KEGG   PATHWAY: mcf05167
Entry
mcf05167                    Pathway                                
Name
Kaposi sarcoma-associated herpesvirus infection - Macaca fascicularis (crab-eating macaque)
Description
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated with the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman's disease (MCD). Like all other herpesviruses, KSHV displays two modes of life cycle, latency and lytic replication, which are characterized by the patterns of viral gene expression. Genes expressed in latency (LANA, v-cyclin, v-FLIP, Kaposins A, B and C and viral miRNAs) are mainly thought to facilitate the establishment of life long latency in its host and survival against the host innate, and adaptive immune surveillance mechanisms. Among the viral proteins shown to be expressed during lytic replication are potent signaling molecules such as vGPCR, vIL6, vIRFs, vCCLs, K1 and K15, which have been implicated experimentally in the angiogenic and inflammatory phenotype observed in KS lesions. Several of these latent viral and lytic proteins are known to transform host cells, linking KSHV with the development of severe human malignancies.
Class
Human Diseases; Infectious disease: viral
Pathway map
mcf05167  Kaposi sarcoma-associated herpesvirus infection
mcf05167

Organism
Macaca fascicularis (crab-eating macaque) [GN:mcf]
Gene
102131458  C3; complement C3 [KO:K03990]
102138517  TLR3; toll-like receptor 3 [KO:K05401]
102122857  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
102141355  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
102126428  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
102144774  TBK1; serine/threonine-protein kinase TBK1 isoform X2 [KO:K05410] [EC:2.7.11.10]
102130894  IRF7; interferon regulatory factor 7 isoform X2 [KO:K09447]
102146717  interferon alpha-17 [KO:K05414]
102140303  interferon alpha-1/13 [KO:K05414]
102140954  IFNA8; interferon alpha-8 [KO:K05414]
102141744  interferon alpha-1/13 [KO:K05414]
102141352  interferon alpha-1/13-like [KO:K05414]
102143043  IFNA6; interferon alpha-6 [KO:K05414]
102144479  interferon alpha-14 [KO:K05414]
102144833  interferon alpha-4-like [KO:K05414]
102145208  interferon alpha-10 [KO:K05414]
102145962  interferon alpha-17 [KO:K05414]
102115289  interferon alpha-17 [KO:K05414]
102142148  IFNA2; interferon alpha-2 [KO:K05414]
123569038  interferon alpha-17-like [KO:K05414]
102146344  interferon alpha-17-like [KO:K05414]
102147079  interferon alpha-17-like [KO:K05414]
102132745  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
102131731  EP300; histone acetyltransferase p300 isoform X2 [KO:K04498] [EC:2.3.1.48]
102135037  CREB-binding protein isoform X2 [KO:K04498] [EC:2.3.1.48]
102115670  IFNB1; interferon beta [KO:K05415]
101926190  IFNAR1; interferon alpha/beta receptor 1 isoform X3 [KO:K05130]
102140083  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
102123983  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
102143094  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
101925134  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
102133020  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
102142271  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
102124745  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
101867352  MAPK13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
101926770  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
102134421  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
101867305  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
102131033  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X2 [KO:K04443] [EC:2.7.11.1]
101925060  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X3 [KO:K04433] [EC:2.7.12.2]
102141549  ZFP36; mRNA decay activator protein ZFP36 [KO:K15308]
102138971  IL6; interleukin-6 precursor [KO:K05405]
102118747  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
102138209  CCR3; C-C chemokine receptor type 3 isoform X1 [KO:K04178]
102139456  CCR5; C-C chemokine receptor type 5 [KO:K04180]
102137577  CCR1; C-C chemokine receptor type 1 [KO:K04176]
102120178  CCR4; C-C chemokine receptor type 4 [KO:K04179]
102132857  CCR8; C-C chemokine receptor type 8 [KO:K04183]
101866285  FADD; FAS-associated death domain protein [KO:K02373]
101865354  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
102143226  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
102132255  BAX; apoptosis regulator BAX isoform X6 [KO:K02159]
102142357  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
102117102  cytochrome c-like [KO:K08738]
102120205  cytochrome c [KO:K08738]
102125088  cytochrome c-like [KO:K08738]
102136392  cytochrome c-like [KO:K08738]
102127614  cytochrome c-like [KO:K08738]
102141866  cytochrome c-like [KO:K08738]
107127908  cytochrome c-like [KO:K08738]
102120841  cytochrome c-like [KO:K08738]
102123704  cytochrome c-like [KO:K08738]
107130218  cytochrome c-like [KO:K08738]
102126830  CASP9; LOW QUALITY PROTEIN: caspase-9 [KO:K04399] [EC:3.4.22.62]
102144182  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
102135285  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102125087  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
101925175  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
102115964  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102146604  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
102115368  IKBKG; NF-kappa-B essential modulator isoform X5 [KO:K07210]
101867458  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
102138273  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101867324  RELA; transcription factor p65 isoform X1 [KO:K04735]
102135998  TP53; cellular tumor antigen p53 isoform X2 [KO:K04451]
102136063  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
101925733  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
102140874  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
102145859  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
102146018  E2F1; transcription factor E2F1 [KO:K17454]
102128093  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
102138138  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
102122138  MAFA-F; mamu class I histocompatibility antigen, alpha chain F precursor [KO:K06751]
102138874  popy class I histocompatibility antigen, alpha chain E isoform X3 [KO:K06751]
102141835  class I histocompatibility antigen, Gogo-B*0101 alpha chain isoform X1 [KO:K06751]
102123548  class I histocompatibility antigen, Gogo-B*0103 alpha chain isoform X1 [KO:K06751]
102138883  MAFA-B; class I histocompatibility antigen, Gogo-B*0103 alpha chain isoform X1 [KO:K06751]
102117143  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, B-1 alpha chain [KO:K06751]
102120132  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0101 alpha chain [KO:K06751]
102140002  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
102116527  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
101866179  IFNGR1; interferon gamma receptor 1 isoform X3 [KO:K05132]
102138837  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
102147235  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
102144416  MICB; MHC class I polypeptide-related sequence B isoform X1 [KO:K07985]
123572792  MHC class I polypeptide-related sequence B-like [KO:K07985]
102143501  CLEC2B; C-type lectin domain family 2 member B isoform X2 [KO:K10071]
102140360  C-type lectin domain family 2 member H-like [KO:K10071]
102117118  ubiquitin-like [KO:K02927]
102115834  ubiquitin-like [KO:K02927]
101866252  UBA52; ubiquitin-60S ribosomal protein L40 isoform X2 [KO:K02927]
102136294  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
102142514  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
101864869  ubiquitin-40S ribosomal protein S27a [KO:K02977]
102146874  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
102141400  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
102123991  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
101926775  UBB; polyubiquitin-B [KO:K04551]
102143130  UBC; polyubiquitin-C [KO:K08770]
102115402  BECN2; beclin-2 [KO:K08334]
101867267  BECN1; beclin-1 isoform X1 [KO:K08334]
102116936  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
102136293  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
102143613  ATG3; ubiquitin-like-conjugating enzyme ATG3 isoform X1 [KO:K08343]
101926715  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A isoform X2 [KO:K10435]
102147181  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
101925226  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B isoform X2 [KO:K10435]
102146106  microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
102133082  microtubule-associated proteins 1A/1B light chain 3B-like [KO:K10435]
102120049  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
101867297  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
102125334  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
102125173  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
101866657  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X2 [KO:K04539]
101925341  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
101925867  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
102146209  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
102141053  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
102145967  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
123568653  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
123572350  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
107128232  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
102125944  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like isoform X1 [KO:K04545]
107127614  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
102133905  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
102126944  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
123570590  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
102134312  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
102142284  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
102118744  HRAS; GTPase HRas isoform X1 [KO:K02833]
102131483  KRAS; GTPase KRas isoform X1 [KO:K07827]
102137913  NRAS; GTPase NRas [KO:K07828]
102125312  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102141214  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102140855  dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
102145011  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102116996  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101866092  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
102126446  JUN; transcription factor AP-1 [KO:K04448]
102143716  FOS; proto-oncogene c-Fos [KO:K04379]
102146644  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
102135867  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
102133347  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
102143464  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102142026  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102122725  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102137291  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
101866246  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102124804  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102144461  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102142406  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102132744  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102128371  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
102123370  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1 [KO:K12365]
101866593  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
102134837  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
102118497  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102126339  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102121272  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102140606  CD200R1L; cell surface glycoprotein CD200 receptor 2 [KO:K21668]
102139962  CD200R1; cell surface glycoprotein CD200 receptor 1 isoform X1 [KO:K21668]
102145713  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
102116225  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
102115729  HCK; tyrosine-protein kinase HCK [KO:K08893] [EC:2.7.10.2]
102118154  LYN; tyrosine-protein kinase Lyn isoform X2 [KO:K05854] [EC:2.7.10.2]
102125035  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
102126975  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X2 [KO:K04431] [EC:2.7.12.2]
102117471  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
102138726  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
101865389  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
102115744  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
102116003  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
102119159  CALML6; calmodulin-like protein 6 [KO:K02183]
102114795  CALML3; calmodulin-like protein 3 [KO:K02183]
102146976  CALML5; calmodulin-like protein 5 [KO:K02183]
102131162  CALM1; calmodulin-1 [KO:K02183]
101866377  CALM3; calmodulin-3 [KO:K02183]
101865168  CALM2; calmodulin-2 [KO:K02183]
102122343  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
102144138  calmodulin-1 [KO:K02183]
101926738  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102134477  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101866070  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102137250  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
101866439  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
102133233  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
102136960  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
102136724  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
102125274  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X2 [KO:K17334]
102127272  CXCL8; interleukin-8 [KO:K10030]
102143028  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
102123272  CXCL2; C-X-C motif chemokine 2 [KO:K05505]
102126138  CXCL1; growth-regulated alpha protein [KO:K05505]
102123657  growth-regulated alpha protein [KO:K05505]
101925353  RCAN1; calcipressin-1 isoform X1 [KO:K17901]
102133679  FGF2; fibroblast growth factor 2 [KO:K18497]
102140241  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
102125183  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
101925495  ANGPT2; angiopoietin-2 isoform X3 [KO:K05466]
101926138  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
102119008  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
102118402  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
102133756  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
102146984  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
102142248  TCF7; LOW QUALITY PROTEIN: transcription factor 7 [KO:K02620]
102125513  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
102116470  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
101925349  LEF1; lymphoid enhancer-binding factor 1 isoform X2 [KO:K04492]
102141699  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X2 [KO:K05870]
102135329  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102127966  MYC; myc proto-oncogene protein [KO:K04377]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00350  Phosphatidylethanolamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:22403573
  Authors
Lee HR, Brulois K, Wong L, Jung JU
  Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
  Journal
Front Microbiol 3:44 (2012)
DOI:10.3389/fmicb.2012.00044
Reference
PMID:18948197
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
Reference
PMID:21040832
  Authors
Cai Q, Verma SC, Lu J, Robertson ES
  Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
  Journal
Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3
Reference
PMID:16760382
  Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
  Journal
J Gen Virol 87:1781-804 (2006)
DOI:10.1099/vir.0.81919-0
Reference
PMID:19230674
  Authors
Areste C, Blackbourn DJ
  Title
Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus.
  Journal
Trends Microbiol 17:119-29 (2009)
DOI:10.1016/j.tim.2008.12.001
Reference
PMID:16905191
  Authors
Mark L, Spiller OB, Villoutreix BO, Blom AM
  Title
Kaposi's sarcoma-associated herpes virus complement control protein: KCP--complement inhibition and more.
  Journal
Mol Immunol 44:11-22 (2007)
DOI:10.1016/j.molimm.2006.06.018
Reference
PMID:11500830
  Authors
Weber KS, Grone HJ, Rocken M, Klier C, Gu S, Wank R, Proudfoot AE, Nelson PJ, Weber C
  Title
Selective recruitment of Th2-type cells and evasion from a cytotoxic immune response mediated by viral macrophage inhibitory protein-II.
  Journal
Eur J Immunol 31:2458-66 (2001)
DOI:10.1002/1521-4141(200108)31:8<2458::AID-IMMU2458>3.0.CO;2-L
Reference
PMID:10666184
  Authors
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KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells.
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The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8.
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J Virol 82:6501-13 (2008)
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The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
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Science 307:739-41 (2005)
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Trends Mol Med 11:309-12 (2005)
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Biochim Biophys Acta 1766:140-58 (2006)
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Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin.
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EMBO J 21:2602-15 (2002)
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Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins.
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J Virol 74:5300-9 (2000)
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Downregulation of gamma interferon receptor 1 by Kaposi's sarcoma-associated herpesvirus K3 and K5.
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J Virol 81:2117-27 (2007)
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Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity.
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Kaposi's sarcoma-associated herpesvirus: a new human tumor virus, but how?
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Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus.
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Biochim Biophys Acta 1602:1-22 (2002)
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Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor.
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J Virol 78:7667-76 (2004)
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The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.
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Cancer Res 60:4873-80 (2000)
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Curr Opin Virol 20:11-19 (2016)
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Akt/TSC/mTOR activation by the KSHV G protein-coupled receptor: emerging insights into the molecular oncogenesis and treatment of Kaposi's sarcoma.
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Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCgamma1 and activating NFAT1-dependent RCAN1 expression.
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PLoS Pathog 8:e1002927 (2012)
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Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus.
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J Virol 88:13161-72 (2014)
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Modulation of host gene expression by the K15 protein of Kaposi's sarcoma-associated herpesvirus.
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J Virol 81:42-58 (2007)
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Cancer Res 66:3658-66 (2006)
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The KSHV viral IL-6 homolog is sufficient to induce blood to lymphatic endothelial cell differentiation.
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Virology 428:112-20 (2012)
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Molecular biology of KSHV lytic reactivation.
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Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers.
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J Mol Med (Berl) 82:223-31 (2004)
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KSHV Genome Replication and Maintenance.
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Front Microbiol 7:54 (2016)
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pathway
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mcf04064  NF-kappa B signaling pathway
mcf04110  Cell cycle
mcf04115  p53 signaling pathway
mcf04140  Autophagy - animal
mcf04144  Endocytosis
mcf04151  PI3K-Akt signaling pathway
mcf04210  Apoptosis
mcf04310  Wnt signaling pathway
mcf04610  Complement and coagulation cascades
mcf04620  Toll-like receptor signaling pathway
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KO pathway
ko05167   
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