KEGG   PATHWAY: uah04072
Entry
uah04072                    Pathway                                
Name
Phospholipase D signaling pathway - Ursus arctos horribilis (North American brown bear)
Description
Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival. PLD activity can be stimulated by a large number of cell surface receptors and is elaborately regulated by intracellular factors, including protein kinase C isoforms, small GTPases of the ARF, Rho and Ras families and the phosphoinositide, phosphatidylinositol 4,5-bisphosphate (PIP2). The PLD-produced PA activates signaling proteins and acts as a node within the membrane to which signaling proteins translocate. Several signaling proteins, including Raf-1 and mTOR, directly bind PA to mediate translocation or activation, respectively.
Class
Environmental Information Processing; Signal transduction
Pathway map
uah04072  Phospholipase D signaling pathway
uah04072

Organism
Ursus arctos horribilis (North American brown bear) [GN:uah]
Gene
113255562  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
113248512  platelet-derived growth factor subunit A isoform X1 [KO:K04359]
113248525  platelet-derived growth factor subunit A isoform X1 [KO:K04359]
113241764  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
113260127  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
113255787  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
113256194  KITLG; kit ligand isoform X1 [KO:K05461]
113243960  insulin-like [KO:K04526]
113257444  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
113262493  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
113263944  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
113262502  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
113242935  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
113244637  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
113255714  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
113269369  GAB2; GRB2-associated-binding protein 2 isoform X1 [KO:K08091]
113245295  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
113242690  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
113270120  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
113269597  SHC4; SHC-transforming protein 4 [KO:K17449]
113266983  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
113270688  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
113266205  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
113241630  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
113257418  GTPase HRas-like [KO:K02833]
113257792  KRAS; GTPase KRas isoform X1 [KO:K07827]
113244394  NRAS; GTPase NRas [KO:K07828]
113253984  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
113243291  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
113246246  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
113266555  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
113249103  ral guanine nucleotide dissociation stimulator-like isoform X1 [KO:K08732]
113249140  ral guanine nucleotide dissociation stimulator-like [KO:K08732]
113247941  ral guanine nucleotide dissociation stimulator-like isoform X1 [KO:K08732]
113250009  ral guanine nucleotide dissociation stimulator-like [KO:K08732]
113258228  RALA; ras-related protein Ral-A isoform X1 [KO:K07834]
113263462  RALB; ras-related protein Ral-B [KO:K07835]
113254799  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
113270537  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
113253989  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
113256705  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
113254730  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
113255266  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
113267192  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
113243572  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113262966  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113266547  TSC1; hamartin isoform X1 [KO:K07206]
113245080  TSC2; tuberin isoform X1 [KO:K07207]
113241493  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
113270510  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
113256876  RHOA; transforming protein RhoA [KO:K04513]
113247486  ARF1; ADP-ribosylation factor 1 [KO:K07937]
113265314  ADP-ribosylation factor 2 [KO:K07937]
113266201  ARF6; ADP-ribosylation factor 6 [KO:K07941]
113258609  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
113252535  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
113267145  uncharacterized protein LOC113267145 [KO:K06856]
113246733  FCER1A; high affinity immunoglobulin epsilon receptor subunit alpha [KO:K08089]
113249061  membrane-spanning 4-domains subfamily A member 3-like [KO:K08090]
113249063  membrane-spanning 4-domains subfamily A member 3-like [KO:K08090]
113249070  MS4A2; high affinity immunoglobulin epsilon receptor subunit beta [KO:K08090]
113246719  FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983]
113264721  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
113270132  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
113265250  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
113271085  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
113255060  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
113262763  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
113241915  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
113241916  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
113241996  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
113243756  AGPAT1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha [KO:K13509] [EC:2.3.1.51]
113248579  uncharacterized protein LOC113248579 isoform X1 [KO:K13509] [EC:2.3.1.51]
113248634  AGPAT2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform X1 [KO:K13509] [EC:2.3.1.51]
113252880  AGPAT3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
113259630  AGPAT4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [KO:K13523] [EC:2.3.1.51 2.3.1.-]
113262188  AGPAT5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X1 [KO:K19007] [EC:2.3.1.51]
113243339  SPHK2; LOW QUALITY PROTEIN: sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
113244597  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
113257190  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
113240885  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
113242822  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
113267646  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
113247020  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
113242809  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
113246140  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
113270193  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
113251371  DGKH; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
113265962  DGKK; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
113264988  DGKZ; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
113268844  DGKE; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
113264725  DGKI; diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
113256448  DGKA; diacylglycerol kinase alpha isoform X1 [KO:K00901] [EC:2.7.1.107]
113253969  DGKG; diacylglycerol kinase gamma [KO:K00901] [EC:2.7.1.107]
113250329  DGKD; diacylglycerol kinase delta [KO:K00901] [EC:2.7.1.107]
113260862  DGKB; diacylglycerol kinase beta [KO:K00901] [EC:2.7.1.107]
113245709  DGKQ; diacylglycerol kinase theta isoform X1 [KO:K00901] [EC:2.7.1.107]
113242688  PLPP2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
113254620  PLPP3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
113255329  PLPP1; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
113264978  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
113259044  AGT; angiotensinogen [KO:K09821]
113258187  AVP; vasopressin-neurophysin 2-copeptin [KO:K05242]
113263279  CXCL8; interleukin-8 [KO:K10030]
113254038  AGTR1; type-1 angiotensin II receptor [KO:K04166]
113255187  proteinase-activated receptor 1 isoform X1 [KO:K03914]
113259527  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
113256929  GRM2; metabotropic glutamate receptor 2 isoform X1 [KO:K04605]
113259411  GRM3; metabotropic glutamate receptor 3 [KO:K04606]
113243819  GRM4; metabotropic glutamate receptor 4 isoform X1 [KO:K04607]
113269419  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
113261566  GRM6; metabotropic glutamate receptor 6 [KO:K04608]
113256634  GRM7; metabotropic glutamate receptor 7 [KO:K04609]
113263666  metabotropic glutamate receptor 8-like [KO:K04610]
113256343  AVPR1A; vasopressin V1a receptor [KO:K04226]
113242430  AVPR1B; vasopressin V1b receptor [KO:K04227]
113247864  AVPR2; vasopressin V2 receptor [KO:K04228]
113260324  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
113256760  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
113242104  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
113257973  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
113251326  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
113254495  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
113250470  CXCR1; C-X-C chemokine receptor type 1 [KO:K04175]
113250472  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
113244175  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
113258243  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
113258346  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
113242038  PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
113267979  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
113269957  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
113265242  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
113258627  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
113271195  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
113271196  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
113243347  CYTH2; cytohesin-2 isoform X1 [KO:K18441]
113244560  CYTH1; cytohesin-1 isoform X1 [KO:K18441]
113241809  CYTH4; cytohesin-4 [KO:K18441]
113267938  CYTH3; cytohesin-3 [KO:K18441]
113258768  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like [KO:K04632]
113258223  neuroendocrine secretory protein 55 [KO:K04632]
113257705  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
113260807  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
113270586  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
113246056  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
113252326  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
113257671  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
113252223  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
113252717  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
113270857  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
113257686  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
113250770  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
113266460  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
113262829  DNM3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
113243001  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00416  Phosphatidate
C00575  3',5'-Cyclic AMP
C00639  Prostaglandin F2alpha
C00681  1-Acyl-sn-glycerol 3-phosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06124  Sphingosine 1-phosphate
Reference
PMID:17245604
  Authors
Oude Weernink PA, Lopez de Jesus M, Schmidt M
  Title
Phospholipase D signaling: orchestration by PIP2 and small GTPases.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 374:399-411 (2007)
DOI:10.1007/s00210-007-0131-4
Reference
PMID:21936578
  Authors
Selvy PE, Lavieri RR, Lindsley CW, Brown HA
  Title
Phospholipase D: enzymology, functionality, and chemical modulation.
  Journal
Chem Rev 111:6064-119 (2011)
DOI:10.1021/cr200296t
Reference
PMID:24995811
  Authors
Brandenburg LO, Pufe T, Koch T
  Title
Role of phospholipase d in g-protein coupled receptor function.
  Journal
Membranes (Basel) 4:302-18 (2014)
DOI:10.3390/membranes4030302
Reference
PMID:17054901
  Authors
Oude Weernink PA, Han L, Jakobs KH, Schmidt M
  Title
Dynamic phospholipid signaling by G protein-coupled receptors.
  Journal
Biochim Biophys Acta 1768:888-900 (2007)
DOI:10.1016/j.bbamem.2006.09.012
Reference
PMID:24990952
  Authors
Foster DA, Salloum D, Menon D, Frias MA
  Title
Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of rapamycin (mTOR).
  Journal
J Biol Chem 289:22583-8 (2014)
DOI:10.1074/jbc.R114.566091
Reference
PMID:16143829
  Authors
Jenkins GM, Frohman MA
  Title
Phospholipase D: a lipid centric review.
  Journal
Cell Mol Life Sci 62:2305-16 (2005)
DOI:10.1007/s00018-005-5195-z
Reference
PMID:19815110
  Authors
Metcalfe DD, Peavy RD, Gilfillan AM
  Title
Mechanisms of mast cell signaling in anaphylaxis.
  Journal
J Allergy Clin Immunol 124:639-46; quiz 647-8 (2009)
DOI:10.1016/j.jaci.2009.08.035
Reference
PMID:18936782
  Authors
Kalesnikoff J, Galli SJ
  Title
New developments in mast cell biology.
  Journal
Nat Immunol 9:1215-23 (2008)
DOI:10.1038/ni.f.216
Reference
PMID:12217395
  Authors
Cockcroft S, Way G, O'Luanaigh N, Pardo R, Sarri E, Fensome A
  Title
Signalling role for ARF and phospholipase D in mast cell exocytosis stimulated by crosslinking of the high affinity FcepsilonR1 receptor.
  Journal
Mol Immunol 38:1277-82 (2002)
DOI:10.1016/S0161-5890(02)00075-5
Reference
PMID:19410013
  Authors
Lee CS, Kim KL, Jang JH, Choi YS, Suh PG, Ryu SH
  Title
The roles of phospholipase D in EGFR signaling.
  Journal
Biochim Biophys Acta 1791:862-8 (2009)
DOI:10.1016/j.bbalip.2009.04.007
Reference
PMID:16622417
  Authors
Lee CS, Kim IS, Park JB, Lee MN, Lee HY, Suh PG, Ryu SH
  Title
The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis.
  Journal
Nat Cell Biol 8:477-84 (2006)
DOI:10.1038/ncb1401
Reference
PMID:14769825
  Authors
Kam Y, Exton JH
  Title
Role of phospholipase D1 in the regulation of mTOR activity by lysophosphatidic acid.
  Journal
FASEB J 18:311-9 (2004)
DOI:10.1096/fj.03-0731com
Reference
PMID:9310372
  Authors
Kozawa O, Blume-Jensen P, Heldin CH, Ronnstrand L
  Title
Involvement of phosphatidylinositol 3'-kinase in stem-cell-factor-induced phospholipase D activation and arachidonic acid release.
  Journal
Eur J Biochem 248:149-55 (1997)
DOI:10.1111/j.1432-1033.1997.00149.x
Reference
PMID:11042115
  Authors
Slaaby R, Du G, Altshuller YM, Frohman MA, Seedorf K
  Title
Insulin-induced phospholipase D1 and phospholipase D2 activity in human embryonic kidney-293 cells mediated by the phospholipase C gamma and protein kinase C alpha signalling cascade.
  Journal
Biochem J 351 Pt 3:613-9 (2000)
DOI:10.1042/bj3510613
Reference
PMID:11991733
  Authors
Fahimi-Vahid M, Gosau N, Michalek C, Han L, Jakobs KH, Schmidt M, Roberts N, Avkiran M, Wieland T
  Title
Distinct signaling pathways mediate cardiomyocyte phospholipase D stimulation by endothelin-1 and thrombin.
  Journal
J Mol Cell Cardiol 34:441-53 (2002)
DOI:10.1006/jmcc.2002.1525
Reference
PMID:10666319
  Authors
Freeman EJ
  Title
The Ang II-induced growth of vascular smooth muscle cells involves a phospholipase D-mediated signaling mechanism.
  Journal
Arch Biochem Biophys 374:363-70 (2000)
DOI:10.1006/abbi.1999.1608
Reference
PMID:9119890
  Authors
Naro F, Donchenko V, Minotti S, Zolla L, Molinaro M, Adamo S
  Title
Role of phospholipase C and D signalling pathways in vasopressin-dependent myogenic differentiation.
  Journal
J Cell Physiol 171:34-42 (1997)
DOI:10.1002/(SICI)1097-4652(199704)171:1<34::AID-JCP5>3.0.CO;2-I
Reference
PMID:10807766
  Authors
Murdoch C, Finn A
  Title
Chemokine receptors and their role in inflammation and infectious diseases.
  Journal
Blood 95:3032-43 (2000)
Reference
PMID:8135758
  Authors
Sugiyama T, Sakai T, Nozawa Y, Oka N
  Title
Prostaglandin F2 alpha-stimulated phospholipase D activation in osteoblast-like MC3T3-E1 cells: involvement in sustained 1,2-diacylglycerol production.
  Journal
Biochem J 298 ( Pt 2):479-84 (1994)
DOI:10.1042/bj2980479
Reference
PMID:17210675
  Authors
Foster DA
  Title
Regulation of mTOR by phosphatidic acid?
  Journal
Cancer Res 67:1-4 (2007)
DOI:10.1158/0008-5472.CAN-06-3016
Reference
PMID:15310762
  Authors
Delon C, Manifava M, Wood E, Thompson D, Krugmann S, Pyne S, Ktistakis NT
  Title
Sphingosine kinase 1 is an intracellular effector of phosphatidic acid.
  Journal
J Biol Chem 279:44763-74 (2004)
DOI:10.1074/jbc.M405771200
Reference
PMID:23076158
  Authors
Park JB, Lee CS, Jang JH, Ghim J, Kim YJ, You S, Hwang D, Suh PG, Ryu SH
  Title
Phospholipase signalling networks in cancer.
  Journal
Nat Rev Cancer 12:782-92 (2012)
DOI:10.1038/nrc3379
Reference
PMID:19264150
  Authors
Foster DA
  Title
Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells.
  Journal
Biochim Biophys Acta 1791:949-55 (2009)
DOI:10.1016/j.bbalip.2009.02.009
Related
pathway
uah00561  Glycerolipid metabolism
uah04010  MAPK signaling pathway
uah04014  Ras signaling pathway
uah04020  Calcium signaling pathway
uah04024  cAMP signaling pathway
uah04071  Sphingolipid signaling pathway
uah04144  Endocytosis
uah04150  mTOR signaling pathway
uah04151  PI3K-Akt signaling pathway
uah04664  Fc epsilon RI signaling pathway
KO pathway
ko04072   
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