KEGG   PATHWAY: scan04010
Entry
scan04010                   Pathway                                
Name
MAPK signaling pathway - Serinus canaria (common canary)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
scan04010  MAPK signaling pathway
scan04010

Other DBs
GO: 0000165
Organism
Serinus canaria (common canary) [GN:scan]
Gene
103819171  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
103820462  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
103816992  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
103823392  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
103819981  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X14 [KO:K04854]
103817830  CACNA1H; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
103813612  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
103822432  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
103813738  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
103817134  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
103816995  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
103820520  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
103812781  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X4 [KO:K04863]
103814617  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X2 [KO:K04865]
103819769  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
103813220  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
103817800  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
103819766  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
103819768  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
103825329  voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
103814927  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
103819765  PRKCA; protein kinase C alpha type isoform X3 [KO:K02677] [EC:2.7.11.13]
103817801  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
103817628  GNA12; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
103815078  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
103813987  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103826268  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103824434  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103821361  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
103816276  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
103823070  RASGRF2; LOW QUALITY PROTEIN: ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
103826949  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
103817484  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
103825944  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X4 [KO:K08018]
103820348  NF1; neurofibromin isoform X1 [KO:K08052]
103821051  RASA1; LOW QUALITY PROTEIN: ras GTPase-activating protein 1 [KO:K04352]
103824743  LOW QUALITY PROTEIN: ras GTPase-activating protein 1-like [KO:K04352]
103815423  RASA2; ras GTPase-activating protein 2 isoform X2 [KO:K08053]
103823268  RAP1A; ras-related protein Rap-1A [KO:K04353]
103813454  RAP1B; ras-related protein Rap-1b [KO:K07836]
103826255  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
103823442  EREG; proepiregulin [KO:K09784]
103823468  AREG; LOW QUALITY PROTEIN: amphiregulin [KO:K09782]
103817397  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
103821418  FGF2; fibroblast growth factor 2 [KO:K18497]
103816506  FGF16; fibroblast growth factor 16 [KO:K04358]
103819601  FGF6; fibroblast growth factor 6 [KO:K04358]
103816025  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
103813872  FGF8; fibroblast growth factor 8 isoform X2 [KO:K04358]
103823450  FGF5; fibroblast growth factor 5 [KO:K04358]
103827318  FGF9; fibroblast growth factor 9 [KO:K04358]
103826197  FGF20; LOW QUALITY PROTEIN: fibroblast growth factor 20 [KO:K04358]
103822218  FGF4; fibroblast growth factor 4 [KO:K04358]
103822219  FGF3; LOW QUALITY PROTEIN: fibroblast growth factor 3 [KO:K04358]
103823777  FGF18; fibroblast growth factor 18 isoform X4 [KO:K04358]
115484358  FGF22; fibroblast growth factor 22 [KO:K04358]
115485473  FGF19; LOW QUALITY PROTEIN: fibroblast growth factor 19 [KO:K22603]
103819695  FGF23; fibroblast growth factor 23 [KO:K22428]
103822331  NGF; beta-nerve growth factor [KO:K02582]
103822085  BDNF; brain-derived neurotrophic factor isoform X2 [KO:K04355]
103819553  NTF3; neurotrophin-3 [KO:K04356]
103826754  INS; insulin [KO:K04526]
103819655  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
103826753  IGF2; insulin-like growth factor II [KO:K13769]
103817870  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
103813271  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
103812525  PDGFD; platelet-derived growth factor D [KO:K05450]
103826223  PDGFC; platelet-derived growth factor C [KO:K05450]
103822422  CSF1; LOW QUALITY PROTEIN: macrophage colony-stimulating factor 1 [KO:K05453]
103813653  KITLG; kit ligand [KO:K05461]
103817849  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
103826914  PGF; placenta growth factor isoform X1 [KO:K16859]
103815820  VEGFD; vascular endothelial growth factor D [KO:K05449]
103825795  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
103813737  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
103814053  ANGPT1; angiopoietin-1 [KO:K05465]
103820138  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
103818847  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
103822866  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
103824040  ephrin-A3-like isoform X1 [KO:K05462]
103822051  EFNA2; ephrin-A2 isoform X1 [KO:K05462]
115484474  LOW QUALITY PROTEIN: uncharacterized protein LOC115484474 [KO:K05462]
103821005  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
103824702  NRTN; neurturin [KO:K25414]
103814961  ARTN; artemin isoform X1 [KO:K25415]
103819418  EGFR; epidermal growth factor receptor isoform X3 [KO:K04361] [EC:2.7.10.1]
103821628  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
103814752  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
103822693  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
103813785  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
103826117  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
103817508  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
103821808  NGFR; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 16 [KO:K02583]
103824820  NTRK1; LOW QUALITY PROTEIN: high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
103822953  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
103821923  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
103816222  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103825217  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
103817301  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
103817300  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
103826188  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
103812551  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
103827338  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
103816498  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
103817296  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
103825225  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
103813465  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
103821834  TEK; angiopoietin-1 receptor isoform X3 [KO:K05121] [EC:2.7.10.1]
103820972  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
103814210  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X2 [KO:K05126] [EC:2.7.10.1]
103819847  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
103826824  SOS2; son of sevenless homolog 2 [KO:K03099]
103821384  SOS1; son of sevenless homolog 1 [KO:K03099]
103824084  HRAS; GTPase HRas [KO:K02833]
103819595  KRAS; GTPase KRas [KO:K07827]
103822405  NRAS; GTPase NRas [KO:K07828]
103827032  RRAS2; ras-related protein R-Ras2 [KO:K07830]
103814330  MRAS; ras-related protein M-Ras [KO:K07831]
103819614  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
103816934  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103816115  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103824555  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
115485326  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
103818074  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103814996  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
103821997  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
103817340  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
103823526  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
103816446  RPS6KA6; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
103815847  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
103813275  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
103822311  ELK4; LOW QUALITY PROTEIN: ETS domain-containing protein Elk-4 [KO:K04376]
103816707  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
103821295  SRF; LOW QUALITY PROTEIN: serum response factor [KO:K04378]
103826521  FOS; proto-oncogene c-Fos [KO:K04379]
103821801  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
103823520  STMN1; stathmin [KO:K04381]
103814801  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
103826978  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
103826981  cytosolic phospholipase A2 epsilon-like isoform X4 [KO:K16342] [EC:3.1.1.4]
103826979  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
103826646  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
103826647  cytosolic phospholipase A2 epsilon-like isoform X1 [KO:K16342] [EC:3.1.1.4]
103826648  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
103826650  cytosolic phospholipase A2 epsilon-like isoform X2 [KO:K16342] [EC:3.1.1.4]
103826977  cytosolic phospholipase A2 epsilon-like isoform X1 [KO:K16342] [EC:3.1.1.4]
103826983  cytosolic phospholipase A2 beta isoform X3 [KO:K16342] [EC:3.1.1.4]
103822662  IL1B; interleukin-1 beta isoform X2 [KO:K04519]
103821503  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
103826906  LOW QUALITY PROTEIN: transforming growth factor beta-3 proprotein [KO:K13377]
115485432  transforming growth factor beta-3 proprotein-like [KO:K13377]
103812440  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X2 [KO:K03158]
103812363  interleukin-1 receptor type 1-like isoform X1 [KO:K04386]
103815624  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
103819385  TGFBR1; TGF-beta receptor type-1 isoform X3 [KO:K04674] [EC:2.7.11.30]
103814641  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
103813156  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
103823387  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
103814184  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
103817879  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103813234  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
103819726  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
103824159  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
103816650  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
103825669  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
103819084  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
103813055  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
103820377  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
103826724  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
103821256  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
103822059  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
103813611  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
103818533  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
103821322  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X4 [KO:K04406] [EC:2.7.11.1]
103812362  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
103816406  NRK; nik-related protein kinase isoform X1 [KO:K04407] [EC:2.7.11.1]
103827218  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
103815510  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
103818797  STK4; serine/threonine-protein kinase 4 [KO:K04411]
103813772  STK3; serine/threonine-protein kinase 3 isoform X3 [KO:K04412]
103812752  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
103821035  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
103814336  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
103812700  mitogen-activated protein kinase kinase kinase 3-like isoform X1 [KO:K04421] [EC:2.7.11.25]
103821658  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
103826623  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
103818563  MAP3K21; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
103815669  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
103814440  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
103818465  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
103819102  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X5 [KO:K04427] [EC:2.7.11.25]
103821627  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
103818052  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
103820134  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
103823926  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
103817610  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X3 [KO:K04432] [EC:2.7.12.2]
103819965  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
103826673  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X2 [KO:K04434]
115484138  LOW QUALITY PROTEIN: C-Jun-amino-terminal kinase-interacting protein 2-like [KO:K04435]
103824367  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X16 [KO:K04436]
103818004  CRKL; crk-like protein [KO:K04438]
103820104  CRK; LOW QUALITY PROTEIN: adapter molecule crk [KO:K04438]
103820688  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
103817284  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
103813947  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
103826066  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103813699  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
103823281  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
103823282  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
103813488  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103818142  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
103822392  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
103816963  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
103826478  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
103819427  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
103816639  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
103815057  JUN; transcription factor AP-1 [KO:K04448]
103814449  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
103822169  MAX; protein max isoform X2 [KO:K04453]
103820992  MEF2C; myocyte-specific enhancer factor 2C isoform X3 [KO:K04454]
103820075  HSPB1; heat shock protein beta-1 [KO:K04455]
103817751  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103826388  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103826341  PPM1A; protein phosphatase 1A isoform X2 [KO:K04457] [EC:3.1.3.16]
103813673  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
103826765  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
103822355  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
103824102  DUSP1; dual specificity protein phosphatase 1 isoform X1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
103819717  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103813832  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103826744  DUSP8; LOW QUALITY PROTEIN: dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103826241  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103824279  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103813409  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
103821494  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
103821565  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
103817100  PPM1B; protein phosphatase 1B isoform X2 [KO:K04461] [EC:3.1.3.16]
103823628  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
103815279  MECOM; histone-lysine N-methyltransferase MECOM isoform X4 [KO:K04462] [EC:2.1.1.367]
103816250  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X2 [KO:K04463] [EC:2.7.12.2]
103824614  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
103821648  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
103814234  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X2 [KO:K04467] [EC:2.7.11.10]
103822735  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103820200  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
103826026  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
103814195  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
115484983  RELB; LOW QUALITY PROTEIN: transcription factor RelB [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
scan04070  Phosphatidylinositol signaling system
scan04110  Cell cycle
scan04115  p53 signaling pathway
scan04210  Apoptosis
scan04310  Wnt signaling pathway
KO pathway
ko04010   
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