KEGG   PATHWAY: hai05169
Entry
hai05169                    Pathway                                
Name
Epstein-Barr virus infection - Hipposideros armiger (great roundleaf bat)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
hai05169  Epstein-Barr virus infection
hai05169

Organism
Hipposideros armiger (great roundleaf bat) [GN:hai]
Gene
109374503  CR2; complement receptor type 2 [KO:K04012]
109385818  CD19; B-lymphocyte antigen CD19 [KO:K06465]
109373047  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
109392411  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
109392415  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
109378577  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
109373106  H-2 class II histocompatibility antigen, E-S beta chain [KO:K06752]
109373108  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
109373109  HLA class II histocompatibility antigen, DQ beta 2 chain-like isoform X1 [KO:K06752]
109377860  HLA class II histocompatibility antigen, DQ beta 2 chain-like isoform X1 [KO:K06752]
109377861  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
109377862  H-2 class II histocompatibility antigen, A-F alpha chain-like [KO:K06752]
109377863  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
109376897  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
109376898  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
109378434  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
109378436  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
109376891  SLA class II histocompatibility antigen, DQ haplotype C beta chain-like isoform X1 [KO:K06752]
109376893  rano class II histocompatibility antigen, A beta chain-like isoform X1 [KO:K06752]
109377864  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
109378145  HLA class II histocompatibility antigen, DO beta chain-like isoform X1 [KO:K06752]
109382017  TLR2; toll-like receptor 2 [KO:K10159]
109393491  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
109388403  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
109394352  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
109381153  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
109392251  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
109380888  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
109389465  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
109379632  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
109386279  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
109377344  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
109383860  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
109372541  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
109384322  RELA; transcription factor p65 isoform X1 [KO:K04735]
109373073  TNF; tumor necrosis factor isoform X1 [KO:K03156]
109387871  IL6; interleukin-6 [KO:K05405]
109371521  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
109383826  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
109381072  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
109381695  TBK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
109386512  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
109375630  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
109391076  IRF3; interferon regulatory factor 3 [KO:K05411]
109374670  interferon alpha-4-like [KO:K05414]
109396418  IFNB1; interferon beta [KO:K05415]
109373231  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
109373246  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
109384938  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
109391605  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
109393276  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
109396910  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
109393688  IRF9; interferon regulatory factor 9 [KO:K04693]
109385455  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
109382229  LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 3-like [KO:K14216] [EC:2.7.7.84]
109382257  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
109371167  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
109391180  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
109377126  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
109389315  FADD; FAS-associated death domain protein [KO:K02373]
109379228  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
109373303  BID; BH3-interacting domain death agonist [KO:K04726]
109393533  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
109390784  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
109391068  BAX; apoptosis regulator BAX [KO:K02159]
109392454  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
109393551  cytochrome c [KO:K08738]
109381354  cytochrome c [KO:K08738]
109382336  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
109381302  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
109395706  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
109378262  uncharacterized protein LOC109378262 [KO:K10785]
109385284  CD3E; T-cell surface glycoprotein CD3 epsilon chain isoform X1 [KO:K06451]
109385282  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
109385283  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
109384944  CD247; T-cell surface glycoprotein CD3 zeta chain isoform X1 [KO:K06453]
109389526  PSMC2; 26S protease regulatory subunit 7 [KO:K03061]
109382668  PSMC1; 26S protease regulatory subunit 4 isoform X1 [KO:K03062]
109374866  PSMC4; 26S protease regulatory subunit 6B [KO:K03063]
109384258  PSMC6; 26S protease regulatory subunit 10B [KO:K03064]
109390170  PSMC3; 26S protease regulatory subunit 6A [KO:K03065]
109380274  PSMC5; 26S protease regulatory subunit 8 [KO:K03066]
109396643  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
109373947  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
109380761  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
109380331  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
109385168  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 isoform X1 [KO:K03036]
109371536  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
109390306  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
109378084  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X1 [KO:K03039]
109372274  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 [KO:K03029]
109379869  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
109395319  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
109380082  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
109393125  SEM1; LOW QUALITY PROTEIN: 26S proteasome complex subunit DSS1 [KO:K10881]
109378146  TAP1; antigen peptide transporter 1 isoform X1 [KO:K05653] [EC:7.4.2.14]
109378144  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
109392427  TAPBP; tapasin [KO:K08058]
109384022  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
109394224  CALR; calreticulin [KO:K08057]
109376402  LOW QUALITY PROTEIN: calreticulin-like [KO:K08057]
109373056  HLA class I histocompatibility antigen, B-73 alpha chain-like [KO:K06751]
109378624  HLA class I histocompatibility antigen, B-15 alpha chain-like isoform X1 [KO:K06751]
109378610  HLA class I histocompatibility antigen, B-46 alpha chain-like [KO:K06751]
109373110  HLA class I histocompatibility antigen, B-67 alpha chain-like [KO:K06751]
109376695  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like [KO:K06751]
109376696  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
109376701  HLA class I histocompatibility antigen, B-37 alpha chain-like isoform X1 [KO:K06751]
109378398  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
109377928  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
109377929  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
109377720  HLA class I histocompatibility antigen, A-30 alpha chain-like [KO:K06751]
109377721  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
109377607  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
109377608  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
109377610  HLA class I histocompatibility antigen, A-30 alpha chain-like isoform X1 [KO:K06751]
109378301  class I histocompatibility antigen, Gogo-A*0201 alpha chain-like [KO:K06751]
109384088  B2M; beta-2-microglobulin [KO:K08055]
109381535  SNW1; SNW domain-containing protein 1 [KO:K06063]
109372345  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
109391669  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
109384760  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
109386033  NCOR2; LOW QUALITY PROTEIN: nuclear receptor corepressor 2 [KO:K06065]
109379565  SAP30; histone deacetylase complex subunit SAP30 [KO:K19202]
109390798  SAP30L; histone deacetylase complex subunit SAP30L isoform X1 [KO:K19202]
109388739  CIR1; corepressor interacting with RBPJ 1 [KO:K06066]
109379963  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
109382706  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
109387269  HES1; transcription factor HES-1 [KO:K06054]
109386679  RUNX3; runt-related transcription factor 3 isoform X1 [KO:K09279]
109383211  MYC; myc proto-oncogene protein [KO:K04377]
109395275  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
109381699  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
109394672  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
109395991  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
109384926  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
109374090  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
109390584  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
109390202  DDB2; DNA damage-binding protein 2 [KO:K10140]
109381899  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
109379157  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
109381238  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
109394108  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
109372681  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
109382484  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
109395865  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
109373811  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
109381083  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109385878  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
109374859  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109385353  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109395015  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
109372771  RELB; transcription factor RelB [KO:K09253]
109379582  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
109390108  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
109395326  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
109382858  NFKBIE; NF-kappa-B inhibitor epsilon [KO:K05872]
109389137  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
109396087  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
109392215  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
109377948  mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
109392748  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
109381672  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
109396595  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
109390353  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
109371344  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
109395979  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
109395980  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
109396629  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
109396630  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
109371251  JUN; transcription factor AP-1 [KO:K04448]
109371257  transcription factor AP-1 [KO:K04448]
109380953  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
109381956  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X1 [KO:K01510] [EC:3.6.1.5]
109393475  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
109379888  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
109381148  CD44; CD44 antigen isoform X1 [KO:K06256]
109374220  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
109392818  CD58; lymphocyte function-associated antigen 3 [KO:K06492]
109391654  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
109393566  VIM; vimentin [KO:K07606]
109385645  TNFAIP3; tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
109382346  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
109395763  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
109394449  LYN; tyrosine-protein kinase Lyn [KO:K05854] [EC:2.7.10.2]
109375897  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
109394834  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
109380150  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
109374529  BTK; tyrosine-protein kinase BTK [KO:K07370] [EC:2.7.10.2]
109391632  TIMM29; uncharacterized protein C19orf52 homolog isoform X1 [KO:K07370] [EC:2.7.10.2]
109380942  BLNK; B-cell linker protein isoform X1 [KO:K07371]
109378365  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
109387065  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
109383166  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
109389297  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
109392488  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
109382891  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
109390747  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
109373596  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
109396675  CCNA2; cyclin-A2 [KO:K06627]
109388453  CCNA1; cyclin-A1 [KO:K06627]
109383495  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
109376215  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
109396882  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
109387138  RB1; retinoblastoma-associated protein [KO:K06618]
109377242  E2F1; transcription factor E2F1 [KO:K17454]
109386699  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
109381623  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
  Journal
F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
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Semin Cancer Biol 22:144-53 (2012)
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Front Oncol 8:265 (2018)
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PLoS Pathog 7:e1001275 (2011)
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Related
pathway
hai03050  Proteasome
hai04010  MAPK signaling pathway
hai04020  Calcium signaling pathway
hai04064  NF-kappa B signaling pathway
hai04110  Cell cycle
hai04115  p53 signaling pathway
hai04210  Apoptosis
hai04612  Antigen processing and presentation
hai04620  Toll-like receptor signaling pathway
hai04622  RIG-I-like receptor signaling pathway
hai04630  JAK-STAT signaling pathway
hai04662  B cell receptor signaling pathway
KO pathway
ko05169   
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