KEGG   PATHWAY: ppad04024
Entry
ppad04024                   Pathway                                
Name
cAMP signaling pathway - Panthera pardus (leopard)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
ppad04024  cAMP signaling pathway
ppad04024

Other DBs
GO: 0019933
Organism
Panthera pardus (leopard) [GN:ppad]
Gene
109256430  VIP; VIP peptides isoform X1 [KO:K05264]
109260948  CRH; corticoliberin [KO:K05256]
109263275  CGA; glycoprotein hormones alpha chain [KO:K08522]
109252872  lutropin subunit beta [KO:K08521]
109246692  GPHA2; glycoprotein hormone alpha-2 [KO:K25483]
109268354  GPHB5; glycoprotein hormone beta-5 [KO:K25484]
109272111  TSHB; thyrotropin subunit beta [KO:K05251]
109262875  POMC; pro-opiomelanocortin [KO:K05228]
109271980  GCG; glucagon isoform X1 [KO:K05259]
109247335  GIP; gastric inhibitory polypeptide [KO:K05258]
109271291  FSHB; follitropin subunit beta [KO:K05250]
109274120  NPPA; natriuretic peptides A [KO:K12334]
109248572  ADCYAP1; pituitary adenylate cyclase-activating polypeptide isoform X1 [KO:K05262]
109272931  ADRB1; beta-1 adrenergic receptor [KO:K04141]
109275924  ADRB2; beta-2 adrenergic receptor isoform X1 [KO:K04142]
109267537  DRD1; D(1A) dopamine receptor [KO:K04144]
109269668  DRD5; D(1B) dopamine receptor [KO:K05840]
109277439  ADORA2A; adenosine receptor A2a isoform X1 [KO:K04266]
109275921  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
109274230  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
109268475  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
109263931  ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587]
109252458  VIPR2; vasoactive intestinal polypeptide receptor 2 isoform X1 [KO:K04590]
109259750  CRHR1; corticotropin-releasing factor receptor 1 isoform X1 [KO:K04578]
109263924  CRHR2; corticotropin-releasing factor receptor 2 isoform X1 [KO:K04579]
109247804  LHCGR; lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
109274402  TSHR; thyrotropin receptor isoform X1 [KO:K04249]
109257618  MC2R; adrenocorticotropic hormone receptor [KO:K04200]
109271569  GLP1R; glucagon-like peptide 1 receptor [KO:K04581]
109253223  GIPR; gastric inhibitory polypeptide receptor isoform X1 [KO:K04580]
109253754  GPR119; glucose-dependent insulinotropic receptor [KO:K08424]
109248008  FSHR; follicle-stimulating hormone receptor isoform X1 [KO:K04247]
109256259  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
109253465  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like isoform X1 [KO:K04632]
109253466  neuroendocrine secretory protein 55 [KO:K04632]
109249630  EDN1; endothelin-1 isoform X1 [KO:K16366]
109254884  EDN2; endothelin-2 [KO:K16367]
109253362  EDN3; endothelin-3 [KO:K05227]
109275291  SST; somatostatin [KO:K05237]
109263839  NPY; pro-neuropeptide Y [KO:K05232]
109254364  GHRL; appetite-regulating hormone isoform X1 [KO:K05254]
109274635  oxytocin-neurophysin 1-like [KO:K05243]
109274290  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
109246388  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
109263313  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
109263374  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
109255362  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
109246616  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
109269060  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
109278635  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
109260850  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 [KO:K04615]
109270091  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
109256643  ADORA1; adenosine receptor A1 [KO:K04265]
109250080  EDNRA; endothelin-1 receptor [KO:K04197]
109262457  NPY1R; neuropeptide Y receptor type 1 [KO:K04204]
109253300  SSTR1; somatostatin receptor type 1 isoform X1 [KO:K04217]
109277008  SSTR2; somatostatin receptor type 2 [KO:K04218]
109259682  SSTR5; somatostatin receptor type 5 [KO:K04221]
109277718  HCAR1; hydroxycarboxylic acid receptor 1 [KO:K08401]
109277717  hydroxycarboxylic acid receptor 2 [KO:K08402]
109251471  free fatty acid receptor 2-like [KO:K04328]
109251473  free fatty acid receptor 2-like isoform X1 [KO:K04328]
109261322  SUCNR1; succinate receptor 1 [KO:K10042]
109266686  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
109254404  OXTR; oxytocin receptor [KO:K04229]
109275135  GHSR; growth hormone secretagogue receptor type 1 [KO:K04284]
109247840  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
109268145  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
109272000  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
109267948  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
109267830  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
109267527  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
109254969  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
109266493  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
109249043  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
109270953  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
109273118  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
109278247  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
109251769  ADCY10; adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
109271587  adenylate cyclase type 10-like isoform X1 [KO:K11265] [EC:4.6.1.1]
109245350  CNGA1; cGMP-gated cation channel alpha-1 [KO:K04948]
109258715  CNGA2; cyclic nucleotide-gated olfactory channel [KO:K04949]
109273068  CNGA3; cyclic nucleotide-gated cation channel alpha-3 [KO:K04950]
109271059  CNGA4; cyclic nucleotide-gated cation channel alpha-4 isoform X1 [KO:K04951]
109270855  CNGB1; cyclic nucleotide-gated cation channel beta-1 isoform X1 [KO:K04952]
109269452  CNGB3; cyclic nucleotide-gated cation channel beta-3 isoform X1 [KO:K04953]
109273951  calmodulin-like protein 6 isoform X1 [KO:K02183]
109246761  CALM2; calmodulin [KO:K02183]
109253192  CALM3; calmodulin isoform X1 [KO:K02183]
109273783  calmodulin-like protein 3 [KO:K02183]
109273784  calmodulin-like [KO:K02183]
109273854  calmodulin-like protein 6 [KO:K02183]
109274449  CALM1; calmodulin [KO:K02183]
109262791  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
109257442  calmodulin-alpha-like [KO:K02183]
109262226  calmodulin-like [KO:K02183]
109264424  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
109275954  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
109248360  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
109267916  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
109267609  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
109263473  BVES; blood vessel epicardial substance isoform X1 [KO:K21108]
109266437  POPDC2; popeye domain-containing protein 2 isoform X1 [KO:K26206]
109263475  POPDC3; popeye domain-containing protein 3 isoform X1 [KO:K26207]
109254391  KCNK2; potassium channel subfamily K member 2 isoform X1 [KO:K04913]
109257670  HCN2; LOW QUALITY PROTEIN: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [KO:K04955]
109262721  HCN4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [KO:K04957]
109264157  ABCC4; multidrug resistance-associated protein 4 isoform X1 [KO:K05673]
109249020  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
109273039  rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
109252867  RRAS; LOW QUALITY PROTEIN: ras-related protein R-Ras [KO:K07829]
109271166  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
109246097  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
109275130  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
109264678  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1-like [KO:K05860] [EC:3.1.4.11]
109278973  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
109276314  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
109264550  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
109272045  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
109259557  ras-related protein Rap-1b [KO:K07836]
109270479  RAP1B; ras-related protein Rap-1b [KO:K07836]
109249680  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
109258267  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
109271959  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
109261030  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
109251192  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
109265228  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
109277132  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
109267249  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
109252207  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
109247805  RHOA; transforming protein RhoA [KO:K04513]
109245430  AFDN; afadin isoform X1 [KO:K05702]
109274075  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
109275159  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
109259912  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
109266953  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
109275060  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
109247606  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
109256570  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109251379  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109257810  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109269114  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
109257492  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
109262816  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
109255967  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
109259699  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109261343  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
109246175  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
109253991  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
109247418  PPP1R1B; protein phosphatase 1 regulatory subunit 1B [KO:K15494]
109266491  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
109246846  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
109277658  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
109265159  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
109270166  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
109256215  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
109245089  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
109255940  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
109269067  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
109263891  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
109278438  CREBBP; LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
109265617  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
109271282  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
109253856  FOS; proto-oncogene c-Fos [KO:K04379]
109266785  JUN; transcription factor AP-1 [KO:K04448]
109268007  GLI3; transcriptional activator GLI3 isoform X1 [KO:K06230]
109270371  GLI1; zinc finger protein GLI1 isoform X1 [KO:K16797]
109251660  protein patched homolog 1 isoform X1 [KO:K06225]
109249888  HHIP; hedgehog-interacting protein [KO:K06231]
109253320  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
109247385  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
109246747  RELA; transcription factor p65 isoform X1 [KO:K04735]
109277011  SOX9; transcription factor SOX-9 isoform X1 [KO:K18435]
109257726  AMH; muellerian-inhibiting factor [KO:K04665]
109265727  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
109269729  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 isoform X1 [KO:K00232] [EC:1.3.3.6]
109276909  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
109251747  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
109274968  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
109246663  BAD; bcl2-associated agonist of cell death [KO:K02158]
109257948  LIPE; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
109248559  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
109268495  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
109270552  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
109272490  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
109259919  TNNI3; troponin I, cardiac muscle isoform X1 [KO:K12044]
109248471  PLN; cardiac phospholamban [KO:K05852]
109256497  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
109255119  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
109277669  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
109248970  RYR2; ryanodine receptor 2 [KO:K04962]
109260229  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
109278305  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
109268638  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
109276963  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
109252879  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
109270049  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
109257731  GRIN3B; glutamate receptor ionotropic, NMDA 3B isoform X1 [KO:K05214]
109275994  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
109262480  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
109250724  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
109258459  GRIA4; glutamate receptor 4 [KO:K05200]
109248378  CFTR; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
109272127  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 isoform X1 [KO:K01539] [EC:7.2.2.13]
109257219  sodium/potassium-transporting ATPase subunit alpha-4 isoform X1 [KO:K01539] [EC:7.2.2.13]
109257221  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
109257944  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539] [EC:7.2.2.13]
109245933  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 isoform X1 [KO:K01540]
109251996  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
109250740  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
109260258  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
109278582  FXYD2; sodium/potassium-transporting ATPase subunit gamma isoform X1 [KO:K01538]
109251489  FXYD1; phospholemman isoform X1 [KO:K13360]
109256776  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
109277687  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
109265308  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
109256714  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
109254361  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
109259867  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
109276255  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
109247930  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
109248097  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
109256096  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
109268687  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1 [KO:K19021] [EC:3.1.4.17]
109271173  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
109254111  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
109266724  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
109247614  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
109246432  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
109245409  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
Reference
PMID:11493633
  Authors
Fimia GM, Sassone-Corsi P
  Title
Cyclic AMP signalling.
  Journal
J Cell Sci 114:1971-2 (2001)
Reference
PMID:18323530
  Authors
Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M
  Title
Cyclic AMP: master regulator of innate immune cell function.
  Journal
Am J Respir Cell Mol Biol 39:127-32 (2008)
DOI:10.1165/rcmb.2008-0091TR
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Related
pathway
ppad00071  Fatty acid degradation
ppad04015  Rap1 signaling pathway
ppad04020  Calcium signaling pathway
ppad04151  PI3K-Akt signaling pathway
ppad04210  Apoptosis
ppad04260  Cardiac muscle contraction
ppad04340  Hedgehog signaling pathway
ppad04720  Long-term potentiation
ppad04740  Olfactory transduction
ppad04972  Pancreatic secretion
ppad04976  Bile secretion
KO pathway
ko04024   
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