Entry
Name
Cytokine-cytokine receptor interaction - Ailuropoda melanoleuca (giant panda)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
aml04060 Cytokine-cytokine receptor interaction
Ortholog table
Organism
Ailuropoda melanoleuca (giant panda) [GN:
aml ]
Gene
100466241 growth-regulated protein homolog gamma-like isoform X1 [KO:K05505 ]
109488324 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
100480371 IL1RN; interleukin-1 receptor antagonist protein isoform X2 [KO:K05481 ]
100480625 interleukin-36 receptor antagonist protein isoform X1 [KO:K05483 ]
100467411 CSF1; macrophage colony-stimulating factor 1 isoform X2 [KO:K05453 ]
100472140 TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
100468235 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
100473862 TNFSF15; tumor necrosis factor ligand superfamily member 15 isoform X1 [KO:K05478 ]
100463573 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
100483079 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
117796995 tumor necrosis factor ligand superfamily member 12-like [KO:K05474 ]
100473610 TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
105241361 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
100468487 TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
100471754 TNFSF18; tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
100466355 tumor necrosis factor ligand superfamily member 13 isoform X1 [KO:K05475 ]
100475623 TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
100470703 TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375 ]
100463584 TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376 ]
100475861 TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377 ]
100474590 GDF3; LOW QUALITY PROTEIN: growth/differentiation factor 3 [KO:K22672 ]
100484470 LOW QUALITY PROTEIN: growth/differentiation factor 3-like [KO:K22672 ]
105240549 AMH; LOW QUALITY PROTEIN: muellerian-inhibiting factor [KO:K04665 ]
100470409 CXCR2; LOW QUALITY PROTEIN: C-X-C chemokine receptor type 2 [KO:K05050 ]
100466247 IL2RA; interleukin-2 receptor subunit alpha isoform X3 [KO:K05068 ]
100468126 IL2RG; cytokine receptor common subunit gamma isoform X2 [KO:K05070 ]
100476095 IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071 ]
105238122 IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074 ]
100469756 CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066 ]
105238364 granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066 ]
100464681 CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061 ]
100471277 IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055 ]
100483131 IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060 ]
100474774 IL12RB1; interleukin-12 receptor subunit beta-1 isoform X2 [KO:K05063 ]
100478166 IL12RB2; interleukin-12 receptor subunit beta-2 isoform X2 [KO:K05064 ]
100483628 IL31RA; LOW QUALITY PROTEIN: interleukin-31 receptor subunit alpha [KO:K22630 ]
100478954 CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059 ]
100465053 OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057 ]
109488333 IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135 ]
100476037 IL20RA; interleukin-20 receptor subunit alpha isoform X2 [KO:K05136 ]
100478388 IL22RA1; interleukin-22 receptor subunit alpha-1 isoform X1 [KO:K05138 ]
100472192 IL1RAP; interleukin-1 receptor accessory protein isoform X2 [KO:K04723 ]
100476189 IL1RL2; LOW QUALITY PROTEIN: interleukin-1 receptor-like 2 [KO:K05172 ]
100476941 IL18RAP; interleukin-18 receptor accessory protein isoform X1 [KO:K05174 ]
100479926 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
100473387 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141 ]
100479494 LTBR; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159 ]
100476581 TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152 ]
100464518 TNFRSF6B; tumor necrosis factor receptor superfamily member 6B isoform X1 [KO:K05143 ]
100473767 FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
100472525 TNFRSF25; tumor necrosis factor receptor superfamily member 25 isoform X1 [KO:K05160 ]
105235183 tumor necrosis factor receptor superfamily member 10A-like [KO:K04722 ]
100467484 TNFRSF21; tumor necrosis factor receptor superfamily member 21 isoform X1 [KO:K05157 ]
100475348 EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X2 [KO:K05162 ]
100482463 EDA2R; tumor necrosis factor receptor superfamily member 27 isoform X2 [KO:K05163 ]
100478241 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
100465761 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
100483336 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147 ]
100477370 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
100473132 TNFRSF8; tumor necrosis factor receptor superfamily member 8 isoform X1 [KO:K05145 ]
100476345 CD40; tumor necrosis factor receptor superfamily member 5 isoform X2 [KO:K03160 ]
100475396 TNFRSF9; tumor necrosis factor receptor superfamily member 9 isoform X1 [KO:K05146 ]
100469971 TNFRSF4; tumor necrosis factor receptor superfamily member 4 isoform X2 [KO:K05142 ]
100472974 TNFRSF18; tumor necrosis factor receptor superfamily member 18 isoform X1 [KO:K05154 ]
100464516 TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
100477179 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
100466414 TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155 ]
100480566 RELT; tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway
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