KEGG   PATHWAY: myb04014
Entry
myb04014                    Pathway                                
Name
Ras signaling pathway - Myotis brandtii (Brandt's bat)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
myb04014  Ras signaling pathway
myb04014

Other DBs
GO: 0032318
Organism
Myotis brandtii (Brandt's bat) [GN:myb]
Gene
102264252  EGF; epidermal growth factor [KO:K04357]
102262078  TGFA; transforming growth factor alpha [KO:K08774]
102256157  FGF1; fibroblast growth factor 1 [KO:K18496]
102246008  FGF2; fibroblast growth factor 2 [KO:K18497]
102250520  FGF3; fibroblast growth factor 3 [KO:K04358]
102260092  FGF17; fibroblast growth factor 17 [KO:K04358]
102254187  FGF22; fibroblast growth factor 22 [KO:K04358]
102255119  FGF6; fibroblast growth factor 6 [KO:K04358]
102251158  FGF16; fibroblast growth factor 16 [KO:K04358]
102250238  FGF10; fibroblast growth factor 10 [KO:K04358]
102259056  FGF8; fibroblast growth factor 8 [KO:K04358]
102262222  FGF18; fibroblast growth factor 18 [KO:K04358]
102261041  FGF9; fibroblast growth factor 9 [KO:K04358]
102260244  FGF5; fibroblast growth factor 5 [KO:K04358]
102259580  FGF20; fibroblast growth factor 20 [KO:K04358]
102261751  FGF7; fibroblast growth factor 7 [KO:K04358]
102249614  FGF19; fibroblast growth factor 19 [KO:K22603]
102260667  FGF21; fibroblast growth factor 21 [KO:K22429]
102240867  FGF23; fibroblast growth factor 23 [KO:K22428]
102245962  NGF; nerve growth factor [KO:K02582]
102247090  BDNF; brain derived neurotrophic factor [KO:K04355]
102244296  NTF3; neurotrophin 3 [KO:K04356]
102260565  NTF4; neurotrophin 4 [KO:K12457]
102254396  insulin [KO:K04526]
102252071  IGF1; insulin like growth factor 1 [KO:K05459]
102247355  IGF2; insulin like growth factor 2 [KO:K13769]
102253551  PDGFA; platelet derived growth factor subunit A [KO:K04359]
102239511  PDGFB; platelet derived growth factor subunit B [KO:K17386]
102248385  PDGFC; platelet derived growth factor C [KO:K05450]
102240259  PDGFD; platelet derived growth factor D [KO:K05450]
102263365  CSF1; colony stimulating factor 1 [KO:K05453]
102250743  KITLG; KIT ligand [KO:K05461]
102264081  FLT3LG; fms related tyrosine kinase 3 ligand [KO:K05454]
102254357  VEGFA; vascular endothelial growth factor A [KO:K05448]
102257492  VEGFB; vascular endothelial growth factor B [KO:K16858]
102243042  PGF; placental growth factor [KO:K16859]
102252136  VEGFC; vascular endothelial growth factor C [KO:K05449]
102260639  VEGFD; vascular endothelial growth factor D [KO:K05449]
102259449  HGF; hepatocyte growth factor [KO:K05460]
102248939  ANGPT1; angiopoietin 1 [KO:K05465]
102260431  ANGPT4; angiopoietin 4 [KO:K05467]
102238988  EFNA5; ephrin A5 [KO:K05462]
102249824  EFNA1; ephrin A1 [KO:K05462]
102258114  EFNA2; ephrin A2 [KO:K05462]
102253384  EFNA4; ephrin A4 [KO:K05462]
102253687  EFNA3; ephrin A3 [KO:K05462]
102257758  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102253832  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
102254053  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
102258015  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
102244827  NGFR; nerve growth factor receptor [KO:K02583]
102238774  NTRK2; neurotrophic receptor tyrosine kinase 2 [KO:K04360] [EC:2.7.10.1]
102252005  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
102253516  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102255326  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102241145  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102256301  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102263655  KIT; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
102244263  FLT3; fms related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
102247542  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
102244559  FLT1; fms related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
102244912  FLT4; fms related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
102256532  KDR; kinase insert domain receptor [KO:K05098] [EC:2.7.10.1]
102263347  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
102241735  TEK; TEK receptor tyrosine kinase [KO:K05121] [EC:2.7.10.1]
102250877  EPHA2; EPH receptor A2 [KO:K05103] [EC:2.7.10.1]
102241832  GRB2; growth factor receptor bound protein 2 [KO:K04364]
102245609  GAB1; GRB2 associated binding protein 1 [KO:K09593]
102256059  GAB2; GRB2 associated binding protein 2 [KO:K08091]
102245916  SHC1; SHC adaptor protein 1 [KO:K06279]
102251506  SHC2; SHC adaptor protein 2 [KO:K17447]
102245983  SHC3; SHC adaptor protein 3 [KO:K17448]
102239285  SHC4; SHC adaptor protein 4 [KO:K17449]
102251345  PTPN11; protein tyrosine phosphatase, non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
102252301  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
102259408  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
102248243  PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
102261553  PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
102262016  RASGRP1; RAS guanyl releasing protein 1 [KO:K04350]
102242639  RASGRP2; RAS guanyl releasing protein 2 [KO:K12361]
102254297  RASGRP3; RAS guanyl releasing protein 3 [KO:K12362]
102251967  RASGRP4; RAS guanyl releasing protein 4 [KO:K12363]
102259670  ZAP70; zeta-chain (TCR) associated protein kinase 70kDa [KO:K07360] [EC:2.7.10.2]
102261789  LAT; linker for activation of T-cells [KO:K07362]
102241064  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
102256020  5-hydroxytryptamine receptor 7 [KO:K04163]
102257321  GNB1; G protein subunit beta 1 [KO:K04536]
102257762  GNB2; G protein subunit beta 2 [KO:K04537]
102262102  GNB3; G protein subunit beta 3 [KO:K07825]
102263696  GNB4; G protein subunit beta 4 [KO:K04538]
102252218  guanine nucleotide-binding protein subunit beta-4-like [KO:K04538]
102242731  GNB5; G protein subunit beta 5 [KO:K04539]
102253997  GNG2; G protein subunit gamma 2 [KO:K07826]
102259768  GNG4; G protein subunit gamma 4 [KO:K04541]
102250530  GNG5; G protein subunit gamma 5 [KO:K04542]
102258952  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
102263275  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
102238618  GNG7; G protein subunit gamma 7 [KO:K04543]
102250013  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
102263426  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
102254808  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
102242875  GNG12; G protein subunit gamma 12 [KO:K04347]
102240295  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04347]
102257413  GNG13; G protein subunit gamma 13 [KO:K04547]
102252604  GNGT2; G protein subunit gamma transducin 2 [KO:K04549]
102244919  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
102252927  PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102242492  RASGRF1; Ras protein specific guanine nucleotide releasing factor 1 [KO:K04349]
102251351  RASGRF2; Ras protein specific guanine nucleotide releasing factor 2 [KO:K12326]
102240692  GRIN1; glutamate ionotropic receptor NMDA type subunit 1 [KO:K05208]
102245838  GRIN2A; glutamate ionotropic receptor NMDA type subunit 2A [KO:K05209]
102249136  GRIN2B; glutamate ionotropic receptor NMDA type subunit 2B [KO:K05210]
102244216  CALM2; calmodulin 2 [KO:K02183]
102251233  CALM1; calmodulin 1 [KO:K02183]
102253504  CALML3; calmodulin-like protein 3 [KO:K02183]
102253811  CALML5; calmodulin like 5 [KO:K02183]
102240022  CALML6; calmodulin like 6 [KO:K02183]
102251350  CALM3; calmodulin 3 [KO:K02183]
102256865  calmodulin [KO:K02183]
102242522  CALML4; calmodulin like 4 [KO:K02183]
102263667  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102244940  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102247606  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102261560  MRAS; muscle RAS oncogene homolog [KO:K07831]
102257602  RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
102238935  NF1; neurofibromin 1 [KO:K08052]
102264248  RASA1; RAS p21 protein activator 1 [KO:K04352]
102242363  RASA2; RAS p21 protein activator 2 [KO:K08053]
102260354  RASA3; RAS p21 protein activator 3 [KO:K12380]
102242613  RASA4; ras GTPase-activating protein 4 [KO:K17630]
102239134  SYNGAP1; synaptic Ras GTPase activating protein 1 [KO:K17631]
102246474  RASAL1; RAS protein activator like 1 [KO:K17632]
102254740  RASAL2; RAS protein activator like 2 [KO:K17633]
102239742  RASAL3; RAS protein activator like 3 [KO:K17634]
102251592  RASSF1; Ras association domain family member 1 [KO:K09850]
102248032  RASSF5; Ras association domain family member 5 [KO:K08015]
102249534  STK4; serine/threonine kinase 4 [KO:K04411]
102259160  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
102239988  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
102249503  RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
102240321  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
102250137  PAK2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
102250915  PAK3; p21 (RAC1) activated kinase 3 [KO:K05733] [EC:2.7.11.1]
102258522  PAK4; p21 (RAC1) activated kinase 4 [KO:K05734] [EC:2.7.11.1]
102240345  PAK5; p21 (RAC1) activated kinase 5 [KO:K05736] [EC:2.7.11.1]
102251863  PAK6; p21 (RAC1) activated kinase 6 [KO:K05735] [EC:2.7.11.1]
102244315  RHOA; ras homolog family member A [KO:K04513]
102260487  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102252921  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102239669  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
102258430  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102253405  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102242302  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102254864  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102254191  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102251050  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102252013  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
102261467  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
102261405  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102255251  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
102263790  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
102239479  BAD; BCL2 associated agonist of cell death [KO:K02158]
102260460  BCL2L1; BCL2 like 1 [KO:K04570]
102240861  FOXO4; forkhead box O4 [KO:K12358]
102262076  FASLG; Fas ligand [KO:K04389]
102261182  RALGAPA2; Ral GTPase activating protein catalytic alpha subunit 2 [KO:K25768]
102242958  RALGAPB; Ral GTPase activating protein non-catalytic beta subunit [KO:K25769]
102240340  RALGDS; ral guanine nucleotide dissociation stimulator [KO:K08732]
102245648  RGL1; ral guanine nucleotide dissociation stimulator like 1 [KO:K17635]
102254804  RALA; RAS like proto-oncogene A [KO:K07834]
102259631  RALB; RAS like proto-oncogene B [KO:K07835]
102264100  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
102239050  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
102238895  EXOC2; exocyst complex component 2 [KO:K17637]
102241250  TBK1; TANK binding kinase 1 [KO:K05410] [EC:2.7.11.10]
102259978  REL; REL proto-oncogene, NF-kB subunit [KO:K09254]
102259984  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
102263026  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102246292  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
102261773  RALBP1; ralA binding protein 1 [KO:K08773]
102257260  CDC42; cell division cycle 42 [KO:K04393]
102239987  cell division control protein 42 homolog [KO:K04393]
102243870  AFDN; afadin, adherens junction formation factor [KO:K05702]
102250951  SHOC2; SHOC2, leucine rich repeat scaffold protein [KO:K19613]
102254003  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102240696  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102245571  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102255250  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102245641  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102246152  PLA1A; phospholipase A1 member A [KO:K13618] [EC:3.1.1.111]
102256183  PLA2G12B; phospholipase A2 group XIIB [KO:K01047] [EC:3.1.1.4]
102242750  PLA2G2C; phospholipase A2 group IIC [KO:K01047] [EC:3.1.1.4]
102243549  PLA2G2D; phospholipase A2 group IID [KO:K01047] [EC:3.1.1.4]
102244422  PLA2G2F; phospholipase A2 group IIF [KO:K01047] [EC:3.1.1.4]
102250907  PLA2G2A; phospholipase A2 group IIA [KO:K01047] [EC:3.1.1.4]
102243838  PLA2G5; phospholipase A2 group V [KO:K01047] [EC:3.1.1.4]
102239221  PLA2G12A; phospholipase A2 group XIIA [KO:K01047] [EC:3.1.1.4]
102239606  PLA2G3; phospholipase A2 group III [KO:K01047] [EC:3.1.1.4]
102247913  PLA2G2E; phospholipase A2 group IIE [KO:K01047] [EC:3.1.1.4]
102263633  PLA2G10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
106725176  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
102241621  PLA2G1B; phospholipase A2 group IB [KO:K01047] [EC:3.1.1.4]
102259120  PLA2G4A; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
102260953  PLA2G4E; phospholipase A2 group IVE [KO:K16342] [EC:3.1.1.4]
102242502  PLA2G4F; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
102241902  PLA2G4D; phospholipase A2 group IVD [KO:K16342] [EC:3.1.1.4]
102258983  PLA2G6; phospholipase A2 group VI [KO:K16343] [EC:3.1.1.4]
102256179  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
102258264  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
102257959  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
102240776  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
102256388  HRAS-like suppressor 2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
102240544  ELK1; ELK1, ETS transcription factor [KO:K04375]
102262972  ETS1; ETS proto-oncogene 1, transcription factor [KO:K02678]
102252687  ETS2; ETS proto-oncogene 2, transcription factor [KO:K21932]
102264162  BRAP; BRCA1 associated protein [KO:K10632] [EC:2.3.2.27]
102252142  KSR1; kinase suppressor of ras 1 [KO:K14958]
102259281  KSR2; kinase suppressor of ras 2 [KO:K18529] [EC:2.7.11.1]
102243853  RAPGEF5; Rap guanine nucleotide exchange factor 5 [KO:K08019]
102258771  RAP1A; RAP1A, member of RAS oncogene family [KO:K04353]
102254910  RAP1B; RAP1B, member of RAS oncogene family [KO:K07836]
102241624  PLCE1; phospholipase C epsilon 1 [KO:K05860] [EC:3.1.4.11]
102260557  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
102243136  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
102249897  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
102238656  RIN1; Ras and Rab interactor 1 [KO:K17638]
102241531  ras and Rab interactor 1-like [KO:K17638]
102255271  ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase [KO:K06619] [EC:2.7.10.2]
102252160  ABL2; ABL proto-oncogene 2, non-receptor tyrosine kinase [KO:K08887] [EC:2.7.10.2]
102239794  RAB5A; RAB5A, member RAS oncogene family [KO:K07887]
102257029  RAB5B; RAB5B, member RAS oncogene family [KO:K07888]
102242981  RAB5C; RAB5C, member RAS oncogene family [KO:K07889]
102239161  ARF6; ADP ribosylation factor 6 [KO:K07941]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
myb04010  MAPK signaling pathway
myb04015  Rap1 signaling pathway
myb04020  Calcium signaling pathway
myb04144  Endocytosis
myb04151  PI3K-Akt signaling pathway
myb04660  T cell receptor signaling pathway
myb04720  Long-term potentiation
myb04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
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