KEGG   PATHWAY: tben04144
Entry
tben04144                   Pathway                                
Name
Endocytosis - Trematomus bernacchii (emerald rockcod)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
tben04144  Endocytosis
tben04144

Other DBs
GO: 0006897
Organism
Trematomus bernacchii (emerald rockcod) [GN:tben]
Gene
117498578  arf6a; ADP-ribosylation factor 6a [KO:K07941]
117469066  arf6b; ADP-ribosylation factor 6b [KO:K07941]
117478991  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a isoform X1 [KO:K00889] [EC:2.7.1.68]
117496007  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
117480370  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
117488315  LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like [KO:K00889] [EC:2.7.1.68]
117476062  LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like [KO:K00889] [EC:2.7.1.68]
117477729  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
117484667  pip5kl1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
117473005  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
117490306  pld2; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
117493835  pld1a; phospholipase D1a [KO:K01115] [EC:3.1.4.4]
117494243  pld1b; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
117480621  dynamin-1-like [KO:K01528] [EC:3.6.5.5]
117476474  dnm1a; dynamin-1a isoform X1 [KO:K01528] [EC:3.6.5.5]
117488844  dnm3b; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
117474619  dynamin-2-like isoform X1 [KO:K23484] [EC:3.6.5.5]
117493394  dnm2a; dynamin-3 isoform X1 [KO:K23484] [EC:3.6.5.5]
117474633  clta; clathrin light chain A isoform X1 [KO:K04644]
117475218  cltb; clathrin light chain B [KO:K04645]
117472776  cltcl1; clathrin heavy chain 1 isoform X1 [KO:K04646]
117469560  cltca; clathrin, heavy chain a (Hc) isoform X1 [KO:K04646]
117470149  clathrin heavy chain 1 isoform X1 [KO:K04646]
117491098  AP-2 complex subunit alpha-2-like isoform X1 [KO:K11824]
117469262  ap2a1; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
117490267  AP-1 complex subunit beta-1 isoform X1 [KO:K11825]
117474850  AP-2 complex subunit mu-B-like isoform X1 [KO:K11826]
117488475  AP-2 complex subunit mu-A isoform X1 [KO:K11826]
117470360  ap2s1; AP-2 complex subunit sigma [KO:K11827]
117468768  ehd2b; EH domain-containing protein 2b isoform X1 [KO:K12469]
117470029  EH domain-containing protein 2-like [KO:K12469]
117468630  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
117472229  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
117470712  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
117478025  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
117500214  zfyve9a; zinc finger FYVE domain-containing protein 9 [KO:K04679]
117476499  zfyve16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
117495189  zfyve9b; LOW QUALITY PROTEIN: zinc finger FYVE domain-containing protein 9 [KO:K04679]
117484765  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
117471175  mothers against decapentaplegic homolog 3 [KO:K23605]
117491556  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
117496075  tfr1b; transferrin receptor 1b [KO:K06503]
117488822  tfr1a; transferrin receptor 1a isoform X1 [KO:K06503]
117486666  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
117488453  egfra; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
117495114  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
117468872  si:ch211-167j9.5; tyrosine kinase receptor Cad96Ca isoform X1 [KO:K05093] [EC:2.7.10.1]
117499570  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
117487249  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
117490519  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
117497008  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
117491654  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
117490235  E3 ubiquitin-protein ligase CBL-like [KO:K04707] [EC:2.3.2.27]
117470234  cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
117472132  cblb; E3 ubiquitin-protein ligase CBL-B-B isoform X1 [KO:K22517] [EC:2.3.2.27]
117474863  cblc; E3 ubiquitin-protein ligase CBL-C isoform X1 [KO:K22518] [EC:2.3.2.27]
117495658  sh3kbp1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
117495416  sh3gl1b; SH3-domain GRB2-like 1b [KO:K11247]
117472306  endophilin-A3-like [KO:K11247]
117469826  endophilin-A1-like [KO:K11247]
117482327  sh3gl2a; SH3 domain containing GRB2 like 2a, endophilin A1 isoform X1 [KO:K11247]
117482446  sh3gl3a; endophilin-A3a [KO:K11247]
117488656  endophilin-A2-like isoform X1 [KO:K11247]
117484106  sh3glb1a; endophilin-B1a [KO:K11248]
117493827  endophilin-B1-like [KO:K11248]
117484663  sh3glb2b; endophilin-B2b isoform X1 [KO:K21269]
117472502  sh3glb2a; endophilin-B2a isoform X1 [KO:K21269]
117485909  myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
117499240  bin1b; myc box-dependent-interacting protein 1b [KO:K12562]
117469457  amph; amphiphysin isoform X1 [KO:K12562]
117480557  epn1; epsin-1 isoform X1 [KO:K12471]
117474715  epn3b; LOW QUALITY PROTEIN: epsin-3 [KO:K12471]
117492382  epn3a; epsin-3 isoform X1 [KO:K12471]
117492533  epn2; epsin-2 isoform X1 [KO:K12471]
117478123  epsin-2-like isoform X1 [KO:K12471]
117473100  uncharacterized protein LOC117473100 isoform X1 [KO:K12472]
117497692  eps15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
117500169  epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
117495243  LOW QUALITY PROTEIN: epidermal growth factor receptor substrate 15-like 1 [KO:K12472]
117490729  sparta; spartin a isoform X1 [KO:K19366]
117468854  spartb; spartin b isoform X1 [KO:K19366]
117476348  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
117472282  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
117469438  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
117471004  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
117471647  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
117487503  rnf41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
117489632  itcha; itchy E3 ubiquitin protein ligase a [KO:K05632] [EC:2.3.2.26]
117494130  itchb; itchy E3 ubiquitin protein ligase b isoform X1 [KO:K05632] [EC:2.3.2.26]
117479973  smurf2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
117481437  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase SMURF2-like [KO:K04678] [EC:2.3.2.26]
117482019  E3 ubiquitin-protein ligase SMURF2-like isoform X1 [KO:K04678] [EC:2.3.2.26]
117492634  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
117483993  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
117480011  ldlra; low density lipoprotein receptor a [KO:K12473]
117481637  ldlrb; low-density lipoprotein receptor [KO:K12473]
117496710  ldlrap1b; low density lipoprotein receptor adapter protein 1b isoform X1 [KO:K12474]
117492265  si:dkey-71h2.2; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
117488139  si:dkey-19b23.8; low density lipoprotein receptor adapter protein 1 [KO:K12474]
117482879  ldlrap1a; low density lipoprotein receptor adapter protein 1a [KO:K12474]
117476284  dab2; disabled homolog 2 isoform X1 [KO:K12475]
117480281  C-C chemokine receptor type 5-like [KO:K04180]
117480282  C-C chemokine receptor type 5-like [KO:K04180]
117469825  C-C chemokine receptor type 1-like [KO:K04180]
117485558  C-X-C chemokine receptor type 1-like isoform X1 [KO:K05050]
117485946  cxcr2; C-X-C chemokine receptor type 1 [KO:K05050]
117499136  C-X-C chemokine receptor type 2-like [KO:K05050]
117485871  C-X-C chemokine receptor type 4-like [KO:K04189]
117488395  C-X-C chemokine receptor type 4-like [KO:K04189]
117490500  grk1b; rhodopsin kinase GRK1b [KO:K00909] [EC:2.7.11.14]
117481006  grk1a; LOW QUALITY PROTEIN: rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
117470549  grk7b; rhodopsin kinase grk7-b [KO:K00909] [EC:2.7.11.14]
117489031  grk7a; rhodopsin kinase grk7a [KO:K00909] [EC:2.7.11.14]
117497082  grk3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
117474950  beta-adrenergic receptor kinase 2-like [KO:K00910] [EC:2.7.11.15]
117473164  grk5l; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
117490792  grk6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
117481436  grk4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
117497595  arrb2b; arrestin, beta 2b [KO:K04439]
117469485  arrb2a; arrestin, beta 2a isoform X1 [KO:K04439]
117489256  arrb1; beta-arrestin-1 [KO:K04439]
117489855  si:dkey-197j19.6; wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
117479740  neural Wiskott-Aldrich syndrome protein-like isoform X1 [KO:K23612]
117483264  waslb; WASP like actin nucleation promoting factor b isoform X1 [KO:K23612]
117498078  zgc:101810; actin-related protein 2 [KO:K17260]
117487205  actin-related protein 2-B-like [KO:K17260]
117481813  LOW QUALITY PROTEIN: actin-related protein 2-B-like [KO:K17260]
117485671  actin-related protein 3-like [KO:K18584]
117470624  actr3b; actin-related protein 3B [KO:K18584]
117477434  actin-related protein 3 [KO:K18584]
117481607  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
117481608  arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
117469285  zgc:86896; actin-related protein 2/3 complex subunit 1A-A [KO:K05757]
117499144  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
117476449  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
117489840  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
117475497  actin-related protein 2/3 complex subunit 4-like [KO:K05755]
117495621  arpc5b; actin-related protein 2/3 complex subunit 5b [KO:K05754]
117478404  LOW QUALITY PROTEIN: WAS/WASL-interacting protein family member 3-like [KO:K19475]
117484879  WAS/WASL-interacting protein family member 2-like [KO:K19475]
117487214  LOW QUALITY PROTEIN: WAS/WASL-interacting protein family member 1-like [KO:K19475]
117481870  wipf2a; WAS/WASL-interacting protein family member 2 [KO:K19475]
117472121  hspa8; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
117480296  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
117492278  heat shock 70 kDa protein 1 [KO:K03283]
117468761  hspa8b; heat shock protein family A (Hsp70) member 8b [KO:K03283]
117476294  heat shock cognate 71 kDa protein-like [KO:K03283]
117494474  hspa1b; heat shock 70 kDa protein 1B [KO:K03283]
117495131  dnajc6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
117491425  washc4; WASH complex subunit 4 isoform X1 [KO:K18465]
117480581  washc5; WASH complex subunit 5 [KO:K18464]
117499523  washc2c; WASH complex subunit 2A isoform X1 [KO:K18462]
117491763  wash1; WASH complex subunit 1 [KO:K18461]
117484857  washc3; WASH complex subunit 3 [KO:K18463]
117489739  capza1a; F-actin-capping protein subunit alpha-1a [KO:K10364]
117479180  F-actin-capping protein subunit alpha-2 [KO:K10364]
117494025  capza1b; F-actin-capping protein subunit alpha-1b [KO:K10364]
117477236  F-actin-capping protein subunit alpha-2-like [KO:K10364]
117490001  capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
117476672  vps29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
117468778  vps26b; vacuolar protein sorting-associated protein 26B isoform X1 [KO:K18466]
117468782  vacuolar protein sorting-associated protein 26B-like [KO:K18466]
117471527  vps26a; vacuolar protein sorting-associated protein 26A [KO:K18466]
117479987  vps35; vacuolar protein sorting-associated protein 35 [KO:K18468]
117490337  snx12; sorting nexin-12 [KO:K17918]
117493090  snx3; sorting nexin-3 [KO:K17918]
117471427  usp8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
117472939  STAM-binding protein-like A [KO:K11866] [EC:3.4.19.12]
117489841  ras-related protein rab7-like [KO:K07897]
117475485  ras-related protein rab7 [KO:K07897]
117475614  si:dkey-13a21.4; ras-related protein Rab-7a [KO:K07897]
117492244  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
117495757  stam2; LOW QUALITY PROTEIN: signal transducing adapter molecule 2 [KO:K04705]
117500258  stam; signal transducing adapter molecule 1 [KO:K04705]
117491621  tsg101a; tumor susceptibility 101a [KO:K12183]
117478838  mvb12ba; multivesicular body subunit 12Ba [KO:K12186]
117472489  mvb12bb; multivesicular body subunit 12Bb isoform X1 [KO:K12186]
117474820  mvb12a; multivesicular body subunit 12A [KO:K12186]
117477548  vps28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
117474716  vps37a; vacuolar protein sorting-associated protein 37A isoform X1 [KO:K12185]
117469020  vacuolar protein sorting-associated protein 37D-like [KO:K12185]
117474877  vps37c; vacuolar protein sorting-associated protein 37C [KO:K12185]
117469897  vps37d; vacuolar protein sorting-associated protein 37D [KO:K12185]
117489088  vps37ba; VPS37B subunit of ESCRT-I a [KO:K12185]
117473524  snf8; vacuolar-sorting protein SNF8 [KO:K12188]
117490316  vps36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
117474054  vps25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
117473904  chmp6b; charged multivesicular body protein 6 [KO:K12195]
117492911  charged multivesicular body protein 6-like [KO:K12195]
117484206  charged multivesicular body protein 4b-like [KO:K12194]
117493957  charged multivesicular body protein 4b [KO:K12194]
117494375  charged multivesicular body protein 4b-like [KO:K12194]
117496406  chmp4c; charged multivesicular body protein 4c [KO:K24782]
117477810  chmp3; charged multivesicular body protein 3 [KO:K12193]
117473526  chmp2a; charged multivesicular body protein 2a [KO:K12191]
117485704  chmp2ba; charged multivesicular body protein 2Ba [KO:K12192]
117473033  chmp7; charged multivesicular body protein 7 [KO:K15053]
117484207  vps4a; vacuolar protein sorting-associated protein 4A isoform X1 [KO:K12196]
117488386  vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
117495278  vacuolar protein sorting-associated protein 4B-like [KO:K12196]
117498776  vta1; vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
117484211  chmp1a; charged multivesicular body protein 1a [KO:K12197]
117475012  charged multivesicular body protein 1b-like [KO:K12197]
117470258  charged multivesicular body protein 1b [KO:K12197]
117496556  chmp5b; charged multivesicular body protein 5 [KO:K12198]
117482538  chmp5a; charged multivesicular body protein 5 [KO:K12198]
117471688  ist1; IST1 homolog isoform X1 [KO:K19476]
117478288  pdcd6ip; programmed cell death 6-interacting protein isoform X1 [KO:K12200]
117482441  spg21; maspardin isoform X1 [KO:K19367]
117475065  igf2r; cation-independent mannose-6-phosphate receptor [KO:K06564]
117472642  snx2; sorting nexin-2 [KO:K17917]
117497299  snx1a; sorting nexin-1a [KO:K17917]
117471695  sorting nexin-1-like [KO:K17917]
117472092  snx6; sorting nexin-6 isoform X1 [KO:K17920]
117486667  sorting nexin-6-like [KO:K17920]
117499894  snx5; sorting nexin-5 [KO:K17920]
117489318  si:dkey-28n18.9; sorting nexin-6 [KO:K17920]
117489901  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
117483562  src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
117491619  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
117496524  uncharacterized protein LOC117496524 isoform X1 [KO:K05069]
117493527  il2rb; LOW QUALITY PROTEIN: interleukin-2 receptor subunit beta [KO:K05069]
117490338  cytokine receptor common subunit gamma-like [KO:K05070]
117490339  cytokine receptor common subunit gamma-like [KO:K05070]
117493938  cytokine receptor common subunit gamma-like [KO:K05070]
117483687  rho-related GTP-binding protein RhoA-C [KO:K04513]
117490008  rho-related GTP-binding protein RhoA-B [KO:K04513]
117494089  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
117494090  rho-related GTP-binding protein RhoA-D [KO:K04513]
117494127  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
117474106  major histocompatibility complex class I-related gene protein-like [KO:K06751]
117482815  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
117482816  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
117482817  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
117482819  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
117482820  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
117482835  major histocompatibility complex class I-related gene protein-like [KO:K06751]
117482851  major histocompatibility complex class I-related gene protein-like [KO:K06751]
117478040  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
117478051  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
117479929  rtbdn; retbindin [KO:K13649]
117470428  folr; folate receptor [KO:K13649]
117497255  cav1; caveolin-1 [KO:K06278]
117489758  caveolin-2-like [KO:K12958]
117489773  zgc:172270; caveolin-2 [KO:K12958]
117497331  cav2; caveolin-2 [KO:K12958]
117494390  zgc:158296; caveolin-2 [KO:K12958]
117489402  cav3; caveolin-3 [KO:K12959]
117498419  ehd3; EH domain-containing protein 3 [KO:K12476]
117469064  ehd4; EH domain-containing protein 4 [KO:K12477]
117491406  eea1; LOW QUALITY PROTEIN: early endosome antigen 1 [KO:K12478]
117468499  rab5ab; RAB5A, member RAS oncogene family, b [KO:K07887]
117477963  rab5aa; RAB5A, member RAS oncogene family, a [KO:K07887]
117495535  ras-related protein Rab-5C-like [KO:K07888]
117495537  ras-related protein Rab-5C-like [KO:K07888]
117495888  rab5b; ras-related protein Rab-5B [KO:K07888]
117473863  ras-related protein Rab-5C-like [KO:K07889]
117492593  rab5c; ras-related protein Rab-5C [KO:K07889]
117469347  ras-related protein Rab-5C-like [KO:K07889]
117469690  rabep1; rab GTPase-binding effector protein 1 [KO:K12480]
117479380  rabenosyn-5 [KO:K12481]
117471890  rab4a; ras-related protein Rab-4A [KO:K07879]
117475056  rufy1; RUN and FYVE domain-containing protein 1 [KO:K12482]
117471417  rufy2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
117487835  ehd1a; EH domain-containing protein 1a [KO:K12483]
117482778  vps45; vacuolar protein sorting-associated protein 45 [KO:K12479]
117485806  sorting nexin-4-like [KO:K17919]
117483058  sorting nexin-4-like [KO:K17919]
117489755  rab22a; ras-related protein Rab-22A [KO:K07891]
117500306  rab31; ras-related protein Rab-31 [KO:K07891]
117486953  rab10; ras-related protein Rab-10 isoform X1 [KO:K07903]
117495650  ras-related protein Rab-8A [KO:K07901]
117495651  ras-related protein Rab-8A-like [KO:K07901]
117495653  ras-related protein Rab-8A-like [KO:K07901]
117500194  ras-related protein Rab-8A-like [KO:K07901]
117484790  rab35b; ras-related protein Rab-35b [KO:K07876]
117492469  si:dkey-16l2.16; ras-related protein Rab-35 [KO:K07876]
117472253  rab11a; ras-related protein Rab-11A [KO:K07904]
117500570  rab11al; RAB11a, member RAS oncogene family, like [KO:K07904]
117495601  ras-related protein Rab-11B-like [KO:K07905]
117489029  ras-related protein Rab-11B [KO:K07905]
117495173  ras-related protein Rab-11B-like [KO:K07905]
117490207  rab11fip5a; LOW QUALITY PROTEIN: rab11 family-interacting protein 1 [KO:K12484]
117490376  rab11 family-interacting protein 1 isoform X1 [KO:K12484]
117496868  rab11fip1a; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
117499798  rab11 family-interacting protein 2 [KO:K12484]
117476598  LOW QUALITY PROTEIN: trichohyalin-like [KO:K12484]
117474670  zfyve27; protrudin isoform X1 [KO:K19368]
117489689  kif5ab; kinesin heavy chain [KO:K10396]
117479622  LOW QUALITY PROTEIN: kinesin-1 heavy chain-like [KO:K10396]
117486348  kinesin heavy chain-like [KO:K10396]
117500181  LOW QUALITY PROTEIN: kinesin-1 heavy chain-like [KO:K10396]
117494457  kif5aa; kinesin family member 5Aa isoform X1 [KO:K10396]
117473655  rab11fip3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
117481686  rab11fip4b; rab11 family-interacting protein 4B isoform X1 [KO:K12485]
117469175  rab11fip4a; rab11 family-interacting protein 4A [KO:K12485]
117483768  LOW QUALITY PROTEIN: partitioning defective 3 homolog [KO:K04237]
117483951  partitioning defective 3 homolog isoform X1 [KO:K04237]
117478275  LOW QUALITY PROTEIN: partitioning defective 6 homolog gamma-like [KO:K06093]
117491853  pard6a; partitioning defective 6 homolog alpha [KO:K06093]
117494362  pard6b; partitioning defective 6 homolog beta [KO:K06093]
117494715  prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
117500250  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
117475456  cdc42; cell division control protein 42 homolog [KO:K04393]
117494784  cdc42l; cell division cycle 42, like [KO:K04393]
117483422  cell division control protein 42 homolog isoform X1 [KO:K04393]
117478019  cell division control protein 42 homolog [KO:K04393]
117474555  LOW QUALITY PROTEIN: stromal membrane-associated protein 1-like [KO:K12486]
117475737  stromal membrane-associated protein 1-like isoform X1 [KO:K12486]
117477560  smap2; stromal membrane-associated protein 2 isoform X1 [KO:K12486]
117470093  git1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
117476078  git2a; ARF GTPase-activating protein GIT2a isoform X1 [KO:K12487]
117476560  git2b; ARF GTPase-activating protein GIT2b isoform X1 [KO:K12487]
117489697  unm_sa1614; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
117495403  asap1b; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
117481086  asap2a; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2a [KO:K12488]
117492993  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2-like [KO:K12488]
117476215  asap3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12488]
117496026  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2-like isoform X1 [KO:K12489]
117486532  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like isoform X1 [KO:K12489]
117488101  acap1; LOW QUALITY PROTEIN: arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [KO:K12489]
117483512  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like isoform X1 [KO:K12489]
117489273  zgc:162872; LOW QUALITY PROTEIN: BAR_ACAPs and ArfGap_ACAP domain-containing protein [KO:K12489]
117470247  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1-like [KO:K18439]
117490685  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 [KO:K18440]
117488122  zmp:0000000660; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 [KO:K18440]
117482579  arap3; LOW QUALITY PROTEIN: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 [KO:K12490]
117488542  agap3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
117471006  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like [KO:K12491]
117483440  agap2; LOW QUALITY PROTEIN: arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 [KO:K17848]
117489316  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like [KO:K17848]
117486477  arfgap1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
117484988  arfgap3; ADP-ribosylation factor GTPase-activating protein 3 [KO:K12493]
117471637  arfgap2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
117473711  PH and SEC7 domain-containing protein 1-like isoform X1 [KO:K12494]
117475193  psd2; LOW QUALITY PROTEIN: PH and SEC7 domain-containing protein 2 [KO:K12494]
117470675  uncharacterized protein LOC117470675 [KO:K12494]
117476513  PH and SEC7 domain-containing protein 4 [KO:K12494]
117478586  IQ motif and SEC7 domain-containing protein 1-like [KO:K12495]
117479527  LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 1-like [KO:K12495]
117484822  LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 3-like [KO:K12495]
117491246  iqsec3b; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
117475405  iqsec1b; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
117477484  iqsec2b; LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 2 [KO:K12495]
117473586  cyth1b; cytohesin-1b isoform X1 [KO:K18441]
117473692  LOW QUALITY PROTEIN: cytohesin-3-like [KO:K18441]
117480630  si:dkey-283b15.4; cytohesin-2 [KO:K18441]
117492348  cyth1a; cytohesin-1a isoform X1 [KO:K18441]
117492909  cyth3b; cytohesin-3 isoform X1 [KO:K18441]
117493247  cytohesin-3-like isoform X1 [KO:K18441]
117471580  cytohesin-4-like [KO:K18441]
117468652  LOW QUALITY PROTEIN: brefeldin A-inhibited guanine nucleotide-exchange protein 1-like [KO:K18442]
117494175  arfgef2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [KO:K18442]
117492026  gbf1; LOW QUALITY PROTEIN: Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 [KO:K18443]
117473516  arf2b; ADP-ribosylation factor 2b [KO:K07937]
117492645  arf2a; ADP-ribosylation factor 2a [KO:K07937]
117488686  arf1; ADP-ribosylation factor 1 [KO:K07937]
117494443  arf3a; ADP-ribosylation factor 3a [KO:K07938]
117489330  ADP-ribosylation factor 3-like [KO:K07938]
117491571  ADP-ribosylation factor 4-like [KO:K07939]
117469153  ADP-ribosylation factor 4 [KO:K07939]
117497904  ADP-ribosylation factor 1-like [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
tben04060  Cytokine-cytokine receptor interaction
tben04070  Phosphatidylinositol signaling system
tben04130  SNARE interactions in vesicular transport
tben04142  Lysosome
tben04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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