KEGG   PATHWAY: pbg05165
Entry
pbg05165                    Pathway                                
Name
Human papillomavirus infection - Prionailurus bengalensis (leopard cat)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
pbg05165  Human papillomavirus infection
pbg05165

Organism
Prionailurus bengalensis (leopard cat) [GN:pbg]
Gene
122472345  WNT1; proto-oncogene Wnt-1 [KO:K03209]
122488137  WNT2; protein Wnt-2 [KO:K00182]
122480945  WNT2B; protein Wnt-2b [KO:K00182]
122485662  WNT3A; protein Wnt-3a isoform X1 [KO:K00312]
122485726  WNT3; proto-oncogene Wnt-3 isoform X1 [KO:K00312]
122480068  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
122487341  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
122473283  WNT5B; protein Wnt-5b [KO:K00444]
122481782  WNT6; protein Wnt-6 [KO:K00445]
122487553  WNT7A; protein Wnt-7a [KO:K00572]
122472908  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
122473140  WNT8A; LOW QUALITY PROTEIN: protein Wnt-8a [KO:K00714]
122492627  WNT8B; protein Wnt-8b [KO:K00714]
122485671  WNT9A; protein Wnt-9a [KO:K01064]
122484683  WNT9B; protein Wnt-9b [KO:K01064]
122481783  WNT10A; protein Wnt-10a [KO:K01357]
122472343  WNT10B; protein Wnt-10b [KO:K01357]
122483317  WNT11; protein Wnt-11 [KO:K01384]
122488147  WNT16; protein Wnt-16 [KO:K01558]
122487862  FZD1; frizzled-1 [KO:K02432]
122481650  FZD7; frizzled-7 [KO:K02432]
122485689  FZD2; frizzled-2 [KO:K02235]
122474036  FZD3; frizzled-3 [KO:K02329]
122483240  FZD4; frizzled-4 isoform X1 [KO:K02354]
122481701  FZD5; frizzled-5 [KO:K02375]
122472158  FZD8; frizzled-8 [KO:K02375]
122495693  FZD6; frizzled-6 [KO:K02376]
122470117  FZD10; frizzled-10 [KO:K02842]
122471360  FZD9; frizzled-9 [KO:K02842]
122479781  DVL1; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
122484851  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
122491668  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
122491479  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
122471934  AXIN1; axin-1 isoform X1 [KO:K02157]
122485808  AXIN2; axin-2 [KO:K04385]
122491978  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
122488602  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
122492117  CTNNB1; catenin beta-1 [KO:K02105]
122493590  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
122495749  TERT; telomerase reverse transcriptase isoform X1 [KO:K11126] [EC:2.7.7.49]
122487396  TCF7; LOW QUALITY PROTEIN: transcription factor 7 [KO:K02620]
122497097  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
122493255  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
122468351  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
122470977  TLR3; toll-like receptor 3 [KO:K05401]
122486740  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
122469573  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
122476520  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
122473944  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
122493856  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
122474874  IFNB1; interferon beta [KO:K05415]
122471738  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
122472804  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
122487486  TADA3; transcriptional adapter 3 isoform X1 [KO:K11315]
122484900  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
122487405  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
122493436  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
122473270  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
122470899  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
122495112  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
122467273  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
122491742  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
122479814  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
122480065  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
122480120  LOW QUALITY PROTEIN: cell division control protein 42 homolog [KO:K04393]
122495906  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
122491584  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
122483264  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
122477819  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
122485038  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
122485900  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
122486789  CRB3; protein crumbs homolog 3 [KO:K06090]
122480579  PATJ; LOW QUALITY PROTEIN: inaD-like protein [KO:K06092]
122469236  PALS1; protein PALS1 [KO:K06091]
122473269  VWF; von Willebrand factor [KO:K03900]
122468795  THBS1; thrombospondin-1 [KO:K16857]
122487123  cartilage oligomeric matrix protein [KO:K04659]
122490195  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
122490330  THBS4; thrombospondin-4 [KO:K04659]
122476162  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
122481737  FN1; fibronectin isoform X1 [KO:K05717]
122487891  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
122486092  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
122473337  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
122481853  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
122481854  collagen alpha-3(IV) chain-like isoform X1 [KO:K06237]
122480338  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
122479647  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
122477549  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
122477664  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
122491072  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
122491073  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
122481956  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
122492002  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
122492003  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
122492004  collagen alpha-4(VI) chain-like isoform X1 [KO:K06238]
122490480  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
122482148  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
122467172  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
122489971  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
122470575  LAMA1; laminin subunit alpha-1 [KO:K05637]
122470645  LAMA3; LOW QUALITY PROTEIN: laminin subunit alpha-3 [KO:K06240]
122467189  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
122489882  LAMA4; LOW QUALITY PROTEIN: laminin subunit alpha-4 [KO:K06241]
122487737  LAMB1; laminin subunit beta-1 [KO:K05636]
122488689  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
122476346  LAMB3; laminin subunit beta-3 [KO:K06244]
122487736  LAMB4; laminin subunit beta-4 [KO:K06245]
122476097  LAMC1; laminin subunit gamma-1 [KO:K05635]
122475881  LAMC2; laminin subunit gamma-2 [KO:K06246]
122475400  LAMC3; laminin subunit gamma-3 [KO:K06247]
122485377  CHAD; chondroadherin [KO:K06248]
122487778  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
122478673  SPP1; osteopontin isoform X1 [KO:K06250]
122485171  VTN; vitronectin [KO:K06251]
122478270  TNXB; tenascin-X isoform X1 [KO:K06252]
122474762  TNC; tenascin isoform X1 [KO:K06252]
122475676  TNN; tenascin-N isoform X1 [KO:K06252]
122476392  TNR; tenascin-R [KO:K06252]
122478677  bone sialoprotein 2 [KO:K06253]
122493962  ITGA1; integrin alpha-1 [KO:K06480]
122493943  ITGA2; integrin alpha-2 [KO:K06481]
122485686  ITGA2B; integrin alpha-IIb [KO:K06476]
122486099  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
122481525  ITGA4; integrin alpha-4 [KO:K06483]
122473531  ITGA5; integrin alpha-5 [KO:K06484]
122481459  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
122473717  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
122473369  ITGA8; integrin alpha-8 [KO:K06584]
122492165  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
122481064  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
122467618  ITGA11; integrin alpha-11 [KO:K06587]
122481545  ITGAV; integrin alpha-V [KO:K06487]
122473976  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
122485742  ITGB3; integrin beta-3 [KO:K06493]
122485907  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
122491534  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
122481375  ITGB6; integrin beta-6 [KO:K06589]
122473466  ITGB7; integrin beta-7 [KO:K06590]
122487978  ITGB8; integrin beta-8 [KO:K06591]
122495851  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
122470298  PXN; paxillin isoform X1 [KO:K05760]
122478253  TNF; tumor necrosis factor [KO:K03156]
122473857  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
122494374  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
122476073  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
122492668  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
122484102  FADD; FAS-associated death domain protein [KO:K02373]
122481641  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
122470647  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
122485866  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
122487407  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
122470396  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
122471830  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
122482942  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
122494778  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
122479068  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
122488685  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
122472031  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
122493393  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
122477430  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
122469001  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
122491961  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
122489533  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
122483982  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
122469195  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
122469554  PPP2R5C; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform [KO:K11584]
122476102  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
122474995  TSC1; hamartin isoform X1 [KO:K07206]
122471824  TSC2; tuberin isoform X1 [KO:K07207]
122488549  RHEB; GTP-binding protein Rheb [KO:K07208]
122479919  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
122473604  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
122484054  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
122485296  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
122489414  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
122483950  BAD; bcl2-associated agonist of cell death [KO:K02158]
122493456  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
122482064  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122491710  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
122491934  PIK3CB; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
122487093  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
122480440  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
122489641  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
122469592  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122494042  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122476061  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122481792  FOXO1; forkhead box protein O1 [KO:K07201]
122473385  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
122489448  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
122484101  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
122472689  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
122489512  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
122473830  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
122487880  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
122494162  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
122495617  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
122473734  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
122482016  RB1; retinoblastoma-associated protein [KO:K06618]
122496302  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
122494201  RBL2; retinoblastoma-like protein 2 [KO:K16332]
122469436  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
122496358  E2F1; transcription factor E2F1 [KO:K17454]
122481431  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
122476514  CCNA2; cyclin-A2 [KO:K06627]
122482919  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
122491906  ATR; LOW QUALITY PROTEIN: serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
122489562  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
122493134  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
122472994  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
122477442  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
122478010  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
122484468  RELA; transcription factor p65 [KO:K04735]
122474007  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
122475072  NFX1; transcriptional repressor NF-X1 isoform X1 [KO:K12236]
122480238  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
122489890  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
122472365  CHD4; LOW QUALITY PROTEIN: chromodomain-helicase-DNA-binding protein 4 [KO:K11643] [EC:5.6.2.-]
122487233  IRF1; interferon regulatory factor 1 [KO:K09444]
122490010  TBPL1; TATA box-binding protein-like 1 isoform X1 [KO:K03120]
122490211  TATA-box-binding protein [KO:K03120]
122467954  TBPL2; TATA box-binding protein-like 2 [KO:K03120]
122490428  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0102 alpha chain [KO:K06751]
122489346  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-C*0203 alpha chain-like [KO:K06751]
122489345  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
122489349  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
122489348  patr class I histocompatibility antigen, alpha chain E-like isoform X1 [KO:K06751]
122485805  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
122478237  H-2 class I histocompatibility antigen, alpha chain-like isoform X1 [KO:K06751]
122478235  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
122478281  H-2 class I histocompatibility antigen, alpha chain-like isoform X1 [KO:K06751]
122477916  BCAP31; B-cell receptor-associated protein 31 isoform X1 [KO:K14009]
122491453  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
122472669  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
122496979  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
122497467  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
122495689  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
122469237  ATP6V1D; V-type proton ATPase subunit D isoform X1 [KO:K02149]
122473778  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
122496802  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
122488240  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
122478278  ATP6V1G2; V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
122475421  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
122475962  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
122495410  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
122488378  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
122484074  TCIRG1; V-type proton ATPase 116 kDa subunit a3 isoform X1 [KO:K02154]
122485604  ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154]
122470138  ATP6V0A2; V-type proton ATPase 116 kDa subunit a2 isoform X1 [KO:K02154]
122494381  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
122495557  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
122488498  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
122492202  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
122471802  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
122480391  ATP6V0B; LOW QUALITY PROTEIN: V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
122482045  LOW QUALITY PROTEIN: V-type proton ATPase 21 kDa proteolipid subunit-like [KO:K03661]
122477931  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
122477450  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
122487677  EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
122485897  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
122469065  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
122497238  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
122484176  HRAS; GTPase HRas isoform X1 [KO:K02833]
122473961  KRAS; GTPase KRas [KO:K07827]
122480981  NRAS; GTPase NRas [KO:K07828]
122487521  RAF1; LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
122468485  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
122486708  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
122470517  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122471493  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
122475760  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
122494350  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
122467218  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
122467219  neuroendocrine secretory protein 55 [KO:K04632]
122480698  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
122486980  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
122494846  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
122481695  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
122488369  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
122483751  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
122486712  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
122476151  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
122474966  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
122488047  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
122480009  UBR4; E3 ubiquitin-protein ligase UBR4 isoform X1 [KO:K10691] [EC:2.3.2.27]
122485615  TUBG1; tubulin gamma-1 chain [KO:K10389]
122485616  tubulin gamma-2 chain isoform X1 [KO:K10389]
122475087  interferon alpha-2-like [KO:K05414]
122474263  interferon alpha-like [KO:K05414]
122474324  interferon alpha-like [KO:K05414]
122474291  interferon alpha-like [KO:K05414]
122474338  interferon alpha-like [KO:K05414]
122474333  interferon alpha [KO:K05414]
122491222  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
122491224  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
122480600  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
122486859  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
122481579  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
122473765  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
122468927  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
122497263  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
122470325  OASL; 2'-5'-oligoadenylate synthase-like protein [KO:K14608]
122470326  2'-5'-oligoadenylate synthase-like protein 2 [KO:K14608]
122491151  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
122479766  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
122496572  JAG1; protein jagged-1 [KO:K06052]
122474354  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
122481027  NOTCH2; neurogenic locus notch homolog protein 2 [KO:K20994]
122487026  NOTCH3; neurogenic locus notch homolog protein 3 [KO:K20995]
122489351  LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 4-like [KO:K20996]
122489356  LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 4-like [KO:K20996]
122489360  LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 4-like [KO:K20996]
122478251  NOTCH4; neurogenic locus notch homolog protein 4 [KO:K20996]
122469289  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
122485976  RFNG; beta-1,3-N-acetylglucosaminyltransferase radical fringe isoform X1 [KO:K05948] [EC:2.4.1.222]
122471220  LFNG; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe [KO:K05948] [EC:2.4.1.222]
122472714  MFNG; beta-1,3-N-acetylglucosaminyltransferase manic fringe [KO:K05948] [EC:2.4.1.222]
122483184  MAML2; mastermind-like protein 2 isoform X1 [KO:K06061]
122485996  MAML1; mastermind-like protein 1 [KO:K06061]
122497146  MAML3; mastermind-like protein 3 isoform X1 [KO:K06061]
122478974  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
122496218  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
122491598  HES1; transcription factor HES-1 [KO:K06054]
122479543  HES2; transcription factor HES-2 [KO:K09087]
122481972  HES6; transcription cofactor HES-6 [KO:K09087]
122484704  HES7; transcription factor HES-7 [KO:K09087]
122479861  HES3; transcription factor HES-3 [KO:K09088]
122479761  HES4; transcription factor HES-4 isoform X1 [KO:K09089]
122479827  HES5; transcription factor HES-5 [KO:K06055]
122489954  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
122482135  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091]
122495517  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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Human papillomavirus oncoproteins: pathways to transformation.
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Nat Rev Cancer 10:550-60 (2010)
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Reference
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Rev Med Virol 25 Suppl 1:24-53 (2015)
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Reference
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Viruses 7:2485-506 (2015)
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Reference
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Human papillomavirus proteins as prospective therapeutic targets.
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Reference
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  Title
Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins.
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Rev Med Virol 19:97-113 (2009)
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Reference
PMID:17645777
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  Title
Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins.
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Cancer Sci 98:1505-11 (2007)
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Reference
PMID:11486705
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  Title
The molecular biology of cervical cancer.
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Cancer Invest 19:621-9 (2001)
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Reference
PMID:10793105
  Authors
zur Hausen H
  Title
Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis.
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J Natl Cancer Inst 92:690-8 (2000)
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Reference
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Reference
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McCance DJ
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Human papillomaviruses and cell signaling.
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Sci STKE 2005:pe29 (2005)
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Reference
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The role of human papilloma virus in the molecular biology of cervical carcinogenesis.
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Reference
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The human papillomavirus family and its role in carcinogenesis.
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Reference
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Regulation of the Wnt/beta-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins.
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Viruses 7:4734-55 (2015)
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Reference
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Sci Rep 5:13446 (2015)
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Reference
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Pathogens 5:E8 (2016)
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Reference
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The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy.
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Viruses 7:3530-51 (2015)
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Reference
PMID:21954943
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  Title
PDZ domains: the building blocks regulating tumorigenesis.
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Biochem J 439:195-205 (2011)
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Reference
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Human tumour viruses and the deregulation of cell polarity in cancer.
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Nat Rev Cancer 12:877-86 (2012)
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Reference
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Human papillomaviruses, cervical cancer and cell polarity.
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Reference
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Cell intrinsic & extrinsic factors in cervical carcinogenesis.
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Reference
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Reference
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Reference
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PMID:22499770
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Mol Cell Proteomics 11:M112.016998 (2012)
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Reference
PMID:9990017
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Zwerschke W, Mazurek S, Massimi P, Banks L, Eigenbrodt E, Jansen-Durr P
  Title
Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
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Reference
PMID:15175323
  Authors
Lu Z, Hu X, Li Y, Zheng L, Zhou Y, Jiang H, Ning T, Basang Z, Zhang C, Ke Y
  Title
Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
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J Biol Chem 279:35664-70 (2004)
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Reference
PMID:18505829
  Authors
Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA
  Title
NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
  Journal
Mol Cell Biol 28:4819-28 (2008)
DOI:10.1128/MCB.01969-07
Reference
PMID:23536685
  Authors
Raff AB, Woodham AW, Raff LM, Skeate JG, Yan L, Da Silva DM, Schelhaas M, Kast WM
  Title
The evolving field of human papillomavirus receptor research: a review of binding and entry.
  Journal
J Virol 87:6062-72 (2013)
DOI:10.1128/JVI.00330-13
Related
pathway
pbg04064  NF-kappa B signaling pathway
pbg04110  Cell cycle
pbg04115  p53 signaling pathway
pbg04150  mTOR signaling pathway
pbg04151  PI3K-Akt signaling pathway
pbg04210  Apoptosis
pbg04310  Wnt signaling pathway
pbg04330  Notch signaling pathway
pbg04510  Focal adhesion
pbg04520  Adherens junction
pbg04530  Tight junction
pbg04612  Antigen processing and presentation
pbg04620  Toll-like receptor signaling pathway
pbg04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

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