KEGG   PATHWAY: cdk05132
Entry
cdk05132                    Pathway                                
Name
Salmonella infection - Camelus dromedarius (Arabian camel)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
cdk05132  Salmonella infection
cdk05132

Organism
Camelus dromedarius (Arabian camel) [GN:cdk]
Gene
105085395  PODXL; podocalyxin [KO:K06817]
105090828  PTPRC; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
105085148  RAB5A; ras-related protein Rab-5A [KO:K07887]
105086384  RAB5B; ras-related protein Rab-5B isoform X2 [KO:K07888]
105090453  RAB5C; ras-related protein Rab-5C [KO:K07889]
105085253  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
105106375  RAB7A; ras-related protein Rab-7a [KO:K07897]
105098619  RAB7B; ras-related protein Rab-7b [KO:K07898]
105094400  PLEKHM1; pleckstrin homology domain-containing family M member 1 [KO:K23282]
105090151  VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
105096037  VPS16; vacuolar protein sorting-associated protein 16 homolog isoform X3 [KO:K20180]
105096865  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
105102526  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
105101744  VPS39; vam6/Vps39-like protein isoform X1 [KO:K20183]
105088275  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
105088117  RILP; rab-interacting lysosomal protein isoform X1 [KO:K13883]
105105620  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
105087164  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
105088721  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
105091089  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X3 [KO:K10415]
105093780  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
105090715  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
105103555  DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 isoform X1 [KO:K10417]
105101992  DYNLL1; dynein light chain 1, cytoplasmic [KO:K10418]
105097800  DYNLL2; dynein light chain 2, cytoplasmic [KO:K10418]
105084947  DYNLRB1; dynein light chain roadblock-type 1 isoform X1 [KO:K10419]
105089429  DYNLRB2; dynein light chain roadblock-type 2 isoform X1 [KO:K10419]
105101595  DYNLT3; dynein light chain Tctex-type 3 [KO:K10420]
105103122  DYNLT1; dynein light chain Tctex-type 1 isoform X1 [KO:K10420]
105105900  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
105100341  DCTN2; dynactin subunit 2 isoform X5 [KO:K10424]
105085596  DCTN3; dynactin subunit 3 [KO:K10425]
105098474  DCTN4; dynactin subunit 4 [KO:K10426]
105094830  DCTN5; dynactin subunit 5 [KO:K10427]
105095796  DCTN6; dynactin subunit 6 [KO:K10428]
105084357  ACTR1A; alpha-centractin [KO:K16575]
105092669  ACTR1B; beta-centractin isoform X1 [KO:K16575]
105086239  ACTR10; actin-related protein 10 isoform X1 [KO:K16576]
105096109  TUBA4A; tubulin alpha-4A chain [KO:K07374]
105095310  tubulin alpha-1A chain-like [KO:K07374]
105100732  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
105091377  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
105095227  tubulin alpha-3 chain-like isoform X1 [KO:K07374]
116150045  tubulin alpha-3 chain [KO:K07374]
105095224  tubulin alpha-3 chain [KO:K07374]
116150047  tubulin alpha-3 chain-like [KO:K07374]
105089297  tubulin alpha-1A chain-like [KO:K07374]
116147140  tubulin alpha-1C chain-like [KO:K07374]
105096135  tubulin alpha-1D chain isoform X1 [KO:K07374]
105103777  TUBA1C; LOW QUALITY PROTEIN: tubulin alpha-1C chain [KO:K07374]
105103779  LOW QUALITY PROTEIN: tubulin alpha-1B chain [KO:K07374]
105087494  TUBB; tubulin beta chain isoform X2 [KO:K07375]
105087583  LOW QUALITY PROTEIN: tubulin beta-2A chain [KO:K07375]
105098536  tubulin beta-2B chain [KO:K07375]
105086496  TUBB6; LOW QUALITY PROTEIN: tubulin beta-6 chain [KO:K07375]
105104555  TUBB4A; tubulin beta-4A chain [KO:K07375]
105105754  tubulin beta-2A chain [KO:K07375]
105104356  TUBB3; tubulin beta-3 chain [KO:K07375]
105105106  TUBB4B; LOW QUALITY PROTEIN: tubulin beta-4B chain [KO:K07375]
105095658  TUBB1; tubulin beta-1 chain [KO:K07375]
116151533  tubulin beta chain-like [KO:K07375]
116151371  tubulin beta chain-like [KO:K07375]
105091291  FYCO1; FYVE and coiled-coil domain-containing protein 1 isoform X1 [KO:K21954]
105105937  ARL8A; LOW QUALITY PROTEIN: ADP-ribosylation factor-like protein 8A [KO:K07955]
105093153  ARL8B; LOW QUALITY PROTEIN: ADP-ribosylation factor-like protein 8B [KO:K07955]
105107061  PLEKHM2; pleckstrin homology domain-containing family M member 2 isoform X2 [KO:K15348]
105084640  KIF5C; LOW QUALITY PROTEIN: kinesin heavy chain [KO:K10396]
105100340  KIF5A; kinesin heavy chain isoform X3 [KO:K10396]
105086860  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
105088615  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
105102569  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
105105985  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
105095455  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
105099610  ACBD3; Golgi resident protein GCP60 [KO:K23935]
105087723  RHOA; transforming protein RhoA [KO:K04513]
105098166  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
105106274  RAB9A; ras-related protein Rab-9A [KO:K07899]
105103252  RAB9B; ras-related protein Rab-9B [KO:K07900]
105099088  GCC2; GRIP and coiled-coil domain-containing protein 2 isoform X1 [KO:K20282]
105100764  STX10; syntaxin-10 isoform X2 [KO:K23937]
105107141  profilin-2-like [KO:K05759]
105101469  PFN1; profilin-1 [KO:K05759]
105099591  PFN3; profilin-3 [KO:K05759]
105100025  PFN4; profilin-4 [KO:K05759]
105089494  PFN2; profilin-2 isoform X1 [KO:K05759]
105098720  FLNA; filamin-A isoform X1 [KO:K04437]
105092193  EXOC7; exocyst complex component 7 isoform X2 [KO:K07195]
105091456  EXOC5; exocyst complex component 5 [KO:K19984]
105085399  EXOC4; exocyst complex component 4 isoform X1 [KO:K06111]
105086129  EXOC2; exocyst complex component 2 isoform X1 [KO:K17637]
105088273  RALA; ras-related protein Ral-A [KO:K07834]
105105716  actin, cytoplasmic 2 [KO:K05692]
105104247  ACTB; actin, cytoplasmic 1 [KO:K05692]
116150665  actin, cytoplasmic 1-like [KO:K05692]
105104077  actin-like [KO:K05692]
105105329  S100A10; protein S100-A10 [KO:K17274]
105102142  ANXA2; annexin A2 [KO:K17092]
105091528  neuroblast differentiation-associated protein AHNAK isoform X1 [KO:K23934]
105104857  AHNAK2; LOW QUALITY PROTEIN: protein AHNAK2 [KO:K23934]
116155471  neuroblast differentiation-associated protein AHNAK-like [KO:K23934]
105086207  RHOJ; rho-related GTP-binding protein RhoJ [KO:K07864]
105094502  ARHGEF26; rho guanine nucleotide exchange factor 26 [KO:K13744]
105096546  RHOG; rho-related GTP-binding protein RhoG [KO:K07863]
105087987  rho-related GTP-binding protein RhoG-like [KO:K07863]
105090675  rho-related GTP-binding protein RhoG-like [KO:K07863]
105085296  ELMO1; engulfment and cell motility protein 1 isoform X4 [KO:K12366]
105087851  ELMO2; engulfment and cell motility protein 2 isoform X1 [KO:K18985]
105091254  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
105102482  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
105100801  MYL5; myosin light chain 5 [KO:K12753]
105092329  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
105084979  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
105092385  MYL10; myosin regulatory light chain 10 [KO:K12756]
105086067  myosin regulatory light chain 12B [KO:K12757]
105086071  myosin regulatory light polypeptide 9 isoform X1 [KO:K12757]
105102741  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
105088450  FHOD1; LOW QUALITY PROTEIN: FH1/FH2 domain-containing protein 1 [KO:K23938]
105088868  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105101000  NCKAP1L; nck-associated protein 1-like [KO:K05750]
105098905  NCKAP1; nck-associated protein 1 isoform X3 [KO:K05750]
105095140  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
105090762  CYFIP1; LOW QUALITY PROTEIN: cytoplasmic FMR1-interacting protein 1 [KO:K05749]
105102339  ABI1; abl interactor 1 isoform X1 [KO:K23649]
105093119  BRK1; protein BRICK1 isoform X1 [KO:K05752]
116150927  probable protein BRICK1 [KO:K05752]
105106341  WASF3; LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein family member 3 [KO:K06083]
105088933  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
105089077  ACTR3; actin-related protein 3 [KO:K18584]
105098690  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
105099363  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
105099397  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
105096071  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
105102494  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
105093134  actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
116158292  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
105096222  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
105092629  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
105097456  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
105102082  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
105104843  MYO6; unconventional myosin-VI isoform X1 [KO:K10358]
105086305  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105107003  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105085928  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105093031  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
105086672  PIK3C2A; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923] [EC:2.7.1.154]
105098645  PIK3C2B; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X1 [KO:K00923] [EC:2.7.1.154]
105096498  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1 [KO:K00923] [EC:2.7.1.154]
105101583  CYTH4; cytohesin-4 isoform X2 [KO:K18441]
105105803  CYTH1; cytohesin-1 isoform X1 [KO:K18441]
105098940  CYTH2; LOW QUALITY PROTEIN: cytohesin-2 [KO:K18441]
105099379  CYTH3; LOW QUALITY PROTEIN: cytohesin-3 [KO:K18441]
105091402  ARF6; ADP-ribosylation factor 6 [KO:K07941]
105094150  ARF1; ADP-ribosylation factor 1 isoform X1 [KO:K07937]
105090435  ADP-ribosylation factor 2 [KO:K07937]
105087152  SNX18; sorting nexin-18 [KO:K17923]
105087237  SNX33; sorting nexin-33 [KO:K17923]
105088312  SNX9; sorting nexin-9 isoform X1 [KO:K17923]
116154059  WASL; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
105085346  neural Wiskott-Aldrich syndrome protein [KO:K23612]
116151035  extensin-like [KO:K23612]
116155497  uncharacterized protein LOC116155497 [KO:K23612]
105087624  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
105089347  TLR6; toll-like receptor 6 isoform X1 [KO:K10169]
105099662  TLR2; toll-like receptor 2 [KO:K10159]
105094263  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
105090692  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
105098101  CD14; monocyte differentiation antigen CD14 [KO:K04391]
105104576  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
105088547  LY96; lymphocyte antigen 96 [KO:K05400]
105099860  TLR5; toll-like receptor 5 [KO:K10168]
105098727  IRAK1; LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
105097094  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
105106823  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
105095522  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
105091931  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
105100906  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
105089299  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
105106603  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
105084316  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
105086448  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
105092140  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
105089560  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105102595  RELA; transcription factor p65 isoform X1 [KO:K04735]
105095844  NOD1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
105088639  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
105103462  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
105097473  HSP90B1; endoplasmin [KO:K09487]
105087544  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
105087860  CSE1L; exportin-2 [KO:K18423]
105090296  KPNA1; importin subunit alpha-5 [KO:K23940]
105085991  KPNA4; importin subunit alpha-3 isoform X1 [KO:K23583]
105101927  KPNA3; importin subunit alpha-4 [KO:K23583]
105097159  RPS3; 40S ribosomal protein S3 [KO:K02985]
105105427  HRAS; GTPase HRas isoform X1 [KO:K02833]
105093099  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105093267  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105105302  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
105095214  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105102769  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105100607  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
105085694  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
105101337  MAPK13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
105101338  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105090355  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
105090356  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
105095916  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
105087572  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
105091591  MAPK10; mitogen-activated protein kinase 10 isoform X4 [KO:K04440] [EC:2.7.11.24]
105094659  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105100625  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105086086  FOS; proto-oncogene c-Fos [KO:K04379]
105092850  JUN; LOW QUALITY PROTEIN: transcription factor AP-1 [KO:K04448]
105087473  TNF; tumor necrosis factor [KO:K03156]
105093155  IL1B; interleukin-1 beta [KO:K04519]
105095065  IL6; interleukin-6 [KO:K05405]
105091344  CXCL8; interleukin-8 [KO:K10030]
105084622  CTNNB1; catenin beta-1 [KO:K02105]
105090254  TCF7; LOW QUALITY PROTEIN: transcription factor 7 [KO:K02620]
105104146  TCF7L1; transcription factor 7-like 1 [KO:K04490]
105091689  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
105105289  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
105096445  MYC; myc proto-oncogene protein [KO:K04377]
105105969  PKN1; serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
105087222  FBXO22; F-box only protein 22 isoform X1 [KO:K10302]
105090262  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
105098228  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
105106196  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
105088459  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
105087177  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
105087178  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
105087344  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
105087019  LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
105096538  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
105098219  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
105085942  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
105102505  tumor necrosis factor receptor superfamily member 10B-like isoform X1 [KO:K04722]
105102515  tumor necrosis factor receptor superfamily member 10A-like isoform X1 [KO:K04722]
105104389  FADD; LOW QUALITY PROTEIN: FAS-associated death domain protein [KO:K02373]
105099181  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
105102433  RIPK3; receptor-interacting serine/threonine-protein kinase 3 isoform X1 [KO:K08847] [EC:2.7.11.1]
105102890  BAX; apoptosis regulator BAX [KO:K02159]
105101376  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
105098528  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]
105095080  cytochrome c [KO:K08738]
105092650  cytochrome c [KO:K08738]
105088999  BCL2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
105084433  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105091687  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
105095722  RHOB; rho-related GTP-binding protein RhoB [KO:K07856]
105089331  RHOH; rho-related GTP-binding protein RhoH [KO:K07873]
105100199  RRAS; ras-related protein R-Ras [KO:K07829]
105099264  AKT3; RAC-gamma serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
105104845  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105093393  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105094684  MLKL; mixed lineage kinase domain-like protein isoform X2 [KO:K08849] [EC:2.7.11.1]
105087938  TXN; thioredoxin [KO:K03671]
105105211  TXN2; thioredoxin, mitochondrial [KO:K03671]
105104203  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
105084774  NAIP; baculoviral IAP repeat-containing protein 1 isoform X1 [KO:K12807]
105095602  NLRC4; NLR family CARD domain-containing protein 4 isoform X1 [KO:K12805]
105089723  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
105100418  CASP1; caspase-1 [KO:K01370] [EC:3.4.22.36]
105094167  IL18; interleukin-18 isoform X1 [KO:K05482]
105100419  caspase-13 [KO:K04394] [EC:3.4.22.57 3.4.22.64]
105105691  GSDMD; gasdermin-D isoform X1 [KO:K20917]
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
cdk04010  MAPK signaling pathway
cdk04064  NF-kappa B signaling pathway
cdk04210  Apoptosis
cdk04217  Necroptosis
cdk04621  NOD-like receptor signaling pathway
KO pathway
ko05132   
LinkDB

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