Entry
Name
Phagosome - Salvelinus namaycush (lake trout)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Salvelinus namaycush (lake trout) [GN:
snh ]
Gene
120065147 vamp3; vesicle-associated membrane protein 3 isoform X1 [KO:K13505 ]
120022588 H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751 ]
120026886 BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751 ]
120026887 class I histocompatibility antigen, F10 alpha chain-like [KO:K06751 ]
120026888 major histocompatibility complex class I-related gene protein-like [KO:K06751 ]
120026889 major histocompatibility complex class I-related gene protein-like [KO:K06751 ]
120026890 major histocompatibility complex class I-related gene protein-like [KO:K06751 ]
120026895 H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751 ]
120026896 H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751 ]
120027448 class I histocompatibility antigen, F10 alpha chain-like [KO:K06751 ]
120028582 major histocompatibility complex class I-related gene protein-like [KO:K06751 ]
120064134 major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751 ]
120018157 H-2 class II histocompatibility antigen, A-Q alpha chain-like [KO:K06752 ]
120041444 H-2 class II histocompatibility antigen, A-Q alpha chain-like [KO:K06752 ]
120031473 H-2 class II histocompatibility antigen, A-Q alpha chain-like isoform X1 [KO:K06752 ]
120031688 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
120035355 H-2 class II histocompatibility antigen, A-Q alpha chain-like isoform X1 [KO:K06752 ]
120037497 H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752 ]
120037498 H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752 ]
120041439 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
120044372 H-2 class II histocompatibility antigen, A-Q alpha chain-like [KO:K06752 ]
120044373 H-2 class II histocompatibility antigen, A-Q alpha chain-like [KO:K06752 ]
120042122 hepatocyte growth factor-regulated tyrosine kinase substrate-like isoform X1 [KO:K12182 ]
120042188 hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182 ]
120017614 atp6v1ba; V-type proton ATPase subunit B, kidney isoform [KO:K02147 ]
120021871 atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147 ]
120021317 V-type proton ATPase 116 kDa subunit a2-like isoform X1 [KO:K02154 ]
120048160 V-type proton ATPase 116 kDa subunit a3-like isoform X1 [KO:K02154 ]
120034052 V-type proton ATPase 116 kDa subunit a1-like isoform X1 [KO:K02154 ]
120027887 si:ch73-173p19.2; V-type proton ATPase 116 kDa subunit a1 [KO:K02154 ]
120035957 V-type proton ATPase 116 kDa subunit a1-like isoform X1 [KO:K02154 ]
120046305 V-type proton ATPase 116 kDa subunit a1-like isoform X1 [KO:K02154 ]
120063012 V-type proton ATPase 116 kDa subunit a2-like isoform X1 [KO:K02154 ]
120022027 LOW QUALITY PROTEIN: cytoplasmic dynein 1 intermediate chain 1 [KO:K10415 ]
120031301 dync1i1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415 ]
120056118 dynein, cytoplasmic 1, intermediate chain 2a-like isoform X1 [KO:K10415 ]
120022249 cytoplasmic dynein 1 light intermediate chain 1-like isoform X1 [KO:K10416 ]
120024873 cytoplasmic dynein 1 light intermediate chain 2-like isoform X1 [KO:K10416 ]
120046231 cytoplasmic dynein 1 light intermediate chain 2-like isoform X1 [KO:K10416 ]
120062225 lamp2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528 ]
120031047 m6pr; cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089 ]
120020334 protein transport protein Sec61 subunit gamma-like isoform X1 [KO:K07342 ]
120055551 protein transport protein Sec61 subunit gamma-like isoform X1 [KO:K07342 ]
120018781 high affinity immunoglobulin gamma Fc receptor I-like isoform X1 [KO:K06498 ]
120040646 ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392 ]
120040650 ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392 ]
Compound
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
Authors
Stuart LM, Ezekowitz RA
Title
Phagocytosis: elegant complexity.
Journal
Reference
Authors
Tjelle TE, Lovdal T, Berg T
Title
Phagosome dynamics and function.
Journal
Reference
Authors
Dupuy AG, Caron E
Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
Journal
Reference
Authors
Brumell JH, Grinstein S
Title
Salmonella redirects phagosomal maturation.
Journal
Reference
Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
Journal
Reference
Authors
Luzio JP, Pryor PR, Bright NA
Title
Lysosomes: fusion and function.
Journal
Reference
Authors
Sumimoto H
Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
Journal
Related pathway
snh04620 Toll-like receptor signaling pathway
KO pathway
LinkDB
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