KEGG   PATHWAY: elk05166
Entry
elk05166                    Pathway                                
Name
Human T-cell leukemia virus 1 infection - Enhydra lutris kenyoni (northern sea otter)
Description
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, and SRF.
Class
Human Diseases; Infectious disease: viral
Pathway map
elk05166  Human T-cell leukemia virus 1 infection
elk05166

Organism
Enhydra lutris kenyoni (northern sea otter) [GN:elk]
Gene
111143335  solute carrier family 2, facilitated glucose transporter member 1 isoform X1 [KO:K07299]
111155526  neuropilin-1 isoform X1 [KO:K06724]
111146783  myc proto-oncogene protein [KO:K04377]
111146202  transformation/transcription domain-associated protein [KO:K08874]
111149712  histone acetyltransferase KAT5 isoform X1 [KO:K11304] [EC:2.3.1.48]
111159766  G1/S-specific cyclin-D2 [KO:K10151]
111162178  integrin alpha-L isoform X1 [KO:K05718]
111155758  integrin beta-2 isoform X1 [KO:K06464]
111162530  intercellular adhesion molecule 1 [KO:K06490]
111140316  GTPase HRas isoform X1 [KO:K02833]
111159984  GTPase KRas isoform X1 [KO:K07827]
111143238  GTPase NRas [KO:K07828]
111153158  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111161815  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
111162236  LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
111142759  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111159821  T-cell surface glycoprotein CD4 isoform X1 [KO:K06454]
111153217  talin-2 isoform X1 [KO:K06271]
111146277  talin-1 [KO:K06271]
111161669  ran-binding protein 3 isoform X1 [KO:K15304]
111156385  GTP-binding nuclear protein Ran isoform X1 [KO:K07936]
111157016  GTP-binding nuclear protein Ran-like [KO:K07936]
111147983  exportin-1 [KO:K14290]
111162396  calreticulin [KO:K08057]
111158868  calnexin [KO:K08054]
111144797  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111154144  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111154566  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111148007  calcineurin subunit B type 1 [KO:K06268]
111146053  calcineurin subunit B type 2 [KO:K06268]
111154209  nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
111141582  LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
111152752  nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
111160328  nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
111157559  interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
111161041  cytokine receptor common subunit gamma [KO:K05070]
111142881  tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
111143876  tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
111151211  signal transducer and activator of transcription 5A [KO:K11223]
111151253  signal transducer and activator of transcription 5B [KO:K11224]
111154869  interleukin-2 [KO:K05429]
111152501  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
111139664  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q8 alpha chain-like [KO:K06751]
111152201  LOW QUALITY PROTEIN: DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
111152203  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
111152204  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
111152405  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-36 alpha chain [KO:K06751]
111140516  beta-2-microglobulin [KO:K08055]
111139000  farnesyl pyrophosphate synthase [KO:K00787] [EC:2.5.1.1 2.5.1.10]
111141207  voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
111157245  ADP/ATP translocase 2 [KO:K05863]
111144412  ADP/ATP translocase 1 [KO:K05863]
111157056  ADP/ATP translocase 4 [KO:K05863]
111157123  ADP/ATP translocase 3 [KO:K05863]
111145442  voltage-dependent anion-selective channel protein 2 [KO:K15040]
111144425  voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
111157699  translocator protein [KO:K05770]
111147875  translocator protein 2 [KO:K05770]
111152764  protein VAC14 homolog isoform X1 [KO:K15305]
111142384  ran-specific GTPase-activating protein isoform X1 [KO:K15306]
111145738  mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
111155369  mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
111140380  mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform X1 [KO:K06637] [EC:2.7.11.1]
111144777  mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
111158407  anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
111145950  anaphase-promoting complex subunit 2 [KO:K03349]
111158104  cell division cycle protein 27 homolog isoform X1 [KO:K03350]
111148974  anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
111156477  anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
111146909  cell division cycle protein 16 homolog isoform X1 [KO:K03353]
111156354  anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
111140959  cell division cycle protein 23 homolog [KO:K03355]
111154722  anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
111160381  anaphase-promoting complex subunit 11 [KO:K03358]
111145882  anaphase-promoting complex subunit CDC26 isoform X1 [KO:K03359]
111155019  anaphase-promoting complex subunit 13 [KO:K12456]
111159437  anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
111144906  anaphase-promoting complex subunit 16 [KO:K25229]
111143139  cell division cycle protein 20 homolog isoform X1 [KO:K03363]
111140992  securin isoform X1 [KO:K06635]
111147482  securin-like [KO:K06635]
111157921  separin [KO:K02365] [EC:3.4.22.49]
111153254  G2/mitotic-specific cyclin-B2 [KO:K21770]
111159872  cyclin-dependent kinase 4 inhibitor B [KO:K04685]
111159871  cyclin-dependent kinase inhibitor 2A-like isoform X1 [KO:K06621]
111160230  cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
111149458  G1/S-specific cyclin-D1 [KO:K04503]
111147855  G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
111147618  cyclin-dependent kinase inhibitor 1 [KO:K06625]
111154269  cyclin-A2 [KO:K06627]
111158563  cyclin-A1 [KO:K06627]
111161443  G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
111146791  G1/S-specific cyclin-E2 [KO:K06626]
111160135  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
111146911  retinoblastoma-associated protein [KO:K06618]
111141556  transcription factor E2F1 [KO:K17454]
111154729  transcription factor E2F2 isoform X1 [KO:K09389]
111138625  transcription factor E2F3 isoform X1 [KO:K06620]
111153730  serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
111147364  serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
111153780  serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
111160086  serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
111161133  cellular tumor antigen p53 [KO:K04451]
111143470  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
111155224  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111143790  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
111155003  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
111147545  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111154641  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
111161374  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111148765  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111150885  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111155042  disks large homolog 1 isoform X1 [KO:K12076]
111144778  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111152248  tumor necrosis factor isoform X1 [KO:K03156]
111159748  tumor necrosis factor receptor superfamily member 1A [KO:K03158]
111156879  mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
111161210  dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
111144860  mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
111158897  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
111154016  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111143174  transcription factor AP-1 [KO:K04448]
111153696  matrilysin [KO:K01397] [EC:3.4.24.23]
111155931  interleukin-1 receptor type 1 [KO:K04386]
111155901  interleukin-1 receptor type 2 [KO:K04387]
111153823  T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
111153962  T-cell surface glycoprotein CD3 epsilon chain isoform X1 [KO:K06451]
111153842  T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
111158066  mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
111144921  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
111144397  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
111139191  NF-kappa-B essential modulator [KO:K07210]
111140276  NF-kappa-B inhibitor alpha isoform X1 [KO:K04734]
111153611  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
111149956  transcription factor p65 [KO:K04735]
111161198  G protein pathway suppressor 2 [KO:K15307]
111159742  tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159]
111141553  tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
111157707  tumor necrosis factor receptor superfamily member 13C isoform X1 [KO:K05151]
111158123  mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
111160543  transcription factor RelB isoform X1 [KO:K09253]
111144738  nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
111161492  mRNA decay activator protein ZFP36 [KO:K15308]
111158621  interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
111149196  interleukin-15 [KO:K05433]
111158614  interleukin-15 receptor subunit alpha [KO:K05074]
111147365  interleukin-6 isoform X1 [KO:K05405]
111141239  granulocyte-macrophage colony-stimulating factor [KO:K05427]
111152291  lymphotoxin-alpha [KO:K05468]
111141775  bcl-2-like protein 1 [KO:K04570]
111157209  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
111161420  transforming growth factor beta-1 isoform X1 [KO:K13375]
111151068  transforming growth factor beta-2 isoform X1 [KO:K13376]
111148592  transforming growth factor beta-3 [KO:K13377]
111146071  TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
111158999  TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
111142395  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
111153179  mothers against decapentaplegic homolog 3 [KO:K23605]
111142438  mothers against decapentaplegic homolog 4 [KO:K04501]
111157054  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
111153427  adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
111154044  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
111162403  adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
111155044  adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
111157825  adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
111157326  adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
111146667  adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
111156133  adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
111162516  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
111143399  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
111142264  nuclear transcription factor Y subunit beta isoform X1 [KO:K08065]
111152451  LOW QUALITY PROTEIN: RLA class II histocompatibility antigen, DP alpha-1 chain [KO:K06752]
111152452  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
111152151  SLA class II histocompatibility antigen, DQ haplotype C beta chain-like [KO:K06752]
111152158  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like isoform X1 [KO:K06752]
111152168  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
111152169  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
111152175  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like isoform X1 [KO:K06752]
111152178  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
111152191  HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752]
111152200  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
111152259  DLA class II histocompatibility antigen, DR-1 beta chain isoform X1 [KO:K06752]
111152356  HLA class II histocompatibility antigen, DQ beta 1 chain isoform X1 [KO:K06752]
111152358  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
111152383  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
111147733  serum response factor [KO:K04378]
111151167  ETS domain-containing protein Elk-4 [KO:K04376]
111150586  ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
111149957  transcription factor PU.1 isoform X1 [KO:K09438]
111154029  protein C-ets-1 isoform X1 [KO:K02678]
111155722  protein C-ets-2 isoform X1 [KO:K21932]
111155727  protein C-ets-2-like [KO:K21932]
111147566  TATA box-binding protein-like protein 1 [KO:K03120]
111158703  TATA-box-binding protein [KO:K03120]
111140634  TATA box-binding protein-like protein 2 [KO:K03120]
111148602  proto-oncogene c-Fos [KO:K04379]
111140945  early growth response protein 1 [KO:K09203]
111149724  fos-related antigen 1 isoform X1 [KO:K04502]
111144964  E3 SUMO-protein ligase EGR2 [KO:K12496]
111147575  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
111151973  cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
111146280  cyclic AMP-responsive element-binding protein 3 [KO:K09048]
111150050  cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
111138943  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
111161856  cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
111142901  cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
111157635  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
111147321  cyclic AMP-responsive element-binding protein 5 [KO:K09047]
111152366  cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
111144042  CREB-regulated transcription coactivator 1 isoform X1 [KO:K15309]
111138927  LOW QUALITY PROTEIN: CREB-regulated transcription coactivator 2 [KO:K16333]
111152573  CREB-regulated transcription coactivator 3 isoform X1 [KO:K16334]
111157665  histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
111156131  LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
111151705  histone acetyltransferase KAT2A isoform X1 [KO:K06062] [EC:2.3.1.48]
111155064  histone acetyltransferase KAT2B [KO:K06062] [EC:2.3.1.48]
111161705  transcription factor E2-alpha isoform X1 [KO:K09063]
111144449  DNA polymerase beta isoform X1 [KO:K02330] [EC:2.7.7.7 4.2.99.-]
111142990  tyrosine-protein kinase Lck [KO:K05856] [EC:2.7.10.2]
111160657  apoptosis regulator BAX isoform X1 [KO:K02159]
111143151  cyclin-dependent kinase 4 inhibitor C [KO:K06622]
111153386  telomerase reverse transcriptase isoform X1 [KO:K11126] [EC:2.7.7.49]
111141206  homeobox protein MSX-2 [KO:K09341]
111145047  homeobox protein MSX-3-like [KO:K09341]
111149256  homeobox protein MSX-1 [KO:K09341]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17384582
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
PMID:16155604
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
PMID:18702816
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
PMID:21994754
  Authors
Jones KS, Lambert S, Bouttier M, Benit L, Ruscetti FW, Hermine O, Pique C
  Title
Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
  Journal
Viruses 3:794-810 (2011)
DOI:10.3390/v3060794
Reference
PMID:21114861
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
DOI:10.1186/1742-4690-7-99
Reference
  Authors
Sinet F.
  Title
Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: a number of proteins play a key role in the establishment and maintenance of viral infection.
  Journal
BioSciences Master Reviews, July 2013
Reference
PMID:18923409
  Authors
Sattentau Q
  Title
Avoiding the void: cell-to-cell spread of human viruses.
  Journal
Nat Rev Microbiol 6:815-26 (2008)
DOI:10.1038/nrmicro1972
Reference
PMID:15040584
  Authors
Vicente-Manzanares M, Sanchez-Madrid F
  Title
Role of the cytoskeleton during leukocyte responses.
  Journal
Nat Rev Immunol 4:110-22 (2004)
DOI:10.1038/nri1268
Reference
PMID:27334587
  Authors
Dutartre H, Claviere M, Journo C, Mahieux R
  Title
Cell-Free versus Cell-to-Cell Infection by Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Type 1: Exploring the Link among Viral Source, Viral Trafficking, and Viral Replication.
  Journal
J Virol 90:7607-17 (2016)
DOI:10.1128/JVI.00407-16
Reference
PMID:15988028
  Authors
Awasthi S, Sharma A, Wong K, Zhang J, Matlock EF, Rogers L, Motloch P, Takemoto S, Taguchi H, Cole MD, Luscher B, Dittrich O, Tagami H, Nakatani Y, McGee M, Girard AM, Gaughan L, Robson CN, Monnat RJ Jr, Harrod R
  Title
A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions.
  Journal
Mol Cell Biol 25:6178-98 (2005)
DOI:10.1128/MCB.25.14.6178-6198.2005
Reference
PMID:21994758
  Authors
Edwards D, Fenizia C, Gold H, de Castro-Amarante MF, Buchmann C, Pise-Masison CA, Franchini G
  Title
Orf-I and orf-II-encoded proteins in HTLV-1 infection and persistence.
  Journal
Viruses 3:861-85 (2011)
DOI:10.3390/v3060861
Reference
PMID:26927155
  Authors
Nakano K, Watanabe T
  Title
HTLV-1 Rex Tunes the Cellular Environment Favorable for Viral Replication.
  Journal
Viruses 8:58 (2016)
DOI:10.3390/v8030058
Reference
PMID:22783232
  Authors
Shida H
  Title
Role of Nucleocytoplasmic RNA Transport during the Life Cycle of Retroviruses.
  Journal
Front Microbiol 3:179 (2012)
DOI:10.3389/fmicb.2012.00179
Reference
PMID:23248621
  Authors
Bai XT, Nicot C
  Title
Overview on HTLV-1 p12, p8, p30, p13: accomplices in persistent infection and viral pathogenesis.
  Journal
Front Microbiol 3:400 (2012)
DOI:10.3389/fmicb.2012.00400
Reference
PMID:18421579
  Authors
Taylor JM, Nicot C
  Title
HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches.
  Journal
Apoptosis 13:733-47 (2008)
DOI:10.1007/s10495-008-0208-7
Reference
PMID:15761473
  Authors
D'Agostino DM, Silic-Benussi M, Hiraragi H, Lairmore MD, Ciminale V
  Title
The human T-cell leukemia virus type 1 p13II protein: effects on mitochondrial function and cell growth.
  Journal
Cell Death Differ 12 Suppl 1:905-15 (2005)
DOI:10.1038/sj.cdd.4401576
Reference
PMID:20332002
  Authors
Silic-Benussi M, Biasiotto R, Andresen V, Franchini G, D'Agostino DM, Ciminale V
  Title
HTLV-1 p13, a small protein with a busy agenda.
  Journal
Mol Aspects Med 31:350-8 (2010)
DOI:10.1016/j.mam.2010.03.001
Reference
PMID:23741982
  Authors
Fuentes-Gonzalez AM, Contreras-Paredes A, Manzo-Merino J, Lizano M
  Title
The modulation of apoptosis by oncogenic viruses.
  Journal
Virol J 10:182 (2013)
DOI:10.1186/1743-422X-10-182
Reference
PMID:21743832
  Authors
Qu Z, Xiao G
  Title
Human T-cell lymphotropic virus: a model of NF-kappaB-associated tumorigenesis.
  Journal
Viruses 3:714-49 (2011)
DOI:10.3390/v3060714
Reference
PMID:21994767
  Authors
Saggioro D
  Title
Anti-apoptotic effect of Tax: an NF-kappaB path or a CREB way?
  Journal
Viruses 3:1001-14 (2011)
DOI:10.3390/v3071001
Reference
PMID:16036567
  Authors
Harhaj EW, Harhaj NS
  Title
Mechanisms of persistent NF-kappaB activation by HTLV-I tax.
  Journal
IUBMB Life 57:83-91 (2005)
DOI:10.1080/15216540500078715
Reference
PMID:16155602
  Authors
Sun SC, Yamaoka S
  Title
Activation of NF-kappaB by HTLV-I and implications for cell transformation.
  Journal
Oncogene 24:5952-64 (2005)
DOI:10.1038/sj.onc.1208969
Reference
PMID:9710600
  Authors
Geleziunas R, Ferrell S, Lin X, Mu Y, Cunningham ET Jr, Grant M, Connelly MA, Hambor JE, Marcu KB, Greene WC
  Title
Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.
  Journal
Mol Cell Biol 18:5157-65 (1998)
DOI:10.1128/MCB.18.9.5157
Reference
PMID:21315773
  Authors
Nakachi S, Nakazato T, Ishikawa C, Kimura R, Mann DA, Senba M, Masuzaki H, Mori N
  Title
Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling.
  Journal
Biochim Biophys Acta 1813:731-41 (2011)
DOI:10.1016/j.bbamcr.2011.02.002
Reference
PMID:26797638
  Authors
James CD, Roberts S
  Title
Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
  Journal
Pathogens 5:E8 (2016)
DOI:10.3390/pathogens5010008
Reference
PMID:26324707
  Authors
Cherian MA, Baydoun HH, Al-Saleem J, Shkriabai N, Kvaratskhelia M, Green P, Ratner L
  Title
Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein.
  Journal
J Biol Chem 290:26270-81 (2015)
DOI:10.1074/jbc.M115.684746
Reference
PMID:11264182
  Authors
Mori N, Morishita M, Tsukazaki T, Giam CZ, Kumatori A, Tanaka Y, Yamamoto N
  Title
Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.
  Journal
Blood 97:2137-44 (2001)
DOI:10.1182/blood.v97.7.2137
Reference
PMID:15310405
  Authors
Azran I, Schavinsky-Khrapunsky Y, Aboud M
  Title
Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.
  Journal
Retrovirology 1:20 (2004)
DOI:10.1186/1742-4690-1-20
Reference
PMID:11244044
  Authors
Yoshida M
  Title
Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
  Journal
Annu Rev Immunol 19:475-96 (2001)
DOI:10.1146/annurev.immunol.19.1.475
Reference
PMID:12802280
  Authors
Gabet AS, Mortreux F, Charneau P, Riou P, Duc-Dodon M, Wu Y, Jeang KT, Wattel E
  Title
Inactivation of hTERT transcription by Tax.
  Journal
Oncogene 22:3734-41 (2003)
DOI:10.1038/sj.onc.1206468
Related
pathway
elk03013  Nucleocytoplasmic transport
elk04010  MAPK signaling pathway
elk04064  NF-kappa B signaling pathway
elk04110  Cell cycle
elk04115  p53 signaling pathway
elk04151  PI3K-Akt signaling pathway
elk04210  Apoptosis
elk04350  TGF-beta signaling pathway
elk04612  Antigen processing and presentation
elk04660  T cell receptor signaling pathway
elk04668  TNF signaling pathway
KO pathway
ko05166   
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