KEGG   PATHWAY: bta05207
Entry
bta05207                    Pathway                                
Name
Chemical carcinogenesis - receptor activation - Bos taurus (cow)
Description
Carcinogenesis is a multistage process that consists of initiation, promotion, and progression stages. Chemicals or environmental factors may act at any of these stages to induce and/or enhance the carcinogenic process. Based on their mode-of-action, carcinogens can be classified as genotoxic or non-genotoxic. Genotoxic agent begins their action at the deoxyribonucleic acid (DNA) level, causing DNA damage through several mechanisms. Non-genotoxic carcinogens are chemicals that cause the development of tumors through multiple non-genotoxic events and epigenetic alterations without direct interaction with DNA. One non-genotoxic mechanism involves receptor activation. Biological mechanisms involving receptor activation fall into two broad categories: (i) those that involve cell surface receptors and some intracellular receptors that activate signal transduction pathways, resulting in biological responses, including gene transcription, and (ii) those that involve intracellular receptors that translocate into the nucleus and act as transcription factors regulating gene expression. Both classes of receptors can be involved in mechanisms of carcinogenesis.
Class
Human Diseases; Cancer: overview
Pathway map
bta05207  Chemical carcinogenesis - receptor activation
bta05207

Organism
Bos taurus (cow) [GN:bta]
Gene
100137872  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100138004  [KO:K00699] [EC:2.4.1.17]
100138040  SOS2; son of sevenless homolog 2 [KO:K03099]
100138908  [KO:K00699] [EC:2.4.1.17]
100139219  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100140261  [KO:K00699] [EC:2.4.1.17]
100170919  MIRLET7C; bta-let-7c [KO:K16980]
100170921  MIRLET7A-3; bta-let-7a-5p [KO:K16980]
100170922  MIRLET7B; bta-let-7b [KO:K16980]
100170929  MIRLET7A-2; bta-let-7a-5p [KO:K16980]
100170931  MIRLET7E; bta-let-7e [KO:K16980]
100295687  [KO:K00799] [EC:2.5.1.18]
100296421  [KO:K00699] [EC:2.4.1.17]
100298939  HRAS; GTPase HRas isoform 1 [KO:K02833]
100300257  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
100313001  MIR141; bta-miR-141 [KO:K17018]
100313025  MIR29D; bta-miR-29d-5p [KO:K16995]
100313099  MIR29E; bta-miR-29e [KO:K16995]
100313105  MIR29B-1; bta-miR-29b [KO:K16995]
100337204  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
100498829  MIR3596; bta-miR-3596 [KO:K16980]
100847184  [KO:K02833]
100848466  PGR; progesterone receptor [KO:K08556]
101905399  [KO:K04368] [EC:2.7.12.2]
132342556  [KO:K00799] [EC:2.5.1.18]
280675  AR; androgen receptor [KO:K08557]
280714  AHR; aryl hydrocarbon receptor [KO:K09093]
280795  FOS; protein c-Fos [KO:K04379]
280831  JUN; transcription factor Jun [KO:K04448]
280991  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
281010  ARNT; aryl hydrocarbon receptor nuclear translocator [KO:K09097]
281020  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
281146  ESR2; estrogen receptor beta [KO:K08551]
281161  FGF2; fibroblast growth factor 2 precursor [KO:K18497]
281572  VEGFA; vascular endothelial growth factor A isoform 3 precursor [KO:K05448]
281601  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
281603  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
281604  ADRB1; beta-1 adrenergic receptor [KO:K04141]
281605  ADRB2; beta-2 adrenergic receptor [KO:K04142]
281606  ADRB3; beta-3 adrenergic receptor [KO:K04143]
281609  AIPL1; aryl-hydrocarbon-interacting protein-like 1 [KO:K17767]
281637  ARRB1; beta-arrestin-1 [KO:K04439]
281638  ARRB2; beta-arrestin-2 [KO:K04439]
281647  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
281713  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
281715  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
281790  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
281791  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
281793  GNAS; SCG6 (secretogranin VI) isoform SCG6 precursor [KO:K04632]
281805  GSTA2; glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
281832  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
281992  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
282001  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
282002  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
282178  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 precursor [KO:K04809]
282181  CHRNB4; neuronal acetylcholine receptor subunit beta-4 precursor [KO:K04815]
282214  CYP3A28; cytochrome P450 3A28 [KO:K07424] [EC:1.14.14.1]
282306  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
282307  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
282308  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
282322  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
282323  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
282325  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
282375  STAT5A; signal transducer and activator of transcription 5A [KO:K11223]
282376  STAT5B; signal transducer and activator of transcription 5B [KO:K11224]
282410  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
282646  HSP90B1; endoplasmin precursor [KO:K09487]
282648  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
282702  CHRNA3; neuronal acetylcholine receptor subunit alpha-3 precursor [KO:K04805]
282870  CYP1A1; cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
286792  UGT1A6; UDP-glucuronosyltransferase 1-6 precursor [KO:K00699] [EC:2.4.1.17]
286865  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
326284  FGF8; fibroblast growth factor 8 precursor [KO:K04358]
326285  FGF10; fibroblast growth factor 10 precursor [KO:K04358]
327672  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
327709  GSTM1; glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
360190  AIP; AH receptor-interacting protein [KO:K17767]
404181  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
407217  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
407238  ESR1; estrogen receptor [KO:K08550]
408013  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
408015  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
414925  BIRC5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
493638  PTGES3; prostaglandin E synthase 3 [KO:K15730] [EC:5.3.99.3]
493711  NR1I3; nuclear receptor subfamily 1 group I member 3 [KO:K08541]
493719  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
503552  CYP1A2; cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
504531  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
504769  CYP2B6; cytochrome P450 family 2 subfamily B member 6 precursor [KO:K07412] [EC:1.14.14.1]
504943  RXRB; retinoic acid receptor RXR-beta [KO:K08525]
505642  GSTO1; glutathione-S-transferase omega 1 [KO:K00799] [EC:2.5.1.18]
505740  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
505993  DLL3; delta-like protein 3 precursor [KO:K06051]
506083  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
506093  GSTT4; glutathione S-transferase, theta 4 [KO:K00799] [EC:2.5.1.18]
506322  NRAS; GTPase NRas [KO:K07828]
507346  MGST3; glutathione S-transferase 3, mitochondrial [KO:K00799] [EC:2.5.1.18]
507554  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
507804  KPNB1; importin subunit beta-1 [KO:K14293]
507988  CYP3A74; cytochrome P450 family 3 subfamily A member 74 [KO:K07424] [EC:1.14.14.1]
508233  RELA; transcription factor p65 [KO:K04735]
508541  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
509107  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
509500  RXRG; retinoic acid receptor RXR-gamma [KO:K08526]
509613  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
509779  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
509827  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
509936  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
510434  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
510708  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
511077  MYC; myc proto-oncogene protein [KO:K04377]
511190  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
511470  CYP1B1; cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
511716  EPHX2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
511743  UGT2A1; UDP-glucuronosyltransferase 2A1 precursor [KO:K00699] [EC:2.4.1.17]
513010  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
513105  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
513592  KPNA2; importin subunit alpha-1 [KO:K15043]
513730  NOTCH2; neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994]
513836  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
513928  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
515301  CDC6; cell division control protein 6 homolog [KO:K02213]
515638  MGC152010; UDP glucuronosyltransferase 2 family precursor [KO:K00699] [EC:2.4.1.17]
516190  GSTT2; glutathione S-transferase theta-2 [KO:K00799] [EC:2.5.1.18]
517246  CYP3A24; cytochrome P450 3A24 isoform X1 [KO:K07424] [EC:1.14.14.1]
517519  CHRNB2; neuronal acetylcholine receptor subunit beta-2 precursor [KO:K04813]
517724  GSTT1; glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
517948  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
517953  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
518746  DLL4; delta-like protein 4 precursor [KO:K06051]
519657  FGF22; fibroblast growth factor 22 precursor [KO:K04358]
520188  CDC25A; M-phase inducer phosphatase 1 [KO:K06645] [EC:3.1.3.48]
520842  KLF4; Krueppel-like factor 4 [KO:K17846]
521196  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
521685  GSTA5; glutathione S-transferase A5 [KO:K00799] [EC:2.5.1.18]
521876  CHRNA9; neuronal acetylcholine receptor subunit alpha-9 precursor [KO:K04810]
522932  PAQR7; membrane progestin receptor alpha [KO:K25039]
524246  EPHX4; epoxide hydrolase 4 isoform 1 [KO:K22369] [EC:3.3.-.-]
524530  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
525246  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
525482  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
526227  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
526682  CYP3A76; cytochrome P450 family 3 subfamily A member 76 [KO:K07424] [EC:1.14.14.1]
526979  [KO:K00699] [EC:2.4.1.17]
527461  PAQR5; membrane progestin receptor gamma isoform X1 [KO:K25041]
529566  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X5 [KO:K09048]
530315  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
530553  [KO:K00699] [EC:2.4.1.17]
530571  CYP2B39; cytochrome P450 2B4-like [KO:K07412] [EC:1.14.14.1]
531018  PAQR8; membrane progestin receptor beta [KO:K25040]
531391  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
531602  KPNA6; importin subunit alpha-7 [KO:K15042]
533199  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
533216  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
533587  UGT2B10; UDP glucuronosyltransferase 2 family, polypeptide B10 precursor [KO:K00699] [EC:2.4.1.17]
533656  VDR; vitamin D3 receptor [KO:K08539]
533908  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
533917  GSTA4; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
533929  FGF18; fibroblast growth factor 18 precursor [KO:K04358]
534129  CREB5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
534712  RB1; retinoblastoma-associated protein [KO:K06618]
534923  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
535017  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
535090  KPNA4; importin subunit alpha-3 [KO:K23583]
535293  EPHX1; epoxide hydrolase 1 precursor [KO:K01253] [EC:3.3.2.9]
535298  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
535369  E2F1; transcription factor E2F1 [KO:K17454]
535603  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
535702  KLF5; Krueppel-like factor 5 [KO:K09206]
535742  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
536771  FGF5; fibroblast growth factor 5 precursor [KO:K04358]
537251  CHRNA4; neuronal acetylcholine receptor subunit alpha-4 precursor [KO:K04806]
537682  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
539020  BCL6; B-cell lymphoma 6 protein [KO:K15618]
539083  FGF20; fibroblast growth factor 20 [KO:K04358]
539521  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
539679  KPNA1; importin subunit alpha-5 [KO:K23940]
540317  FGF6; fibroblast growth factor 6 [KO:K04358]
540544  [KO:K00699] [EC:2.4.1.17]
540547  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
540615  [KO:K00699] [EC:2.4.1.17]
540662  WNT1; proto-oncogene Wnt-1 precursor [KO:K03209]
540719  KPNA3; importin subunit alpha-4 [KO:K23583]
540758  FGF16; fibroblast growth factor 16 [KO:K04358]
541140  KRAS; GTPase KRas [KO:K07827]
613731  FGF9; fibroblast growth factor 9 [KO:K04358]
613905  GSTO2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
615013  BAD; bcl2-associated agonist of cell death [KO:K02158]
615303  [KO:K00699] [EC:2.4.1.17]
615507  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
615514  [KO:K00799] [EC:2.5.1.18]
615537  GSTM2; glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
615552  MGST2; microsomal glutathione S-transferase 2 precursor [KO:K00799] [EC:2.5.1.18]
616115  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
616885  FGF7; fibroblast growth factor 7 precursor [KO:K04358]
617882  EPHX3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
618474  FGF4; fibroblast growth factor 4 precursor [KO:K04358]
618481  FGF3; fibroblast growth factor 3 [KO:K04358]
751790  UGT1A1; UDP-glucuronosyltransferase 1-1 precursor [KO:K00699] [EC:2.4.1.17]
767874  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
768055  GSTA3; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
777644  GSTA1; glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
781988  [KO:K00699] [EC:2.4.1.17]
782370  [KO:K00699] [EC:2.4.1.17]
783596  KPNA5; importin subunit alpha-6 [KO:K15042]
783681  JAG1; protein jagged-1 precursor [KO:K06052]
783879  GSTM1; glutathione S-transferase mu 1 [KO:K00799] [EC:2.5.1.18]
785086  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
785216  [KO:K00799] [EC:2.5.1.18]
788151  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
788775  DLL1; delta-like protein 1 [KO:K06051]
789280  KPNA7; importin subunit alpha-8 [KO:K15043]
790973  MIR29A; bta-miR-29a [KO:K16995]
790974  MIRLET7F-2; bta-let-7f [KO:K16980]
791024  MIR98; bta-miR-98 [KO:K16980]
791025  MIRLET7D; bta-let-7d [KO:K16980]
791042  MIR29B-2; bta-miR-29b [KO:K16995]
791043  MIR29C; bta-miR-29c [KO:K16995]
791050  MIRLET7G; bta-let-7g [KO:K16980]
791056  MIRLET7A-1; bta-let-7a-5p [KO:K16980]
791061  MIRLET7F-1; bta-let-7f [KO:K16980]
791064  MIRLET7I; bta-let-7i [KO:K16980]
Compound
C00076  Calcium cation
C00410  Progesterone
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00780  Serotonin
C00788  L-Adrenaline
C00951  Estradiol-17beta
C03690  Bis(2-ethylhexyl)phthalate
C04623  DDT
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06697  Arsenite
C06790  Trichloroethene
C06916  Clofibrate
C07020  Gemfibrozil
C07434  Phenobarbital
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C08150  Medroxyprogesterone acetate
C11042  Hexachlorobenzene
C11150  Trichloroacetate
C11371  Nafenopin
C11906  Sodium arsenite
C13624  Bisphenol A
C14240  Di(2-ethylhexyl) adipate
C14573  3,3',4,4',5-Pentachlorobiphenyl
C15995  Bombesin
C16452  N'-Nitrosonornicotine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
Reference
PMID:15660110
  Authors
Luch A.
  Title
Nature and nurture - lessons from chemical carcinogenesis.
  Journal
Nat Rev Cancer 5:113-25 (2005)
DOI:10.1038/nrc1546
Reference
PMID:19631282
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Hernandez LG, van Steeg H, Luijten M, van Benthem J
  Title
Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach.
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Mutat Res 682:94-109 (2009)
DOI:10.1016/j.mrrev.2009.07.002
Reference
PMID:21444681
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Wu CH, Lee CH, Ho YS
  Title
Nicotinic acetylcholine receptor-based blockade: applications of molecular targets for cancer therapy.
  Journal
Clin Cancer Res 17:3533-41 (2011)
DOI:10.1158/1078-0432.CCR-10-2434
Reference
PMID:19194381
  Authors
Schuller HM
  Title
Is cancer triggered by altered signalling of nicotinic acetylcholine receptors?
  Journal
Nat Rev Cancer 9:195-205 (2009)
DOI:10.1038/nrc2590
Reference
PMID:21541211
  Authors
Singh S, Pillai S, Chellappan S
  Title
Nicotinic acetylcholine receptor signaling in tumor growth and metastasis.
  Journal
J Oncol 2011:456743 (2011)
DOI:10.1155/2011/456743
Reference
PMID:31956359
  Authors
Cheng WL, Chen KY, Lee KY, Feng PH, Wu SM
  Title
Nicotinic-nAChR signaling mediates drug resistance in lung cancer.
  Journal
J Cancer 11:1125-1140 (2020)
DOI:10.7150/jca.36359
Reference
PMID:24827506
  Authors
Grando SA
  Title
Connections of nicotine to cancer.
  Journal
Nat Rev Cancer 14:419-29 (2014)
DOI:10.1038/nrc3725
Reference
PMID:24398389
  Authors
Schaal C, Chellappan SP
  Title
Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers.
  Journal
Mol Cancer Res 12:14-23 (2014)
DOI:10.1158/1541-7786.MCR-13-0541
Reference
PMID:21640716
  Authors
Improgo MR, Tapper AR, Gardner PD
  Title
Nicotinic acetylcholine receptor-mediated mechanisms in lung cancer.
  Journal
Biochem Pharmacol 82:1015-21 (2011)
DOI:10.1016/j.bcp.2011.05.020
Reference
PMID:18262664
  Authors
Egleton RD, Brown KC, Dasgupta P
  Title
Nicotinic acetylcholine receptors in cancer: multiple roles in proliferation and inhibition of apoptosis.
  Journal
Trends Pharmacol Sci 29:151-8 (2008)
DOI:10.1016/j.tips.2007.12.006
Reference
PMID:24830349
  Authors
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Related
pathway
bta00980  Metabolism of xenobiotics by cytochrome P450
bta03320  PPAR signaling pathway
bta04010  MAPK signaling pathway
bta04024  cAMP signaling pathway
bta04150  mTOR signaling pathway
bta04151  PI3K-Akt signaling pathway
bta04370  VEGF signaling pathway
bta04915  Estrogen signaling pathway
bta05204  Chemical carcinogenesis - DNA adducts
bta05206  MicroRNAs in cancer
bta05208  Chemical carcinogenesis - reactive oxygen species
KO pathway
ko05207   

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