KEGG   PATHWAY: dsp04062
Entry
dsp04062                    Pathway                                
Name
Chemokine signaling pathway - Dipodomys spectabilis (banner-tailed kangaroo rat)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
dsp04062  Chemokine signaling pathway
dsp04062

Other DBs
GO: 0070098
Organism
Dipodomys spectabilis (banner-tailed kangaroo rat) [GN:dsp]
Gene
122106718  permeability factor 2-like [KO:K05505]
122106721  growth-regulated alpha protein-like [KO:K05505]
122106896  alveolar macrophage chemotactic factor-like [KO:K05506]
122106703  platelet basic protein-like [KO:K10029]
122106900  Cxcl8; interleukin-8 [KO:K10030]
122106866  Cxcl9; C-X-C motif chemokine 9 [KO:K05416]
122106717  Cxcl10; C-X-C motif chemokine 10 [KO:K12671]
122106769  Cxcl11; C-X-C motif chemokine 11 [KO:K12672]
122122261  Cxcl12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
122106723  Cxcl13; C-X-C motif chemokine 13 [KO:K10032]
122108636  Cxcl16; C-X-C motif chemokine 16 [KO:K10035]
122100925  Cxcl14; C-X-C motif chemokine 14 [KO:K10033]
122103863  lymphotactin-like [KO:K05507]
122116292  Cx3cl1; fractalkine [KO:K05508]
122118582  C-C motif chemokine 2-like [KO:K14624]
122118629  C-C motif chemokine 3-like [KO:K05408]
122119336  C-C motif chemokine 3-like [KO:K05408]
122118636  C-C motif chemokine 4 [KO:K12964]
122119221  Ccl5; C-C motif chemokine 5 [KO:K12499]
122119322  C-C motif chemokine 6-like [KO:K05510]
122118591  C-C motif chemokine 7-like [KO:K05509]
122118599  eotaxin-like [KO:K16597]
122119446  Ccl14; C-C motif chemokine 14 [KO:K21092]
122119717  C-C motif chemokine 15-like [KO:K05511]
122116326  Ccl17; C-C motif chemokine 17 [KO:K21083]
122122770  Ccl19; C-C motif chemokine 19 [KO:K05512]
122107546  Ccl20; C-C motif chemokine 20 [KO:K14625]
122122007  Ccl21; C-C motif chemokine 21 [KO:K16062]
122116308  Ccl22; C-C motif chemokine 22 [KO:K21095]
122119556  Ccl25; C-C motif chemokine 25 [KO:K13072]
122121286  uncharacterized protein LOC122121286 [KO:K16598]
122121291  Ccl27; C-C motif chemokine 27 [KO:K16598]
122116950  Ccl28; C-C motif chemokine 28 [KO:K05513]
122107411  C-X-C chemokine receptor type 2-like [KO:K05050]
122107404  C-X-C chemokine receptor type 1-like [KO:K04175]
122120658  Cxcr3; C-X-C chemokine receptor type 3 [KO:K04188]
122110827  Cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
122110285  Cxcr5; C-X-C chemokine receptor type 5 isoform X1 [KO:K04190]
122100695  Cxcr6; C-X-C chemokine receptor type 6 [KO:K04191]
122100707  Xcr1; LOW QUALITY PROTEIN: chemokine XC receptor 1 [KO:K04193]
122124889  Cx3cr1; LOW QUALITY PROTEIN: CX3C chemokine receptor 1 [KO:K04192]
122116088  Ccr6; C-C chemokine receptor type 6 [KO:K04181]
122096099  Ccr4; C-C chemokine receptor type 4 [KO:K04179]
122103234  Ccr7; C-C chemokine receptor type 7 [KO:K04182]
122095629  C-C chemokine receptor type 2-like [KO:K04177]
122095631  C-C chemokine receptor type 5-like [KO:K04180]
122095735  C-C chemokine receptor type 1-like [KO:K04176]
122095665  Ccr3; C-C chemokine receptor type 3 [KO:K04178]
122103373  Ccr10; C-C chemokine receptor type 10 [KO:K04185]
122124653  Jak2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
122100890  Jak3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
122115055  Stat1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
122124118  Stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
122103310  Stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
122100261  signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
122095572  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
122111882  Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
122105366  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
122128067  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
122120987  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
122122500  Adcy3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
122113375  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
122097950  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
122106258  Adcy6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
122119361  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
122125337  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
122123783  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
122104508  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
122119798  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
122121929  Lyn; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
122120233  Hck; tyrosine-protein kinase HCK isoform X1 [KO:K08893] [EC:2.7.10.2]
122115233  Fgr; tyrosine-protein kinase Fgr [KO:K08891] [EC:2.7.10.2]
122120491  Src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
122109169  Shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
122122823  Shc2; SHC-transforming protein 2 [KO:K17447]
122113790  Shc3; SHC-transforming protein 3 [KO:K17448]
122114464  Shc4; LOW QUALITY PROTEIN: SHC-transforming protein 4 [KO:K17449]
122128376  Grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
122104519  Sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
122106484  Sos2; son of sevenless homolog 2 [KO:K03099]
122095011  Hras; GTPase HRas isoform X1 [KO:K02833]
122098841  Kras; GTPase KRas isoform X1 [KO:K07827]
122118367  Nras; GTPase NRas [KO:K07828]
122107826  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
122105936  Braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
122114391  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
122095844  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122096287  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
122095294  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
122121501  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122107232  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
122123339  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
122108047  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
122100872  Pik3r2; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
122117343  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
122111901  Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
122119152  Pik3r6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
122120285  Pik3r5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
122127324  Prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
122097416  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122101263  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122126696  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122104495  Foxo3; forkhead box protein O3 [KO:K09408]
122115917  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
122107663  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
122097005  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
122106511  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
122097420  Nfkbib; NF-kappa-B inhibitor beta [KO:K02581]
122127164  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
122105094  Rela; transcription factor p65 isoform X1 [KO:K04735]
122105036  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
122097538  Gsk3a; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
122096813  Gsk3b; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
122101061  Itk; tyrosine-protein kinase ITK/TSK [KO:K07363] [EC:2.7.10.2]
122104889  Vav3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
122122780  Vav1; proto-oncogene vav [KO:K05730]
122108904  Vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
122113510  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
122119204  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
122099403  Rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
122115583  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
122119115  cell division control protein 42 homolog [KO:K04393]
122115178  Cdc42; cell division control protein 42 homolog [KO:K04393]
122098811  Was; wiskott-Aldrich syndrome protein [KO:K05747]
122095683  Rhoa; transforming protein RhoA [KO:K04513]
122115017  transforming protein RhoA-like [KO:K04513]
122104238  Rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
122108760  Rock2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
122127332  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
122113749  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
122099244  Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
122114508  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
122106523  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
122105120  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
122113060  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
122105860  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
122122831  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
122115548  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
122115891  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
122099305  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
122125901  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
122104437  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
122113091  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
122121653  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
122111861  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
122104327  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
122101888  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
122111933  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
122102139  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
122127883  Prex1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
122120767  LOW QUALITY PROTEIN: engulfment and cell motility protein 1-like [KO:K12366]
122120775  LOW QUALITY PROTEIN: engulfment and cell motility protein 1-like [KO:K12366]
122120796  LOW QUALITY PROTEIN: engulfment and cell motility protein 1-like [KO:K12366]
122120802  LOW QUALITY PROTEIN: engulfment and cell motility protein 1-like [KO:K12366]
122120852  Elmo1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
122101084  LOW QUALITY PROTEIN: dedicator of cytokinesis protein 2-like [KO:K12367]
122125312  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
122099008  Pxn; paxillin isoform X1 [KO:K05760]
122126159  Bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
122095902  Crkl; crk-like protein [KO:K04438]
122102190  Crk; adapter molecule crk isoform X1 [KO:K04438]
122123482  Ptk2b; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
122095118  Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
122120299  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
122105124  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
122120360  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
122114401  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
122120202  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
122104915  Rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
122104391  Rap1a; ras-related protein Rap-1A isoform X1 [KO:K04353]
122124042  Rap1b; ras-related protein Rap-1b [KO:K07836]
122113067  Pard3; partitioning defective 3 homolog isoform X1 [KO:K04237]
122114257  Tiam1; rho guanine nucleotide exchange factor TIAM1 [KO:K05731]
122116145  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
122107987  Prkcd; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
122114842  Ncf1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
122122879  Grk1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
122104916  Grk2; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
122097920  Grk3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
122096515  Grk6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
122100679  Grk4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
122126856  Grk5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
122114172  Arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
122108635  Arrb2; beta-arrestin-2 isoform X1 [KO:K04439]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
dsp04010  MAPK signaling pathway
dsp04060  Cytokine-cytokine receptor interaction
dsp04120  Ubiquitin mediated proteolysis
dsp04630  JAK-STAT signaling pathway
dsp04670  Leukocyte transendothelial migration
dsp04810  Regulation of actin cytoskeleton
KO pathway
ko04062   
LinkDB

DBGET integrated database retrieval system