KEGG   PATHWAY: ecb04062
Entry
ecb04062                    Pathway                                
Name
Chemokine signaling pathway - Equus caballus (horse)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
ecb04062  Chemokine signaling pathway
ecb04062

Other DBs
GO: 0070098
Organism
Equus caballus (horse) [GN:ecb]
Gene
100034121  CXCL1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) precursor [KO:K05505]
100233237  CXCL2; C-X-C motif chemokine 2 precursor [KO:K05505]
100056258  MIP-2BETA; uncharacterized protein LOC100056258 precursor [KO:K05505]
100033988  CXCL6; C-X-C motif chemokine 6 precursor [KO:K05506]
100055973  PPBP; platelet basic protein [KO:K10029]
100037400  CXCL8; interleukin-8 precursor [KO:K10030]
100057927  CXCL9; C-X-C motif chemokine 9 precursor [KO:K05416]
100050993  CXCL10; C-X-C motif chemokine 10 precursor [KO:K12671]
100629807  CXCL11; C-X-C motif chemokine 11 precursor [KO:K12672]
100049872  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
100629997  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
100061442  CXCL16; C-X-C motif chemokine 16 [KO:K10035]
100630489  platelet factor 4 isoform X1 [KO:K05407]
100072697  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
100057696  XCL1; lymphotactin [KO:K05507]
102150350  CX3CL1; fractalkine isoform X1 [KO:K05508]
102150259  CCL1; C-C motif chemokine 1 [KO:K05514]
100034136  CCL2; C-C motif chemokine 2 precursor [KO:K14624]
100057909  CCL3; C-C motif chemokine 3 precursor [KO:K05408]
100057859  CCL4; C-C motif chemokine 4 [KO:K12964]
100033925  CCL5; C-C motif chemokine 5 precursor [KO:K12499]
100071714  C-C motif chemokine 7 [KO:K05509]
100033927  CCL8; C-C motif chemokine 8 precursor [KO:K16596]
100033949  CCL11; eotaxin precursor [KO:K16597]
100033951  CCL13; C-C motif chemokine 13 precursor [KO:K16595]
100071548  C-C motif chemokine 14 [KO:K21092]
100071540  CCL15; C-C motif chemokine 15 isoform X1 [KO:K05511]
100146114  CCL16; C-C motif chemokine 16 [KO:K21093]
100630824  CCL17; C-C motif chemokine 17 isoform X2 [KO:K21083]
100630643  CCL19; C-C motif chemokine 19 [KO:K05512]
111770212  C-C motif chemokine 19-like isoform X1 [KO:K05512]
100629808  CCL20; C-C motif chemokine 20 isoform X1 [KO:K14625]
100063059  C-C motif chemokine 21 [KO:K16062]
100060619  LOW QUALITY PROTEIN: C-C motif chemokine 21 [KO:K16062]
100062332  CCL22; C-C motif chemokine 22 [KO:K21095]
100061208  CCL24; C-C motif chemokine 24 [KO:K21097]
100066885  CCL25; C-C motif chemokine 25 [KO:K13072]
100630602  CCL26; C-C motif chemokine 26 [KO:K21096]
102147669  CCL27; C-C motif chemokine 27 [KO:K16598]
111770210  uncharacterized protein LOC111770210 isoform X1 [KO:K16598]
100629419  CCL28; C-C motif chemokine 28 [KO:K05513]
100055552  CXCR2; C-X-C chemokine receptor type 2 isoform X1 [KO:K05050]
100058291  C-X-C chemokine receptor type 2 [KO:K04175]
100056190  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
100050974  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
111774227  C-X-C chemokine receptor type 5 isoform X1 [KO:K04190]
111774228  C-X-C chemokine receptor type 5 isoform X1 [KO:K04190]
100630558  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
100065485  XCR1; chemokine XC receptor 1 [KO:K04193]
100068350  CX3CR1; CX3C chemokine receptor 1 isoform X1 [KO:K04192]
100055409  CCR8; C-C chemokine receptor type 8 [KO:K04183]
100055159  CCR6; C-C chemokine receptor type 6 [KO:K04181]
100065535  CCR9; C-C chemokine receptor type 9 [KO:K04184]
100056549  CCR4; C-C chemokine receptor type 4 [KO:K04179]
100067673  CCR7; C-C chemokine receptor type 7 [KO:K04182]
100048936  CCR2; C-C chemokine receptor type 2 [KO:K04177]
100048935  CCR5; C-C chemokine receptor type 5 [KO:K04180]
100065466  C-C chemokine receptor type 1 [KO:K04176]
100065437  CCR3; C-C chemokine receptor type 3 [KO:K04178]
100065946  CCR10; C-C chemokine receptor type 10 [KO:K04185]
100051487  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
100147451  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
100069633  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
100052513  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
100034011  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
100052954  signal transducer and activator of transcription 5B isoform X3 [KO:K11224]
100055673  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100062085  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
100058238  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
100065563  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100071337  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
100055961  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
100054305  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100070498  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
100051295  ADCY6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
100058891  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100057796  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100066046  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
100052828  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100064302  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X3 [KO:K04345] [EC:2.7.11.11]
100053129  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
100068557  HCK; tyrosine-protein kinase HCK [KO:K08893] [EC:2.7.10.2]
100056804  FGR; tyrosine-protein kinase Fgr [KO:K08891] [EC:2.7.10.2]
100069870  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100063053  SHC1; SHC-transforming protein 1 isoform X2 [KO:K06279]
100146209  SHC2; SHC-transforming protein 2 [KO:K17447]
100061926  SHC3; SHC-transforming protein 3 [KO:K17448]
100055699  SHC4; SHC-transforming protein 4 [KO:K17449]
100051866  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100053889  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100066282  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100055481  HRAS; GTPase HRas isoform X1 [KO:K02833]
100064473  KRAS; GTPase KRas isoform X1 [KO:K07827]
100051785  LOW QUALITY PROTEIN: GTPase KRas-like [KO:K07827]
100059469  NRAS; GTPase NRas [KO:K07828]
100051110  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100065760  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
100065996  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
100057701  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
100066173  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100051623  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100058141  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100051753  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100052122  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100050227  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
100146348  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100050532  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
100062810  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X3 [KO:K21290]
100062779  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
100064240  PRKCZ; protein kinase C zeta type isoform X3 [KO:K18952] [EC:2.7.11.13]
100064671  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100054961  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100061130  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100066558  FOXO3; forkhead box protein O3 [KO:K09408]
100070393  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100050167  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100058432  IKBKG; NF-kappa-B essential modulator [KO:K07210]
100058000  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100064368  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
100067894  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X4 [KO:K02580]
100057483  RELA; transcription factor p65 [KO:K04735]
100055447  BAD; bcl2-associated agonist of cell death [KO:K02158]
100069693  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
100061033  GSK3B; glycogen synthase kinase-3 beta isoform X6 [KO:K03083] [EC:2.7.11.26]
100071232  ITK; tyrosine-protein kinase ITK/TSK isoform X1 [KO:K07363] [EC:2.7.10.2]
100057737  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
100069175  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
100066010  VAV1; proto-oncogene vav [KO:K05730]
100061732  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100054701  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X2 [KO:K07860]
100054738  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
100063217  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100058188  CDC42; cell division control protein 42 homolog [KO:K04393]
100147507  WAS; wiskott-Aldrich syndrome protein [KO:K05747]
100053343  RHOA; transforming protein RhoA [KO:K04513]
100034056  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
100072339  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
100061395  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
100067486  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
100052560  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X2 [KO:K07825]
100058274  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
100146498  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
100630067  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
100063795  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
100058605  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
100064813  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
100059736  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
106782014  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
100630493  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
100051499  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
100063518  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
100630574  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
100065327  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
100051430  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
100069660  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X2 [KO:K04549]
100071328  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1 [KO:K12365]
100055551  ELMO1; engulfment and cell motility protein 1 isoform X6 [KO:K12366]
100070446  DOCK2; dedicator of cytokinesis protein 2 [KO:K12367]
100058245  PTK2; focal adhesion kinase 1 isoform X12 [KO:K05725] [EC:2.7.10.2]
100053811  PXN; paxillin isoform X1 [KO:K05760]
100068908  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
100072356  CRK; adapter molecule crk isoform X1 [KO:K04438]
100050855  CRKL; crk-like protein [KO:K04438]
100054547  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
100063136  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
100057315  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
100051558  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100055407  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100051485  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100070545  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X3 [KO:K01116] [EC:3.1.4.11]
100055670  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2 [KO:K05859] [EC:3.1.4.11]
102150244  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
100049912  ras-related protein Rap-1A [KO:K04353]
100058930  RAP1A; ras-related protein Rap-1A [KO:K04353]
100052025  RAP1B; ras-related protein Rap-1b [KO:K07836]
100060218  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
100052764  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
100069215  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100051333  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
100146522  NCF1; neutrophil cytosol factor 1 [KO:K08011]
100062922  GRK7; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
100069151  GRK1; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
100065495  GRK3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
100059001  GRK2; beta-adrenergic receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
111767400  GRK3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
100068570  GRK6; G protein-coupled receptor kinase 6 isoform X4 [KO:K08291] [EC:2.7.11.16]
100053624  GRK4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
100065919  GRK5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
100064657  ARRB1; beta-arrestin-1 isoform X4 [KO:K04439]
100072892  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
ecb04010  MAPK signaling pathway
ecb04060  Cytokine-cytokine receptor interaction
ecb04120  Ubiquitin mediated proteolysis
ecb04630  JAK-STAT signaling pathway
ecb04670  Leukocyte transendothelial migration
ecb04810  Regulation of actin cytoskeleton
KO pathway
ko04062   
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