KEGG   PATHWAY: chx04621
Entry
chx04621                    Pathway                                
Name
NOD-like receptor signaling pathway - Capra hircus (goat)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
chx04621  NOD-like receptor signaling pathway
chx04621

Organism
Capra hircus (goat) [GN:chx]
Gene
102187833  NOD1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
102169397  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
102171591  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
102181262  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102177406  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
102181421  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
102169137  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
102175660  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102174096  RELA; transcription factor p65 [KO:K04735]
100860816  IL1B; interleukin-1 beta [KO:K04519]
100861190  IL18; interleukin-18 [KO:K05482]
100860785  IL6; interleukin-6 precursor [KO:K05405]
100861232  TNF; tumor necrosis factor [KO:K03156]
102178438  CXCL8; interleukin-8 [KO:K10030]
102182115  growth-regulated alpha protein [KO:K05505]
102182683  growth-regulated alpha protein-like [KO:K05505]
102182395  growth-regulated protein homolog gamma isoform X1 [KO:K05505]
102175889  C-C motif chemokine 2 [KO:K14624]
102171272  CCL5; C-C motif chemokine 5 [KO:K12499]
100861191  BAC7.5; Bac7.5 protein precursor [KO:K13916]
100861213  BAC5; cathelicidin-2 precursor [KO:K13916]
100861192  MAP28; MAP28 protein precursor [KO:K13916]
100861275  MAP34-B; MAP34-B protein precursor [KO:K13916]
102181444  LOW QUALITY PROTEIN: cathelicidin-3-like [KO:K13916]
102170003  cathelicidin-2 [KO:K13916]
102169231  cathelicidin-1 [KO:K13916]
102171106  cathelin-related peptide SC5 [KO:K13916]
100861169  LOW QUALITY PROTEIN: beta-defensin 1-like [KO:K21100]
100861170  LOW QUALITY PROTEIN: beta-defensin 1 [KO:K21100]
102188015  beta-defensin 103A [KO:K23126]
102186424  NOD2; nucleotide-binding oligomerization domain-containing protein 2 [KO:K10165]
102172719  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X2 [KO:K04427] [EC:2.7.11.25]
102185161  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
102187405  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
102169658  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
102186040  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102188824  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102182774  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102170408  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100861087  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102180926  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
100860996  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102189174  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
102184510  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
102185423  JUN; transcription factor AP-1 [KO:K04448]
102171213  ATG16L1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
102169291  ATG5; autophagy protein 5 isoform X1 [KO:K08339]
102190519  ATG12; ubiquitin-like protein ATG12 [KO:K08336]
100861246  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
102184507  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
102182439  GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
106502794  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
102175424  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
102185857  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
102172911  SUGT1; protein SGT1 homolog [KO:K12795]
102169684  sharpin [KO:K20894]
102181220  RBCK1; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
102191244  RNF31; E3 ubiquitin-protein ligase RNF31 [KO:K11974] [EC:2.3.2.31]
102170035  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
102180538  CARD6; caspase recruitment domain-containing protein 6 [KO:K12797]
102187099  TRIP6; thyroid receptor-interacting protein 6 [KO:K12792]
102168578  ERBIN; protein LAP2 isoform X1 [KO:K12796]
102173952  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
102173485  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
102184255  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
102188243  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
102172830  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
102170987  CARD9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
102182977  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
102178286  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
102171742  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
102181474  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
102183809  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
102185959  TANK; TRAF family member-associated NF-kappa-B activator isoform X3 [KO:K12650]
102171811  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
106503773  IRF7; interferon regulatory factor 7 [KO:K09447]
108635529  interferon alpha-H-like [KO:K05414]
108633160  interferon alpha-1-like [KO:K05414]
100860850  IFNA; interferon-alpha precursor [KO:K05414]
102174842  interferon alpha-1-like [KO:K05414]
102179943  interferon alpha-H-like [KO:K05414]
102180761  interferon alpha-H [KO:K05414]
102181299  interferon alpha-H-like [KO:K05414]
108636621  interferon alpha-H-like [KO:K05414]
108636627  interferon alpha-H-like [KO:K05414]
102181867  interferon beta-2 [KO:K05415]
102189208  LOW QUALITY PROTEIN: interferon beta-2 [KO:K05415]
102181595  interferon beta-2-like [KO:K05415]
108636544  interferon beta-2-like [KO:K05415]
108636629  interferon beta-2-like [KO:K05415]
108636632  interferon beta-2-like [KO:K05415]
108636634  interferon beta-2 [KO:K05415]
108633243  interferon beta-2-like [KO:K05415]
102175496  NLRX1; NLR family member X1 isoform X1 [KO:K12653]
102170958  ANTXR2; anthrax toxin receptor 2 [KO:K20909]
102174753  ANTXR1; anthrax toxin receptor 1 [KO:K20909]
102169512  NLRP1; NACHT, LRR and PYD domains-containing protein 1 [KO:K12798]
100861338  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
100861254  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
102180684  BCL2L1; bcl-2-like protein 1 [KO:K04570]
102183607  bcl-2-like protein 1 [KO:K04570]
102173295  CTSB; cathepsin B precursor [KO:K01363] [EC:3.4.22.1]
102173382  NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
102174365  PANX1; pannexin-1 [KO:K03443]
102174145  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
102171382  TRPM2; transient receptor potential cation channel subfamily M member 2 [KO:K04977] [EC:3.6.1.13]
102173747  TRPM7; transient receptor potential cation channel subfamily M member 7 [KO:K04982] [EC:2.7.11.1]
102187347  TRPV2; transient receptor potential cation channel subfamily V member 2 [KO:K04971]
102185783  CASR; extracellular calcium-sensing receptor precursor [KO:K04612]
102174303  GPRC6A; LOW QUALITY PROTEIN: G-protein coupled receptor family C group 6 member A [KO:K04622]
102188148  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
102180505  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
102169966  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
102189653  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
102188092  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
102170858  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
102184768  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
102173290  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
102169457  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
102176666  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
102184878  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
102190983  2'-5'-oligoadenylate synthase 1 isoform X3 [KO:K14216] [EC:2.7.7.84]
102186893  2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
102191823  RNASEL; LOW QUALITY PROTEIN: 2-5A-dependent ribonuclease [KO:K01165]
102170728  DHX33; putative ATP-dependent RNA helicase DHX33 [KO:K17820] [EC:5.6.2.6]
102191461  MFN1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
102181325  MFN2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
102178407  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
102185184  RIPK3; receptor-interacting serine/threonine-protein kinase 3 isoform X1 [KO:K08847] [EC:2.7.11.1]
102180018  DNM1L; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
102173810  NAMPT; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
102175938  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
102188617  cytochrome b-245 light chain [KO:K08009]
102183379  TXNIP; thioredoxin-interacting protein [KO:K20910]
102187487  TXN; thioredoxin [KO:K03671]
102173536  TXN2; thioredoxin, mitochondrial [KO:K03671]
102171902  NEK7; serine/threonine-protein kinase Nek7 isoform X1 [KO:K20876] [EC:2.7.11.34]
102171696  BRCC3; lys-63-specific deubiquitinase BRCC36 isoform X1 [KO:K11864] [EC:3.4.19.-]
102189098  lys-63-specific deubiquitinase BRCC36 isoform X1 [KO:K11864] [EC:3.4.19.-]
100860851  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
100861006  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
102191567  GPSM3; G-protein-signaling modulator 3 isoform X1 [KO:K15838]
102186453  MEFV; pyrin [KO:K12803]
102187808  PSTPIP1; proline-serine-threonine phosphatase-interacting protein 1 isoform X1 [KO:K12804]
102169919  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
102170760  FADD; FAS-associated death domain protein [KO:K02373]
102188566  NACHT, LRR and PYD domains-containing protein 6 [KO:K20863]
108634514  NLRP6; NACHT, LRR and PYD domains-containing protein 6 [KO:K20863]
102188793  NACHT, LRR and PYD domains-containing protein 7 [KO:K20864]
102168479  NLRP12; NACHT, LRR and PYD domains-containing protein 12 [KO:K20865]
102185222  NAIP; baculoviral IAP repeat-containing protein 1 [KO:K12807]
102189315  NLRC4; NLR family CARD domain-containing protein 4 [KO:K12805]
102171471  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
102174264  guanylate-binding protein 5 isoform X1 [KO:K20898]
102184679  LOW QUALITY PROTEIN: interferon-inducible protein AIM2 [KO:K12966]
102173932  interferon-activable protein 203 isoform X1 [KO:K20914]
102182833  TP53BP1; tumor suppressor p53-binding protein 1 isoform X1 [KO:K20915]
102181169  RHOA; transforming protein RhoA [KO:K04513]
102172617  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
102183285  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
102177369  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
102181554  guanylate-binding protein 4 isoform X1 [KO:K20899]
102170144  guanylate-binding protein 1 isoform X1 [KO:K20899]
102186299  guanylate-binding protein 1 [KO:K20899]
102191717  uncharacterized protein LOC102191717 [KO:K04394] [EC:3.4.22.57 3.4.22.64]
102185480  GSDMD; gasdermin-D isoform X1 [KO:K20917]
102191552  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
102175057  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
102182846  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
102188492  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
102189170  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
102190301  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
102190231  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
100860955  TLR4; toll-like receptor 4 precursor [KO:K10160]
102170774  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
102174883  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
102171575  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
102171058  STING1; stimulator of interferon genes protein [KO:K12654]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
Related
pathway
chx04010  MAPK signaling pathway
chx04064  NF-kappa B signaling pathway
chx04140  Autophagy - animal
chx04620  Toll-like receptor signaling pathway
KO pathway
ko04621   
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