KEGG   PATHWAY: sara04072
Entry
sara04072                   Pathway                                
Name
Phospholipase D signaling pathway - Sorex araneus (European shrew)
Description
Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival. PLD activity can be stimulated by a large number of cell surface receptors and is elaborately regulated by intracellular factors, including protein kinase C isoforms, small GTPases of the ARF, Rho and Ras families and the phosphoinositide, phosphatidylinositol 4,5-bisphosphate (PIP2). The PLD-produced PA activates signaling proteins and acts as a node within the membrane to which signaling proteins translocate. Several signaling proteins, including Raf-1 and mTOR, directly bind PA to mediate translocation or activation, respectively.
Class
Environmental Information Processing; Signal transduction
Pathway map
sara04072  Phospholipase D signaling pathway
sara04072

Organism
Sorex araneus (European shrew) [GN:sara]
Gene
101541792  EGF; pro-epidermal growth factor [KO:K04357]
101545086  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
101547238  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
101543883  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101538791  PDGFC; platelet-derived growth factor C [KO:K05450]
101540449  KITLG; kit ligand isoform X2 [KO:K05461]
101545195  INS; insulin [KO:K04526]
101551461  probable insulin-like peptide 5 [KO:K04526]
101552863  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101539850  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101540263  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
101547411  KIT; mast/stem cell growth factor receptor Kit isoform X2 [KO:K05091] [EC:2.7.10.1]
101540495  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
101544020  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101549545  GAB1; GRB2-associated-binding protein 1 [KO:K09593]
101540482  GAB2; GRB2-associated-binding protein 2 [KO:K08091]
101553821  SHC1; SHC-transforming protein 1 isoform X2 [KO:K06279]
101550526  SHC2; SHC-transforming protein 2 [KO:K17447]
101550468  SHC3; SHC-transforming protein 3 [KO:K17448]
101537303  SHC4; LOW QUALITY PROTEIN: SHC-transforming protein 4 [KO:K17449]
101556236  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
101552022  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
101550972  SOS1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
101555769  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101546777  HRAS; GTPase HRas [KO:K02833]
101557531  KRAS; GTPase KRas isoform X1 [KO:K07827]
101559343  NRAS; GTPase NRas [KO:K07828]
101543627  MRAS; ras-related protein M-Ras [KO:K07831]
101546930  RRAS; ras-related protein R-Ras [KO:K07829]
101554147  RRAS2; ras-related protein R-Ras2 [KO:K07830]
101554760  RALGDS; ral guanine nucleotide dissociation stimulator [KO:K08732]
101550569  ras-related protein O-RAL-like [KO:K07834]
101556703  RALA; ras-related protein Ral-A [KO:K07834]
101550413  RALB; ras-related protein Ral-B [KO:K07835]
101542917  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101556597  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101548304  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101547106  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101541868  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101540938  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101543096  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101559009  AKT2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101543371  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101554144  TSC1; hamartin isoform X1 [KO:K07206]
101543551  TSC2; tuberin isoform X1 [KO:K07207]
101549145  RHEB; GTP-binding protein Rheb [KO:K07208]
101554656  MTOR; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101544191  transforming protein RhoA [KO:K04513]
101557527  LOW QUALITY PROTEIN: transforming protein RhoA-like [KO:K04513]
101558217  ADP-ribosylation factor 1-like isoform X1 [KO:K07937]
101557261  ARF1; ADP-ribosylation factor 1 isoform X1 [KO:K07937]
101538210  ADP-ribosylation factor 2 isoform X1 [KO:K07937]
101552429  ADP-ribosylation factor 1-like isoform X1 [KO:K07937]
101555245  ARF6; ADP-ribosylation factor 6 [KO:K07941]
101545860  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [KO:K01116] [EC:3.1.4.11]
101554088  PLCG2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101553484  LOW QUALITY PROTEIN: uncharacterized protein LOC101553484 [KO:K06856]
101557492  uncharacterized protein LOC101557492 [KO:K06856]
101546778  LOW QUALITY PROTEIN: putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
101542253  FCER1A; high affinity immunoglobulin epsilon receptor subunit alpha [KO:K08089]
101551080  MS4A2; high affinity immunoglobulin epsilon receptor subunit beta [KO:K08090]
101555828  FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983]
101538710  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
101551795  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
101551961  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101538228  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
101550489  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
101557523  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
101555471  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
101555733  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
101555205  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
101543498  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
101544574  AGPAT1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X1 [KO:K13509] [EC:2.3.1.51]
101548816  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha-like [KO:K13509] [EC:2.3.1.51]
101546036  AGPAT2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
101539747  AGPAT3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
101551436  AGPAT4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [KO:K13523] [EC:2.3.1.51 2.3.1.-]
101537782  AGPAT5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
101538217  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
101554247  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
101545329  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101550720  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101555057  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101559341  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101541587  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
101545848  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
101542963  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
101546238  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
101545446  phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
101541849  DGKG; diacylglycerol kinase gamma isoform X1 [KO:K00901] [EC:2.7.1.107]
101540118  DGKE; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
101548111  DGKH; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
101552903  DGKD; diacylglycerol kinase delta [KO:K00901] [EC:2.7.1.107]
101547805  DGKQ; diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
101558054  DGKK; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
101553339  DGKI; diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
101543265  DGKA; diacylglycerol kinase alpha [KO:K00901] [EC:2.7.1.107]
101548362  DGKB; diacylglycerol kinase beta [KO:K00901] [EC:2.7.1.107]
101543251  DGKZ; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
101550415  PPAP2A; lipid phosphate phosphohydrolase 1 isoform X2 [KO:K01080] [EC:3.1.3.4]
101549487  PPAP2C; lipid phosphate phosphohydrolase 2 [KO:K01080] [EC:3.1.3.4]
101537287  PPAP2B; lipid phosphate phosphohydrolase 3 [KO:K01080] [EC:3.1.3.4]
101546501  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
101553203  AGT; angiotensinogen [KO:K09821]
101559441  CXCL8; interleukin-8 [KO:K10030]
101537266  AGTR1; type-1 angiotensin II receptor [KO:K04166]
101544230  F2R; proteinase-activated receptor 1 [KO:K03914]
101542044  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
101555036  GRM2; metabotropic glutamate receptor 2 [KO:K04605]
101548725  GRM3; metabotropic glutamate receptor 3 isoform X1 [KO:K04606]
101537408  GRM4; metabotropic glutamate receptor 4 isoform X1 [KO:K04607]
101558999  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
101545963  GRM6; metabotropic glutamate receptor 6 [KO:K04608]
101542612  GRM7; metabotropic glutamate receptor 7 [KO:K04609]
101546632  GRM8; metabotropic glutamate receptor 8 isoform X1 [KO:K04610]
101538157  AVPR1A; vasopressin V1a receptor [KO:K04226]
101553428  AVPR1B; vasopressin V1b receptor [KO:K04227]
101548653  AVPR2; vasopressin V2 receptor [KO:K04228]
101548706  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
101543935  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
101538328  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
101552106  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
101543906  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
105942807  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
101542202  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
101555581  C-X-C chemokine receptor type 2-like [KO:K05050]
101551223  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
101546811  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
101547690  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101559179  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
101539799  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
101544808  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
101539190  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
101539743  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
101551468  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
101537808  PIK3R6; LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
101537775  CYTH2; cytohesin-2 isoform X2 [KO:K18441]
101555505  CYTH1; cytohesin-1 isoform X1 [KO:K18441]
101555388  CYTH4; cytohesin-4 [KO:K18441]
101538394  CYTH3; cytohesin-3 [KO:K18441]
101539470  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
101557843  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101539413  ADCY2; LOW QUALITY PROTEIN: adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
101547055  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
101539776  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
101551819  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
101549131  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
101543858  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
101550559  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101551730  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101540127  RAPGEF3; rap guanine nucleotide exchange factor 3 [KO:K08014]
101558391  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
101539353  DNM1; dynamin-1 isoform X4 [KO:K01528] [EC:3.6.5.5]
101545775  DNM3; dynamin-3 [KO:K01528] [EC:3.6.5.5]
101551688  DNM2; dynamin-2 [KO:K23484] [EC:3.6.5.5]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00416  Phosphatidate
C00575  3',5'-Cyclic AMP
C00639  Prostaglandin F2alpha
C00681  1-Acyl-sn-glycerol 3-phosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06124  Sphingosine 1-phosphate
Reference
PMID:17245604
  Authors
Oude Weernink PA, Lopez de Jesus M, Schmidt M
  Title
Phospholipase D signaling: orchestration by PIP2 and small GTPases.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 374:399-411 (2007)
DOI:10.1007/s00210-007-0131-4
Reference
PMID:21936578
  Authors
Selvy PE, Lavieri RR, Lindsley CW, Brown HA
  Title
Phospholipase D: enzymology, functionality, and chemical modulation.
  Journal
Chem Rev 111:6064-119 (2011)
DOI:10.1021/cr200296t
Reference
PMID:24995811
  Authors
Brandenburg LO, Pufe T, Koch T
  Title
Role of phospholipase d in g-protein coupled receptor function.
  Journal
Membranes (Basel) 4:302-18 (2014)
DOI:10.3390/membranes4030302
Reference
PMID:17054901
  Authors
Oude Weernink PA, Han L, Jakobs KH, Schmidt M
  Title
Dynamic phospholipid signaling by G protein-coupled receptors.
  Journal
Biochim Biophys Acta 1768:888-900 (2007)
DOI:10.1016/j.bbamem.2006.09.012
Reference
PMID:24990952
  Authors
Foster DA, Salloum D, Menon D, Frias MA
  Title
Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of rapamycin (mTOR).
  Journal
J Biol Chem 289:22583-8 (2014)
DOI:10.1074/jbc.R114.566091
Reference
PMID:16143829
  Authors
Jenkins GM, Frohman MA
  Title
Phospholipase D: a lipid centric review.
  Journal
Cell Mol Life Sci 62:2305-16 (2005)
DOI:10.1007/s00018-005-5195-z
Reference
PMID:19815110
  Authors
Metcalfe DD, Peavy RD, Gilfillan AM
  Title
Mechanisms of mast cell signaling in anaphylaxis.
  Journal
J Allergy Clin Immunol 124:639-46; quiz 647-8 (2009)
DOI:10.1016/j.jaci.2009.08.035
Reference
PMID:18936782
  Authors
Kalesnikoff J, Galli SJ
  Title
New developments in mast cell biology.
  Journal
Nat Immunol 9:1215-23 (2008)
DOI:10.1038/ni.f.216
Reference
PMID:12217395
  Authors
Cockcroft S, Way G, O'Luanaigh N, Pardo R, Sarri E, Fensome A
  Title
Signalling role for ARF and phospholipase D in mast cell exocytosis stimulated by crosslinking of the high affinity FcepsilonR1 receptor.
  Journal
Mol Immunol 38:1277-82 (2002)
DOI:10.1016/S0161-5890(02)00075-5
Reference
PMID:19410013
  Authors
Lee CS, Kim KL, Jang JH, Choi YS, Suh PG, Ryu SH
  Title
The roles of phospholipase D in EGFR signaling.
  Journal
Biochim Biophys Acta 1791:862-8 (2009)
DOI:10.1016/j.bbalip.2009.04.007
Reference
PMID:16622417
  Authors
Lee CS, Kim IS, Park JB, Lee MN, Lee HY, Suh PG, Ryu SH
  Title
The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis.
  Journal
Nat Cell Biol 8:477-84 (2006)
DOI:10.1038/ncb1401
Reference
PMID:14769825
  Authors
Kam Y, Exton JH
  Title
Role of phospholipase D1 in the regulation of mTOR activity by lysophosphatidic acid.
  Journal
FASEB J 18:311-9 (2004)
DOI:10.1096/fj.03-0731com
Reference
PMID:9310372
  Authors
Kozawa O, Blume-Jensen P, Heldin CH, Ronnstrand L
  Title
Involvement of phosphatidylinositol 3'-kinase in stem-cell-factor-induced phospholipase D activation and arachidonic acid release.
  Journal
Eur J Biochem 248:149-55 (1997)
DOI:10.1111/j.1432-1033.1997.00149.x
Reference
PMID:11042115
  Authors
Slaaby R, Du G, Altshuller YM, Frohman MA, Seedorf K
  Title
Insulin-induced phospholipase D1 and phospholipase D2 activity in human embryonic kidney-293 cells mediated by the phospholipase C gamma and protein kinase C alpha signalling cascade.
  Journal
Biochem J 351 Pt 3:613-9 (2000)
DOI:10.1042/bj3510613
Reference
PMID:11991733
  Authors
Fahimi-Vahid M, Gosau N, Michalek C, Han L, Jakobs KH, Schmidt M, Roberts N, Avkiran M, Wieland T
  Title
Distinct signaling pathways mediate cardiomyocyte phospholipase D stimulation by endothelin-1 and thrombin.
  Journal
J Mol Cell Cardiol 34:441-53 (2002)
DOI:10.1006/jmcc.2002.1525
Reference
PMID:10666319
  Authors
Freeman EJ
  Title
The Ang II-induced growth of vascular smooth muscle cells involves a phospholipase D-mediated signaling mechanism.
  Journal
Arch Biochem Biophys 374:363-70 (2000)
DOI:10.1006/abbi.1999.1608
Reference
PMID:9119890
  Authors
Naro F, Donchenko V, Minotti S, Zolla L, Molinaro M, Adamo S
  Title
Role of phospholipase C and D signalling pathways in vasopressin-dependent myogenic differentiation.
  Journal
J Cell Physiol 171:34-42 (1997)
DOI:10.1002/(SICI)1097-4652(199704)171:1<34::AID-JCP5>3.0.CO;2-I
Reference
PMID:10807766
  Authors
Murdoch C, Finn A
  Title
Chemokine receptors and their role in inflammation and infectious diseases.
  Journal
Blood 95:3032-43 (2000)
Reference
PMID:8135758
  Authors
Sugiyama T, Sakai T, Nozawa Y, Oka N
  Title
Prostaglandin F2 alpha-stimulated phospholipase D activation in osteoblast-like MC3T3-E1 cells: involvement in sustained 1,2-diacylglycerol production.
  Journal
Biochem J 298 ( Pt 2):479-84 (1994)
DOI:10.1042/bj2980479
Reference
PMID:17210675
  Authors
Foster DA
  Title
Regulation of mTOR by phosphatidic acid?
  Journal
Cancer Res 67:1-4 (2007)
DOI:10.1158/0008-5472.CAN-06-3016
Reference
PMID:15310762
  Authors
Delon C, Manifava M, Wood E, Thompson D, Krugmann S, Pyne S, Ktistakis NT
  Title
Sphingosine kinase 1 is an intracellular effector of phosphatidic acid.
  Journal
J Biol Chem 279:44763-74 (2004)
DOI:10.1074/jbc.M405771200
Reference
PMID:23076158
  Authors
Park JB, Lee CS, Jang JH, Ghim J, Kim YJ, You S, Hwang D, Suh PG, Ryu SH
  Title
Phospholipase signalling networks in cancer.
  Journal
Nat Rev Cancer 12:782-92 (2012)
DOI:10.1038/nrc3379
Reference
PMID:19264150
  Authors
Foster DA
  Title
Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells.
  Journal
Biochim Biophys Acta 1791:949-55 (2009)
DOI:10.1016/j.bbalip.2009.02.009
Related
pathway
sara00561  Glycerolipid metabolism
sara04010  MAPK signaling pathway
sara04014  Ras signaling pathway
sara04020  Calcium signaling pathway
sara04024  cAMP signaling pathway
sara04071  Sphingolipid signaling pathway
sara04144  Endocytosis
sara04150  mTOR signaling pathway
sara04151  PI3K-Akt signaling pathway
sara04664  Fc epsilon RI signaling pathway
KO pathway
ko04072   
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