KEGG   PATHWAY: mnp05152
Entry
mnp05152                    Pathway                                
Name
Tuberculosis - Mustela nigripes (black-footed ferret)
Description
Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
mnp05152  Tuberculosis
mnp05152

Organism
Mustela nigripes (black-footed ferret) [GN:mnp]
Gene
132017188  TNF; tumor necrosis factor isoform X1 [KO:K03156]
132019939  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
132006073  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
132017355  FADD; FAS-associated death domain protein isoform X1 [KO:K02373]
132013450  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
132013448  CASP10; caspase-10 [KO:K04400] [EC:3.4.22.63]
132006389  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
132019997  BID; BH3-interacting domain death agonist [KO:K04726]
132006078  BAX; apoptosis regulator BAX [KO:K02159]
132015876  cytochrome c [KO:K08738]
132013022  cytochrome c, testis-specific [KO:K08738]
132001514  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
132019338  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
132000311  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
132025379  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
132005674  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
132019536  BAD; bcl2-associated agonist of cell death [KO:K02158]
132023669  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
132016071  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
132016520  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
132002521  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
132028323  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
132020570  IFNG; interferon gamma [KO:K04687]
132018188  IFNGR1; interferon gamma receptor 1 [KO:K05132]
132012363  IFNGR2; interferon gamma receptor 2 [KO:K05133]
132000969  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
132024863  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
132013398  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
132026903  CIITA; MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
132001473  RFX5; DNA-binding protein RFX5 isoform X1 [KO:K08061]
132011212  RFXANK; DNA-binding protein RFXANK [KO:K08062]
132002961  RFXAP; regulatory factor X-associated protein [KO:K08063]
132018075  NFYA; nuclear transcription factor Y subunit alpha isoform X1 [KO:K08064]
132008783  LOW QUALITY PROTEIN: nuclear transcription factor Y subunit beta-like [KO:K08065]
132019303  NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
132005152  nuclear transcription factor Y subunit beta-like [KO:K08065]
132000656  NFYC; nuclear transcription factor Y subunit gamma isoform X1 [KO:K08066]
132013496  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
132017201  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
132017846  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
132017848  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
132017849  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
132017850  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
132017851  HLA class II histocompatibility antigen, DQ alpha 2 chain-like isoform X1 [KO:K06752]
132017853  HLA class II histocompatibility antigen, DQ beta 2 chain [KO:K06752]
132017854  HLA class II histocompatibility antigen, DQ beta 2 chain-like isoform X1 [KO:K06752]
132017861  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
132017862  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
132017864  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
132017866  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
132018592  uncharacterized protein LOC132018592 [KO:K06752]
132018593  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
132018594  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
132028326  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
132019189  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
132026956  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
132026140  IL10; interleukin-10 [KO:K05443]
132027593  IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
132001448  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
132019885  C-type lectin domain family 4 member E-like isoform X1 [KO:K10059]
132026228  FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983]
132019482  CLEC7A; C-type lectin domain family 7 member A isoform X1 [KO:K10074]
132021907  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
132024902  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
132024248  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
132023653  MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1 [KO:K07369] [EC:3.4.22.-]
132001076  BCL10; B-cell lymphoma/leukemia 10 [KO:K07368]
132005391  NOD2; nucleotide-binding oligomerization domain-containing protein 2 isoform X1 [KO:K10165]
132026122  LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 2-like [KO:K08846] [EC:2.7.11.1]
132014142  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
132028559  HSPA9; stress-70 protein, mitochondrial [KO:K04043]
132023053  LOW QUALITY PROTEIN: 60 kDa heat shock protein, mitochondrial-like [KO:K04077] [EC:5.6.1.7]
132026648  60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
132013421  HSPD1; 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
132022749  lipopolysaccharide-binding protein-like [KO:K05399]
132021916  LBP; lipopolysaccharide-binding protein isoform X1 [KO:K05399]
132000985  TLR2; toll-like receptor 2 [KO:K10159]
132005384  TLR1; toll-like receptor 1 [KO:K05398]
132005360  TLR6; toll-like receptor 6 [KO:K10169]
132024470  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
132028592  CD14; monocyte differentiation antigen CD14 [KO:K04391]
132026165  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
132011660  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
132019603  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
132007541  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
132009886  IRAK2; interleukin-1 receptor-associated kinase-like 2 isoform X1 [KO:K04731] [EC:2.7.11.1]
132021320  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
132001757  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
132018657  RELA; transcription factor p65 [KO:K04735]
132017920  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
132017921  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
132019083  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
132019085  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
132008541  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
132023779  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
132026755  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
132001060  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
132016577  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
132027429  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
132003357  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
132015023  IL6; interleukin-6 [KO:K05405]
132012091  IL12A; interleukin-12 subunit alpha [KO:K05406]
132027813  IL12B; interleukin-12 subunit beta [KO:K05425]
132002682  LOW QUALITY PROTEIN: interleukin-18-like [KO:K05482]
132028277  IL18; interleukin-18 [KO:K05482]
132019805  IL23A; interleukin-23 subunit alpha isoform X1 [KO:K05426]
132022475  IL1A; interleukin-1 alpha [KO:K04383]
132022474  IL1B; interleukin-1 beta [KO:K04519]
132022021  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
132005148  CEBPG; CCAAT/enhancer-binding protein gamma [KO:K10049]
132011389  toll-like receptor 9 isoform X1 [KO:K10161]
132008962  interferon alpha-1/2-like [KO:K05414]
132009102  interferon alpha-1/2-like [KO:K05414]
132009158  interferon alpha-3-like [KO:K05414]
132009205  interferon alpha-1/2-like [KO:K05414]
132009311  interferon alpha-1/2-like [KO:K05414]
132024131  interferon alpha-1/2-like [KO:K05414]
132024132  interferon alpha-1/2-like [KO:K05414]
132024134  interferon alpha-1/2-like [KO:K05414]
132025116  interferon alpha-1/2-like [KO:K05414]
132025119  interferon alpha-1/2-like [KO:K05414]
132025120  interferon alpha-1/2-like [KO:K05414]
132025121  interferon alpha-1/2-like [KO:K05414]
132025122  interferon alpha-1/2-like [KO:K05414]
132025123  interferon alpha-1/2-like [KO:K05414]
132025124  interferon alpha-14-like [KO:K05414]
132025125  IFNB1; interferon beta [KO:K05415]
132009677  CD209; CD209 antigen isoform X1 [KO:K06563]
132026896  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
132011318  RHOA; transforming protein RhoA [KO:K04513]
132016769  LSP1; lymphocyte-specific protein 1 isoform X1 [KO:K14957]
132000770  PLK3; serine/threonine-protein kinase PLK3 isoform X1 [KO:K08862] [EC:2.7.11.21]
132003869  KSR1; kinase suppressor of Ras 1 isoform X1 [KO:K14958]
132011570  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
132005078  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
132025704  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
132000151  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
132019859  25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial [KO:K07438] [EC:1.14.15.18]
132019622  VDR; vitamin D3 receptor [KO:K08539]
132009789  CAMP; cathelicidin antimicrobial peptide isoform X1 [KO:K13916]
132010864  C3; complement C3 [KO:K03990]
132026678  integrin alpha-X-like isoform X1 [KO:K06462]
132012472  ITGB2; integrin beta-2 [KO:K06464]
132026679  integrin alpha-M-like isoform X1 [KO:K06461]
132004542  MRC2; LOW QUALITY PROTEIN: C-type mannose receptor 2 [KO:K06560]
132020128  MRC1; macrophage mannose receptor 1 [KO:K06560]
132013779  PLA2R1; secretory phospholipase A2 receptor isoform X1 [KO:K06560]
132004218  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
132005224  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
132015160  calmodulin-1-like [KO:K02183]
132002170  CALML6; calmodulin-like protein 6 [KO:K02183]
132005201  CALM3; calmodulin-3 [KO:K02183]
132020019  calmodulin-like protein 3 [KO:K02183]
132020856  calmodulin-like [KO:K02183]
131999557  CALML4; calmodulin-like protein 4 [KO:K02183]
132021617  CALM2; calmodulin-2 [KO:K02183]
132000098  CALM1; calmodulin-1 [KO:K02183]
132023584  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
132011760  RAB5A; ras-related protein Rab-5A [KO:K07887]
132019782  RAB5B; ras-related protein Rab-5B [KO:K07888]
132003597  RAB5C; ras-related protein Rab-5C [KO:K07889]
132019367  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
132011609  RAB7A; ras-related protein Rab-7a [KO:K07897]
132016741  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
132015663  ATP6V0A4; V-type proton ATPase 116 kDa subunit a 4 [KO:K02154]
132023083  ATP6V0A2; V-type proton ATPase 116 kDa subunit a 2 [KO:K02154]
132017705  TCIRG1; V-type proton ATPase 116 kDa subunit a 3 isoform X1 [KO:K02154]
132003734  ATP6V0A1; V-type proton ATPase 116 kDa subunit a 1 isoform X1 [KO:K02154]
132005038  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
132014133  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
132013103  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
132007568  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
132027004  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
132000741  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit c'' [KO:K03661]
132007712  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
132002484  LAMP1; lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528]
132001718  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
132016503  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
131999012  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
132025071  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
132026758  CORO1A; coronin-1A isoform X1 [KO:K13882]
131999471  immunoglobulin gamma-1 heavy chain-like [KO:K06856]
131999488  uncharacterized protein LOC131999488 [KO:K06856]
132001425  FCGR1A; high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
132025750  low affinity immunoglobulin gamma Fc region receptor II-like isoform X1 [KO:K12560]
132025751  low affinity immunoglobulin gamma Fc region receptor III-A [KO:K06463]
Compound
C00076  Calcium cation
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C01561  Calcidiol
C01673  Calcitriol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C06124  Sphingosine 1-phosphate
C19190  Trehalose-6,6'-dibehenate
C21790  Mycobacterial trehalose dimycolate
G13101  Lipomannan
G13105  Triacylated phosphatidyl-myo-inositol pentamannoside
G13106  Triacylated phosphatidyl-myo-inositol hexamannoside
G13108  Triacylated phosphatidyl-myo-inositol dimannoside
G13109  Tetraacylated phosphatidyl-myo-inositol dimannoside
G13112  Tetraacylated phosphatidyl-myo-inositol hexamannoside
G13113  Tetraacylated phosphatidyl-myo-inositol pentamannoside
G13114  Lipoarabinomannan
G13115  Mannose-capped lipoarabinomannan
Reference
PMID:21274449
  Authors
Saiga H, Shimada Y, Takeda K
  Title
Innate immune effectors in mycobacterial infection.
  Journal
Clin Dev Immunol 2011:347594 (2011)
DOI:10.1155/2011/347594
Reference
PMID:20415982
  Authors
Dheda K, Schwander SK, Zhu B, van Zyl-Smit RN, Zhang Y
  Title
The immunology of tuberculosis: from bench to bedside.
  Journal
Respirology 15:433-50 (2010)
DOI:10.1111/j.1440-1843.2010.01739.x
Reference
PMID:11932234
  Authors
van Crevel R, Ottenhoff TH, van der Meer JW
  Title
Innate immunity to Mycobacterium tuberculosis.
  Journal
Clin Microbiol Rev 15:294-309 (2002)
DOI:10.1128/CMR.15.2.294-309.2002
Reference
PMID:18288961
  Authors
Torrelles JB, Azad AK, Henning LN, Carlson TK, Schlesinger LS
  Title
Role of C-type lectins in mycobacterial infections.
  Journal
Curr Drug Targets 9:102-12 (2008)
DOI:10.2174/138945008783502467
Reference
PMID:17359235
  Authors
Jo EK, Yang CS, Choi CH, Harding CV
  Title
Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.
  Journal
Cell Microbiol 9:1087-98 (2007)
DOI:10.1111/j.1462-5822.2007.00914.x
Reference
PMID:21274433
  Authors
Marakalala MJ, Graham LM, Brown GD
  Title
The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections.
  Journal
Clin Dev Immunol 2010:567571 (2010)
DOI:10.1155/2010/567571
Reference
PMID:15083155
  Authors
Koul A, Herget T, Klebl B, Ullrich A
  Title
Interplay between mycobacteria and host signalling pathways.
  Journal
Nat Rev Microbiol 2:189-202 (2004)
DOI:10.1038/nrmicro840
Reference
PMID:20199890
  Authors
Torrelles JB, Schlesinger LS
  Title
Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host.
  Journal
Tuberculosis (Edinb) 90:84-93 (2010)
DOI:10.1016/j.tube.2010.02.003
Reference
PMID:15228522
  Authors
Briken V, Porcelli SA, Besra GS, Kremer L
  Title
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
  Journal
Mol Microbiol 53:391-403 (2004)
DOI:10.1111/j.1365-2958.2004.04183.x
Reference
PMID:19563525
  Authors
Baena A, Porcelli SA
  Title
Evasion and subversion of antigen presentation by Mycobacterium tuberculosis.
  Journal
Tissue Antigens 74:189-204 (2009)
DOI:10.1111/j.1399-0039.2009.01301.x
Reference
PMID:19369951
  Authors
Flannagan RS, Cosio G, Grinstein S
  Title
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.
  Journal
Nat Rev Microbiol 7:355-66 (2009)
DOI:10.1038/nrmicro2128
Reference
PMID:18541216
  Authors
Pieters J
  Title
Mycobacterium tuberculosis and the macrophage: maintaining a balance.
  Journal
Cell Host Microbe 3:399-407 (2008)
DOI:10.1016/j.chom.2008.05.006
Reference
PMID:19634703
  Authors
Scherr N, Jayachandran R, Mueller P, Pieters J
  Title
Interference of Mycobacterium tuberculosis with macrophage responses.
  Journal
Indian J Exp Biol 47:401-6 (2009)
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:17785780
  Authors
Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A
  Title
Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells.
  Journal
J Immunol 179:3463-71 (2007)
DOI:10.4049/jimmunol.179.6.3463
Reference
PMID:18407066
  Authors
Master SS, Rampini SK, Davis AS, Keller C, Ehlers S, Springer B, Timmins GS, Sander P, Deretic V
  Title
Mycobacterium tuberculosis prevents inflammasome activation.
  Journal
Cell Host Microbe 3:224-32 (2008)
DOI:10.1016/j.chom.2008.03.003
Reference
PMID:11378475
  Authors
Shtrichman R, Samuel CE
  Title
The role of gamma interferon in antimicrobial immunity.
  Journal
Curr Opin Microbiol 4:251-9 (2001)
DOI:10.1016/S1369-5274(00)00199-5
Related
pathway
mnp04010  MAPK signaling pathway
mnp04210  Apoptosis
mnp04612  Antigen processing and presentation
mnp04620  Toll-like receptor signaling pathway
mnp04621  NOD-like receptor signaling pathway
mnp04630  JAK-STAT signaling pathway
KO pathway
ko05152   
LinkDB

DBGET integrated database retrieval system