KEGG   PATHWAY: dsp05168
Entry
dsp05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Dipodomys spectabilis (banner-tailed kangaroo rat)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
dsp05168  Herpes simplex virus 1 infection
dsp05168

Organism
Dipodomys spectabilis (banner-tailed kangaroo rat) [GN:dsp]
Gene
122111282  Lta; lymphotoxin-alpha [KO:K05468]
122122846  Tnfsf14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
122127335  Tnfrsf14; tumor necrosis factor receptor superfamily member 14 [KO:K05152]
122099715  Traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
122109749  Traf5; TNF receptor-associated factor 5 [KO:K09849]
122107663  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
122115917  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
122097005  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
122106511  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
122127164  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
122105094  Rela; transcription factor p65 isoform X1 [KO:K04735]
122110391  Birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
122118582  C-C motif chemokine 2-like [KO:K14624]
122110366  Nectin1; nectin-1 isoform X1 [KO:K06081]
122125802  Nectin2; nectin-2 isoform X1 [KO:K06531]
122113541  paired immunoglobulin-like type 2 receptor alpha isoform X1 [KO:K15411]
122113543  paired immunoglobulin-like type 2 receptor alpha isoform X1 [KO:K15411]
122113544  paired immunoglobulin-like type 2 receptor beta isoform X1 [KO:K15411]
122098592  Ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
122124347  Itga5; integrin alpha-5 [KO:K06484]
122103395  Itgb3; integrin beta-3 [KO:K06493]
122120491  Src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
122113605  Syk; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
122108960  Card9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
122125825  Irf3; interferon regulatory factor 3 [KO:K05411]
122118962  Ifnb1; interferon beta [KO:K05415]
122100440  Tp53; cellular tumor antigen p53 [KO:K04451]
122122722  C3; complement C3 [KO:K03990]
122107097  C5; complement C5 [KO:K03994]
122098766  properdin [KO:K15412]
122127146  Tlr2; toll-like receptor 2 [KO:K10159]
122095671  toll-like receptor 9 isoform X1 [KO:K10161]
122096770  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
122095034  Irf7; interferon regulatory factor 7 isoform X1 [KO:K09447]
122125841  Tlr3; toll-like receptor 3 [KO:K05401]
122099354  Ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
122106144  Irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
122097062  Irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
122117775  Traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
122107728  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
122123572  Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
122102982  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
122100606  Il1b; interleukin-1 beta [KO:K04519]
122119221  Ccl5; C-C motif chemokine 5 [KO:K12499]
122112101  interleukin-6-like [KO:K05405]
122112102  interleukin-6-like [KO:K05405]
122112217  interleukin-6-like [KO:K05405]
122111281  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
122112737  Il12a; interleukin-12 subunit alpha [KO:K05406]
122125036  Il12b; interleukin-12 subunit beta [KO:K05425]
122123200  Ddx58; antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
122124962  Ifih1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
122120262  Mavs; mitochondrial antiviral-signaling protein [KO:K12648]
122122592  Traf3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
122109675  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
122124190  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
122118940  interferon alpha-3-like [KO:K05414]
122118944  interferon alpha-3-like [KO:K05414]
122118945  interferon alpha-3-like [KO:K05414]
122118948  interferon alpha-3-like [KO:K05414]
122118949  interferon alpha-3-like [KO:K05414]
122118950  interferon alpha-3-like [KO:K05414]
122118956  interferon alpha-2-like [KO:K05414]
122118961  interferon alpha-2-like [KO:K05414]
122118984  interferon alpha-3-like [KO:K05414]
122113960  Cgas; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
122118148  Sting1; stimulator of interferon genes protein [KO:K12654]
122104673  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
122098491  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
122122432  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
122113589  Eif2ak1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]
122104582  Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
122116859  Eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
122114393  Eif2ak4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
122117971  Eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
122098558  Eif2b1; translation initiation factor eIF-2B subunit alpha [KO:K03239]
122118802  Eif2b2; translation initiation factor eIF-2B subunit beta [KO:K03754]
122111946  Eif2b3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
122122552  Eif2b4; translation initiation factor eIF-2B subunit delta isoform X1 [KO:K03680]
122096758  Eif2b5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
122098546  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
122103844  Rnasel; 2-5A-dependent ribonuclease isoform X1 [KO:K01165]
122097003  Hcfc1; host cell factor 1 isoform X1 [KO:K14966]
122119155  Hcfc2; host cell factor 2 isoform X1 [KO:K27390]
122097375  Pou2f2; POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364]
122106059  Pou2f1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
122110336  Pou2f3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
122114214  Ifnar1; interferon alpha/beta receptor 1 [KO:K05130]
122114217  Ifnar2; interferon alpha/beta receptor 2 [KO:K05131]
122096608  Socs3; suppressor of cytokine signaling 3 [KO:K04696]
122110980  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
122119834  Tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
122115055  Stat1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
122124118  Stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
122113394  Irf9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
122110547  Znf304; zinc finger protein 304 isoform X1 [KO:K09228]
122110548  zinc finger protein 17-like [KO:K09228]
122110549  zinc finger protein 416-like [KO:K09228]
122110550  zinc finger protein 551-like [KO:K09228]
122110551  Znf583; zinc finger protein 583 [KO:K09228]
122110552  Znf471; zinc finger protein 471 isoform X1 [KO:K09228]
122110553  Znf667; zinc finger protein 667 isoform X1 [KO:K09228]
122110605  zinc finger protein 665-like [KO:K09228]
122110606  LOW QUALITY PROTEIN: zinc finger protein 772-like [KO:K09228]
122110650  zinc finger protein 416-like isoform X1 [KO:K09228]
122110651  zinc finger protein interacting with ribonucleoprotein K-like isoform X1 [KO:K09228]
122110652  zinc finger protein 132-like [KO:K09228]
122110665  Znf606; zinc finger protein 606 isoform X1 [KO:K09228]
122110669  zinc finger protein 2-like [KO:K09228]
122110674  zinc finger protein 883-like [KO:K09228]
122110677  zinc finger protein 660-like isoform X1 [KO:K09228]
122110679  Znf8; zinc finger protein 8 [KO:K09228]
122110680  zinc finger protein 160-like isoform X1 [KO:K09228]
122110685  zinc finger protein 154-like isoform X1 [KO:K09228]
122110687  Znf211; LOW QUALITY PROTEIN: zinc finger protein 211 [KO:K09228]
122110721  zinc finger protein interacting with ribonucleoprotein K-like isoform X1 [KO:K09228]
122118500  Znf286a; zinc finger protein 286A [KO:K09228]
122118540  zinc finger protein OZF-like [KO:K09228]
122118564  LOW QUALITY PROTEIN: zinc finger protein 2 homolog [KO:K09228]
122118565  LOW QUALITY PROTEIN: zinc finger protein 658B-like [KO:K09228]
122118567  zinc finger protein 2 homolog [KO:K09228]
122118570  LOW QUALITY PROTEIN: zinc finger protein OZF-like [KO:K09228]
122111228  Znf311; LOW QUALITY PROTEIN: zinc finger protein 311 [KO:K09228]
122128317  zinc finger protein 251-like [KO:K09228]
122095855  Znf74; zinc finger protein 74 [KO:K09228]
122111401  Zfp57; zinc finger protein 57 homolog isoform X1 [KO:K09228]
122111515  Znf184; zinc finger protein 184 [KO:K09228]
122111726  Znf41; zinc finger protein 41 [KO:K09228]
122119566  Znf557; zinc finger protein 557 [KO:K09228]
122119644  zinc finger protein 709-like [KO:K09228]
122119694  zinc finger protein 26-like isoform X1 [KO:K09228]
122119695  zinc finger protein 26-like [KO:K09228]
122119696  zinc finger protein 345-like [KO:K09228]
122119697  zinc finger protein 561-like [KO:K09228]
122119698  zinc finger protein 699-like [KO:K09228]
122119715  zinc finger protein 709-like [KO:K09228]
122119716  zinc finger protein 14-like isoform X1 [KO:K09228]
122119718  zinc finger protein 33B-like [KO:K09228]
122119816  LOW QUALITY PROTEIN: zinc finger protein 317-like [KO:K09228]
122096140  Znf133; zinc finger protein 133 [KO:K09228]
122096294  Znf768; zinc finger protein 768 [KO:K09228]
122096295  zinc finger protein 689 [KO:K09228]
122096296  zinc finger protein 764-like isoform X1 [KO:K09228]
122096297  Znf688; zinc finger protein 688 isoform X1 [KO:K09228]
122104736  LOW QUALITY PROTEIN: zinc finger protein 433-like [KO:K09228]
122112168  zinc finger protein 567-like isoform X1 [KO:K09228]
122119883  zinc finger protein 14-like [KO:K09228]
122096678  zinc finger protein 26 isoform X1 [KO:K09228]
122096682  Znf140; zinc finger protein 140 isoform X1 [KO:K09228]
122120356  Znf334; zinc finger protein 334 isoform X1 [KO:K09228]
122097031  Zfp92; zinc finger protein 92 homolog [KO:K09228]
122097077  Znf275; zinc finger protein 275 isoform X1 [KO:K09228]
122097330  Znf792; zinc finger protein 792 [KO:K09228]
122097365  Znf45; zinc finger protein 45 [KO:K09228]
122112847  zinc finger protein 14-like [KO:K09228]
122120880  zinc finger protein 567-like [KO:K09228]
122121216  zinc finger protein 501-like [KO:K09228]
122121333  Znf2; zinc finger protein 2 isoform X1 [KO:K09228]
122097467  LOW QUALITY PROTEIN: zinc finger protein 420-like [KO:K09228]
122097469  zinc finger protein 540-like [KO:K09228]
122097471  zinc finger protein 790-like [KO:K09228]
122097472  Znf569; zinc finger protein 569 isoform X1 [KO:K09228]
122097474  zinc finger protein 568-like isoform X1 [KO:K09228]
122097475  zinc finger protein 420 isoform X1 [KO:K09228]
122097476  Znf875; zinc finger protein 875 isoform X1 [KO:K09228]
122097478  Znf567; zinc finger protein 567 [KO:K09228]
122097484  Znf382; zinc finger protein 382 [KO:K09228]
122097485  zinc finger protein 420-like isoform X1 [KO:K09228]
122097487  zinc finger protein 14 homolog isoform X1 [KO:K09228]
122097488  zinc finger protein 30 homolog [KO:K09228]
122097489  zinc finger protein 570-like [KO:K09228]
122097491  Znf565; zinc finger protein 565 [KO:K09228]
122097492  zinc finger protein 570-like isoform X1 [KO:K09228]
122097534  Znf599; zinc finger protein 599 [KO:K09228]
122105847  Znf786; zinc finger protein 786 [KO:K09228]
122105848  zinc finger protein 282-like [KO:K09228]
122105884  Znf282; zinc finger protein 282 [KO:K09228]
122105885  Znf783; protein ZNF783 [KO:K09228]
122105886  Znf212; zinc finger protein 212 [KO:K09228]
122105974  zinc finger protein 777 isoform X1 [KO:K09228]
122105989  zinc finger protein 746 isoform X1 [KO:K09228]
122105998  Znf398; zinc finger protein 398 [KO:K09228]
122113559  Znf484; zinc finger protein 484 [KO:K09228]
122113583  Znf3; zinc finger protein 3 [KO:K09228]
122113679  zinc finger protein 316-like [KO:K09228]
122113760  zinc finger protein 883-like isoform X1 [KO:K09228]
122113848  Rbak; RB-associated KRAB zinc finger protein [KO:K09228]
122121967  Zfp37; zinc finger protein 37 homolog [KO:K09228]
122122029  zinc finger protein 2-like [KO:K09228]
122122100  Znf189; zinc finger protein 189 isoform X1 [KO:K09228]
122106287  Znf641; zinc finger protein 641 [KO:K09228]
122106374  zinc finger protein 883-like isoform X1 [KO:K09228]
122113866  Znf12; zinc finger protein 12 isoform X1 [KO:K09228]
122122270  Znf248; zinc finger protein 248 [KO:K09228]
122122272  zinc finger protein 25-like [KO:K09228]
122122375  Znf33b; zinc finger protein 33B [KO:K09228]
122098798  zinc finger protein 81-like [KO:K09228]
122098799  LOW QUALITY PROTEIN: zinc finger protein 182-like [KO:K09228]
122098817  zinc finger protein 2 homolog isoform X1 [KO:K09228]
122098908  zinc finger protein 7-like isoform X1 [KO:K09228]
122098909  zinc finger protein 251-like [KO:K09228]
122098910  LOW QUALITY PROTEIN: zinc finger protein 250-like [KO:K09228]
122098924  Znf623; zinc finger protein 623 [KO:K09228]
122098933  zinc finger protein 883-like [KO:K09228]
122098946  zinc finger protein 39-like isoform X1 [KO:K09228]
122106817  zinc finger protein 350-like [KO:K09228]
122123231  LOW QUALITY PROTEIN: zinc finger protein 33B-like [KO:K09228]
122099324  zinc finger protein 556-like [KO:K09228]
122099527  zinc finger protein 717-like [KO:K09228]
122099534  LOW QUALITY PROTEIN: zinc finger protein OZF-like [KO:K09228]
122115268  Znf436; zinc finger protein 436 [KO:K09228]
122123232  zinc finger protein 624-like [KO:K09228]
122123233  LOW QUALITY PROTEIN: zinc finger protein 33B-like [KO:K09228]
122123234  zinc finger protein 33B-like [KO:K09228]
122123235  zinc finger protein 33B-like [KO:K09228]
122123253  LOW QUALITY PROTEIN: zinc finger protein 33B-like [KO:K09228]
122123286  LOW QUALITY PROTEIN: zinc finger protein OZF-like [KO:K09228]
122123287  zinc finger protein 2 homolog [KO:K09228]
122123289  LOW QUALITY PROTEIN: zinc finger protein 33B-like [KO:K09228]
122123293  zinc finger protein 717-like [KO:K09228]
122123295  zinc finger protein OZF-like [KO:K09228]
122123296  zinc finger protein 33B-like [KO:K09228]
122123304  LOW QUALITY PROTEIN: zinc finger protein 2 homolog [KO:K09228]
122123307  LOW QUALITY PROTEIN: zinc finger protein OZF-like [KO:K09228]
122123309  LOW QUALITY PROTEIN: zinc finger protein 2-like [KO:K09228]
122123315  zinc finger protein OZF-like [KO:K09228]
122123317  LOW QUALITY PROTEIN: zinc finger protein 2 homolog [KO:K09228]
122123320  zinc finger protein OZF-like [KO:K09228]
122123324  zinc finger protein 2-like [KO:K09228]
122123332  zinc finger protein OZF-like [KO:K09228]
122123333  zinc finger protein OZF-like [KO:K09228]
122123337  zinc finger protein OZF-like [KO:K09228]
122123338  zinc finger protein 157-like [KO:K09228]
122123722  Znf205; zinc finger protein 205 [KO:K09228]
122099851  zinc finger protein 709-like [KO:K09228]
122100250  zinc finger protein 14-like isoform X1 [KO:K09228]
122100275  zinc finger protein 791-like [KO:K09228]
122100309  zinc finger protein 883-like [KO:K09228]
122100310  zinc finger protein OZF-like isoform X1 [KO:K09228]
122100312  zinc finger protein 709-like isoform X1 [KO:K09228]
122115415  zinc finger protein 354A [KO:K09228]
122115442  Znf879; zinc finger protein 879 isoform X1 [KO:K09228]
122115473  Znf354c; zinc finger protein 354C [KO:K09228]
122115497  Znf454; zinc finger protein 454 isoform X1 [KO:K09228]
122123747  Znf597; zinc finger protein 597 [KO:K09228]
122123894  Znf200; zinc finger protein 200 isoform X1 [KO:K09228]
122100903  zinc finger protein 20-like isoform X1 [KO:K09228]
122108683  zinc finger protein 69 homolog isoform X1 [KO:K09228]
122108994  zinc finger protein 709-like [KO:K09228]
122125578  Znf473; zinc finger protein 473 [KO:K09228]
122102203  zinc finger protein 717-like isoform X1 [KO:K09228]
122125813  Znf615; zinc finger protein 615 isoform X1 [KO:K09228]
122125815  zinc finger protein 347-like [KO:K09228]
122125816  zinc finger protein 160-like [KO:K09228]
122125817  Znf649; zinc finger protein 649 isoform X1 [KO:K09228]
122126132  Zfp90; zinc finger protein 90 homolog isoform X1 [KO:K09228]
122126245  Zfp1; zinc finger protein 1 homolog [KO:K09228]
122126271  Znf23; zinc finger protein 23 isoform X1 [KO:K09228]
122104259  Znf397; zinc finger protein 397 [KO:K09228]
122120786  zinc finger protein 2 homolog [KO:K09228]
122110607  LOW QUALITY PROTEIN: uncharacterized protein LOC122110607 [KO:K09228]
122124303  Ifng; interferon gamma [KO:K04687]
122118073  Ifngr1; interferon gamma receptor 1 isoform X1 [KO:K05132]
122114285  Ifngr2; interferon gamma receptor 2 isoform X1 [KO:K05133]
122124653  Jak2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
122111402  Daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
122107388  Sp100; nuclear autoantigen Sp-100 isoform X1 [KO:K15413]
122123005  Pml; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
122111481  Tap1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
122111482  Tap2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
122111413  tapasin [KO:K08058]
122114339  Pdia3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
122106128  calreticulin-like [KO:K08057]
122100316  Calr; calreticulin [KO:K08057]
122111313  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
122111314  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
122111316  patr class I histocompatibility antigen, B-2 alpha chain-like isoform X1 [KO:K06751]
122111318  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
122111319  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
122111320  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
122111321  HLA class I histocompatibility antigen, B alpha chain-like isoform X1 [KO:K06751]
122111322  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
122111324  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
122111325  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
122111326  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
122114656  B2m; beta-2-microglobulin [KO:K08055]
122111099  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
122111100  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
122111152  HLA class II histocompatibility antigen, DO beta chain-like [KO:K06752]
122111153  HLA class II histocompatibility antigen, DR beta 4 chain-like [KO:K06752]
122111154  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
122111155  HLA class II histocompatibility antigen, DR beta 4 chain-like [KO:K06752]
122111156  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
122111157  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
122111160  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
122111352  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
122111353  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
122118063  Cd74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
122095294  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
122121501  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122107232  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
122123339  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
122108047  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
122100872  Pik3r2; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
122117343  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
122097416  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122101263  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122126696  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122108951  Tsc1; hamartin isoform X1 [KO:K07206]
122123834  Tsc2; tuberin isoform X1 [KO:K07207]
122105955  Rheb; GTP-binding protein Rheb [KO:K07208]
122121508  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
122107645  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
122111052  Srpk1; LOW QUALITY PROTEIN: SRSF protein kinase 1 [KO:K15409] [EC:2.7.11.1]
122103558  Srsf1; serine/arginine-rich splicing factor 1 [KO:K12890]
122128367  Srsf2; serine/arginine-rich splicing factor 2 [KO:K12891]
122111048  Srsf3; serine/arginine-rich splicing factor 3 [KO:K12892]
122118639  Srsf5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
122120556  Srsf6; serine/arginine-rich splicing factor 6 isoform X1 [KO:K12893]
122115186  Srsf4; serine/arginine-rich splicing factor 4 isoform X1 [KO:K12893]
122104507  Srsf7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
122099056  Srsf9; serine/arginine-rich splicing factor 9 [KO:K21123]
122104902  Nxf1; nuclear RNA export factor 1 [KO:K14284]
122114924  Nxf3; nuclear RNA export factor 3 [KO:K14284]
122099414  Alyref; THO complex subunit 4 [KO:K12881]
122103807  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
122116005  Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
122102541  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
122126138  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
122099877  Fadd; FAS-associated death domain protein [KO:K02373]
122096450  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
122101664  Bid; BH3-interacting domain death agonist isoform X1 [KO:K04726]
122125840  Bax; apoptosis regulator BAX [KO:K02159]
122111128  Bak1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
122105036  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
122119434  Bcl2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
122120267  Bcl2l1; bcl-2-like protein 1 isoform X1 [KO:K04570]
122110854  cytochrome c-like [KO:K08738]
122112201  cytochrome c, somatic [KO:K08738]
122115021  cytochrome c, testis-specific [KO:K08738]
122124195  cytochrome c, somatic-like [KO:K08738]
122116980  cytochrome c, somatic-like [KO:K08738]
122117286  cytochrome c, somatic-like [KO:K08738]
122119240  Apaf1; apoptotic protease-activating factor 1 [KO:K02084]
122099125  Casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
122126104  Casp3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
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Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
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Semin Immunopathol 31:207-21 (2009)
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Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
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Cell Microbiol 6:401-10 (2004)
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Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
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Su C, Zhan G, Zheng C
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Evasion of host antiviral innate immunity by HSV-1, an update.
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Virol J 13:38 (2016)
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Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
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Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
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Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
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Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
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J Virol 92:e00099-17 (2018)
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Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
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Design and application of oncolytic HSV vectors for glioblastoma therapy.
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Expert Rev Neurother 9:505-17 (2009)
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Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
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The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
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Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
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Fleming SB
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Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
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Vaccines (Basel) 4:E23 (2016)
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Reference
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Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
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J Virol 78:6282-6 (2004)
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Reference
PMID:23864622
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Gu H, Zheng Y, Roizman B
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Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
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J Virol 87:10244-54 (2013)
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Reference
PMID:21994592
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Tavalai N, Stamminger T
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Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
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Viruses 1:1240-64 (2009)
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Reference
PMID:21146386
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Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
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Viral evasion of T cell immunity: ancient mechanisms offering new applications.
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Curr Opin Immunol 23:96-103 (2011)
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Reference
PMID:12960333
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Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
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J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
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Virology 479-480:568-77 (2015)
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Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
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Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
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J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
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Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
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Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
dsp03040  Spliceosome
dsp03050  Proteasome
dsp04115  p53 signaling pathway
dsp04151  PI3K-Akt signaling pathway
dsp04210  Apoptosis
dsp04610  Complement and coagulation cascades
dsp04612  Antigen processing and presentation
dsp04620  Toll-like receptor signaling pathway
dsp04622  RIG-I-like receptor signaling pathway
dsp04630  JAK-STAT signaling pathway
KO pathway
ko05168   
LinkDB

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