KEGG   PATHWAY: uar04510
Entry
uar04510                    Pathway                                
Name
Focal adhesion - Ursus americanus (American black bear)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
uar04510  Focal adhesion
uar04510

Other DBs
GO: 0005925
Organism
Ursus americanus (American black bear) [GN:uar]
Gene
123789274  COL1A2; collagen alpha-2(I) chain [KO:K06236]
123776788  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
123794804  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
123780205  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
123784800  COL4A6; LOW QUALITY PROTEIN: collagen alpha-6(IV) chain [KO:K06237]
123778093  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
123778094  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
123776743  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
123776744  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
123788369  collagen alpha-4(VI) chain-like isoform X1 [KO:K06238]
123788370  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
123788457  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
123790031  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
123779137  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
123779139  COL6A1; LOW QUALITY PROTEIN: collagen alpha-1(VI) chain [KO:K06238]
123797422  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
123790824  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
123776118  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
123782078  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
123797600  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
123781999  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
123790672  LAMA5; laminin subunit alpha-5 [KO:K06240]
123792966  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
123789409  LAMB1; laminin subunit beta-1 [KO:K05636]
123779916  LAMB2; laminin subunit beta-2 [KO:K06243]
123785811  LAMB3; laminin subunit beta-3 isoform X1 [KO:K06244]
123789617  LAMB4; laminin subunit beta-4 [KO:K06245]
123801431  LAMC1; laminin subunit gamma-1 [KO:K05635]
123801399  LAMC2; laminin subunit gamma-2 [KO:K06246]
123775703  LAMC3; laminin subunit gamma-3 isoform X1 [KO:K06247]
123776820  CHAD; LOW QUALITY PROTEIN: chondroadherin [KO:K06248]
123789379  RELN; LOW QUALITY PROTEIN: reelin [KO:K06249] [EC:3.4.21.-]
123804137  THBS1; thrombospondin-1 [KO:K16857]
123779882  cartilage oligomeric matrix protein isoform X1 [KO:K04659]
123783393  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
123791530  THBS4; thrombospondin-4 [KO:K04659]
123775437  THBS2; thrombospondin-2 [KO:K04659]
123798278  FN1; fibronectin isoform X1 [KO:K05717]
123788294  SPP1; osteopontin isoform X1 [KO:K06250]
123776873  VTN; vitronectin [KO:K06251]
123801411  TNR; tenascin-R [KO:K06252]
123801422  TNN; tenascin-N isoform X1 [KO:K06252]
123788031  TNC; tenascin isoform X1 [KO:K06252]
123790969  TNXB; tenascin-X isoform X1 [KO:K06252]
123781568  VWF; LOW QUALITY PROTEIN: von Willebrand factor [KO:K03900]
123788290  LOW QUALITY PROTEIN: bone sialoprotein 2 [KO:K06253]
123803661  ITGA1; integrin alpha-1 [KO:K06480]
123803701  ITGA2; integrin alpha-2 [KO:K06481]
123803148  ITGA2B; integrin alpha-IIb [KO:K06476]
123776779  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
123798102  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
123794668  ITGA5; integrin alpha-5 [KO:K06484]
123780702  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
123787285  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
123785864  ITGA8; integrin alpha-8 [KO:K06584]
123792843  ITGA9; integrin alpha-9 [KO:K06585]
123778699  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
123800835  ITGA11; integrin alpha-11 [KO:K06587]
123798116  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
123784876  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
123803040  ITGB3; integrin beta-3 [KO:K06493]
123803018  ITGB4; LOW QUALITY PROTEIN: integrin beta-4 [KO:K06525]
123802198  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
123781472  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
123794706  ITGB7; integrin beta-7 [KO:K06590]
123789193  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
123783330  EMP2; epithelial membrane protein 2 [KO:K26256]
123802515  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
123780665  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
123792511  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
123793193  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
123793362  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
123780774  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
123796996  VEGFA; vascular endothelial growth factor A [KO:K05448]
123778493  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
123798976  PGF; placenta growth factor isoform X1 [KO:K16859]
123802596  VEGFC; vascular endothelial growth factor C [KO:K05449]
123797262  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
123789349  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
123804080  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
123803639  PDGFRB; LOW QUALITY PROTEIN: platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
123790797  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
123803979  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
123786270  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
123791948  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
123790499  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
123789034  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
123779529  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
123781735  EMP1; epithelial membrane protein 1 [KO:K26255]
123796968  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
123776341  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
123795705  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
123780073  RHOA; transforming protein RhoA [KO:K04513]
123790225  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
123782085  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
123778572  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
123779111  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
123777844  MYL5; myosin light chain 5 [KO:K12753]
123789626  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
123796948  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
123777317  MYL10; myosin regulatory light chain 10 [KO:K12756]
123782001  myosin regulatory light polypeptide 9 isoform X1 [KO:K12757]
123782002  myosin regulatory light chain 12B [KO:K12757]
123784777  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
123799882  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
123795174  serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
123778467  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
123779126  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
123780848  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
123785739  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
123786950  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
123801590  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
123802103  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
123798683  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
123776613  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
123787715  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
123796830  PIP5K1C; LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
123776489  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
123802532  ACTB; actin, cytoplasmic 1 [KO:K05692]
123777926  ACTG1; actin, cytoplasmic 2 [KO:K05692]
123796881  RASGRF1; LOW QUALITY PROTEIN: ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
123791973  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
123784522  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
123799050  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
123781159  TLN1; talin-1 [KO:K06271]
123795529  TLN2; talin-2 isoform X1 [KO:K06271]
123787808  FLNA; LOW QUALITY PROTEIN: filamin-A [KO:K04437]
123798792  FLNB; filamin-B isoform X1 [KO:K27392]
123788286  PXN; paxillin isoform X1 [KO:K05760]
123782737  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
123788831  ZYX; zyxin isoform X1 [KO:K06273]
123799614  vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
123782824  VCL; vinculin isoform X1 [KO:K05700]
123780636  PARVB; beta-parvin isoform X1 [KO:K06275]
123780834  PARVG; gamma-parvin isoform X1 [KO:K06275]
123791652  PARVA; alpha-parvin [KO:K06275]
123783746  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
123793473  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123784096  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123791373  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123784023  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
123792803  CTNNB1; catenin beta-1 [KO:K02105]
123803224  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
123778823  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
123786995  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
123779697  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
123786407  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
123788422  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123779078  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123800228  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
123793748  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
123779926  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
123795550  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
123795136  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
123779019  VAV1; proto-oncogene vav [KO:K05730]
123775750  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
123802589  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
123780787  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
123777961  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
123804163  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
123802208  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
123794865  PAK3; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
123784330  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
123799754  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
123804233  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
123803163  cell division control protein 42 homolog [KO:K04393]
123782153  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
123791314  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
123795650  CRKL; crk-like protein [KO:K04438]
123776898  CRK; adapter molecule crk isoform X1 [KO:K04438]
123800053  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
123775730  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
123795072  RAP1A; ras-related protein Rap-1A [KO:K04353]
123787151  RAP1B; ras-related protein Rap-1b [KO:K07836]
123800287  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
123788054  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
123790496  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
123795376  JUN; transcription factor AP-1 [KO:K04448]
123788872  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
123789035  CAV1; caveolin-1 isoform X1 [KO:K06278]
123789036  CAV2; caveolin-2 [KO:K12958]
123799238  CAV3; caveolin-3 [KO:K12959]
123792961  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
123783413  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
123794070  LOW QUALITY PROTEIN: SHC-transforming protein 2-like [KO:K17447]
123776524  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
123801854  SHC4; SHC-transforming protein 4 [KO:K17449]
123802938  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
123799809  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
123793291  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
123775506  HRAS; GTPase HRas isoform X1 [KO:K02833]
123802053  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
123800861  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
123795639  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
123784602  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
123787940  ELK1; LOW QUALITY PROTEIN: ETS domain-containing protein Elk-1 [KO:K04375]
123778441  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
123781570  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
123779180  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
123792498  baculoviral IAP repeat-containing protein 3-like [KO:K16060]
123792499  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
123792333  E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
123778440  BAD; bcl2-associated agonist of cell death [KO:K02158]
123787450  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
uar04010  MAPK signaling pathway
uar04060  Cytokine-cytokine receptor interaction
uar04070  Phosphatidylinositol signaling system
uar04110  Cell cycle
uar04151  PI3K-Akt signaling pathway
uar04310  Wnt signaling pathway
uar04512  ECM-receptor interaction
uar04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
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