KEGG   PATHWAY: hhv05205
Entry
hhv05205                    Pathway                                
Name
Proteoglycans in cancer - Hyaena hyaena (striped hyena)
Description
Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis and metastasis, affecting tumor progress. The four main types of proteoglycans include hyaluronan (HA), which does not occur as a PG but in free form, heparan sulfate proteoglycans (HSPGs), chondroitin sulfate proteoglycans (CSPGs), dematan sulfate proteoglycans (DSPG) and keratan sulfate proteoglycans (KSPGs) [BR:00535]. Among these proteoglycans such as HA, acting with CD44, promotes tumor cell growth and migration, whereas other proteoglycans such as syndecans (-1~-4), glypican (-1, -3) and perlecan may interact with growth factors, cytokines, morphogens and enzymes through HS chains [BR:00536], also leading to tumor growth and invasion. In contrast, some of the small leucine-rich proteolgycans, such as decorin and lumican, can function as tumor repressors, and modulate the signaling pathways by the interaction of their core proteins and multiple receptors.
Class
Human Diseases; Cancer: overview
Pathway map
hhv05205  Proteoglycans in cancer
hhv05205

Organism
Hyaena hyaena (striped hyena) [GN:hhv]
Gene
120232548  CD44; CD44 antigen isoform X1 [KO:K06256]
120228611  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
120242904  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
120233897  CTTN; src substrate cortactin isoform X1 [KO:K06106]
120229105  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
120228194  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
120226858  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
120247171  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
120247312  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
120223392  HRAS; GTPase HRas isoform X1 [KO:K02833]
120223531  KRAS; GTPase KRas [KO:K07827]
120243068  NRAS; GTPase NRas [KO:K07828]
120244187  RRAS; ras-related protein R-Ras [KO:K07829]
120244997  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
120222404  MRAS; ras-related protein M-Ras [KO:K07831]
120232948  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
120231327  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
120219872  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
120221655  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
120242086  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
120238830  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
120242212  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
120227958  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
120248522  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
120233626  cell division control protein 42 homolog [KO:K04393]
120231260  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
120219889  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
120237592  estrogen receptor-like [KO:K08550]
120222308  estrogen receptor [KO:K08550]
120233874  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
120228024  ACTB; actin, cytoplasmic 1 [KO:K05692]
120228303  ACTG1; actin, cytoplasmic 2 [KO:K05692]
120227474  FLNA; filamin-A isoform X1 [KO:K04437]
120229608  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
120229789  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
120241163  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
120229394  RHOA; transforming protein RhoA [KO:K04513]
120249159  transforming protein RhoA-like [KO:K04513]
120220661  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
120231144  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
120233997  ANK1; ankyrin-1 isoform X1 [KO:K10380]
120220209  ANK2; ankyrin-2 isoform X1 [KO:K09255]
120244136  ANK3; ankyrin-3 isoform X1 [KO:K09259]
120242435  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
120233608  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
120220979  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
120246696  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
120219997  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
120239233  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
120247089  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
120235277  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120244696  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120247774  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120231816  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
120233909  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
120239251  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
120235890  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
120233963  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
120228862  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
120239719  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
120229970  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
120230566  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
120237135  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
120237482  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
120238181  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
120233726  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
120238899  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
120222252  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
120236563  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
120220435  homeobox protein NANOG-like [KO:K10164]
120222697  NANOG; homeobox protein NANOG [KO:K10164]
120234203  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
120248173  DROSHA; ribonuclease 3 [KO:K03685] [EC:3.1.26.3]
120248434  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
120229492  TWIST2; twist-related protein 2 [KO:K09069]
120236217  TWIST1; twist-related protein 1 [KO:K09069]
120243885  HOXD10; homeobox protein Hox-D10 [KO:K09295]
120237080  DCN; decorin [KO:K04660]
120245431  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
120233674  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
120233604  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
120241500  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
120233932  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
120241926  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
120247235  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
120232432  40S ribosomal protein S6-like [KO:K02991]
120239889  RPS6; 40S ribosomal protein S6 [KO:K02991]
120248530  40S ribosomal protein S6-like [KO:K02991]
120238884  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
120223824  CAV1; caveolin-1 isoform X1 [KO:K06278]
120223825  CAV2; caveolin-2 [KO:K12958]
120231339  CAV3; caveolin-3 [KO:K12959]
120219966  CD63; CD63 antigen [KO:K06497]
120233834  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
120246375  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
120243258  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
120233209  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
120240966  TLR4; toll-like receptor 4 [KO:K10160]
120244298  PDCD4; programmed cell death protein 4 [KO:K16865]
120221913  TNF; tumor necrosis factor [KO:K03156]
120240593  IL12B; interleukin-12 subunit beta [KO:K05425]
120219930  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
120245818  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
120240874  MYC; myc proto-oncogene protein [KO:K04377]
120230647  CTNNB1; catenin beta-1 [KO:K02105]
120237461  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
120236513  TFAP4; transcription factor AP-4 isoform X1 [KO:K09108]
120231199  VEGFA; vascular endothelial growth factor A [KO:K05448]
120243048  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
120223826  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
120229982  CBL; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
120232244  THBS1; thrombospondin-1 [KO:K16857]
120238088  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
120243271  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
120237082  LUM; lumican [KO:K08122]
120224200  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
120223778  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
120234269  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
120240795  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
120231386  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
120221741  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
120229672  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
120246450  HPSE; heparanase [KO:K07964] [EC:3.2.1.166]
120223178  inactive heparanase-2 [KO:K07965] [EC:3.2.1.-]
120222387  SDC1; syndecan-1 [KO:K06257]
120233712  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
120243707  PLAUR; urokinase plasminogen activator surface receptor [KO:K03985]
120234406  COL1A2; collagen alpha-2(I) chain [KO:K06236]
120229071  COL1A1; collagen alpha-1(I) chain [KO:K06236]
120248043  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
120222633  ITGB1; integrin beta-1 [KO:K05719]
120244887  VTN; vitronectin [KO:K06251]
120241461  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
120244266  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
120232421  FN1; fibronectin isoform X1 [KO:K05717]
120245869  ITGB5; integrin beta-5 [KO:K06588]
120221164  hepatocyte growth factor-like [KO:K05460]
120245413  HGF; hepatocyte growth factor [KO:K05460]
120223020  WNT1; proto-oncogene Wnt-1 [KO:K03209]
120243796  FZD1; frizzled-1 [KO:K02432]
120248935  FZD7; frizzled-7 isoform X1 [KO:K02432]
120222268  FZD2; frizzled-2 [KO:K02235]
120220149  FZD3; frizzled-3 isoform X1 [KO:K02329]
120246706  FZD4; frizzled-4 [KO:K02354]
120237396  FZD5; frizzled-5 [KO:K02375]
120225614  FZD8; frizzled-8 [KO:K02375]
120232875  FZD6; frizzled-6 isoform X1 [KO:K02376]
120243450  FZD10; frizzled-10 [KO:K02842]
120239316  FZD9; frizzled-9 [KO:K02842]
120220031  ITGA5; integrin alpha-5 [KO:K06484]
120246124  SDC2; syndecan-2 [KO:K16336]
120245160  EZR; ezrin isoform X1 [KO:K08007]
120229862  RDX; radixin isoform X1 [KO:K05762]
120224027  MSN; moesin [KO:K05763]
120242616  SDC4; syndecan-4 [KO:K16338]
120238033  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
120238662  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
120240798  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
120236974  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
120242567  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
120220282  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
120244628  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
120228585  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
120228197  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
120234190  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
120233260  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
120239766  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
120236469  NUDT16L1; tudor-interacting repair regulator protein isoform X1 [KO:K16867]
120230646  PXN; paxillin isoform X1 [KO:K05760]
120232325  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
120245649  HBEGF; proheparin-binding EGF-like growth factor [KO:K08523]
120229500  GPC1; glypican-1 [KO:K08107]
120225512  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
120226895  insulin-like growth factor II isoform X1 [KO:K13769]
120236823  GPC3; glypican-3 [KO:K08109]
120224618  WNT2; protein Wnt-2 [KO:K00182]
120247131  WNT2B; protein Wnt-2b [KO:K00182]
120244272  WNT3; proto-oncogene Wnt-3 [KO:K00312]
120222424  WNT3A; protein Wnt-3a [KO:K00312]
120232996  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
120234450  WNT5B; protein Wnt-5b [KO:K00444]
120248968  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
120232462  WNT6; protein Wnt-6 [KO:K00445]
120235209  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
120247152  WNT7A; protein Wnt-7a [KO:K00572]
120243200  WNT8B; protein Wnt-8b [KO:K00714]
120220758  WNT8A; LOW QUALITY PROTEIN: protein Wnt-8a [KO:K00714]
120244261  WNT9B; protein Wnt-9b [KO:K01064]
120222452  WNT9A; protein Wnt-9a [KO:K01064]
120232455  WNT10A; protein Wnt-10a [KO:K01357]
120223019  WNT10B; protein Wnt-10b [KO:K01357]
120229583  WNT11; protein Wnt-11 [KO:K01384]
120224601  WNT16; protein Wnt-16 [KO:K01558]
120230892  SHH; sonic hedgehog protein isoform X1 [KO:K11988]
120232439  IHH; indian hedgehog protein [KO:K11989]
120240837  PTCH1; protein patched homolog 1 isoform X1 [KO:K06225]
120239637  SMO; smoothened homolog isoform X1 [KO:K06226]
120221389  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X1 [KO:K06255]
120224186  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
120224188  procathepsin L-like isoform X1 [KO:K01365] [EC:3.4.22.15]
120224189  procathepsin L-like isoform X1 [KO:K01365] [EC:3.4.22.15]
120224190  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
120224191  LOW QUALITY PROTEIN: procathepsin L-like [KO:K01365] [EC:3.4.22.15]
120224193  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
120226506  procathepsin L isoform X1 [KO:K01365] [EC:3.4.22.15]
120226507  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
120240822  CTSV; cathepsin L2 [KO:K01365] [EC:3.4.22.15]
120241649  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
120245321  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
120233796  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
120233829  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
120234701  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
120235253  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
120229893  HSPB2; heat shock protein beta-2 [KO:K09543]
120220450  PTPN6; tyrosine-protein phosphatase non-receptor type 6 [KO:K05697] [EC:3.1.3.48]
Compound
C00426  Dermatan sulfate
C00573  Keratan sulfate
C00607  Chondroitin sulfate
C00925  Heparan sulfate
G10505  Hyaluronic acid
G13063  Binding domain for FGF2 in heparin/heparan sulfate
G13064  Binding domain for HGF in heparin/heparan sulfate
Reference
PMID:18450475
  Authors
Bourguignon LY
  Title
Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression.
  Journal
Semin Cancer Biol 18:251-9 (2008)
DOI:10.1016/j.semcancer.2008.03.007
Reference
PMID:12729888
  Authors
Briggs MW, Sacks DB
  Title
IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton.
  Journal
FEBS Lett 542:7-11 (2003)
DOI:10.1016/S0014-5793(03)00333-8
Reference
PMID:12748184
  Authors
Bourguignon LY, Singleton PA, Zhu H, Diedrich F
  Title
Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression.
  Journal
J Biol Chem 278:29420-34 (2003)
DOI:10.1074/jbc.M301885200
Reference
PMID:15655247
  Authors
Bourguignon LY, Gilad E, Rothman K, Peyrollier K
  Title
Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.
  Journal
J Biol Chem 280:11961-72 (2005)
DOI:10.1074/jbc.M411985200
Reference
PMID:11717317
  Authors
Turley EA, Noble PW, Bourguignon LY
  Title
Signaling properties of hyaluronan receptors.
  Journal
J Biol Chem 277:4589-92 (2002)
DOI:10.1074/jbc.R100038200
Reference
PMID:9346940
  Authors
Bourguignon LY, Zhu H, Chu A, Iida N, Zhang L, Hung MC
  Title
Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation.
  Journal
J Biol Chem 272:27913-8 (1997)
DOI:10.1074/jbc.272.44.27913
Reference
PMID:22735579
  Authors
Neill T, Schaefer L, Iozzo RV
  Title
Decorin: a guardian from the matrix.
  Journal
Am J Pathol 181:380-7 (2012)
DOI:10.1016/j.ajpath.2012.04.029
Reference
PMID:22194599
  Authors
Neill T, Painter H, Buraschi S, Owens RT, Lisanti MP, Schaefer L, Iozzo RV
  Title
Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1alpha, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.
  Journal
J Biol Chem 287:5492-506 (2012)
DOI:10.1074/jbc.M111.283499
Reference
PMID:19433454
  Authors
Goldoni S, Humphries A, Nystrom A, Sattar S, Owens RT, McQuillan DJ, Ireton K, Iozzo RV
  Title
Decorin is a novel antagonistic ligand of the Met receptor.
  Journal
J Cell Biol 185:743-54 (2009)
DOI:10.1083/jcb.200901129
Reference
PMID:15994311
  Authors
Zhu JX, Goldoni S, Bix G, Owens RT, McQuillan DJ, Reed CC, Iozzo RV
  Title
Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis.
  Journal
J Biol Chem 280:32468-79 (2005)
DOI:10.1074/jbc.M503833200
Reference
PMID:20974860
  Authors
Buraschi S, Pal N, Tyler-Rubinstein N, Owens RT, Neill T, Iozzo RV
  Title
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.
  Journal
J Biol Chem 285:42075-85 (2010)
DOI:10.1074/jbc.M110.172841
Reference
PMID:18798267
  Authors
Goldoni S, Iozzo RV
  Title
Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs.
  Journal
Int J Cancer 123:2473-9 (2008)
DOI:10.1002/ijc.23930
Reference
PMID:23058688
  Authors
Sofeu Feugaing DD, Gotte M, Viola M
  Title
More than matrix: the multifaceted role of decorin in cancer.
  Journal
Eur J Cell Biol 92:1-11 (2013)
DOI:10.1016/j.ejcb.2012.08.004
Reference
PMID:22087031
  Authors
Merline R, Moreth K, Beckmann J, Nastase MV, Zeng-Brouwers J, Tralhao JG, Lemarchand P, Pfeilschifter J, Schaefer RM, Iozzo RV, Schaefer L
  Title
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21.
  Journal
Sci Signal 4:ra75 (2011)
DOI:10.1126/scisignal.2001868
Reference
PMID:22033227
  Authors
Teng YH, Aquino RS, Park PW
  Title
Molecular functions of syndecan-1 in disease.
  Journal
Matrix Biol 31:3-16 (2012)
DOI:10.1016/j.matbio.2011.10.001
Reference
PMID:11830493
  Authors
Derksen PW, Keehnen RM, Evers LM, van Oers MH, Spaargaren M, Pals ST
  Title
Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma.
  Journal
Blood 99:1405-10 (2002)
DOI:10.1182/blood.V99.4.1405
Reference
PMID:19733083
  Authors
Fux L, Ilan N, Sanderson RD, Vlodavsky I
  Title
Heparanase: busy at the cell surface.
  Journal
Trends Biochem Sci 34:511-9 (2009)
DOI:10.1016/j.tibs.2009.06.005
Reference
PMID:18812315
  Authors
Purushothaman A, Chen L, Yang Y, Sanderson RD
  Title
Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.
  Journal
J Biol Chem 283:32628-36 (2008)
DOI:10.1074/jbc.M806266200
Reference
PMID:19255147
  Authors
Beauvais DM, Ell BJ, McWhorter AR, Rapraeger AC
  Title
Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor.
  Journal
J Exp Med 206:691-705 (2009)
DOI:10.1084/jem.20081278
Reference
PMID:20655987
  Authors
Mahtouk K, Tjin EP, Spaargaren M, Pals ST
  Title
The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas.
  Journal
Biochim Biophys Acta 1806:208-19 (2010)
DOI:10.1016/j.bbcan.2010.07.006
Reference
PMID:11931647
  Authors
Munesue S, Kusano Y, Oguri K, Itano N, Yoshitomi Y, Nakanishi H, Yamashina I, Okayama M
  Title
The role of syndecan-2 in regulation of actin-cytoskeletal organization of Lewis lung carcinoma-derived metastatic clones.
  Journal
Biochem J 363:201-9 (2002)
DOI:10.1042/bj3630201
Reference
PMID:10687947
  Authors
Nugent MA, Iozzo RV
  Title
Fibroblast growth factor-2.
  Journal
Int J Biochem Cell Biol 32:115-20 (2000)
DOI:10.1016/S1357-2725(99)00123-5
Reference
PMID:10633082
  Authors
Baciu PC, Saoncella S, Lee SH, Denhez F, Leuthardt D, Goetinck PF
  Title
Syndesmos, a protein that interacts with the cytoplasmic domain of syndecan-4, mediates cell spreading and actin cytoskeletal organization.
  Journal
J Cell Sci 113 Pt 2:315-24 (2000)
Reference
PMID:12509413
  Authors
Thodeti CK, Albrechtsen R, Grauslund M, Asmar M, Larsson C, Takada Y, Mercurio AM, Couchman JR, Wewer UM
  Title
ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA.
  Journal
J Biol Chem 278:9576-84 (2003)
DOI:10.1074/jbc.M208937200
Reference
PMID:14711376
  Authors
Beauvais DM, Rapraeger AC
  Title
Syndecans in tumor cell adhesion and signaling.
  Journal
Reprod Biol Endocrinol 2:3 (2004)
DOI:10.1186/1477-7827-2-3
Reference
PMID:17971838
  Authors
Morgan MR, Humphries MJ, Bass MD
  Title
Synergistic control of cell adhesion by integrins and syndecans.
  Journal
Nat Rev Mol Cell Biol 8:957-69 (2007)
DOI:10.1038/nrm2289
Reference
PMID:18505598
  Authors
Filmus J, Capurro M, Rast J
  Title
Glypicans.
  Journal
Genome Biol 9:224 (2008)
DOI:10.1186/gb-2008-9-5-224
Reference
PMID:23305321
  Authors
Filmus J, Capurro M
  Title
Glypican-3: a marker and a therapeutic target in hepatocellular carcinoma.
  Journal
FEBS J 280:2471-6 (2013)
DOI:10.1111/febs.12126
Reference
PMID:22563565
  Authors
Gao W, Ho M
  Title
The role of glypican-3 in regulating Wnt in hepatocellular carcinomas.
  Journal
Cancer Rep 1:14-19 (2011)
Reference
PMID:24412155
  Authors
Filmus J, Capurro M
  Title
The role of glypicans in Hedgehog signaling.
  Journal
Matrix Biol 35:248-52 (2014)
DOI:10.1016/j.matbio.2013.12.007
Reference
PMID:18413366
  Authors
Cheng W, Tseng CJ, Lin TT, Cheng I, Pan HW, Hsu HC, Lee YM
  Title
Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathway.
  Journal
Carcinogenesis 29:1319-26 (2008)
DOI:10.1093/carcin/bgn091
Reference
PMID:21155971
  Authors
Iozzo RV, Sanderson RD
  Title
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis.
  Journal
J Cell Mol Med 15:1013-31 (2011)
DOI:10.1111/j.1582-4934.2010.01236.x
Reference
PMID:18949819
  Authors
Nikitovic D, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN
  Title
Lumican, a small leucine-rich proteoglycan.
  Journal
IUBMB Life 60:818-23 (2008)
DOI:10.1002/iub.131
Related
pathway
hhv04010  MAPK signaling pathway
hhv04020  Calcium signaling pathway
hhv04066  HIF-1 signaling pathway
hhv04150  mTOR signaling pathway
hhv04151  PI3K-Akt signaling pathway
hhv04210  Apoptosis
hhv04310  Wnt signaling pathway
hhv04340  Hedgehog signaling pathway
hhv04350  TGF-beta signaling pathway
hhv04370  VEGF signaling pathway
hhv04510  Focal adhesion
hhv04520  Adherens junction
hhv04810  Regulation of actin cytoskeleton
KO pathway
ko05205   
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