KEGG   PATHWAY: pviv05164
Entry
pviv05164                   Pathway                                
Name
Influenza A - Prionailurus viverrinus (fishing cat)
Description
Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains that cause pandemics arise from avian influenza virus by genetic reassortment among influenza viruses and two surface glycoproteins HA and NA form the basis of serologically distinct virus types. The innate immune system recognizes invaded virus through multiple mechanisms. Viral non-structural NS1 protein is a multifunctional virulence factor that interfere IFN-mediated antiviral response. It inhibits IFN production by blocking activation of transcription factors such as NF-kappa B and IRF3. NS1 further inhibits the activation of IFN-induced antiviral genes. PB1-F2 protein is another virulence factor that induce apoptosis of infected cells, which results in life-threatening bronchiolitis.
Class
Human Diseases; Infectious disease: viral
Pathway map
pviv05164  Influenza A
pviv05164

Organism
Prionailurus viverrinus (fishing cat) [GN:pviv]
Gene
125166706  PLG; plasminogen isoform X1 [KO:K01315] [EC:3.4.21.7]
125160507  serine protease 1 [KO:K01312] [EC:3.4.21.4]
125160511  anionic trypsin-like [KO:K01312] [EC:3.4.21.4]
125159128  transmembrane protease serine 2-like isoform X1 [KO:K09633] [EC:3.4.21.122]
125175000  TMPRSS2; transmembrane protease serine 2 [KO:K09633] [EC:3.4.21.122]
125176951  TMPRSS4; transmembrane protease serine 4 [KO:K09635] [EC:3.4.21.-]
125164879  transmembrane protease serine 11D-like [KO:K09641] [EC:3.4.21.-]
125154310  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
125148827  OAS3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
125148828  OAS2; 2'-5'-oligoadenylate synthase 2 isoform X1 [KO:K14216] [EC:2.7.7.84]
125149587  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
125155730  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
125156360  DNAJB1; dnaJ homolog subfamily B member 1 isoform X1 [KO:K09507]
125165903  DNAJC3; dnaJ homolog subfamily C member 3 [KO:K09523]
125163061  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
125168921  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
125151669  TRIM25; E3 ubiquitin/ISG15 ligase TRIM25 isoform X1 [KO:K10652] [EC:2.3.2.27]
125150585  RIGI; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
125171890  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
125176762  NLRX1; NLR family member X1 [KO:K12653]
125162013  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
125147812  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
125163712  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
125159286  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
125152517  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
125168989  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
125163593  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
125176511  RELA; transcription factor p65 [KO:K04735]
125158595  CALCOCO2; calcium-binding and coiled-coil domain-containing protein 2 isoform X1 [KO:K21348]
125163418  TLR3; toll-like receptor 3 [KO:K05401]
125161093  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
125167483  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
125169650  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
125155367  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
125153270  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
125154001  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
125170911  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
125150458  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
125157872  TLR7; toll-like receptor 7 isoform X1 [KO:K05404]
125174804  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
125170096  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
125176255  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
125162334  IL1A; interleukin-1 alpha [KO:K04383]
125162335  IL1B; interleukin-1 beta [KO:K04519]
125152182  IL6; interleukin-6 isoform X1 [KO:K05405]
125175189  IL12A; interleukin-12 subunit alpha [KO:K05406]
125148412  IL12B; interleukin-12 subunit beta [KO:K05425]
125165327  TNF; tumor necrosis factor [KO:K03156]
125163304  CXCL8; interleukin-8 [KO:K10030]
125151584  C-C motif chemokine 2 [KO:K14624]
125151883  CCL5; C-C motif chemokine 5 isoform X1 [KO:K12499]
125164441  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
125150189  ICAM1; intercellular adhesion molecule 1 isoform X1 [KO:K06490]
125150359  interferon alpha-like [KO:K05414]
125150391  interferon alpha-like [KO:K05414]
125150421  interferon alpha [KO:K05414]
125150431  interferon alpha [KO:K05414]
125150435  interferon alpha-like [KO:K05414]
125150749  interferon alpha-2-like [KO:K05414]
125150820  interferon alpha-2-like [KO:K05414]
125150775  interferon beta [KO:K05415]
125174560  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
125175082  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
125173198  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
125150147  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
125152024  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
125173414  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
125170213  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
125167371  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
125174999  interferon-induced GTP-binding protein Mx1 [KO:K14754]
125154926  ADAR; double-stranded RNA-specific adenosine deaminase isoform X1 [KO:K12968] [EC:3.5.4.37]
125167943  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
125170497  IFNG; interferon gamma [KO:K04687]
125166166  IFNGR1; interferon gamma receptor 1 [KO:K05132]
125174887  IFNGR2; interferon gamma receptor 2 [KO:K05133]
125150241  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
125153973  CIITA; MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
125166246  HLA class II histocompatibility antigen, DO beta chain-like isoform X1 [KO:K06752]
125166290  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
125166723  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
125165363  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
125165364  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
125165420  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
125165421  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
125165749  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
125165819  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
125165820  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
125165821  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
125165833  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
125167255  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
125154180  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
125176286  IL18; interleukin-18 [KO:K05482]
125150400  IL33; interleukin-33 [KO:K12967]
125161995  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
125172124  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
125150373  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
125174838  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
125175184  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
125172980  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
125167750  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125152911  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125155304  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125165233  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
125170174  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
125161240  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
125174978  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
125176960  LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A-like [KO:K04722]
125154937  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
125148091  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
125170769  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
125152758  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
125146980  FADD; FAS-associated death domain protein [KO:K02373]
125172184  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
125169613  BID; BH3-interacting domain death agonist [KO:K04726]
125152529  BAX; apoptosis regulator BAX [KO:K02159]
125166045  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
125170847  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
125159261  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
125163449  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
125163794  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
125157944  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
125154798  ADP/ATP translocase 2-like [KO:K05863]
125150988  cytochrome c-like [KO:K08738]
125161133  cytochrome c [KO:K08738]
125170217  cytochrome c-like isoform X1 [KO:K08738]
125171605  cytochrome c, testis-specific-like [KO:K08738]
125169849  cytochrome c-like [KO:K08738]
125175154  cytochrome c-like [KO:K08738]
125170378  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
125172087  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
125163566  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
125151344  CPSF4L; putative cleavage and polyadenylation specificity factor subunit 4-like protein [KO:K14404]
125154352  CPSF4; cleavage and polyadenylation specificity factor subunit 4 isoform X1 [KO:K14404]
125158762  PABPN1L; embryonic polyadenylate-binding protein 2 [KO:K14396]
125167924  PABPN1; polyadenylate-binding protein 2 isoform X1 [KO:K14396]
125175972  NXF1; nuclear RNA export factor 1 [KO:K14284]
125157012  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
125157018  LOW QUALITY PROTEIN: nuclear RNA export factor 3-like [KO:K14284]
125157098  nuclear RNA export factor 2-like isoform X1 [KO:K14284]
125157101  LOW QUALITY PROTEIN: nuclear RNA export factor 3-like [KO:K14284]
125157357  nuclear RNA export factor 2-like isoform X1 [KO:K14284]
125161493  NXT1; NTF2-related export protein 1 [KO:K14285]
125157839  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
125152867  HNRNPUL1; heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X1 [KO:K15047]
125162290  RAE1; mRNA export factor RAE1 [KO:K14298]
125147172  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
125158284  RSAD2; radical S-adenosyl methionine domain-containing protein 2 isoform X1 [KO:K15045]
125155324  FDPS; farnesyl pyrophosphate synthase isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
125151135  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
125152491  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
125167652  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
125149335  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
125154521  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
125149069  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
125151565  ACTG1; actin, cytoplasmic 2 [KO:K05692]
125154076  ACTB; actin, cytoplasmic 1 [KO:K05692]
125167936  RAB11A; ras-related protein Rab-11A [KO:K07904]
125160543  RAB11B; ras-related protein Rab-11B [KO:K07905]
125162098  XPO1; exportin-1 isoform X1 [KO:K14290]
125174629  KPNA1; importin subunit alpha-5 isoform X1 [KO:K23940]
125151997  KPNA2; importin subunit alpha-1 [KO:K15043]
125154130  KPNA7; importin subunit alpha-8 [KO:K15043]
125166655  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
125172490  KPNA6; importin subunit alpha-7 isoform X1 [KO:K15042]
Compound
C00027  Hydrogen peroxide
C00080  H+
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:24225499
  Authors
Edinger TO, Pohl MO, Stertz S
  Title
Entry of influenza A virus: host factors and antiviral targets.
  Journal
J Gen Virol 95:263-77 (2014)
DOI:10.1099/vir.0.059477-0
Reference
PMID:19565019
  Authors
Kido H, Okumura Y, Takahashi E, Pan HY, Wang S, Chida J, Le TQ, Yano M
  Title
Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses.
  Journal
J Mol Genet Med 3:167-75 (2008)
Reference
PMID:27751627
  Authors
Ramakrishnan B, Viswanathan K, Tharakaraman K, Dancik V, Raman R, Babcock GJ, Shriver Z, Sasisekharan R
  Title
A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza.
  Journal
Trends Microbiol 24:933-943 (2016)
DOI:10.1016/j.tim.2016.09.003
Reference
PMID:18588994
  Authors
Thanh TT, van Doorn HR, de Jong MD
  Title
Human H5N1 influenza: current insight into pathogenesis.
  Journal
Int J Biochem Cell Biol 40:2671-4 (2008)
DOI:10.1016/j.biocel.2008.05.019
Reference
PMID:23977434
  Authors
Michael P, Brabant D, Bleiblo F, Ramana CV, Rutherford M, Khurana S, Tai TC, Kumar A, Kumar A
  Title
Influenza A induced cellular signal transduction pathways.
  Journal
J Thorac Dis 5 Suppl 2:S132-41 (2013)
DOI:10.3978/j.issn.2072-1439.2013.07.42
Reference
PMID:20020828
  Authors
Hale BG, Albrecht RA, Garcia-Sastre A
  Title
Innate immune evasion strategies of influenza viruses.
  Journal
Future Microbiol 5:23-41 (2010)
DOI:10.2217/fmb.09.108
Reference
PMID:21698289
  Authors
Sharma K, Tripathi S, Ranjan P, Kumar P, Garten R, Deyde V, Katz JM, Cox NJ, Lal RB, Sambhara S, Lal SK
  Title
Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.
  Journal
PLoS One 6:e20215 (2011)
DOI:10.1371/journal.pone.0020215
Reference
PMID:19782761
  Authors
Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S
  Title
Interplay between influenza A virus and the innate immune signaling.
  Journal
Microbes Infect 12:81-7 (2010)
DOI:10.1016/j.micinf.2009.09.007
Reference
PMID:23170167
  Authors
van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
  Title
Evasion of influenza A viruses from innate and adaptive immune responses.
  Journal
Viruses 4:1438-76 (2012)
DOI:10.3390/v4091438
Reference
PMID:30487536
  Authors
Long JS, Mistry B, Haslam SM, Barclay WS
  Title
Host and viral determinants of influenza A virus species specificity.
  Journal
Nat Rev Microbiol 17:67-81 (2019)
DOI:10.1038/s41579-018-0115-z
Reference
PMID:29556226
  Authors
Chen X, Liu S, Goraya MU, Maarouf M, Huang S, Chen JL
  Title
Host Immune Response to Influenza A Virus Infection.
  Journal
Front Immunol 9:320 (2018)
DOI:10.3389/fimmu.2018.00320
Reference
PMID:20130137
  Authors
Lu X, Masic A, Li Y, Shin Y, Liu Q, Zhou Y
  Title
The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1.
  Journal
J Gen Virol 91:1439-49 (2010)
DOI:10.1099/vir.0.018465-0
Reference
PMID:18980544
  Authors
Ichinohe T, Iwasaki A, Hasegawa H
  Title
Innate sensors of influenza virus: clues to developing better intranasal vaccines.
  Journal
Expert Rev Vaccines 7:1435-45 (2008)
DOI:10.1586/14760584.7.9.1435
Reference
PMID:27231932
  Authors
Le Sage V, Cinti A, Amorim R, Mouland AJ
  Title
Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway.
  Journal
Viruses 8:E152 (2016)
DOI:10.3390/v8060152
Reference
PMID:30510918
  Authors
Fan Y, Sanyal S, Bruzzone R
  Title
Breaking Bad: How Viruses Subvert the Cell Cycle.
  Journal
Front Cell Infect Microbiol 8:396 (2018)
DOI:10.3389/fcimb.2018.00396
Reference
PMID:21971186
  Authors
Varga ZT, Palese P
  Title
The influenza A virus protein PB1-F2: killing two birds with one stone?
  Journal
Virulence 2:542-6 (2011)
DOI:10.4161/viru.2.6.17812
Reference
PMID:30254192
  Authors
Atkin-Smith GK, Duan M, Chen W, Poon IKH
  Title
The induction and consequences of Influenza A virus-induced cell death.
  Journal
Cell Death Dis 9:1002 (2018)
DOI:10.1038/s41419-018-1035-6
Reference
PMID:30545063
  Authors
Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML
  Title
Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins.
  Journal
Viruses 10:E708 (2018)
DOI:10.3390/v10120708
Reference
PMID:21253874
  Authors
Dai X, Zhang L, Hong T
  Title
Host cellular signaling induced by influenza virus.
  Journal
Sci China Life Sci 54:68-74 (2011)
DOI:10.1007/s11427-010-4116-z
Reference
PMID:26008706
  Authors
Li J, Yu M, Zheng W, Liu W
  Title
Nucleocytoplasmic shuttling of influenza A virus proteins.
  Journal
Viruses 7:2668-82 (2015)
DOI:10.3390/v7052668
Reference
PMID:30079062
  Authors
Dou D, Revol R, Ostbye H, Wang H, Daniels R
  Title
Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement.
  Journal
Front Immunol 9:1581 (2018)
DOI:10.3389/fimmu.2018.01581
Reference
PMID:23236273
  Authors
Paterson D, Fodor E
  Title
Emerging roles for the influenza A virus nuclear export protein (NEP).
  Journal
PLoS Pathog 8:e1003019 (2012)
DOI:10.1371/journal.ppat.1003019
Related
pathway
pviv00900  Terpenoid backbone biosynthesis
pviv03013  Nucleocytoplasmic transport
pviv03015  mRNA surveillance pathway
pviv04010  MAPK signaling pathway
pviv04110  Cell cycle
pviv04144  Endocytosis
pviv04210  Apoptosis
pviv04620  Toll-like receptor signaling pathway
pviv04621  NOD-like receptor signaling pathway
pviv04622  RIG-I-like receptor signaling pathway
pviv04630  JAK-STAT signaling pathway
pviv05416  Viral myocarditis
KO pathway
ko05164   
LinkDB

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