KEGG   PATHWAY: otw04218
Entry
otw04218                    Pathway                                
Name
Cellular senescence - Oncorhynchus tshawytscha (Chinook salmon)
Description
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class
Cellular Processes; Cell growth and death
Pathway map
otw04218  Cellular senescence
otw04218

Other DBs
GO: 0090398
Organism
Oncorhynchus tshawytscha (Chinook salmon) [GN:otw]
Gene
112231247  transforming growth factor beta-1 proprotein [KO:K13375]
112228884  transforming growth factor beta-1 proprotein [KO:K13375]
112240152  transforming growth factor beta-1 proprotein-like [KO:K13375]
112255920  transforming growth factor beta-2 proprotein-like [KO:K13376]
112223175  transforming growth factor beta-2 proprotein [KO:K13376]
112234066  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
112221169  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
112217963  transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
112256698  transforming growth factor beta-3 proprotein [KO:K13377]
112238812  transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
112233166  transforming growth factor beta-3 proprotein-like [KO:K13377]
112260530  TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
112227836  tgfbr1b; TGF-beta receptor type-1 isoform X2 [KO:K04674] [EC:2.7.11.30]
112226882  TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
112215283  TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
112264984  TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
112225563  TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
112239812  LOW QUALITY PROTEIN: TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
112239013  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
112241489  TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
112229968  TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
121843252  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
112263143  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
112248205  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
112235777  mothers against decapentaplegic homolog 3 [KO:K23605]
112238080  smad3b; mothers against decapentaplegic homolog 3b isoform X1 [KO:K23605]
112238791  cdkn2a/b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
112216345  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
112254694  cyclin-dependent kinase 4-like isoform X1 [KO:K02089] [EC:2.7.11.22]
112259968  cyclin-dependent kinase 6 isoform X2 [KO:K02091] [EC:2.7.11.22]
112258622  cdk21; cyclin-dependent kinase 4 isoform X1 [KO:K02091] [EC:2.7.11.22]
112229496  cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
112218887  G1/S-specific cyclin-D1 [KO:K04503]
112252678  G1/S-specific cyclin-D1 [KO:K04503]
112263573  G1/S-specific cyclin-D1 [KO:K04503]
112249039  G1/S-specific cyclin-D1 [KO:K04503]
112214224  G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
112252585  G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
112216983  G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
112218786  ccnd2a; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
112259254  ccndx; LOW QUALITY PROTEIN: cyclin Dx [KO:K10151]
112254562  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
112228649  rb1; retinoblastoma-associated protein [KO:K06618]
112266855  rbl1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
112218825  rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
112252634  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
112264064  retinoblastoma-like protein 2 [KO:K16332]
112249362  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
112244985  transcription factor E2F1 [KO:K17454]
112221983  e2f1; transcription factor E2F1 [KO:K17454]
112262220  transcription factor E2F2-like [KO:K09389]
112255724  e2f2; transcription factor E2F2 [KO:K09389]
112238727  transcription factor E2F3 [KO:K06620]
112236875  e2f3; transcription factor E2F3 [KO:K06620]
112243729  transcription factor E2F3-like [KO:K06620]
112249215  transcription factor E2F4 isoform X1 [KO:K04682]
112260341  e2f5; transcription factor E2F5 isoform X1 [KO:K04682]
112252590  e2f4; transcription factor E2F4 [KO:K04682]
112263742  transcription factor E2F4 [KO:K04682]
112218793  transcription factor E2F4 [KO:K04682]
112267269  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112216060  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
112260202  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112227144  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112251044  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
112265788  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112266167  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
112260699  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112250738  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112260309  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112244626  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
112252131  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112226747  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112248937  phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
112230790  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
112234933  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
112250872  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
112220315  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112239895  foxo1a; forkhead box protein O1-A [KO:K07201]
112218371  forkhead box protein O1-A [KO:K07201]
112228186  forkhead box protein O1-A [KO:K07201]
112217801  foxo3b; forkhead box protein O3B [KO:K09408]
112261501  forkhead box protein O3 [KO:K09408]
112250331  forkhead box protein O3-like [KO:K09408]
112256920  forkhead box protein O3 [KO:K09408]
112217839  cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
112254565  cyclin-dependent kinase inhibitor 1C [KO:K06625]
112214357  cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
112216848  cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
112254710  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
112216259  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
112222881  ccne2; G1/S-specific cyclin-E2 [KO:K06626]
112263558  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
112249067  G1/S-specific cyclin-E1 [KO:K06626]
112222880  G1/S-specific cyclin-E2-like [KO:K06626]
112264791  H-2 class I histocompatibility antigen, Q9 alpha chain [KO:K06751]
112267276  major histocompatibility complex class I-related gene protein isoform X1 [KO:K06751]
112233299  major histocompatibility complex class I-related gene protein-like [KO:K06751]
112233300  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
112233323  H-2 class I histocompatibility antigen, alpha chain-like [KO:K06751]
112233327  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
112234362  LOW QUALITY PROTEIN: major histocompatibility complex class I-related gene protein [KO:K06751]
112264773  class I histocompatibility antigen, F10 alpha chain [KO:K06751]
112264767  major histocompatibility complex class I-related gene protein isoform X2 [KO:K06751]
112264770  H-2 class I histocompatibility antigen, Q10 alpha chain isoform X1 [KO:K06751]
112244620  class I histocompatibility antigen, F10 alpha chain isoform X1 [KO:K06751]
112252543  GTPase KRas isoform X1 [KO:K07827]
112226270  zgc:55558 [KO:K07827]
112218714  kras; GTPase KRas isoform X1 [KO:K07827]
112249307  rras2; ras-related protein R-Ras2 [KO:K07830]
112261637  rras; ras-related protein R-Ras [KO:K07830]
112261648  ras-related protein R-Ras [KO:K07830]
112263826  ras-related protein R-Ras2 isoform X1 [KO:K07830]
112253803  ras-related protein M-Ras [KO:K07831]
112225639  mrasa; ras-related protein M-Ras [KO:K07831]
112246677  ras-related protein M-Ras-like [KO:K07831]
112266533  ras-related protein M-Ras-like [KO:K07831]
112252501  GTPase HRas [KO:K02833]
112218668  GTPase HRas [KO:K02833]
112250387  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112256640  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112225150  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112261841  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112230362  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112265711  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112224566  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112265172  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112217662  RAC-alpha serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
112231417  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
112267273  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112219359  tsc1b; LOW QUALITY PROTEIN: hamartin [KO:K07206]
112248911  tsc1a; TSC complex subunit 1a isoform X1 [KO:K07206]
112230526  hamartin-like [KO:K07206]
112242265  LOW QUALITY PROTEIN: tuberin [KO:K07207]
112254607  GTP-binding protein Rheb [KO:K07208]
112217539  GTP-binding protein Rheb [KO:K07208]
112247671  GTP-binding protein Rheb isoform X1 [KO:K07208]
112215328  GTP-binding protein Rheb isoform X1 [KO:K07208]
112227773  GTP-binding protein Rheb isoform X1 [KO:K07208]
112241353  GTP-binding protein Rheb-like [KO:K07208]
121843888  GTP-binding protein Rheb-like [KO:K07208]
112215922  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
112253032  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112254533  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112224277  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112223442  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112252524  NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
112252789  NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
112256353  cyclin-A2 [KO:K06627]
112221066  cyclin-A2 [KO:K06627]
112238479  ccna1; cyclin-A1 [KO:K06627]
112220543  mybl2b; v-myb avian myeloblastosis viral oncogene homolog-like 2b [KO:K21769]
112254334  myb-related protein B isoform X2 [KO:K21769]
112236654  lin9; protein lin-9 homolog isoform X1 [KO:K21773]
112222746  protein lin-37 homolog isoform X1 [KO:K21774]
112226962  protein lin-37 homolog isoform X1 [KO:K21774]
112256684  protein lin-52 homolog [KO:K21775]
112233154  protein lin-52 homolog [KO:K21775]
112218416  tesmin; spexin prohormone 2 isoform X1 [KO:K21776]
112219642  protein lin-54 homolog [KO:K21776]
112257454  lin54; protein lin-54 homolog [KO:K21776]
112236719  rbb4l; histone-binding protein RBBP7 isoform X1 [KO:K10752]
112256623  histone-binding protein RBBP4 isoform X1 [KO:K10752]
112261862  histone-binding protein RBBP4 [KO:K10752]
112234199  forkhead box protein M1-like isoform X1 [KO:K09406]
112264571  forkhead box protein M1-like [KO:K09406]
112250064  mycb; transcriptional regulator Myc-B isoform X1 [KO:K04377]
112215682  transcriptional regulator Myc [KO:K04377]
112266912  mych; myelocytomatosis oncogene homolog [KO:K04377]
112254112  transcriptional regulator Myc-2 [KO:K04377]
112227947  transcriptional regulator Myc [KO:K04377]
112262208  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
112260048  cellular tumor antigen p53 [KO:K04451]
112214763  cellular tumor antigen p53 isoform X1 [KO:K04451]
112229014  tp53; cellular tumor antigen p53 [KO:K04451]
112244670  ras association domain-containing protein 5 isoform X1 [KO:K08015]
112254331  ras association domain-containing protein 5 isoform X4 [KO:K08015]
112250296  F-box and WD repeat domain-containing 11-B-like [KO:K03362]
112257606  F-box and WD repeat domain-containing 11-B isoform X1 [KO:K03362]
112256132  F-box and WD repeat domain-containing 11-B isoform X2 [KO:K03362]
112220820  F-box and WD repeat domain-containing 11-B [KO:K03362]
112218816  hipk3a; homeodomain-interacting protein kinase 3 isoform X1 [KO:K08826] [EC:2.7.11.1]
112266062  homeodomain-interacting protein kinase 4-like [KO:K08826] [EC:2.7.11.1]
112255370  hipk1b; homeodomain-interacting protein kinase 1 [KO:K08826] [EC:2.7.11.1]
112218752  homeodomain-interacting protein kinase 2-like isoform X8 [KO:K08826] [EC:2.7.11.1]
112216283  homeodomain-interacting protein kinase 1 isoform X1 [KO:K08826] [EC:2.7.11.1]
112253486  homeodomain-interacting protein kinase 3 [KO:K08826] [EC:2.7.11.1]
112221804  homeodomain-interacting protein kinase 1-like isoform X1 [KO:K08826] [EC:2.7.11.1]
112252559  homeodomain-interacting protein kinase 2-like isoform X7 [KO:K08826] [EC:2.7.11.1]
112259017  serine/threonine-protein phosphatase alpha-2 isoform [KO:K06269] [EC:3.1.3.16]
112248359  serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
112223856  ppp1cab; protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
112260058  serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
112250506  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
112258985  serine/threonine-protein phosphatase alpha-2 isoform [KO:K06269] [EC:3.1.3.16]
112217890  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
112214774  serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
112263044  serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
112215764  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
112222214  RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
112262497  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
112250875  map2k2a; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
112231367  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
112237794  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
112262493  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112251950  mapk3; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112251959  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112237408  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112242516  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112265611  protein c-ets-1-B isoform X1 [KO:K02678]
112228340  protein c-ets-1-B [KO:K02678]
112267185  protein c-ets-1-B isoform X1 [KO:K02678]
112257868  map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
112224035  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
121843802  dual specificity mitogen-activated protein kinase kinase 6-like isoform X1 [KO:K04433] [EC:2.7.12.2]
112252549  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
112214239  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
112214240  mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
112221631  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
112221641  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
112215918  mapk13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
112254157  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
112221833  mitogen-activated protein kinase 14A [KO:K04441] [EC:2.7.11.24]
112216970  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
112216971  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
112235071  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
112218743  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
112216384  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
112250716  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
112251192  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
112260284  growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
112249878  growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
112252104  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
112263967  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
112230512  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
112219828  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
112219829  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
112230565  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
112248817  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
112227088  growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
112253102  cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
112255192  cyclin-dependent kinase 1 isoform X1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
112230962  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
112220405  G2/mitotic-specific cyclin-B1 [KO:K05868]
112264049  G2/mitotic-specific cyclin-B1-like [KO:K05868]
112249181  G2/mitotic-specific cyclin-B2 isoform X2 [KO:K21770]
112263712  ccnb2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
112259703  ccnb3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
112231150  G2/mitotic-specific cyclin-B3 [KO:K21771]
112237647  mre11a; double-strand break repair protein MRE11 [KO:K10865]
112258132  rad50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
112235342  LOW QUALITY PROTEIN: nibrin [KO:K10867]
112235370  nbn; nibrin [KO:K10867]
112267156  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
112248230  serine/threonine-protein kinase Chk2-like [KO:K06641] [EC:2.7.11.1]
112263301  chek2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
112220955  rad9a; cell cycle checkpoint control protein RAD9A [KO:K10994] [EC:3.1.11.2]
112263046  rad9b; cell cycle checkpoint control protein RAD9B isoform X1 [KO:K10995]
112257353  rad1; cell cycle checkpoint protein RAD1 [KO:K02830] [EC:3.1.11.2]
112227739  hus1; checkpoint protein HUS1 isoform X1 [KO:K10903]
112267688  atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
112236999  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
112221034  sequestosome-1 [KO:K14381]
112256318  sqstm1; sequestosome-1 [KO:K14381]
112217691  gata4; transcription factor GATA-4 [KO:K09183]
112259034  E3 ubiquitin ligase TRAF3IP2 isoform X1 [KO:K21124]
112217531  traf3ip2a; E3 ubiquitin ligase TRAF3IP2 [KO:K21124]
112248139  traf3ip2l; uncharacterized protein traf3ip2l isoform X1 [KO:K21124]
112220841  nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
112256149  nuclear factor NF-kappa-B p105 subunit-like [KO:K02580]
112260059  transcription factor p65 [KO:K04735]
112214775  putative transcription factor p65 homolog isoform X1 [KO:K04735]
112235861  il6; interleukin-6 [KO:K05405]
112264462  interleukin-6-like isoform X1 [KO:K05405]
112220612  C-X-C motif chemokine 11-1 [KO:K10030]
112234506  permeability factor 2 [KO:K10030]
112247010  interleukin-8 [KO:K10030]
112234589  permeability factor 2-like [KO:K10030]
112264992  interleukin-8 [KO:K10030]
112226459  insulin-like growth factor-binding protein 3 [KO:K10138]
112248249  insulin-like growth factor-binding protein 3 [KO:K10138]
112251323  igfbp3; insulin-like growth factor-binding protein 3 [KO:K10138]
112260576  insulin-like growth factor-binding protein 3 isoform X1 [KO:K10138]
112259747  plasminogen activator inhibitor 1 [KO:K03982]
112214536  plasminogen activator inhibitor 1 [KO:K03982]
112248503  eukaryotic translation initiation factor 4E-binding protein 2 [KO:K07205]
112262850  eukaryotic translation initiation factor 4E-binding protein 2 [KO:K07205]
112239434  MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
112222267  MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
112215728  MAP kinase-activated protein kinase 2-like [KO:K04443] [EC:2.7.11.1]
112265110  mRNA decay activator protein ZFP36L1 [KO:K18753]
112250486  zfp36l1b; mRNA decay activator protein ZFP36L1b [KO:K18753]
112237118  mRNA decay activator protein ZFP36L2-A [KO:K18753]
112217918  mRNA decay activator protein ZFP36L1 [KO:K18753]
112261545  zfp36l1a; mRNA decay activator protein ZFP36L1a isoform X1 [KO:K18753]
112252867  mRNA decay activator protein ZFP36L2-A [KO:K18753]
112256895  mRNA decay activator protein ZFP36L1 [KO:K18753]
112266764  mRNA decay activator protein ZFP36L2 [KO:K18753]
112265104  mRNA decay activator protein ZFP36 isoform X1 [KO:K18753]
112266759  zgc:114130; mRNA decay activator protein ZFP36L1 isoform X1 [KO:K18753]
112255325  voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
112244799  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
112215828  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
112222121  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
112248245  transient receptor potential cation channel subfamily V member 4-like [KO:K04973]
112263282  trpv4; transient receptor potential cation channel subfamily V member 4 isoform X1 [KO:K04973]
112249377  trpm7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
112259847  calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
112231173  si:dkeyp-50d11.2; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
112214584  calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
112266445  capn1b; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
112224715  calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
112255810  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
112236242  capn1a; calpain 1, (mu/I) large subunit a isoform X1 [KO:K01367] [EC:3.4.22.52]
112256945  calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
112223208  calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
112266430  capn8; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
112266436  calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
112223950  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
112236240  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
112244558  calmodulin-1 [KO:K02183]
112228803  calm3b; calmodulin-1 [KO:K02183]
112250465  calmodulin-1 [KO:K02183]
112217936  calmodulin-1 [KO:K02183]
112219085  calml4b; calmodulin-like protein 4 [KO:K02183]
112241263  calml4a; calmodulin-like protein 4a [KO:K02183]
112255235  LOW QUALITY PROTEIN: calglandulin-like [KO:K02183]
112256797  calm1a; calmodulin-1 [KO:K02183]
112231342  calmodulin-1 isoform X1 [KO:K02183]
112244957  calmodulin-1 [KO:K02183]
112252861  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
112266669  calmodulin-1 [KO:K02183]
112265077  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
112261010  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
112214716  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
112228932  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
112248675  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
112262665  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
112219575  ppp3ccb; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
112220556  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
112230646  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
112257024  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
112257493  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
112265382  calcineurin subunit B type 1 isoform X1 [KO:K06268]
112230382  calcineurin subunit B type 1 [KO:K06268]
112224708  calcineurin subunit B type 1 [KO:K06268]
112223349  calcineurin subunit B type 1-like isoform X1 [KO:K06268]
112232340  nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
112230033  nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
112223134  nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
112264948  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
112222616  nuclear factor of activated T-cells, cytoplasmic 2-like [KO:K17332]
112255046  nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
112221783  nuclear factor of activated T-cells, cytoplasmic 2 isoform X3 [KO:K17332]
112216305  nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
112218821  nfatc3b; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
112252629  nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
112237386  nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
112260738  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
112227350  LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
112254359  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
112262812  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
112220132  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
112255286  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
112232084  inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
112218717  inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
112232649  inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
112221364  inositol 1,4,5-trisphosphate receptor type 3-like isoform X1 [KO:K04960]
112231200  si:dkey-251i10.1; ADP/ATP translocase 2 [KO:K05863]
112256202  ADP/ATP translocase 2 [KO:K05863]
112231671  slc25a4; ADP/ATP translocase 1 [KO:K05863]
112228151  ADP/ATP translocase 2-like [KO:K05863]
112220897  slc25a5; ADP/ATP translocase 2 [KO:K05863]
112261444  ADP/ATP translocase 2-like [KO:K05863]
112247602  peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
112256343  peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
112258095  voltage-dependent anion-selective channel protein 1-like isoform X1 [KO:K05862]
112228201  voltage-dependent anion-selective channel protein 1 [KO:K05862]
112258062  voltage-dependent anion-selective channel protein 2 [KO:K15040]
112253177  voltage-dependent anion-selective channel protein 2 [KO:K15040]
112256114  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
112224693  voltage-dependent anion-selective channel protein 2 [KO:K15040]
112219591  voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15041]
112262761  voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15041]
112248606  voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15041]
112257487  voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15041]
112243879  calcium uniporter protein, mitochondrial [KO:K20858]
121840053  mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07909  Sirolimus
C16844  Hydroxyl radical
Reference
PMID:24954210
  Authors
Munoz-Espin D, Serrano M
  Title
Cellular senescence: from physiology to pathology.
  Journal
Nat Rev Mol Cell Biol 15:482-96 (2014)
DOI:10.1038/nrm3823
Reference
PMID:26646499
  Authors
Childs BG, Durik M, Baker DJ, van Deursen JM
  Title
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
  Journal
Nat Med 21:1424-35 (2015)
DOI:10.1038/nm.4000
Reference
PMID:26105537
  Authors
Sharpless NE, Sherr CJ
  Title
Forging a signature of in vivo senescence.
  Journal
Nat Rev Cancer 15:397-408 (2015)
DOI:10.1038/nrc3960
Reference
PMID:26435346
  Authors
Fridlyanskaya I, Alekseenko L, Nikolsky N
  Title
Senescence as a general cellular response to stress: A mini-review.
  Journal
Exp Gerontol 72:124-8 (2015)
DOI:10.1016/j.exger.2015.09.021
Reference
PMID:27417123
  Authors
Lujambio A
  Title
To clear, or not to clear (senescent cells)? That is the question.
  Journal
Bioessays 38 Suppl 1:S56-64 (2016)
DOI:10.1002/bies.201670910
Reference
PMID:26564316
  Authors
Di Mitri D, Alimonti A
  Title
Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer.
  Journal
Trends Cell Biol 26:215-26 (2016)
DOI:10.1016/j.tcb.2015.10.005
Reference
PMID:27574725
  Authors
Francica P, Aebersold DM, Medova M
  Title
Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer.
  Journal
Biochem Pharmacol 126:1-12 (2017)
DOI:10.1016/j.bcp.2016.08.022
Reference
PMID:23982440
  Authors
Bartling B
  Title
Cellular senescence in normal and premature lung aging.
  Journal
Z Gerontol Geriatr 46:613-22 (2013)
DOI:10.1007/s00391-013-0543-3
Reference
PMID:24238962
  Authors
Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M
  Title
Programmed cell senescence during mammalian embryonic development.
  Journal
Cell 155:1104-18 (2013)
DOI:10.1016/j.cell.2013.10.019
Reference
PMID:26697828
  Authors
Herranz N, Gallage S, Gil J
  Title
TORn about SASP regulation.
  Journal
Cell Cycle 14:3771-2 (2015)
DOI:10.1080/15384101.2015.1105694
Reference
PMID:28410770
  Authors
Martin N, Bernard D
  Title
Calcium signaling and cellular senescence.
  Journal
Cell Calcium S0143-4160(17)30049-0 (2017)
DOI:10.1016/j.ceca.2017.04.001
Reference
PMID:25764980
  Authors
Farfariello V, Iamshanova O, Germain E, Fliniaux I, Prevarskaya N
  Title
Calcium homeostasis in cancer: A focus on senescence.
  Journal
Biochim Biophys Acta 1853:1974-9 (2015)
DOI:10.1016/j.bbamcr.2015.03.005
Reference
PMID:24062309
  Authors
McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA
  Title
Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype.
  Journal
J Biol Chem 288:32149-59 (2013)
DOI:10.1074/jbc.M113.493841
Reference
PMID:27288568
  Authors
Donninger H, Schmidt ML, Mezzanotte J, Barnoud T, Clark GJ
  Title
Ras signaling through RASSF proteins.
  Journal
Semin Cell Dev Biol 58:86-95 (2016)
DOI:10.1016/j.semcdb.2016.06.007
Reference
PMID:28455242
  Authors
Barnoud T, Schmidt ML, Donninger H, Clark GJ
  Title
The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.
  Journal
Cancer Lett 400:30-36 (2017)
DOI:10.1016/j.canlet.2017.04.030
Reference
PMID:26404840
  Authors
Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ
  Title
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
  Journal
Science 349:aaa5612 (2015)
DOI:10.1126/science.aaa5612
Reference
PMID:26777575
  Authors
Cao X, Li M
  Title
A New Pathway for Senescence Regulation.
  Journal
Genomics Proteomics Bioinformatics 13:333-5 (2015)
DOI:10.1016/j.gpb.2015.11.002
Reference
PMID:25564883
  Authors
Gire V, Dulic V
  Title
Senescence from G2 arrest, revisited.
  Journal
Cell Cycle 14:297-304 (2015)
DOI:10.1080/15384101.2014.1000134
Reference
PMID:24981831
  Authors
Mowla SN, Lam EW, Jat PS
  Title
Cellular senescence and aging: the role of B-MYB.
  Journal
Aging Cell 13:773-9 (2014)
DOI:10.1111/acel.12242
Reference
PMID:22546858
  Authors
Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Ronty M, Kinnula VL, Rahman I
  Title
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
  Journal
J Clin Invest 122:2032-45 (2012)
DOI:10.1172/JCI60132
Reference
PMID:23542362
  Authors
Hwang JW, Yao H, Caito S, Sundar IK, Rahman I
  Title
Redox regulation of SIRT1 in inflammation and cellular senescence.
  Journal
Free Radic Biol Med 61:95-110 (2013)
DOI:10.1016/j.freeradbiomed.2013.03.015
Related
pathway
otw04020  Calcium signaling pathway
otw04068  FoxO signaling pathway
otw04110  Cell cycle
otw04115  p53 signaling pathway
otw04150  mTOR signaling pathway
KO pathway
ko04218   
LinkDB

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