KEGG   PATHWAY: bta05208
Entry
bta05208                    Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Bos taurus (cow)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
bta05208  Chemical carcinogenesis - reactive oxygen species
bta05208

Organism
Bos taurus (cow) [GN:bta]
Gene
100137872  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100138040  SOS2; son of sevenless homolog 2 [KO:K03099]
100138102  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
100139386  20ALPHA-HSD; placental and ovary 20alpha hydroxysteroid dehydrogenase protein [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
100140312  SLC26A1; sulfate anion transporter 1 [KO:K14700]
100270792  COX6B1; cytochrome c oxidase subunit 6B1 [KO:K02267]
100295687  [KO:K00799] [EC:2.5.1.18]
100297222  [KO:K00417]
100298939  HRAS; GTPase HRas isoform 1 [KO:K02833]
100300550  COX7B; cytochrome c oxidase subunit 7B, mitochondrial precursor [KO:K02271]
100847184  [KO:K02833]
101902002  [KO:K02266]
101902937  [KO:K02272]
101903026  [KO:K14394] [EC:3.1.3.2 3.1.3.48]
101903567  [KO:K02272]
101904690  [KO:K03945]
101905399  [KO:K04368] [EC:2.7.12.2]
101905997  [KO:K02272]
101906178  [KO:K11352]
101906363  [KO:K03947]
101906743  [KO:K02272]
101906916  [KO:K02128]
101907294  [KO:K03959]
112441473  [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
112441538  [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
112447079  [KO:K02272]
112449293  [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
132342088  [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
132342107  [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
132342342  [KO:K02268]
132342556  [KO:K00799] [EC:2.5.1.18]
132343467  [KO:K02135]
132343845  [KO:K02270]
132343906  [KO:K02270]
132344161  [KO:K02268]
132344463  [KO:K05863]
132345003  [KO:K02135]
132345058  [KO:K02268]
132346172  [KO:K02270]
132346262  [KO:K03949]
280714  AHR; aryl hydrocarbon receptor [KO:K09093]
280795  FOS; protein c-Fos [KO:K04379]
280831  JUN; transcription factor Jun [KO:K04448]
280844  LPO; lactoperoxidase precursor [KO:K12550] [EC:1.11.1.7]
280855  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
280977  ACP1; low molecular weight phosphotyrosine protein phosphatase [KO:K14394] [EC:3.1.3.2 3.1.3.48]
280991  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
281010  ARNT; aryl hydrocarbon receptor nuclear translocator [KO:K09097]
281073  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
281090  COX4I1; cytochrome c oxidase subunit 4 isoform 1, mitochondrial precursor [KO:K02263]
281091  COX8A; cytochrome c oxidase subunit 8A, mitochondrial precursor [KO:K02273]
281111  CYBA; cytochrome b-245 light chain [KO:K08009]
281345  NCF1; neutrophil cytosol factor 1 [KO:K08011]
281346  NCF2; neutrophil cytosol factor 2 [KO:K08010]
281440  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
281480  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor [KO:K00234] [EC:1.3.5.1]
281481  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor [KO:K00237]
281495  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
281496  SOD2; superoxide dismutase [Mn], mitochondrial precursor [KO:K04564] [EC:1.15.1.1]
281570  UQCR11; cytochrome b-c1 complex subunit 10 [KO:K00420]
281572  VEGFA; vascular endothelial growth factor A isoform 3 precursor [KO:K05448]
281640  ATP5PO; ATP synthase subunit O, mitochondrial precursor [KO:K02137]
281742  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
281805  GSTA2; glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
281814  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
281854  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
281855  IKBKG; NF-kappa-B essential modulator [KO:K07210]
282119  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
282120  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
282138  AKR1C4; dihydrodiol dehydrogenase 3 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
282199  COX6A1; cytochrome c oxidase subunit 6A1, mitochondrial precursor [KO:K02266]
282200  COX6A2; cytochrome c oxidase subunit 6A2, mitochondrial precursor [KO:K02266]
282213  CYP2E1; cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
282289  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial precursor [KO:K03967]
282290  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial precursor [KO:K03943] [EC:7.1.1.2]
282291  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
282306  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
282307  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
282308  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
282393  UQCRC1; cytochrome b-c1 complex subunit 1, mitochondrial precursor [KO:K00414]
282394  UQCRC2; cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
282478  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
282479  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
282480  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
282517  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial precursor [KO:K03964]
282578  ATP5F1A; ATP synthase subunit alpha, mitochondrial precursor [KO:K02132]
282690  ATP5PF; ATP synthase-coupling factor 6, mitochondrial precursor [KO:K02131]
282701  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial precursor [KO:K02127]
282710  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
282716  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
282870  CYP1A1; cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
282879  HGF; hepatocyte growth factor precursor [KO:K05460]
286840  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor [KO:K00235] [EC:1.3.5.1]
286865  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
286885  UQCRQ; cytochrome b-c1 complex subunit 8 [KO:K00418]
287012  COX5B; cytochrome c oxidase subunit 5B, mitochondrial precursor [KO:K02265]
287014  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial precursor [KO:K03942] [EC:7.1.1.2]
287020  UQCRFS1; cytochrome b-c1 complex subunit Rieske, mitochondrial precursor [KO:K00411] [EC:7.1.1.8]
287027  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
287327  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial precursor [KO:K03936] [EC:7.1.1.2]
288380  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor [KO:K03934] [EC:7.1.1.2]
326346  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
327660  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
327665  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
327668  ATP5F1C; ATP synthase subunit gamma, mitochondrial precursor [KO:K02136]
327670  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
327672  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
327673  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
327675  ATP5F1B; ATP synthase subunit beta, mitochondrial precursor [KO:K02133] [EC:7.1.2.2]
327680  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial precursor [KO:K03937]
327688  COX7A2; cytochrome c oxidase subunit 7A2, mitochondrial precursor [KO:K02270]
327690  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
327691  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial precursor [KO:K03939]
327696  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor [KO:K00236]
327697  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial precursor [KO:K03935] [EC:7.1.1.2]
327698  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
327701  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
327702  NDUFAB1; acyl carrier protein, mitochondrial precursor [KO:K03955]
327704  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
327706  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
327709  GSTM1; glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
327710  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
327713  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial precursor [KO:K03958]
327714  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
327717  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial precursor [KO:K03944]
327718  COX7C; cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
3283877  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
3283878  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
3283879  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
3283880  COX2; cytochrome c oxidase subunit II [KO:K02261]
3283881  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
3283882  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
3283883  COX3; cytochrome c oxidase subunit III [KO:K02262]
3283884  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
3283885  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
3283886  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
3283887  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
3283888  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
3283889  CYTB; cytochrome b [KO:K00412]
337887  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial precursor [KO:K02128]
338046  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
338053  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial precursor [KO:K02128]
338057  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
338060  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial precursor [KO:K03954]
338061  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial precursor [KO:K03961]
338063  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
338064  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
338065  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
338073  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
338079  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial precursor [KO:K03940] [EC:7.1.1.2]
338081  ATP5F1D; ATP synthase subunit delta, mitochondrial precursor [KO:K02134]
338084  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
338086  COX7A1; cytochrome c oxidase subunit 7A1, mitochondrial precursor [KO:K02270]
378474  NOX4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
404161  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial precursor [KO:K11351]
404188  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial precursor [KO:K03953]
407217  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
414346  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor [KO:K09565] [EC:5.2.1.8]
444878  COX5A; cytochrome c oxidase subunit 5A, mitochondrial precursor [KO:K02264]
493719  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
497024  NFE2L2; nuclear factor erythroid 2-related factor 2 [KO:K05638]
503552  CYP1A2; cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
503554  COX6B2; cytochrome c oxidase subunit 6B2 [KO:K02267]
504531  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
505482  AS3MT; arsenite methyltransferase [KO:K07755] [EC:2.1.1.137]
505642  GSTO1; glutathione-S-transferase omega 1 [KO:K00799] [EC:2.5.1.18]
505708  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
506093  GSTT4; glutathione S-transferase, theta 4 [KO:K00799] [EC:2.5.1.18]
506270  PTK2; PTK2 protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
506322  NRAS; GTPase NRas [KO:K07828]
506594  [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
507346  MGST3; glutathione S-transferase 3, mitochondrial [KO:K00799] [EC:2.5.1.18]
508150  PTPRJ; receptor-type tyrosine-protein phosphatase eta [KO:K05698] [EC:3.1.3.48]
508233  RELA; transcription factor p65 [KO:K04735]
508367  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
508658  PTPN1; tyrosine-protein phosphatase non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
508958  SLC26A9; solute carrier family 26 member 9 isoform X2 [KO:K14706]
510180  MGC127133; 20-beta-hydroxysteroid dehydrogenase-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
510434  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
511470  CYP1B1; cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
511716  EPHX2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
511845  ABL2; tyrosine-protein kinase ABL2 [KO:K08887] [EC:2.7.10.2]
512500  CYC1; cytochrome c1, heme protein, mitochondrial [KO:K00413]
512943  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
512953  [KO:K02132]
513221  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
513953  SLC26A2; sulfate transporter [KO:K14701]
514514  SLC26A6; solute carrier family 26 member 6 [KO:K14704]
514554  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
515946  CBR1; carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
516190  GSTT2; glutathione S-transferase theta-2 [KO:K00799] [EC:2.5.1.18]
517724  GSTT1; glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
517948  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
519632  NQO1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
521196  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
521681  NOX1; NADPH oxidase 1 [KO:K08008]
521685  GSTA5; glutathione S-transferase A5 [KO:K00799] [EC:2.5.1.18]
522159  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
524246  EPHX4; epoxide hydrolase 4 isoform 1 [KO:K22369] [EC:3.3.-.-]
526469  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
526769  [KO:K07293] [EC:3.1.3.48]
527068  [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
530315  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
531391  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
531682  CAT; catalase [KO:K03781] [EC:1.11.1.6]
532791  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
533199  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
533270  PRKD1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
533590  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X3 [KO:K07293] [EC:3.1.3.48]
533917  GSTA4; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
534125  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
534492  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
534923  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
535293  EPHX1; epoxide hydrolase 1 precursor [KO:K01253] [EC:3.3.2.9]
535298  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
535327  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
535530  FOXO3; forkhead box protein O3 [KO:K09408]
535742  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
536051  BRAF; serine/threonine-protein kinase B-raf isoform X9 [KO:K04365] [EC:2.7.11.1]
537380  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
537631  MAPK10; mitogen-activated protein kinase 10 isoform 2 [KO:K04440] [EC:2.7.11.24]
537682  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
538060  [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
538447  PRKD3; serine/threonine-protein kinase D3 [KO:K06070] [EC:2.7.11.13]
539941  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
540176  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial precursor [KO:K02128]
540225  COX7A2L; cytochrome c oxidase subunit 7A-related protein, mitochondrial precursor [KO:K02270]
540421  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
540786  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
540876  ABL1; tyrosine-protein kinase ABL1 [KO:K06619] [EC:2.7.10.2]
541140  KRAS; GTPase KRas [KO:K07827]
541168  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
613541  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
613899  UQCRH; cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
613905  GSTO2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
614700  COX6C; cytochrome c oxidase subunit 6C [KO:K02268]
615013  BAD; bcl2-associated agonist of cell death [KO:K02158]
615507  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
615514  [KO:K00799] [EC:2.5.1.18]
615537  GSTM2; glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
615552  MGST2; microsomal glutathione S-transferase 2 precursor [KO:K00799] [EC:2.5.1.18]
615697  CYP2F1; LOW QUALITY PROTEIN: cytochrome P450 2F3 [KO:K07416] [EC:1.14.14.1]
615757  COX8B; cytochrome c oxidase subunit 8B, mitochondrial precursor [KO:K02273]
616109  UQCR10; cytochrome b-c1 complex subunit 9 [KO:K00419]
616115  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
616871  UQCRB; cytochrome b-c1 complex subunit 7 [KO:K00417]
617230  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
617882  EPHX3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
617917  AKR1C3; aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
618339  COX4I2; cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
618607  AKR1A1; aldo-keto reductase family 1 member A1 [KO:K00002] [EC:1.1.1.2]
618906  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
767916  COX7B2; cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
768055  GSTA3; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
777644  GSTA1; glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
782486  [KO:K02268]
782793  PRKD2; serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
782884  [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
783202  [KO:K02273]
783879  GSTM1; glutathione S-transferase mu 1 [KO:K00799] [EC:2.5.1.18]
785216  [KO:K00799] [EC:2.5.1.18]
787122  [KO:K05863]
787278  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
788745  [KO:K02127]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
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Related
pathway
bta00190  Oxidative phosphorylation
bta00980  Metabolism of xenobiotics by cytochrome P450
bta04010  MAPK signaling pathway
bta04064  NF-kappa B signaling pathway
bta04066  HIF-1 signaling pathway
bta04151  PI3K-Akt signaling pathway
bta04370  VEGF signaling pathway
bta05207  Chemical carcinogenesis - receptor activation
bta05211  Renal cell carcinoma
bta05215  Prostate cancer
bta05219  Bladder cancer
bta05221  Acute myeloid leukemia
bta05222  Small cell lung cancer
bta05223  Non-small cell lung cancer
bta05224  Breast cancer
bta05225  Hepatocellular carcinoma
KO pathway
ko05208   

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