KEGG   PATHWAY: afb05168
Entry
afb05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Anoplopoma fimbria (sablefish)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
afb05168  Herpes simplex virus 1 infection
afb05168

Organism
Anoplopoma fimbria (sablefish) [GN:afb]
Gene
129109266  tnfb; tumor necrosis factor b (TNF superfamily, member 2) [KO:K05468]
129096309  tumor necrosis factor ligand superfamily member 14-like [KO:K05477]
129098887  tnfsf14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
129099956  tumor necrosis factor receptor superfamily member 14-like [KO:K05152]
129099957  tumor necrosis factor receptor superfamily member 14-like isoform X1 [KO:K05152]
129115061  tumor necrosis factor receptor superfamily member 14-like [KO:K05152]
129116108  tumor necrosis factor receptor superfamily member 14-like [KO:K05152]
129116109  tumor necrosis factor receptor superfamily member 14-like isoform X1 [KO:K05152]
129116116  tumor necrosis factor receptor superfamily member 14-like [KO:K05152]
129116117  tumor necrosis factor receptor superfamily member 14-like isoform X1 [KO:K05152]
129101424  LOW QUALITY PROTEIN: TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
129102855  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
129095574  traf5; TNF receptor-associated factor 5 [KO:K09849]
129101396  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
129091327  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
129092009  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
129100170  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
129107007  NF-kappa-B inhibitor alpha-like [KO:K04734]
129103149  nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734]
129089970  nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
129093238  rela; transcription factor p65 isoform X1 [KO:K04735]
129113780  birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
129094355  nectin1b; LOW QUALITY PROTEIN: nectin cell adhesion molecule 1b [KO:K06081]
129105058  si:ch211-141e20.2; nectin-3-like protein isoform X1 [KO:K06081]
129113938  nectin1a; nectin cell adhesion molecule 1a [KO:K06081]
129109531  nectin-2-like isoform X1 [KO:K06531]
129100406  ptpn11b; tyrosine-protein phosphatase non-receptor type 11b isoform X1 [KO:K07293] [EC:3.1.3.48]
129102254  ptpn11a; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
129105437  integrin alpha-5-like [KO:K06484]
129100280  itga5; LOW QUALITY PROTEIN: integrin alpha-5 [KO:K06484]
129091085  itgb3b; integrin beta-3b [KO:K06493]
129098443  integrin beta-3-like [KO:K06493]
129099351  src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
129105318  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
129102340  syk; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
129101453  card9; caspase recruitment domain-containing protein 9 [KO:K12794]
129091070  irf3; interferon regulatory factor 3 [KO:K05411]
129093061  tp53; cellular tumor antigen p53 [KO:K04451]
129095872  complement C3-like [KO:K03990]
129116349  LOW QUALITY PROTEIN: complement C3-like [KO:K03990]
129116350  complement C3-like [KO:K03990]
129101870  c5; LOW QUALITY PROTEIN: complement C5 [KO:K03994]
129115687  LOW QUALITY PROTEIN: properdin-like [KO:K15412]
129095397  toll-like receptor 2 [KO:K10159]
129093095  LOW QUALITY PROTEIN: toll-like receptor 2 [KO:K10159]
129109086  tlr18; toll-like receptor 18 [KO:K10159]
129110486  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
129107827  irf7; interferon regulatory factor 7 isoform X1 [KO:K09447]
129095929  tlr3; toll-like receptor 3 [KO:K05401]
129088914  ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
129107767  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
129088922  irak1; LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
129101016  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
129106910  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
129103542  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
129095614  tab1; LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
129107031  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
129100909  interleukin-1 beta-like [KO:K04519]
129100910  interleukin-1 beta-like [KO:K04519]
129115985  interleukin-1 beta-like [KO:K04519]
129097347  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
129089316  interleukin-12 subunit alpha-like [KO:K05406]
129096969  il12a; interleukin-12 subunit alpha [KO:K05406]
129090530  il12ba; interleukin 12Ba [KO:K05425]
129100825  si:dkey-88e18.2; interleukin-12 subunit beta [KO:K05425]
129113850  il12bb; interleukin-12 subunit beta [KO:K05425]
129104388  ifih1; interferon-induced helicase C domain-containing protein 1 isoform X1 [KO:K12647] [EC:5.6.2.6]
129103431  mavs; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
129103095  traf3; TNF receptor-associated factor 3 [KO:K03174]
129105674  ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
129112705  tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
129091508  interferon a3-like [KO:K05414]
129091523  interferon a3-like [KO:K05414]
129091525  interferon a3-like [KO:K05414]
129091528  interferon a3-like [KO:K05414]
129091532  interferon a3-like [KO:K05414]
129098191  ifnphi1; interferon phi 1 [KO:K05414]
129097087  cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
129092545  cgasa; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
129089690  sting1; stimulator of interferon genes protein [KO:K12654]
129100702  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
129090950  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
129106905  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
129102995  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
129097879  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
129093233  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
129091243  eif2ak1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]
129092304  eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
129092306  interferon-induced, double-stranded RNA-activated protein kinase-like [KO:K16195] [EC:2.7.11.1]
129092307  interferon-induced, double-stranded RNA-activated protein kinase-like [KO:K16195] [EC:2.7.11.1]
129103062  eif2ak3; LOW QUALITY PROTEIN: eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
129102997  eif2ak4; eIF-2-alpha kinase GCN2 [KO:K16196] [EC:2.7.11.1]
129107079  eif2s1b; eukaryotic translation initiation factor 2 subunit 1b [KO:K03237]
129102266  eif2b1; translation initiation factor eIF-2B subunit alpha isoform X1 [KO:K03239]
129107325  eif2b2; translation initiation factor eIF-2B subunit beta [KO:K03754]
129114441  eif2b3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
129107202  eif2b4; translation initiation factor eIF-2B subunit delta isoform X1 [KO:K03680]
129113571  eif2b5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
129106458  hcfc1a; host cell factor 1a [KO:K14966]
129112678  hcfc2; host cell factor 2 [KO:K27390]
129109515  pou2f2a; LOW QUALITY PROTEIN: POU domain, class 2, transcription factor 2 [KO:K09364]
129113067  pou2f3; POU domain, class 2, transcription factor 3 [KO:K09364]
129097601  LOW QUALITY PROTEIN: POU domain, class 2, transcription factor 1 [KO:K09364]
129104590  pou2f1b; POU domain, class 2, transcription factor 1b [KO:K09364]
129104331  interferon alpha/beta receptor 2-like [KO:K05131]
129091078  socs3b; LOW QUALITY PROTEIN: suppressor of cytokine signaling 3b [KO:K04696]
129098418  socs3a; suppressor of cytokine signaling 3a [KO:K04696]
129094115  jak1; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
129097988  tyk2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
129104815  signal transducer and activator of transcription 1-alpha/beta-like [KO:K11220]
129111532  stat1a; signal transducer and activator of transcription 1a [KO:K11220]
129106335  stat2; signal transducer and activator of transcription 2 [KO:K11221]
129110560  irf9; interferon regulatory factor 9 isoform X1 [KO:K04693]
129089293  zinc finger protein 345-like [KO:K09228]
129109718  zinc finger protein 184-like isoform X1 [KO:K09228]
129109927  zinc finger protein 436 [KO:K09228]
129110104  im:7147486; zinc finger protein Xfin [KO:K09228]
129110117  si:dkeyp-84f3.5; zinc finger protein 184 [KO:K09228]
129100696  zinc finger and SCAN domain-containing protein 2-like [KO:K09228]
129100697  zinc finger protein OZF-like [KO:K09228]
129100703  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
129100709  zinc finger protein OZF-like [KO:K09228]
129110895  zinc finger protein 497-like [KO:K09228]
129095839  zinc finger protein 271-like [KO:K09228]
129091191  zinc finger protein 569-like [KO:K09228]
129091216  zinc finger protein 300-like [KO:K09228]
129091443  zinc finger protein 135-like [KO:K09228]
129091457  zinc finger protein 16-like isoform X1 [KO:K09228]
129101180  zinc finger protein OZF-like [KO:K09228]
129101492  zinc finger protein 883-like [KO:K09228]
129101494  zinc finger protein 93-like [KO:K09228]
129101495  zinc finger protein 699-like [KO:K09228]
129101496  zinc finger protein 625-like [KO:K09228]
129112514  zinc finger protein 184-like isoform X1 [KO:K09228]
129112545  zinc finger protein 11-like [KO:K09228]
129101731  zinc finger protein OZF-like [KO:K09228]
129101732  zinc finger protein with KRAB and SCAN domains 8-like [KO:K09228]
129101733  zinc finger protein OZF-like [KO:K09228]
129101734  LOW QUALITY PROTEIN: zinc finger protein OZF-like [KO:K09228]
129101736  zinc finger protein OZF-like [KO:K09228]
129101737  LOW QUALITY PROTEIN: zinc finger protein OZF-like [KO:K09228]
129101739  zinc finger protein 287-like [KO:K09228]
129112669  zinc finger protein 184-like [KO:K09228]
129091909  zinc finger protein 253-like [KO:K09228]
129096851  zinc finger protein ZFP2-like [KO:K09228]
129096861  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
129096867  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
129096876  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
129096879  zinc finger protein 771-like [KO:K09228]
129096880  zinc finger protein 260-like [KO:K09228]
129096885  zinc finger protein 32-like isoform X1 [KO:K09228]
129096889  zinc finger protein 32-like [KO:K09228]
129096892  LOW QUALITY PROTEIN: zinc finger protein 629-like [KO:K09228]
129096894  LOW QUALITY PROTEIN: zinc finger protein 177-like [KO:K09228]
129096895  LOW QUALITY PROTEIN: zinc finger protein 180-like [KO:K09228]
129096903  LOW QUALITY PROTEIN: zinc finger and SCAN domain-containing protein 5C-like [KO:K09228]
129096906  LOW QUALITY PROTEIN: zinc finger protein 79-like [KO:K09228]
129097001  zinc finger protein 26-like [KO:K09228]
129097004  zinc finger protein 62 homolog [KO:K09228]
129102635  endothelial zinc finger protein induced by tumor necrosis factor alpha-like isoform X1 [KO:K09228]
129097645  zinc finger protein 675-like [KO:K09228]
129107832  zinc finger protein 554-like [KO:K09228]
129107834  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
129115147  zinc finger and SCAN domain-containing protein 2-like [KO:K09228]
129092602  zinc finger protein 569-like [KO:K09228]
129097732  zinc finger protein 135-like [KO:K09228]
129116616  zinc finger protein 572-like [KO:K09228]
129093262  oocyte zinc finger protein XlCOF6-like isoform X1 [KO:K09228]
129098287  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
129093808  zinc finger protein 436-like [KO:K09228]
129098600  zinc finger protein with KRAB and SCAN domains 8-like isoform X1 [KO:K09228]
129108635  zinc finger protein 572-like [KO:K09228]
129108902  zinc finger protein 3-like [KO:K09228]
129088886  zinc finger protein 665-like [KO:K09228]
129088912  oocyte zinc finger protein XlCOF6-like [KO:K09228]
129088979  zinc finger protein 420-like isoform X1 [KO:K09228]
129088990  zgc:171422; zinc finger protein ZFMSA12A isoform X1 [KO:K09228]
129095854  zinc finger protein 250-like [KO:K09228]
129096066  zinc finger protein 239-like [KO:K09228]
129097648  zinc finger protein 850-like [KO:K09228]
129112645  zinc finger protein 345-like isoform X1 [KO:K09228]
129092158  ifngr1l; interferon gamma receptor 1-like [KO:K05132]
129100838  jak2b; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
129101993  jak2a; tyrosine-protein kinase JAK2a [KO:K04447] [EC:2.7.10.2]
129097589  daxx; death domain-associated protein 6 [KO:K02308]
129109229  tap1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
129091428  tap2t; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
129097299  tap2a; antigen peptide transporter 2a [KO:K05654] [EC:7.4.2.14]
129097128  tapbp.1; TAP binding protein (tapasin), tandem duplicate 1 [KO:K08058]
129096871  protein disulfide-isomerase A3-like isoform X1 [KO:K08056] [EC:5.3.4.1]
129108640  pdia3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
129089039  LOW QUALITY PROTEIN: calreticulin-like [KO:K08057]
129111966  calr3b; calreticulin 3b [KO:K08057]
129094284  calr; calreticulin [KO:K08057]
129096886  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
129096897  major histocompatibility complex class I-related gene protein-like [KO:K06751]
129096898  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
129096899  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
129096901  major histocompatibility complex class I-related gene protein-like [KO:K06751]
129096902  major histocompatibility complex class I-related gene protein-like [KO:K06751]
129096977  major histocompatibility complex class I-related gene protein-like [KO:K06751]
129097327  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
129097328  major histocompatibility complex class I-related gene protein-like [KO:K06751]
129116783  major histocompatibility complex class I-related gene protein-like [KO:K06751]
129116835  LOW QUALITY PROTEIN: major histocompatibility complex class I-related gene protein-like [KO:K06751]
129112361  beta-2-microglobulin-like [KO:K08055]
129112391  beta-2-microglobulin-like [KO:K08055]
129105569  boLa class II histocompatibility antigen, DQB*0101 beta chain-like isoform X1 [KO:K06752]
129110247  H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752]
129105972  H-2 class II histocompatibility antigen, A-Q alpha chain-like [KO:K06752]
129116874  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
129116877  H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752]
129093689  rano class II histocompatibility antigen, B alpha chain-like [KO:K06752]
129109359  H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752]
129109360  HLA class II histocompatibility antigen, DR beta 5 chain-like [KO:K06752]
129109390  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
129089845  H-2 class II histocompatibility antigen gamma chain-like [KO:K06505]
129099623  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
129090356  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
129115605  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
129093032  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
129094279  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
129094332  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) [KO:K02649]
129094609  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
129110782  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
129101175  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
129112007  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
129102021  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
129105750  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129096351  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129091996  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129103636  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129115847  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
129116975  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
129101167  LOW QUALITY PROTEIN: hamartin-like [KO:K07206]
129102195  tsc1b; TSC complex subunit 1b isoform X1 [KO:K07206]
129095966  tsc2; tuberin isoform X1 [KO:K07207]
129105603  rhebl1; ras homolog, mTORC1 binding like 1 [KO:K07208]
129088911  rheb; GTP-binding protein Rheb [KO:K07208]
129099278  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
129101212  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
129102552  eukaryotic translation initiation factor 4E-binding protein 2-like [KO:K07205]
129099802  srpk1a; SRSF protein kinase 1a isoform X1 [KO:K15409] [EC:2.7.11.1]
129105380  srpk1b; SRSF protein kinase 1b isoform X1 [KO:K15409] [EC:2.7.11.1]
129111166  srsf1a; serine/arginine-rich splicing factor 1A [KO:K12890]
129113037  serine/arginine-rich splicing factor 1B-like [KO:K12890]
129090939  srsf2a; LOW QUALITY PROTEIN: serine and arginine rich splicing factor 2a [KO:K12891]
129098748  srsf2b; serine/arginine-rich splicing factor 2b isoform X1 [KO:K12891]
129105341  srsf3a; serine/arginine-rich splicing factor 3a isoform X1 [KO:K12892]
129105566  srsf3b; serine/arginine-rich splicing factor 3b [KO:K12892]
129100344  serine/arginine-rich splicing factor 6-like isoform X1 [KO:K12893]
129106744  srsf5b; serine and arginine rich splicing factor 5b isoform X1 [KO:K12893]
129097351  srsf4; serine/arginine-rich splicing factor 4 [KO:K12893]
129103179  srsf5a; LOW QUALITY PROTEIN: serine and arginine rich splicing factor 5a [KO:K12893]
129111923  srsf7a; serine and arginine rich splicing factor 7a [KO:K12896]
129102311  srsf9; serine/arginine-rich splicing factor 9 [KO:K21123]
129090227  nxf1a; nuclear RNA export factor 1 isoform X1 [KO:K14284]
129095987  THO complex subunit 4-like [KO:K12881]
129098542  alyref; LOW QUALITY PROTEIN: THO complex subunit 4 [KO:K12881]
129110212  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
129094969  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
129090345  cd40lg; CD40 ligand [KO:K04389]
129092378  fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
129099422  si:ch211-112c15.8; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A [KO:K03158]
129109549  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
129105866  tradd; LOW QUALITY PROTEIN: tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
129099702  fadd; protein FADD [KO:K02373]
129104346  casp10; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
129088904  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
129088905  caspase-8-like [KO:K04398] [EC:3.4.22.61]
129088906  caspase-8-like [KO:K04398] [EC:3.4.22.61]
129108685  bida; BH3 interacting domain death agonist [KO:K04726]
129102887  zgc:153993; apoptosis regulator BAX [KO:K02159]
129098058  apoptosis regulator BAX-like [KO:K02159]
129098304  apoptosis regulator BAX-like [KO:K02159]
129093541  badb; BCL2 associated agonist of cell death b [KO:K02158]
129117031  bcl2b; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
129100373  bcl2l1; bcl-2-like protein 1 [KO:K04570]
129105950  bcl-2-like protein 1 [KO:K04570]
129092227  cytochrome c [KO:K08738]
129097450  cytochrome c-a-like [KO:K08738]
129104567  cytochrome c-b [KO:K08738]
129112780  apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
129099432  casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
129089954  caspase-3-like [KO:K02187] [EC:3.4.22.56]
129095256  caspase-3-like [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
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Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
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Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
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Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
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PLoS Pathog 10:e1004477 (2014)
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Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
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Cell Microbiol 6:401-10 (2004)
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Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
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J Biol Chem 278:36596-602 (2003)
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Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
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J Mol Biol 426:1133-47 (2014)
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Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
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Evasion of host antiviral innate immunity by HSV-1, an update.
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Virol J 13:38 (2016)
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Reference
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  Authors
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Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
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Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
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Trends Microbiol 12:353-6 (2004)
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Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
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J Virol 92:e00099-17 (2018)
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Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
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Expert Rev Neurother 9:505-17 (2009)
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Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
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Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
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Reference
PMID:12826401
  Authors
Wysocka J, Herr W
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The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
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Trends Biochem Sci 28:294-304 (2003)
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Reference
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Fleming SB
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Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
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Vaccines (Basel) 4:E23 (2016)
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Reference
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Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
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J Virol 78:6282-6 (2004)
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Reference
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J Virol 87:10244-54 (2013)
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Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
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Viruses 1:1240-64 (2009)
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Reference
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Viral evasion of T cell immunity: ancient mechanisms offering new applications.
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Curr Opin Immunol 23:96-103 (2011)
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Reference
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Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
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J Immunol 171:3075-83 (2003)
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Reference
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Liu X, Cohen JI
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The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
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Virology 479-480:568-77 (2015)
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Reference
PMID:28468873
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Vink EI, Smiley JR, Mohr I
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Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
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J Virol 91:e00295-17 (2017)
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Reference
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Sandri-Goldin RM
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The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
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Front Biosci 13:5241-56 (2008)
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Reference
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Sandri-Goldin RM
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Viral regulation of mRNA export.
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J Virol 78:4389-96 (2004)
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Reference
PMID:27154074
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Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
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Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
afb03040  Spliceosome
afb03050  Proteasome
afb04115  p53 signaling pathway
afb04210  Apoptosis
afb04620  Toll-like receptor signaling pathway
afb04622  RIG-I-like receptor signaling pathway
KO pathway
ko05168   
LinkDB

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