10.3748/wjg.v13.i36.4865
Reference
PMID:16611896
  Authors
Saito K, Meyer K, Warner R, Basu A, Ray RB, Ray R
  Title
Hepatitis C virus core protein inhibits tumor necrosis factor alpha-mediated apoptosis by a protective effect involving cellular FLICE inhibitory protein.
  Journal
J Virol 80:4372-9 (2006)
DOI:10.1128/JVI.80.9.4372-4379.2006
Reference
PMID:19148799
  Authors
Koike K
  Title
Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection.
  Journal
J Gastroenterol 44 Suppl 19:82-8 (2009)
DOI:10.1007/s00535-008-2276-4
Reference
PMID:17764115
  Authors
Tanaka N, Moriya K, Kiyosawa K, Koike K, Aoyama T
  Title
Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: implications for HCV-associated hepatocarcinogenesis.
  Journal
Int J Cancer 122:124-31 (2008)
DOI:10.1002/ijc.23056
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Related
pathway
oor03320  PPAR signaling pathway
oor04010  MAPK signaling pathway
oor04144  Endocytosis
oor04210  Apoptosis
oor04514  Cell adhesion molecules
oor04620  Toll-like receptor signaling pathway
oor04622  RIG-I-like receptor signaling pathway
oor04630  JAK-STAT signaling pathway
oor04668  TNF signaling pathway
KO pathway
ko05160   
LinkDB

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