KEGG   PATHWAY: panu05161
Entry
panu05161                   Pathway                                
Name
Hepatitis B - Papio anubis (olive baboon)
Description
Hepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and converted into a covalently closed circular molecule cccDNA. The cccDNA is the template for transcription of all viral RNAs including the pregenomic RNA (pgRNA), encoding for 7 viral proteins: large, middle, and small envelope proteins (LHBs, MHBs, and SHBs) that form the surface antigen (HBsAg), the core antigen (HBcAg), the e antigen (HBeAg), the HBV polymerase, and the regulatory protein X (HBx). The pgRNA interacts with the viral polymerase protein to initiate the encapsidation into the core particles. Through endoplasmic reticulum, the core particles finish assembling with the envelope proteins and are released. HBV infection leads to a wide spectrum of liver diseases raging from chronic hepatitis, cirrhosis to hepatocellular carcinoma. The mechanism of liver injury is still not clear. However, HBV proteins target host proteins, involved in a variety of functions, thus regulating transcription, cellular signaling cascades, proliferation, differentiation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
Pathway map
panu05161  Hepatitis B
panu05161

Organism
Papio anubis (olive baboon) [GN:panu]
Gene
101006455  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X1 [KO:K06255]
101012376  SLC10A1; sodium/bile acid cotransporter [KO:K14341]
101006627  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
101009253  TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
100997116  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
101016512  TGFBR1; TGF-beta receptor type-1 isoform X2 [KO:K04674] [EC:2.7.11.30]
101023107  TGFBR2; TGF-beta receptor type-2 isoform X2 [KO:K04388] [EC:2.7.11.30]
101013089  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
100999911  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
101005010  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
101022320  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101019884  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101000645  MYC; myc proto-oncogene protein [KO:K04377]
101021894  EGR2; E3 SUMO-protein ligase EGR2 isoform X1 [KO:K12496]
101000512  EGR3; early growth response protein 3 isoform X1 [KO:K12497]
101027061  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
101002586  CREBBP; CREB-binding protein isoform X5 [KO:K04498] [EC:2.3.1.48]
101000210  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101001825  DDB1; DNA damage-binding protein 1 [KO:K10610]
100998564  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
100137396  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
101022263  YWHAQ; 14-3-3 protein theta isoform X4 [KO:K16197]
101021050  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
101022352  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
101012101  14-3-3 protein zeta/delta [KO:K16197]
101015667  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [KO:K04430] [EC:2.7.12.2]
101004976  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101008699  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101002278  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100510873  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X4 [KO:K02649]
101009981  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101002971  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100997634  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101000402  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100381179  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100998877  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101016447  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X5 [KO:K07209] [EC:2.7.11.10]
101023751  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101026781  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X6 [KO:K02580]
101017078  RELA; transcription factor p65 isoform X1 [KO:K04735]
101003884  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
101026183  BCL2; apoptosis regulator Bcl-2 isoform X3 [KO:K02161]
101012551  BAD; bcl2-associated agonist of cell death [KO:K02158]
101017433  FADD; FAS-associated death domain protein [KO:K02373]
101009470  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
101011831  CASP10; caspase-10 isoform X1 [KO:K04400] [EC:3.4.22.63]
101008656  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
101023208  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
101025906  cytochrome c-like [KO:K08738]
101020480  cytochrome c-like [KO:K08738]
101021327  cytochrome c-like [KO:K08738]
101014039  cytochrome c-like [KO:K08738]
101008579  cytochrome c [KO:K08738]
100997529  cytochrome c [KO:K08738]
101021349  cytochrome c-like [KO:K08738]
100997503  cytochrome c-like [KO:K08738]
101019410  cytochrome c-like [KO:K08738]
103878393  cytochrome c-like [KO:K08738]
108582823  cytochrome c-like [KO:K08738]
101014473  cytochrome c-like [KO:K08738]
101009907  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
101023728  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
101005329  LOW QUALITY PROTEIN: caspase-12 [KO:K04741] [EC:3.4.22.-]
101006161  BIRC5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
101006608  TP53; cellular tumor antigen p53 [KO:K04451]
100999197  CCNA2; cyclin-A2 [KO:K06627]
101003474  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
101025892  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
101000606  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
101025307  CCNE2; G1/S-specific cyclin-E2 isoform X3 [KO:K06626]
101017005  RB1; retinoblastoma-associated protein [KO:K06618]
101000533  E2F1; transcription factor E2F1 [KO:K17454]
101015623  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
101025116  E2F3; transcription factor E2F3 isoform X3 [KO:K06620]
100137266  ATP6AP1; V-type proton ATPase subunit S1 precursor [KO:K03662]
101016532  PRKCA; protein kinase C alpha type isoform X4 [KO:K02677] [EC:2.7.11.13]
101009865  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100137333  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100997330  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
101002848  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X2 [KO:K17332]
101000384  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X3 [KO:K17333]
100997355  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
101002872  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
101007171  JAK2; tyrosine-protein kinase JAK2 isoform X4 [KO:K04447] [EC:2.7.10.2]
101014985  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
101020681  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
100998929  STAT3; signal transducer and activator of transcription 3 isoform X9 [KO:K04692]
101005886  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101011342  STAT2; LOW QUALITY PROTEIN: signal transducer and activator of transcription 2 [KO:K11221]
101007479  STAT4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222]
100998364  signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
101000002  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
101023204  STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225]
101019427  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]
101023887  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
101025530  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101002675  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
101022024  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101003749  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101002992  HRAS; GTPase HRas isoform X2 [KO:K02833]
101017528  KRAS; GTPase KRas isoform X2 [KO:K07827]
101026253  NRAS; GTPase NRas isoform X2 [KO:K07828]
101010894  JUN; transcription factor AP-1 [KO:K04448]
101019266  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
101011350  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
101017891  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
101004296  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
101020406  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101004434  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
101008452  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101013627  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101007514  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X4 [KO:K09047]
100381196  CXCL8; interleukin-8 precursor [KO:K10030]
101016590  PCNA; proliferating cell nuclear antigen [KO:K04802]
101019640  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
101022780  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
101009029  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101008394  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101004074  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101012041  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101006756  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101021141  FOS; proto-oncogene c-Fos isoform X1 [KO:K04379]
101021974  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
103884712  TLR2; toll-like receptor 2 [KO:K10159]
101005327  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
101025351  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
101009041  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
101007351  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
101018336  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
101002649  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101011339  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
100997900  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
101013055  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
100381195  IL6; interleukin-6 precursor [KO:K05405]
101012583  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
101001515  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X4 [KO:K04433] [EC:2.7.12.2]
101001103  MAPK12; mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
101002393  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101024189  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101024771  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101011807  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
103885341  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
101003041  TLR3; toll-like receptor 3 [KO:K05401]
101015106  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
100997060  DDX58; probable ATP-dependent RNA helicase DDX58 isoform X2 [KO:K12646] [EC:5.6.2.6]
101024962  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
101008300  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
101015482  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
101001355  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X2 [KO:K07211] [EC:2.7.11.10]
100999858  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101023873  DDX3X; ATP-dependent RNA helicase DDX3X isoform X1 [KO:K11594] [EC:5.6.2.7]
101013579  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
101005316  IRF7; interferon regulatory factor 7 isoform X5 [KO:K09447]
101023828  LOW QUALITY PROTEIN: interferon alpha-21 [KO:K05414]
101016516  interferon alpha-1/13 [KO:K05414]
116270026  interferon alpha-1/13 [KO:K05414]
101019008  LOW QUALITY PROTEIN: interferon alpha-1/13 [KO:K05414]
101018652  LOW QUALITY PROTEIN: interferon alpha-1/13 [KO:K05414]
101017918  interferon alpha-8 [KO:K05414]
101018287  interferon alpha-2 [KO:K05414]
101019380  interferon alpha-6 [KO:K05414]
101021706  interferon alpha-14 [KO:K05414]
101023118  interferon alpha-4 [KO:K05414]
101024523  IFNB1; interferon beta [KO:K05415]
100137245  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
Compound
C00076  Calcium cation
Reference
PMID:30059722
  Authors
Caballero A, Tabernero D, Buti M, Rodriguez-Frias F
  Title
Hepatitis B virus: The challenge of an ancient virus with multiple faces and a remarkable replication strategy.
  Journal
Antiviral Res 158:34-44 (2018)
DOI:10.1016/j.antiviral.2018.07.019
Reference
PMID:22869468
  Authors
Walsh R, Locarnini S
  Title
Hepatitis B precore protein: pathogenic potential and therapeutic promise.
  Journal
Yonsei Med J 53:875-85 (2012)
DOI:10.3349/ymj.2012.53.5.875
Reference
PMID:26239691
  Authors
Liang TJ, Block TM, McMahon BJ, Ghany MG, Urban S, Guo JT, Locarnini S, Zoulim F, Chang KM, Lok AS
  Title
Present and future therapies of hepatitis B: From discovery to cure.
  Journal
Hepatology 62:1893-908 (2015)
DOI:10.1002/hep.28025
Reference
PMID:26776362
  Authors
Morikawa K, Suda G, Sakamoto N
  Title
Viral life cycle of hepatitis B virus: Host factors and druggable targets.
  Journal
Hepatol Res 46:871-7 (2016)
DOI:10.1111/hepr.12650
Reference
PMID:19201080
  Authors
Feitelson MA, Reis HM, Tufan NL, Sun B, Pan J, Lian Z
  Title
Putative roles of hepatitis B x antigen in the pathogenesis of chronic liver disease.
  Journal
Cancer Lett 286:69-79 (2009)
DOI:10.1016/j.canlet.2008.12.010
Reference
PMID:19263472
  Authors
Murata M, Matsuzaki K, Yoshida K, Sekimoto G, Tahashi Y, Mori S, Uemura Y, Sakaida N, Fujisawa J, Seki T, Kobayashi K, Yokote K, Koike K, Okazaki K
  Title
Hepatitis B virus X protein shifts human hepatic transforming growth factor (TGF)-beta signaling from tumor suppression to oncogenesis in early chronic hepatitis B.
  Journal
Hepatology 49:1203-17 (2009)
DOI:10.1002/hep.22765
Reference
PMID:15173177
  Authors
Yoo YG, Lee MO
  Title
Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor.
  Journal
J Biol Chem 279:36242-9 (2004)
DOI:10.1074/jbc.M401290200
Reference
PMID:16459163
  Authors
Zhang X, Zhang H, Ye L
  Title
Effects of hepatitis B virus X protein on the development of liver cancer.
  Journal
J Lab Clin Med 147:58-66 (2006)
DOI:10.1016/j.lab.2005.10.003
Reference
PMID:19854353
  Authors
Benhenda S, Cougot D, Buendia MA, Neuveut C
  Title
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
  Journal
Adv Cancer Res 103:75-109 (2009)
DOI:10.1016/S0065-230X(09)03004-8
Reference
PMID:21994562
  Authors
Benhenda S, Cougot D, Neuveut C, Buendia MA
  Title
Liver cell transformation in chronic HBV infection.
  Journal
Viruses 1:630-46 (2009)
DOI:10.3390/v1030630
Reference
PMID:11099494
  Authors
Diao J, Khine AA, Sarangi F, Hsu E, Iorio C, Tibbles LA, Woodgett JR, Penninger J, Richardson CD
  Title
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway.
  Journal
J Biol Chem 276:8328-40 (2001)
DOI:10.1074/jbc.M006026200
Reference
PMID:16891440
  Authors
Park NH, Song IH, Chung YH
  Title
Chronic hepatitis B in hepatocarcinogenesis.
  Journal
Postgrad Med J 82:507-15 (2006)
DOI:10.1136/pgmj.2006.047431
Reference
PMID:28820498
  Authors
Lin S, Zhang YJ
  Title
Interference of Apoptosis by Hepatitis B Virus.
  Journal
Viruses 9:E230 (2017)
DOI:10.3390/v9080230
Reference
PMID:16173017
  Authors
Zhang X, Dong N, Yin L, Cai N, Ma H, You J, Zhang H, Wang H, He R, Ye L
  Title
Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues.
  Journal
J Med Virol 77:374-81 (2005)
DOI:10.1002/jmv.20466
Reference
PMID:18481805
  Authors
Kim HJ, Kim SY, Kim J, Lee H, Choi M, Kim JK, Ahn JK
  Title
Hepatitis B virus X protein induces apoptosis by enhancing translocation of Bax to mitochondria.
  Journal
IUBMB Life 60:473-80 (2008)
DOI:10.1002/iub.68
Reference
PMID:21647825
  Authors
Ng SA, Lee C
  Title
Hepatitis B virus X gene and hepatocarcinogenesis.
  Journal
J Gastroenterol 46:974-90 (2011)
DOI:10.1007/s00535-011-0415-9
Reference
PMID:9195957
  Authors
Cong YS, Yao YL, Yang WM, Kuzhandaivelu N, Seto E
  Title
The hepatitis B virus X-associated protein, XAP3, is a protein kinase C-binding protein.
  Journal
J Biol Chem 272:16482-9 (1997)
DOI:10.1074/jbc.272.26.16482
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:9738022
  Authors
Lee YH, Yun Y
  Title
HBx protein of hepatitis B virus activates Jak1-STAT signaling.
  Journal
J Biol Chem 273:25510-5 (1998)
DOI:10.1074/jbc.273.39.25510
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Reference
PMID:17059849
  Authors
Chami M, Oules B, Paterlini-Brechot P
  Title
Cytobiological consequences of calcium-signaling alterations induced by human viral proteins.
  Journal
Biochim Biophys Acta 1763:1344-62 (2006)
DOI:10.1016/j.bbamcr.2006.09.025
Reference
PMID:11743185
  Authors
Ganem D
  Title
Virology. The X files--one step closer to closure.
  Journal
Science 294:2299-300 (2001)
DOI:10.1126/science.1067850
Reference
PMID:15132991
  Authors
Chung TW, Lee YC, Kim CH
  Title
Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential.
  Journal
FASEB J 18:1123-5 (2004)
DOI:10.1096/fj.03-1429fje
Reference
PMID:18605975
  Authors
Gurtsevitch VE
  Title
Human oncogenic viruses: hepatitis B and hepatitis C viruses and their role in hepatocarcinogenesis.
  Journal
Biochemistry (Mosc) 73:504-13 (2008)
DOI:10.1134/S0006297908050039
Reference
PMID:21994545
  Authors
Schadler S, Hildt E
  Title
HBV life cycle: entry and morphogenesis.
  Journal
Viruses 1:185-209 (2009)
DOI:10.3390/v1020185
Reference
PMID:28862649
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:E24 (2017)
DOI:10.3390/vaccines5030024
Reference
PMID:28704708
  Authors
Nosratabadi R, Alavian SM, Zare-Bidaki M, Shahrokhi VM, Arababadi MK
  Title
Innate immunity related pathogen recognition receptors and chronic hepatitis B infection.
  Journal
Mol Immunol 90:64-73 (2017)
DOI:10.1016/j.molimm.2017.07.002
Reference
PMID:24530748
  Authors
Bagheri V, Askari A, Arababadi MK, Kennedy D
  Title
Can Toll-Like Receptor (TLR) 2 be considered as a new target for immunotherapy against hepatitis B infection?
  Journal
Hum Immunol 75:549-54 (2014)
DOI:10.1016/j.humimm.2014.02.018
Reference
PMID:25550115
  Authors
Zhang E, Lu M
  Title
Toll-like receptor (TLR)-mediated innate immune responses in the control of hepatitis B virus (HBV) infection.
  Journal
Med Microbiol Immunol 204:11-20 (2015)
DOI:10.1007/s00430-014-0370-1
Reference
PMID:20375222
  Authors
Yu S, Chen J, Wu M, Chen H, Kato N, Yuan Z
  Title
Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3.
  Journal
J Gen Virol 91:2080-90 (2010)
DOI:10.1099/vir.0.020552-0
Reference
PMID:23363957
  Authors
Revill P, Yuan Z
  Title
New insights into how HBV manipulates the innate immune response to establish acute and persistent infection.
  Journal
Antivir Ther 18:1-15 (2013)
DOI:10.3851/IMP2542
Reference
PMID:28893934
  Authors
Hopcraft SE, Damania B
  Title
Tumour viruses and innate immunity.
  Journal
Philos Trans R Soc Lond B Biol Sci 372:20160267 (2017)
DOI:10.1098/rstb.2016.0267
Reference
PMID:22504921
  Authors
Dandri M, Locarnini S
  Title
New insight in the pathobiology of hepatitis B virus infection.
  Journal
Gut 61 Suppl 1:i6-17 (2012)
DOI:10.1136/gutjnl-2012-302056
Related
pathway
panu04010  MAPK signaling pathway
panu04064  NF-kappa B signaling pathway
panu04110  Cell cycle
panu04115  p53 signaling pathway
panu04151  PI3K-Akt signaling pathway
panu04210  Apoptosis
panu04620  Toll-like receptor signaling pathway
panu04622  RIG-I-like receptor signaling pathway
panu04630  JAK-STAT signaling pathway
KO pathway
ko05161   
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