KEGG   PATHWAY: pcoo05168
Entry
pcoo05168                   Pathway                                
Name
Herpes simplex virus 1 infection - Puma concolor (puma)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
pcoo05168  Herpes simplex virus 1 infection
pcoo05168

Organism
Puma concolor (puma) [GN:pcoo]
Gene
112853730  LTA; lymphotoxin-alpha [KO:K05468]
112852881  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
112871795  TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152]
112860577  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
112857763  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
112858003  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
112854253  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
112871176  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
112855073  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
112858048  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
112851941  RELA; transcription factor p65 [KO:K04735]
112865900  baculoviral IAP repeat-containing protein 3-like [KO:K16060]
112865907  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
112852822  C-C motif chemokine 2 [KO:K14624]
112865834  NECTIN1; nectin-1 [KO:K06081]
112850713  NECTIN2; nectin-2 [KO:K06531]
112860158  paired immunoglobulin-like type 2 receptor alpha isoform X1 [KO:K15411]
112870329  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
112848412  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
112867444  ITGA5; integrin alpha-5 [KO:K06484]
112862191  ITGB3; LOW QUALITY PROTEIN: integrin beta-3 [KO:K06493]
112869273  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
112868539  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
112851074  IRF3; LOW QUALITY PROTEIN: interferon regulatory factor 3 [KO:K05411]
112849621  IFNB1; interferon beta [KO:K05415]
112856999  TP53; LOW QUALITY PROTEIN: cellular tumor antigen p53 [KO:K04451]
112865031  C5; complement C5 [KO:K03994]
112870578  CFP; properdin [KO:K15412]
112858853  toll-like receptor 2 [KO:K10159]
112852470  TLR9; toll-like receptor 9 [KO:K10161]
112850482  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
112852158  IRF7; interferon regulatory factor 7 [KO:K09447]
112870031  TLR3; toll-like receptor 3 [KO:K05401]
112867801  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
112870846  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
112865434  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
112861992  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
112863443  TAB1; LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
112862397  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
112864068  IL1B; interleukin-1 beta [KO:K04519]
112852789  CCL5; C-C motif chemokine 5 [KO:K12499]
112866659  IL6; interleukin-6 [KO:K05405]
112853630  TNF; tumor necrosis factor [KO:K03156]
112849717  IL12A; interleukin-12 subunit alpha [KO:K05406]
112861083  IL12B; interleukin-12 subunit beta [KO:K05425]
112864196  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
112848925  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
112869235  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
112855336  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
112857735  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
112863806  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
112849322  interferon alpha-2-like [KO:K05414]
112857196  interferon beta-like [KO:K05414]
112862518  CGAS; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
112861316  TMEM173; stimulator of interferon genes protein [KO:K12654]
112870325  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
112864257  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
112851965  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
112859956  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
112864251  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
112864237  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
112855240  EIF2AK4; eIF-2-alpha kinase GCN2 [KO:K16196] [EC:2.7.11.1]
112855314  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
112870142  EIF2B1; translation initiation factor eIF-2B subunit alpha [KO:K03239]
112856039  EIF2B2; translation initiation factor eIF-2B subunit beta [KO:K03754]
112869560  EIF2B3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
112864347  EIF2B4; translation initiation factor eIF-2B subunit delta isoform X1 [KO:K03680]
112849604  EIF2B5; translation initiation factor eIF-2B subunit epsilon isoform X1 [KO:K03240]
112870096  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
112870260  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
112870493  OAS3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
112857855  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
112870844  HCFC1; host cell factor 1 [KO:K14966]
112863322  HCFC2; host cell factor 2 [KO:K27390]
112863157  POU2F1; POU domain, class 2, transcription factor 1 [KO:K09364]
112851332  POU2F2; POU domain, class 2, transcription factor 2 [KO:K09364]
112865831  POU2F3; POU domain, class 2, transcription factor 3 [KO:K09364]
112849641  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
112849290  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
112871857  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
112852708  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
112869860  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
112863559  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
112855980  IRF9; interferon regulatory factor 9 [KO:K04693]
112855091  zinc finger protein 84-like [KO:K09228]
112855092  zinc finger protein 140 [KO:K09228]
112849249  zinc finger protein 678-like [KO:K09228]
112868523  zinc finger protein 331-like [KO:K09228]
112868587  ZNF169; zinc finger protein 169 [KO:K09228]
112868593  ZNF658; zinc finger protein 658 [KO:K09228]
112868600  ZNF782; zinc finger protein 782 [KO:K09228]
112868601  ZNF510; zinc finger protein 510 [KO:K09228]
112868657  zinc finger protein 658B-like [KO:K09228]
112868672  ZNF484; zinc finger protein 484 [KO:K09228]
112855963  LOW QUALITY PROTEIN: zinc finger protein 585A-like [KO:K09228]
112855964  ZNF10; zinc finger protein 10 [KO:K09228]
112850000  ZFP37; zinc finger protein 37 homolog [KO:K09228]
112850062  zinc finger protein 620-like [KO:K09228]
112850060  zinc finger protein 883-like [KO:K09228]
112850129  zinc finger protein 620-like [KO:K09228]
112850136  ZNF621; zinc finger protein 621 [KO:K09228]
112850256  ZNF662; zinc finger protein 662 isoform X1 [KO:K09228]
112856093  ZNF764; zinc finger protein 764 isoform X1 [KO:K09228]
112856116  ZNF688; zinc finger protein 688 isoform X1 [KO:K09228]
112856248  zinc finger protein 501-like [KO:K09228]
112856259  ZNF689; zinc finger protein 689 [KO:K09228]
112856268  ZNF785; LOW QUALITY PROTEIN: zinc finger protein 785 [KO:K09228]
112856275  ZNF768; zinc finger protein 768 [KO:K09228]
112863257  ZNF684; zinc finger protein 684 [KO:K09228]
112863265  LOW QUALITY PROTEIN: zinc finger protein 684-like [KO:K09228]
112869460  ZNF133; zinc finger protein 133 isoform X1 [KO:K09228]
112869466  LOW QUALITY PROTEIN: zinc finger protein 525-like [KO:K09228]
112850675  zinc finger protein 416-like isoform X1 [KO:K09228]
112850680  ZNF599; zinc finger protein 599 [KO:K09228]
112850704  zinc finger protein 324A-like [KO:K09228]
112850773  ZNF114; zinc finger protein 114 [KO:K09228]
112856399  zinc finger protein 268 [KO:K09228]
112856489  zinc finger protein 605 isoform X1 [KO:K09228]
112856950  ZNF624; zinc finger protein 624 [KO:K09228]
112856952  ZNF286A; zinc finger protein 286A [KO:K09228]
112869889  ZNF596; zinc finger protein 596 [KO:K09228]
112869941  zinc finger protein 705A-like [KO:K09228]
112869942  zinc finger protein 705A-like [KO:K09228]
112869956  zinc finger protein 14-like [KO:K09228]
112869957  LOW QUALITY PROTEIN: zinc finger protein 501-like [KO:K09228]
112869958  zinc finger protein 14-like [KO:K09228]
112850821  zinc finger protein 665-like [KO:K09228]
112850850  zinc finger protein 345-like [KO:K09228]
112850851  zinc finger protein 2-like [KO:K09228]
112850852  zinc finger protein 577-like [KO:K09228]
112850853  zinc finger protein 649-like [KO:K09228]
112850854  ZNF614; LOW QUALITY PROTEIN: zinc finger protein 614 [KO:K09228]
112850865  zinc finger protein 829-like [KO:K09228]
112850866  LOW QUALITY PROTEIN: zinc finger protein 2 homolog [KO:K09228]
112850871  putative zinc finger protein 56 [KO:K09228]
112850875  LOW QUALITY PROTEIN: putative zinc finger protein 726P1 [KO:K09228]
112850876  zinc finger protein 883-like [KO:K09228]
112850879  zinc finger protein 345-like [KO:K09228]
112850882  zinc finger protein 260-like [KO:K09228]
112850885  zinc finger protein 501-like [KO:K09228]
112850887  LOW QUALITY PROTEIN: zinc finger protein 677-like [KO:K09228]
112850888  zinc finger protein 677-like [KO:K09228]
112850890  zinc finger protein 677-like [KO:K09228]
112850892  LOW QUALITY PROTEIN: zinc finger protein 677-like [KO:K09228]
112850894  zinc finger protein 677-like [KO:K09228]
112850896  zinc finger protein 665-like [KO:K09228]
112850899  zinc finger protein 345-like [KO:K09228]
112850901  zinc finger protein 883-like [KO:K09228]
112850902  LOW QUALITY PROTEIN: zinc finger protein 420-like [KO:K09228]
112850903  zinc finger protein 345-like [KO:K09228]
112850950  endothelial zinc finger protein induced by tumor necrosis factor alpha-like [KO:K09228]
112850955  zinc finger protein 805-like [KO:K09228]
112850956  LOW QUALITY PROTEIN: zinc finger protein 543-like [KO:K09228]
112850957  ZNF547; zinc finger protein 547 [KO:K09228]
112850958  LOW QUALITY PROTEIN: zinc finger protein 17-like [KO:K09228]
112850959  zinc finger protein 805-like [KO:K09228]
112850961  zinc finger protein 547-like [KO:K09228]
112850965  LOW QUALITY PROTEIN: zinc finger protein 551-like [KO:K09228]
112850967  LOW QUALITY PROTEIN: zinc finger protein 154-like [KO:K09228]
112850968  zinc finger protein 135-like [KO:K09228]
112850969  zinc finger protein 501-like [KO:K09228]
112850971  ZNF132; zinc finger protein 132 [KO:K09228]
112850987  ZNF304; zinc finger protein 304 isoform X1 [KO:K09228]
112850988  zinc finger protein 264-like [KO:K09228]
112850989  LOW QUALITY PROTEIN: zinc finger protein interacting with ribonucleoprotein K-like [KO:K09228]
112850990  zinc finger protein 772-like [KO:K09228]
112850991  zinc finger protein 773-like [KO:K09228]
112851008  zinc finger protein 567 isoform X1 [KO:K09228]
112851009  zinc finger protein 383-like isoform X1 [KO:K09228]
112851012  zinc finger protein 585A-like isoform X1 [KO:K09228]
112851015  ZNF792; zinc finger protein 792 [KO:K09228]
112851016  zinc finger protein 790-like [KO:K09228]
112851017  ZNF527; zinc finger protein 527 [KO:K09228]
112851018  ZNF568; zinc finger protein 568 [KO:K09228]
112851019  zinc finger protein 420-like isoform X1 [KO:K09228]
112851021  ZNF382; zinc finger protein 382 [KO:K09228]
112851028  ZNF793; zinc finger protein 793 [KO:K09228]
112851031  zinc finger protein 570 [KO:K09228]
112851104  zinc finger protein 28 homolog isoform X1 [KO:K09228]
112851106  zinc finger protein 708-like [KO:K09228]
112851108  zinc finger protein 260-like [KO:K09228]
112851109  ZNF667; zinc finger protein 667 [KO:K09228]
112851111  ZNF583; zinc finger protein 583 [KO:K09228]
112851112  zinc finger protein 470 [KO:K09228]
112851113  ZNF331; zinc finger protein 331 [KO:K09228]
112857048  zinc finger protein 436-like [KO:K09228]
112857220  ZNF23; zinc finger protein 23 [KO:K09228]
112857221  ZNF19; zinc finger protein 19 [KO:K09228]
112863709  ZNF79; zinc finger protein 79 [KO:K09228]
112864070  zinc finger protein 2 isoform X1 [KO:K09228]
112870203  ZFP69B; zinc finger protein 69 homolog B isoform X1 [KO:K09228]
112870220  ZFP69; zinc finger protein 69 homolog isoform X1 [KO:K09228]
112870252  ZNF74; zinc finger protein 74 [KO:K09228]
112851181  ZNF473; LOW QUALITY PROTEIN: zinc finger protein 473 [KO:K09228]
112851182  ZNF175; zinc finger protein 175 [KO:K09228]
112851183  ZNF615; zinc finger protein 615 [KO:K09228]
112851184  zinc finger protein 432-like isoform X1 [KO:K09228]
112851185  zinc finger protein 350-like [KO:K09228]
112851188  zinc finger protein 415-like [KO:K09228]
112851230  LOW QUALITY PROTEIN: zinc finger protein OZF-like [KO:K09228]
112851235  zinc finger protein 586-like [KO:K09228]
112851236  LOW QUALITY PROTEIN: zinc finger protein 501-like [KO:K09228]
112851256  zinc finger protein 181-like [KO:K09228]
112851258  ZNF30; LOW QUALITY PROTEIN: zinc finger protein 30 [KO:K09228]
112851279  zinc finger protein 420-like [KO:K09228]
112851280  LOW QUALITY PROTEIN: zinc finger protein 573-like [KO:K09228]
112851309  zinc finger protein 780B-like [KO:K09228]
112851353  ZNF45; zinc finger protein 45 [KO:K09228]
112851354  zinc finger protein-like [KO:K09228]
112851355  zinc finger protein 234-like [KO:K09228]
112851356  ZNF233; LOW QUALITY PROTEIN: zinc finger protein 233 [KO:K09228]
112851357  ZNF229; zinc finger protein 229 [KO:K09228]
112851358  zinc finger protein 418-like isoform X1 [KO:K09228]
112851359  zinc finger protein 211-like [KO:K09228]
112851360  zinc finger protein 256-like isoform X1 [KO:K09228]
112851361  ZNF544; zinc finger protein 544 [KO:K09228]
112851362  ZNF606; zinc finger protein 606 [KO:K09228]
112851364  ZNF8; zinc finger protein 8 [KO:K09228]
112851365  zinc finger protein 211-like isoform X1 [KO:K09228]
112851367  zinc finger protein 154-like isoform X1 [KO:K09228]
112851368  zinc finger protein 530-like [KO:K09228]
112851372  ZNF584; zinc finger protein 584 [KO:K09228]
112851373  ZNF671; zinc finger protein 671 [KO:K09228]
112851397  ZNF112; zinc finger protein 112 [KO:K09228]
112851399  ZNF227; zinc finger protein 227 [KO:K09228]
112851400  zinc finger protein 226-like isoform X1 [KO:K09228]
112851402  ZNF235; zinc finger protein 235 [KO:K09228]
112851403  ZNF283; zinc finger protein 283 [KO:K09228]
112851404  ZNF404; zinc finger protein 404 [KO:K09228]
112851422  ZNF180; zinc finger protein 180 [KO:K09228]
112851423  ZNF285; zinc finger protein 285 [KO:K09228]
112851510  zinc finger protein 25-like [KO:K09228]
112851512  LOW QUALITY PROTEIN: zinc finger protein 33B-like [KO:K09228]
112851513  zinc finger protein 33B-like [KO:K09228]
112851514  zinc finger protein 33B-like [KO:K09228]
112851515  zinc finger protein 37A-like [KO:K09228]
112851549  zinc finger protein 33B-like [KO:K09228]
112851550  ZNF248; zinc finger protein 248 [KO:K09228]
112851551  ZNF25; zinc finger protein 25 isoform X1 [KO:K09228]
112857465  ZFP1; zinc finger protein 1 homolog [KO:K09228]
112864145  zinc finger protein 501-like [KO:K09228]
112864146  zinc finger protein 2-like [KO:K09228]
112864254  ZNF514; zinc finger protein 514 [KO:K09228]
112870570  ZNF157; zinc finger protein 157 [KO:K09228]
112870571  ZNF41; LOW QUALITY PROTEIN: zinc finger protein 41 [KO:K09228]
112870572  ZNF630; zinc finger protein 630 [KO:K09228]
112870808  ZNF182; zinc finger protein 182 [KO:K09228]
112871110  ZNF275; LOW QUALITY PROTEIN: zinc finger protein 275 [KO:K09228]
112852245  zinc finger protein OZF-like [KO:K09228]
112852253  ZNF846; zinc finger protein 846 [KO:K09228]
112852289  zinc finger protein 709-like [KO:K09228]
112852290  LOW QUALITY PROTEIN: zinc finger protein 709-like [KO:K09228]
112852291  zinc finger protein 791-like [KO:K09228]
112852438  ZNF589; LOW QUALITY PROTEIN: zinc finger protein 589 [KO:K09228]
112872004  ZNF189; zinc finger protein 189 isoform X1 [KO:K09228]
112852666  ZNF317; zinc finger protein 317 [KO:K09228]
112852667  zinc finger protein 177-like [KO:K09228]
112852711  ZNF333; zinc finger protein 333 [KO:K09228]
112852801  ZNF554; zinc finger protein 554 [KO:K09228]
112852802  zinc finger protein 555-like [KO:K09228]
112852803  LOW QUALITY PROTEIN: zinc finger protein 556-like [KO:K09228]
112852804  zinc finger protein 883-like [KO:K09228]
112852805  zinc finger protein 77-like [KO:K09228]
112852806  LOW QUALITY PROTEIN: zinc finger protein 57-like [KO:K09228]
112852808  zinc finger protein 77-like [KO:K09228]
112852809  zinc finger protein 77-like [KO:K09228]
112852810  zinc finger protein 77-like [KO:K09228]
112852812  zinc finger protein 77-like [KO:K09228]
112859445  ZNF16; zinc finger protein 16 isoform X1 [KO:K09228]
112859446  ZNF34; zinc finger protein 34 [KO:K09228]
112859447  ZNF250; zinc finger protein 250 [KO:K09228]
112865531  ZNF214; zinc finger protein 214 [KO:K09228]
112865767  LOW QUALITY PROTEIN: zinc finger protein 205-like [KO:K09228]
112853054  zinc finger protein 791-like [KO:K09228]
112853178  ZNF597; zinc finger protein 597 [KO:K09228]
112853226  ZNF200; zinc finger protein 200 [KO:K09228]
112853240  ZNF205; zinc finger protein 205 [KO:K09228]
112859556  ZNF623; zinc finger protein 623 [KO:K09228]
112859653  zinc finger protein 7-like [KO:K09228]
112859940  zinc finger protein 501-like [KO:K09228]
112859965  ZNF316; zinc finger protein 316 [KO:K09228]
112859967  zinc finger protein 300-like [KO:K09228]
112853430  ZNF184; zinc finger protein 184 [KO:K09228]
112853618  ZFP57; zinc finger protein 57 homolog [KO:K09228]
112860071  ZNF3; zinc finger protein 3 isoform X1 [KO:K09228]
112860129  ZNF713; zinc finger protein 713 [KO:K09228]
112860138  zinc finger protein 12 isoform X1 [KO:K09228]
112866488  ZNF282; zinc finger protein 282 [KO:K09228]
112866489  ZNF783; protein ZNF783 [KO:K09228]
112866490  ZNF746; LOW QUALITY PROTEIN: zinc finger protein 746 [KO:K09228]
112860496  zinc finger protein 182-like [KO:K09228]
112866973  ZNF425; zinc finger protein 425 [KO:K09228]
112866974  ZNF398; LOW QUALITY PROTEIN: zinc finger protein 398 [KO:K09228]
112866976  ZNF777; zinc finger protein 777 [KO:K09228]
112866977  ZNF212; zinc finger protein 212 [KO:K09228]
112867008  ZNF786; zinc finger protein 786 [KO:K09228]
112860989  zinc finger protein 208-like [KO:K09228]
112860992  zinc finger protein 354C-like [KO:K09228]
112861060  ZNF300; zinc finger protein 300 isoform X1 [KO:K09228]
112848739  ZNF436; zinc finger protein 436 [KO:K09228]
112854593  ZNF485; zinc finger protein 485 [KO:K09228]
112854707  zinc finger protein 883-like [KO:K09228]
112867672  ZNF641; zinc finger protein 641 [KO:K09228]
112868195  zinc finger protein 271-like [KO:K09228]
112863468  IFNG; interferon gamma [KO:K04687]
112861963  IFNGR1; interferon gamma receptor 1 [KO:K05132]
112849760  IFNGR2; interferon gamma receptor 2 [KO:K05133]
112868696  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
112862436  DAXX; death domain-associated protein 6 [KO:K02308]
112867368  SP100; nuclear autoantigen Sp-100 [KO:K15413]
112855523  PML; protein PML [KO:K10054] [EC:2.3.2.-]
112862344  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
112862082  TAP2; LOW QUALITY PROTEIN: antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
112862480  TAPBP; tapasin [KO:K08058]
112854989  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
112852509  CALR; calreticulin [KO:K08057]
112861479  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
112853671  HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
112853699  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
112853701  HLA class I histocompatibility antigen, Cw-6 alpha chain-like [KO:K06751]
112853765  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
112853766  HLA class I histocompatibility antigen, Cw-6 alpha chain-like [KO:K06751]
112853799  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-OKO alpha chain [KO:K06751]
112855325  B2M; beta-2-microglobulin [KO:K08055]
112862042  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
112862071  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
112862094  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
112862131  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
112862364  HLA class II histocompatibility antigen, DO beta chain-like [KO:K06752]
112862858  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
112862859  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DRB1-10 beta chain-like [KO:K06752]
112862863  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
112860492  CD74; HLA class II histocompatibility antigen gamma chain [KO:K06505]
112849397  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112849524  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112848856  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
112861619  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112868847  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
112863208  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112851313  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112871843  TSC1; hamartin [KO:K07206]
112853203  TSC2; tuberin [KO:K07207]
112866512  RHEB; GTP-binding protein Rheb [KO:K07208]
112848905  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
112861965  SRPK1; SRSF protein kinase 1 [KO:K15409] [EC:2.7.11.1]
112853397  SRSF1; serine/arginine-rich splicing factor 1 [KO:K12890]
112861961  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
112855932  SRSF5; serine/arginine-rich splicing factor 5 [KO:K12893]
112869495  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
112871849  SRSF4; serine/arginine-rich splicing factor 4 isoform X1 [KO:K12893]
112870162  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
112868776  LOW QUALITY PROTEIN: nuclear RNA export factor 3-like [KO:K14284]
112870711  nuclear RNA export factor 3-like [KO:K14284]
112870713  nuclear RNA export factor 2-like [KO:K14284]
112870715  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
112851890  NXF1; nuclear RNA export factor 1 [KO:K14284]
112863203  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
112851504  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
112867910  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
112851989  FADD; FAS-associated death domain protein [KO:K02373]
112871959  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
112867264  BID; BH3-interacting domain death agonist [KO:K04726]
112861960  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
112852108  BAD; bcl2-associated agonist of cell death [KO:K02158]
112868295  BCL2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
112869207  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
112870556  cytochrome c-like [KO:K08738]
112866368  cytochrome c, testis-specific-like [KO:K08738]
112866541  cytochrome c [KO:K08738]
112863492  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
112861739  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
112870035  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
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Vaccines (Basel) 4:E23 (2016)
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Reference
PMID:15163721
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
  Journal
J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
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Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
pcoo03040  Spliceosome
pcoo03050  Proteasome
pcoo04115  p53 signaling pathway
pcoo04151  PI3K-Akt signaling pathway
pcoo04210  Apoptosis
pcoo04610  Complement and coagulation cascades
pcoo04612  Antigen processing and presentation
pcoo04620  Toll-like receptor signaling pathway
pcoo04622  RIG-I-like receptor signaling pathway
pcoo04630  JAK-STAT signaling pathway
KO pathway
ko05168   
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