KEGG   PATHWAY: uah05162
Entry
uah05162                    Pathway                                
Name
Measles - Ursus arctos horribilis (North American brown bear)
Description
Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. MV infection is characterized by virus-induced immune suppression that can lead to increased susceptibility to secondary bacterial and viral infections. The P, V and C proteins act as virulence factors to suppress innate immune response in host by inhibiting signaling for both type I IFN induction and JAK/STAT-mediated interferon-stimulated gene (ISG) induction. Moreover,  H protein expressed on viral particles and binding to SLAM or CD46,  as well as N protein liberated from infected cells and interacting with Fc-gamma R, causes an inhibition of IL-12 synthesis in dendritic cells. IL-12 is a key cytokine inducing cellular immune responses to protect host from the harm caused by pathogenic infections.
Class
Human Diseases; Infectious disease: viral
Pathway map
uah05162  Measles
uah05162

Organism
Ursus arctos horribilis (North American brown bear) [GN:uah]
Gene
113246893  MSN; moesin [KO:K05763]
113246638  SLAMF1; signaling lymphocytic activation molecule isoform X1 [KO:K06536]
113242920  CD209; CD209 antigen isoform X1 [KO:K06563]
113260537  DDX58; probable ATP-dependent RNA helicase DDX58 isoform X1 [KO:K12646] [EC:5.6.2.6]
113250835  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
113258384  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
113267235  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
113242466  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
113256330  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
113243290  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
113251823  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
113245546  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
113247832  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
113243600  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
113266131  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
113263101  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
113244102  RELA; transcription factor p65 [KO:K04735]
113240728  TLR7; toll-like receptor 7 [KO:K05404]
113256623  TLR9; toll-like receptor 9 [KO:K10161]
113253781  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
113247859  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
113257718  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
113248784  IRF7; interferon regulatory factor 7 [KO:K09447]
113260290  interferon alpha-1/2-like [KO:K05414]
113260291  interferon alpha-1/2-like [KO:K05414]
113260293  interferon alpha-1/2-like [KO:K05414]
113260294  interferon alpha-2-like [KO:K05414]
113260295  IFNB1; interferon beta [KO:K05415]
113255769  TLR2; toll-like receptor 2 [KO:K10159]
113266343  TLR4; toll-like receptor 4 [KO:K10160]
113265029  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
113252303  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
113258441  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
113243726  CSNK2B; casein kinase II subunit beta [KO:K03115]
113259486  TNFAIP3; tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
113264818  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
113259542  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
113263180  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
113261548  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
113243106  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
113254611  JUN; transcription factor AP-1 [KO:K04448]
113270317  FOS; proto-oncogene c-Fos [KO:K04379]
113268160  IL1A; interleukin-1 alpha [KO:K04383]
113242506  IL1B; interleukin-1 beta [KO:K04519]
113261280  IL6; interleukin-6 [KO:K05405]
113254130  IL12A; interleukin-12 subunit alpha [KO:K05406]
113263879  IL12B; interleukin-12 subunit beta [KO:K05425]
113264796  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
113261532  RACK1; receptor of activated protein C kinase 1 [KO:K14753]
113254577  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
113242985  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
113250654  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
113256419  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
113245987  IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
113266985  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
113266813  OAS3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
113245303  ADAR; double-stranded RNA-specific adenosine deaminase isoform X1 [KO:K12968] [EC:3.5.4.37]
113256649  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
113256765  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
113267934  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
113241346  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
113242804  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
113242045  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
113248370  ras-related protein Rab-9A-like [KO:K07899]
113240722  RAB9A; ras-related protein Rab-9A [KO:K07899]
113248103  RAB9B; ras-related protein Rab-9B [KO:K07900]
113250194  heat shock 70 kDa protein 1 [KO:K03283]
113250195  heat shock 70 kDa protein 1 [KO:K03283]
113243744  heat shock 70 kDa protein 1-like [KO:K03283]
113268759  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
113259928  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
113252798  EIF3H; eukaryotic translation initiation factor 3 subunit H [KO:K03247]
113248303  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
113248323  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
113263266  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 isoform X1 [KO:K10144] [EC:2.3.2.27]
113271152  TP53; cellular tumor antigen p53 [KO:K04451]
113270591  TP73; tumor protein p73 [KO:K10148]
113243380  BBC3; bcl-2-binding component 3 [KO:K10132]
113262825  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
113258968  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
113252355  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
113243978  FADD; FAS-associated death domain protein [KO:K02373]
113250592  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
113258065  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
113243322  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
113243812  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
113253490  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
113258461  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
113244178  BAD; bcl2-associated agonist of cell death [KO:K02158]
113248234  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]
113261698  cytochrome c [KO:K08738]
113256111  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
113270476  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
113262259  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
113257870  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
113243982  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
113258003  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
113261302  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
113252919  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
113244704  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
113256363  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
113259981  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
113256451  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
113265359  uncharacterized protein LOC113265359 [KO:K10785]
113260002  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
113260003  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
113260001  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
113250560  CD28; T-cell-specific surface glycoprotein CD28 [KO:K06470]
113255635  IL2; interleukin-2 [KO:K05429]
113241140  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
113249383  interleukin-2 receptor subunit beta-like isoform X1 [KO:K05069]
113249385  interleukin-2 receptor subunit beta-like isoform X1 [KO:K05069]
113245610  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
113256705  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
113254730  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
113255266  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
113254799  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
113270537  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
113253989  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
113250824  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
113267192  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
113243572  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113262966  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113251972  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
113256691  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
113265422  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
113265423  STAT5A; signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
113265424  signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
113268760  FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b [KO:K12560]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:19203113
  Authors
Schneider-Schaulies S, Schneider-Schaulies J
  Title
Measles virus-induced immunosuppression.
  Journal
Curr Top Microbiol Immunol 330:243-69 (2009)
DOI:10.1007/978-3-540-70617-5_12
Reference
PMID:19203114
  Authors
Hahm B
  Title
Hostile communication of measles virus with host innate immunity and dendritic cells.
  Journal
Curr Top Microbiol Immunol 330:271-87 (2009)
DOI:10.1007/978-3-540-70617-5_13
Reference
PMID:19198566
  Authors
Gerlier D, Valentin H
  Title
Measles virus interaction with host cells and impact on innate immunity.
  Journal
Curr Top Microbiol Immunol 329:163-91 (2009)
DOI:10.1007/978-3-540-70523-9_8
Reference
PMID:16690907
  Authors
Schneider-Schaulies S, Dittmer U
  Title
Silencing T cells or T-cell silencing: concepts in virus-induced immunosuppression.
  Journal
J Gen Virol 87:1423-38 (2006)
DOI:10.1099/vir.0.81713-0
Reference
PMID:22049305
  Authors
Avota E, Gassert E, Schneider-Schaulies S
  Title
Cytoskeletal dynamics: concepts in measles virus replication and immunomodulation.
  Journal
Viruses 3:102-17 (2011)
DOI:10.3390/v3020102
Reference
PMID:27854326
  Authors
Jiang Y, Qin Y, Chen M
  Title
Host-Pathogen Interactions in Measles Virus Replication and Anti-Viral Immunity.
  Journal
Viruses 8:E308 (2016)
DOI:10.3390/v8110308
Reference
PMID:18922877
  Authors
Pfaller CK, Conzelmann KK
  Title
Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction.
  Journal
J Virol 82:12365-73 (2008)
DOI:10.1128/JVI.01321-08
Reference
PMID:17720800
  Authors
Yokota S, Okabayashi T, Yokosawa N, Fujii N
  Title
Measles virus P protein suppresses Toll-like receptor signal through up-regulation of ubiquitin-modifying enzyme A20.
  Journal
FASEB J 22:74-83 (2008)
DOI:10.1096/fj.07-8976com
Reference
PMID:23146309
  Authors
Delpeut S, Noyce RS, Siu RW, Richardson CD
  Title
Host factors and measles virus replication.
  Journal
Curr Opin Virol 2:773-83 (2012)
DOI:10.1016/j.coviro.2012.10.008
Reference
PMID:26878224
  Authors
Shah M, Anwar MA, Kim JH, Choi S
  Title
Advances in Antiviral Therapies Targeting Toll-like Receptors.
  Journal
Expert Opin Investig Drugs 25:437-53 (2016)
DOI:10.1517/13543784.2016.1154040
Reference
PMID:12620806
  Authors
Yokota S, Saito H, Kubota T, Yokosawa N, Amano K, Fujii N
  Title
Measles virus suppresses interferon-alpha signaling pathway: suppression of Jak1 phosphorylation and association of viral accessory proteins, C and V, with interferon-alpha receptor complex.
  Journal
Virology 306:135-46 (2003)
DOI:10.1016/S0042-6822(02)00026-0
Reference
PMID:12804771
  Authors
Takeuchi K, Kadota SI, Takeda M, Miyajima N, Nagata K
  Title
Measles virus V protein blocks interferon (IFN)-alpha/beta but not IFN-gamma signaling by inhibiting STAT1 and STAT2 phosphorylation.
  Journal
FEBS Lett 545:177-82 (2003)
DOI:10.1016/S0014-5793(03)00528-3
Reference
PMID:12805463
  Authors
Palosaari H, Parisien JP, Rodriguez JJ, Ulane CM, Horvath CM
  Title
STAT protein interference and suppression of cytokine signal transduction by measles virus V protein.
  Journal
J Virol 77:7635-44 (2003)
DOI:10.1128/JVI.77.13.7635-7644.2003
Reference
PMID:14585342
  Authors
Shaffer JA, Bellini WJ, Rota PA
  Title
The C protein of measles virus inhibits the type I interferon response.
  Journal
Virology 315:389-97 (2003)
DOI:10.1016/S0042-6822(03)00537-3
Reference
PMID:16971451
  Authors
Carsillo T, Traylor Z, Choi C, Niewiesk S, Oglesbee M
  Title
hsp72, a host determinant of measles virus neurovirulence.
  Journal
J Virol 80:11031-9 (2006)
DOI:10.1128/JVI.01438-06
Reference
PMID:15914229
  Authors
Zhang X, Bourhis JM, Longhi S, Carsillo T, Buccellato M, Morin B, Canard B, Oglesbee M
  Title
Hsp72 recognizes a P binding motif in the measles virus N protein C-terminus.
  Journal
Virology 337:162-74 (2005)
DOI:10.1016/j.virol.2005.03.035
Reference
PMID:29712906
  Authors
Ke Z, Strauss JD, Hampton CM, Brindley MA, Dillard RS, Leon F, Lamb KM, Plemper RK, Wright ER
  Title
Promotion of virus assembly and organization by the measles virus matrix protein.
  Journal
Nat Commun 9:1736 (2018)
DOI:10.1038/s41467-018-04058-2
Reference
PMID:24155404
  Authors
Pfaller CK, Radeke MJ, Cattaneo R, Samuel CE
  Title
Measles virus C protein impairs production of defective copyback double-stranded viral RNA and activation of protein kinase R.
  Journal
J Virol 88:456-68 (2014)
DOI:10.1128/JVI.02572-13
Reference
PMID:17686838
  Authors
Sato H, Masuda M, Kanai M, Tsukiyama-Kohara K, Yoneda M, Kai C
  Title
Measles virus N protein inhibits host translation by binding to eIF3-p40.
  Journal
J Virol 81:11569-76 (2007)
DOI:10.1128/JVI.00570-07
Reference
PMID:19895323
  Authors
Sion-Vardy N, Lasarov I, Delgado B, Gopas J, Benharroch D, Ariad S
  Title
Measles virus: evidence for association with lung cancer.
  Journal
Exp Lung Res 35:701-12 (2009)
DOI:10.3109/01902140902853176
Reference
PMID:16140759
  Authors
Chen M, Cortay JC, Logan IR, Sapountzi V, Robson CN, Gerlier D
  Title
Inhibition of ubiquitination and stabilization of human ubiquitin E3 ligase PIRH2 by measles virus phosphoprotein.
  Journal
J Virol 79:11824-36 (2005)
DOI:10.1128/JVI.79.18.11824-11836.2005
Reference
PMID:16699046
  Authors
Cruz CD, Palosaari H, Parisien JP, Devaux P, Cattaneo R, Ouchi T, Horvath CM
  Title
Measles virus V protein inhibits p53 family member p73.
  Journal
J Virol 80:5644-50 (2006)
DOI:10.1128/JVI.02400-05
Reference
PMID:10756053
  Authors
Servet-Delprat C, Vidalain PO, Azocar O, Le Deist F, Fischer A, Rabourdin-Combe C
  Title
Consequences of Fas-mediated human dendritic cell apoptosis induced by measles virus.
  Journal
J Virol 74:4387-93 (2000)
DOI:10.1128/JVI.74.9.4387-4393.2000
Reference
PMID:20601611
  Authors
Kushwah R, Hu J
  Title
Dendritic cell apoptosis: regulation of tolerance versus immunity.
  Journal
J Immunol 185:795-802 (2010)
DOI:10.4049/jimmunol.1000325
Reference
PMID:10590149
  Authors
Vidalain PO, Azocar O, Lamouille B, Astier A, Rabourdin-Combe C, Servet-Delprat C
  Title
Measles virus induces functional TRAIL production by human dendritic cells.
  Journal
J Virol 74:556-9 (2000)
DOI:10.1128/JVI.74.1.556-559.2000
Reference
PMID:11846228
  Authors
Vidalain PO, Azocar O, Rabourdin-Combe C, Servet-Delprat C
  Title
Measle virus-infected dendritic cells develop immunosuppressive and cytotoxic activities.
  Journal
Immunobiology 204:629-38 (2001)
DOI:10.1078/0171-2985-00102
Reference
PMID:10423127
  Authors
Engelking O, Fedorov LM, Lilischkis R, ter Meulen V, Schneider-Schaulies S
  Title
Measles virus-induced immunosuppression in vitro is associated with deregulation of G1 cell cycle control proteins.
  Journal
J Gen Virol 80 ( Pt 7):1599-608 (1999)
DOI:10.1099/0022-1317-80-7-1599
Reference
PMID:30510918
  Authors
Fan Y, Sanyal S, Bruzzone R
  Title
Breaking Bad: How Viruses Subvert the Cell Cycle.
  Journal
Front Cell Infect Microbiol 8:396 (2018)
DOI:10.3389/fcimb.2018.00396
Reference
PMID:20636817
  Authors
Griffin DE
  Title
Measles virus-induced suppression of immune responses.
  Journal
Immunol Rev 236:176-89 (2010)
DOI:10.1111/j.1600-065X.2010.00925.x
Reference
PMID:11385511
  Authors
Avota E, Avots A, Niewiesk S, Kane LP, Bommhardt U, ter Meulen V, Schneider-Schaulies S
  Title
Disruption of Akt kinase activation is important for immunosuppression induced by measles virus.
  Journal
Nat Med 7:725-31 (2001)
DOI:10.1038/89106
Reference
PMID:15308747
  Authors
Avota E, Muller N, Klett M, Schneider-Schaulies S
  Title
Measles virus interacts with and alters signal transduction in T-cell lipid rafts.
  Journal
J Virol 78:9552-9 (2004)
DOI:10.1128/JVI.78.17.9552-9559.2004
Reference
PMID:16963735
  Authors
Yanagi Y, Takeda M, Ohno S
  Title
Measles virus: cellular receptors, tropism and pathogenesis.
  Journal
J Gen Virol 87:2767-79 (2006)
DOI:10.1099/vir.0.82221-0
Reference
PMID:16237742
  Authors
Kerdiles YM, Sellin CI, Druelle J, Horvat B
  Title
Immunosuppression caused by measles virus: role of viral proteins.
  Journal
Rev Med Virol 16:49-63 (2006)
DOI:10.1002/rmv.486
Related
pathway
uah04110  Cell cycle
uah04115  p53 signaling pathway
uah04120  Ubiquitin mediated proteolysis
uah04210  Apoptosis
uah04620  Toll-like receptor signaling pathway
uah04622  RIG-I-like receptor signaling pathway
uah04630  JAK-STAT signaling pathway
uah04658  Th1 and Th2 cell differentiation
uah04660  T cell receptor signaling pathway
KO pathway
ko05162   
LinkDB

DBGET integrated database retrieval system