KEGG   PATHWAY: lcat04020
Entry
lcat04020                   Pathway                                
Name
Calcium signaling pathway - Lemur catta (Ring-tailed lemur)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
lcat04020  Calcium signaling pathway
lcat04020

Other DBs
GO: 0019722
Organism
Lemur catta (Ring-tailed lemur) [GN:lcat]
Gene
123636834  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
123623895  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
123640278  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
123628453  ATP2B3; LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 3 [KO:K05850] [EC:7.2.2.10]
123638112  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
123639459  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
123627012  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
123641300  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
123627599  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
123621759  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
123625701  ADORA2A; LOW QUALITY PROTEIN: adenosine receptor A2a [KO:K04266]
123650568  ADORA2B; adenosine receptor A2b [KO:K04267]
123650240  ADRB1; beta-1 adrenergic receptor [KO:K04141]
123638093  ADRB2; beta-2 adrenergic receptor [KO:K04142]
123626686  ADRB3; beta-3 adrenergic receptor [KO:K04143]
123623141  DRD1; D(1A) dopamine receptor [KO:K04144]
123623497  HRH2; histamine H2 receptor isoform X1 [KO:K04150]
123638899  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
123647286  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
123643682  5-hydroxytryptamine receptor 5B [KO:K04161]
123634740  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
123649961  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
123622308  neuroendocrine secretory protein 55-like [KO:K04632]
123622310  guanine nucleotide-binding protein G(s) subunit alpha isoforms short isoform X1 [KO:K04632]
123621827  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
123647256  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
123648063  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
123636670  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
123650680  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
123625466  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
123644339  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
123632319  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
123637748  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
123635476  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
123633210  PLN; cardiac phospholamban [KO:K05852]
123640999  SLN; sarcolipin [KO:K22642]
123649699  MRLN; myoregulin [KO:K22643]
123627637  C26H4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
123650802  SMIM6; small integral membrane protein 6 [KO:K26468]
123632523  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
123626067  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
123620633  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
123623835  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
123642324  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
123637351  STIM2; stromal interaction molecule 2 [KO:K18196]
123626085  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
123632581  ORAI2; protein orai-2 isoform X1 [KO:K16057]
123632714  ORAI3; protein orai-3 [KO:K16058]
123640189  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
123623167  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
123628833  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
123626819  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
123637429  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
123646347  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
123627022  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
123620133  CACNA1G; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
123631435  CACNA1H; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
123640335  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
123645215  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
123645581  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
123632367  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
123639979  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
123650764  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
123623873  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
123645739  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
123632440  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
123620634  P2RX1; P2X purinoceptor 1 [KO:K05215]
123625599  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
123642698  P2RX3; P2X purinoceptor 3 [KO:K05217]
123626081  P2RX4; P2X purinoceptor 4 [KO:K05218]
123620642  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
123626245  P2RX6; P2X purinoceptor 6 isoform X1 [KO:K05221]
123626078  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
123624371  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
123627597  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
123632875  RYR3; ryanodine receptor 3 [KO:K04963]
123633225  TRDN; triadin [KO:K23449]
123635185  CASQ1; calsequestrin-1 [KO:K23468]
123635089  CASQ2; calsequestrin-2 [KO:K23445]
123644702  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
123649207  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
123646880  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
123626643  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
123638882  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
123622561  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
123630151  AGTR1; type-1 angiotensin II receptor [KO:K04166]
123638469  EDNRA; endothelin-1 receptor [KO:K04197]
123648979  EDNRB; endothelin receptor type B [KO:K04198]
123648568  F2R; proteinase-activated receptor 1 [KO:K03914]
123633346  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
123642238  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
123628551  GRPR; gastrin-releasing peptide receptor [KO:K04169]
123638901  HRH1; histamine H1 receptor [KO:K04149]
123649230  5-hydroxytryptamine receptor 2A [KO:K04157]
123628101  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
123643858  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
123636433  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
123622757  NTSR1; neurotensin receptor type 1 [KO:K04211]
123623505  OXTR; oxytocin receptor [KO:K04229]
123639567  AVPR1A; vasopressin V1a receptor [KO:K04226]
123627124  AVPR1B; vasopressin V1b receptor [KO:K04227]
123650705  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
123634315  PTAFR; platelet-activating factor receptor [KO:K04279]
123637820  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
123635520  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
123634696  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
123644885  BDKRB1; B1 bradykinin receptor [KO:K03915]
123644886  BDKRB2; B2 bradykinin receptor [KO:K03916]
123637098  TACR1; substance-P receptor [KO:K04222]
123650435  TACR2; substance-K receptor isoform X1 [KO:K04223]
123627635  TACR3; neuromedin-K receptor [KO:K04224]
123633528  TBXA2R; thromboxane A2 receptor [KO:K04264]
123644531  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
123636514  CCKAR; cholecystokinin receptor type A [KO:K04194]
123642350  CCKBR; LOW QUALITY PROTEIN: gastrin/cholecystokinin type B receptor [KO:K04195]
123643287  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
123646308  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
123633418  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
123646016  GNA14; guanine nucleotide-binding protein subunit alpha-14 isoform X1 [KO:K04636]
123633362  GNA15; guanine nucleotide-binding protein subunit alpha-15 isoform X1 [KO:K04637]
123627755  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
123637024  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
123632534  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
123639237  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
123638516  PDGFC; platelet-derived growth factor C [KO:K05450]
123641878  PDGFD; platelet-derived growth factor D [KO:K05450]
123637917  FGF1; fibroblast growth factor 1 [KO:K18496]
123638827  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
123637964  FGF18; fibroblast growth factor 18 [KO:K04358]
123622454  FGF7; fibroblast growth factor 7 [KO:K04358]
123632208  FGF22; fibroblast growth factor 22 [KO:K04358]
123640719  FGF6; fibroblast growth factor 6 [KO:K04358]
123648417  FGF10; fibroblast growth factor 10 [KO:K04358]
123649197  FGF9; fibroblast growth factor 9 [KO:K04358]
123641892  FGF4; fibroblast growth factor 4 [KO:K04358]
123626358  FGF20; fibroblast growth factor 20 [KO:K04358]
123626704  FGF17; fibroblast growth factor 17 [KO:K04358]
123642170  FGF3; fibroblast growth factor 3 [KO:K04358]
123650103  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
123627370  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
123642172  FGF19; fibroblast growth factor 19 [KO:K22603]
123623856  FGF21; fibroblast growth factor 21 [KO:K22429]
123640148  FGF23; fibroblast growth factor 23 [KO:K22428]
123631928  VEGFA; vascular endothelial growth factor A [KO:K05448]
123641432  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
123638671  VEGFC; vascular endothelial growth factor C [KO:K05449]
123628106  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
123635087  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
123647201  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
123623267  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
123648068  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
123647442  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
123620839  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
123639666  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
123643488  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
123624835  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
123638073  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
123626670  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
123650464  FGFR2; LOW QUALITY PROTEIN: fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
123622909  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
123623468  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
123648918  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
123621678  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
123624844  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
123634790  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
123634791  high affinity nerve growth factor receptor-like [KO:K03176] [EC:2.7.10.1]
123645777  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
123645162  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
123646854  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
123623256  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
123649762  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
123643379  LOW QUALITY PROTEIN: uncharacterized protein LOC123643379 [KO:K06856]
123643441  immunoglobulin gamma-1 heavy chain-like [KO:K06856]
123643449  immunoglobulin delta heavy chain-like [KO:K06856]
123643456  immunoglobulin epsilon heavy chain-like [KO:K06856]
123643464  uncharacterized protein LOC123643464 [KO:K06856]
123621046  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
123644007  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
123627239  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
123622057  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
123622065  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
123624366  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
123641430  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
123622735  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
123625473  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
123650260  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
123640691  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
123623574  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
123639915  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
123632820  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
123637315  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
123626018  TPCN1; two pore channel protein 1 isoform X1 [KO:K16896]
123642805  TPCN2; two pore channel protein 2 isoform X1 [KO:K14077]
123635291  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
123635464  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
123635463  MCOLN3; mucolipin-3 [KO:K04994]
123623864  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
123620485  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
123650367  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
123637772  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
123650270  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
123626606  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
123628780  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
123637707  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
123638639  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
123628071  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
123650352  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
123623191  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
123622169  TNNC2; troponin C, skeletal muscle [KO:K12042]
123636893  CALM2; calmodulin-2 [KO:K02183]
123645611  CALM1; calmodulin-1 [KO:K02183]
123623035  CALML3; calmodulin-like protein 3 [KO:K02183]
123623036  CALML5; calmodulin-like protein 5 [KO:K02183]
123631755  CALML4; calmodulin-like protein 4 [KO:K02183]
123623919  CALM3; calmodulin-3 [KO:K02183]
123634905  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
123636681  calmodulin-alpha-like [KO:K02183]
123632666  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
123632711  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
123625145  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
123628105  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
123630468  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
123638169  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
123622844  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
123625139  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
123626382  calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
123626821  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
123638072  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
123647608  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
123650285  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
123627700  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
123648496  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
123626515  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123650296  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123627290  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123636996  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
123645740  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
123631859  TFEB; transcription factor EB [KO:K15590]
123621580  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
123622732  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
123625176  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
123650673  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
123626251  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
123620296  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
123647518  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
123639689  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
123647146  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
123643211  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
123626648  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
123624304  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
123627537  ITPKB; inositol-trisphosphate 3-kinase B isoform X1 [KO:K00911] [EC:2.7.1.127]
123627920  ITPKA; inositol-trisphosphate 3-kinase A isoform X1 [KO:K00911] [EC:2.7.1.127]
123621118  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
123632490  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
123624654  PRKCG; LOW QUALITY PROTEIN: protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
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Berridge MJ, Bootman MD, Roderick HL.
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Calcium signalling: dynamics, homeostasis and remodelling.
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Nat Rev Mol Cell Biol 4:517-29 (2003)
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Reference
PMID:11413485
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The versatility and universality of calcium signalling.
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Nat Rev Mol Cell Biol 1:11-21 (2000)
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Reference
PMID:15111104
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Wang MC, Dolphin A, Kitmitto A.
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FEBS Lett 564:245-50 (2004)
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Reference
PMID:11299192
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Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
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Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
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Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
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Am J Physiol Cell Physiol 281:C1743-56 (2001)
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Reference
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  Authors
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  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
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J Biol Chem 269:7390-6 (1994)
Reference
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  Authors
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J Bioenerg Biomembr 35:577-98 (2003)
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Reference
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  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
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Trends Pharmacol Sci 18:124-34 (1997)
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Reference
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A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
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Neurosci Res 38:3-17 (2000)
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Reference
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Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
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J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
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Reference
PMID:14572802
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Bruce JI, Straub SV, Yule DI.
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Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
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Cell Calcium 34:431-44 (2003)
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Reference
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  Authors
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  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
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Mol Cell Biochem 193:89-98 (1999)
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Reference
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Mitochondrial intermembrane junctional complexes and their role in cell death.
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J Physiol 529 Pt 1:11-21 (2000)
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Extracellular-signal-regulated kinase signalling in neurons.
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Curr Opin Neurobiol 9:544-53 (1999)
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Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
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Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
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Mol Biol Cell 14:4003-14 (2003)
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Reference
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Tornquist K
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Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
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Acta Physiol (Oxf) 204:151-7 (2012)
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Reference
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Feske S
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Immunodeficiency due to defects in store-operated calcium entry.
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Ann N Y Acad Sci 1238:74-90 (2011)
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Reference
PMID:22002090
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Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
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STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
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Braz J Med Biol Res 44:1080-7 (2011)
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Seikagaku 80:1123-8 (2008)
Reference
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Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
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The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
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Pflugers Arch 458:869-76 (2009)
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Reference
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Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
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Eur Biophys J 39:27-36 (2009)
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Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
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J Physiol 593:3261-6 (2015)
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Reference
PMID:20807542
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Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
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J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
lcat04010  MAPK signaling pathway
lcat04070  Phosphatidylinositol signaling system
lcat04210  Apoptosis
lcat04720  Long-term potentiation
lcat04730  Long-term depression
KO pathway
ko04020   
LinkDB

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