Entry
Name
Herpes simplex virus 1 infection - Theropithecus gelada (gelada)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
BRITE hierarchy
Pathway map
tge05168 Herpes simplex virus 1 infection
Ortholog table
Organism
Theropithecus gelada (gelada) [GN:
tge ]
Gene
112613108 TNFSF14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477 ]
112617618 TNFRSF14; tumor necrosis factor receptor superfamily member 14 [KO:K05152 ]
112624752 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
112605791 BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060 ]
112621400 paired immunoglobulin-like type 2 receptor alpha isoform X1 [KO:K15411 ]
112608008 CARD9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794 ]
112618384 MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729 ]
112633811 TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403 ]
112622975 TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
112632848 MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648 ]
112606994 PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1 [KO:K06269 ] [EC:3.1.3.16 ]
112636950 PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269 ] [EC:3.1.3.16 ]
112605212 EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195 ] [EC:2.7.11.1 ]
112629021 EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237 ]
112633998 EIF2B1; translation initiation factor eIF-2B subunit alpha isoform X1 [KO:K03239 ]
112629259 EIF2B2; translation initiation factor eIF-2B subunit beta [KO:K03754 ]
112636275 EIF2B3; translation initiation factor eIF-2B subunit gamma isoform X1 [KO:K03241 ]
112636930 EIF2B4; translation initiation factor eIF-2B subunit delta isoform X1 [KO:K03680 ]
112618280 EIF2B5; translation initiation factor eIF-2B subunit epsilon isoform X1 [KO:K03240 ]
112606519 POU2F3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364 ]
112622584 POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364 ]
112612109 POU2F2; POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364 ]
112635950 STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220 ]
112634334 STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221 ]
112612939 ZNF324B; LOW QUALITY PROTEIN: zinc finger protein 324B [KO:K09228 ]
112612998 HKR1; Krueppel-related zinc finger protein 1 isoform X1 [KO:K09228 ]
112613213 ZNF780A; LOW QUALITY PROTEIN: zinc finger protein 780A [KO:K09228 ]
112613591 ZIK1; zinc finger protein interacting with ribonucleoprotein K isoform X1 [KO:K09228 ]
112614468 ZSCAN32; zinc finger and SCAN domain-containing protein 32 isoform X1 [KO:K09228 ]
112630657 ZNF705D; LOW QUALITY PROTEIN: zinc finger protein 705D [KO:K09228 ]
112612071 LOW QUALITY PROTEIN: putative zinc finger protein 730 [KO:K09228 ]
112634293 RBAK; RB-associated KRAB zinc finger protein isoform X1 [KO:K09228 ]
112622167 LOW QUALITY PROTEIN: patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751 ]
112622184 popy class I histocompatibility antigen, alpha chain E-like isoform X1 [KO:K06751 ]
112622185 popy class I histocompatibility antigen, alpha chain E-like isoform X1 [KO:K06751 ]
112622400 HLA class I histocompatibility antigen, A-3 alpha chain isoform X1 [KO:K06751 ]
112622401 class I histocompatibility antigen, Gogo-B*0101 alpha chain isoform X1 [KO:K06751 ]
112622403 HLA class I histocompatibility antigen, B-14 alpha chain isoform X1 [KO:K06751 ]
112622405 HLA class I histocompatibility antigen, A-11 alpha chain-like isoform X1 [KO:K06751 ]
112622406 class I histocompatibility antigen, Gogo-B*0102 alpha chain-like isoform X1 [KO:K06751 ]
112622407 class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751 ]
112622412 HLA class I histocompatibility antigen, B-14 alpha chain-like isoform X1 [KO:K06751 ]
112622432 LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751 ]
112616913 class I histocompatibility antigen, Gogo-B*0103 alpha chain-like isoform X1 [KO:K06751 ]
112616914 HLA class I histocompatibility antigen, Cw-12 alpha chain-like [KO:K06751 ]
112617631 HLA class I histocompatibility antigen, A-74 alpha chain-like [KO:K06751 ]
112617695 HLA class I histocompatibility antigen, B-14 alpha chain-like [KO:K06751 ]
112617731 HLA class I histocompatibility antigen, A-11 alpha chain-like isoform X1 [KO:K06751 ]
112617747 class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751 ]
112617766 HLA class I histocompatibility antigen, B-40 alpha chain-like [KO:K06751 ]
112617801 HLA class I histocompatibility antigen, B-14 alpha chain-like isoform X1 [KO:K06751 ]
112617929 class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751 ]
112617939 mamu class I histocompatibility antigen, alpha chain F isoform X1 [KO:K06751 ]
112622042 HLA class II histocompatibility antigen, DP beta 1 chain isoform X1 [KO:K06752 ]
112622043 LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752 ]
112622088 HLA class II histocompatibility antigen, DRB1-9 beta chain isoform X1 [KO:K06752 ]
112622413 HLA class II histocompatibility antigen, DRB1-1 beta chain-like isoform X1 [KO:K06752 ]
112622414 HLA class II histocompatibility antigen, DRB1-10 beta chain-like isoform X1 [KO:K06752 ]
112622415 HLA class II histocompatibility antigen, DR beta 5 chain isoform X1 [KO:K06752 ]
112622416 HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752 ]
112622558 HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752 ]
112622838 HLA class II histocompatibility antigen, DO alpha chain isoform X1 [KO:K06752 ]
112622959 mamu class II histocompatibility antigen, DR alpha chain isoform X1 [KO:K06752 ]
112623006 HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752 ]
112623007 HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752 ]
112623510 HLA class II histocompatibility antigen, DO beta chain [KO:K06752 ]
112623518 HLA class II histocompatibility antigen, DQ beta 1 chain isoform X1 [KO:K06752 ]
112623519 HLA class II histocompatibility antigen, DQ alpha 2 chain [KO:K06752 ]
112626003 CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505 ]
112618874 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
112634042 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
112619294 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
112614522 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
112625914 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
112612001 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649 ]
112630672 EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205 ]
112606576 serine/arginine-rich splicing factor 8-like isoform X1 [KO:K12891 ]
112606748 SRSF8; serine/arginine-rich splicing factor 8 isoform X1 [KO:K12891 ]
112610349 SRSF2; serine/arginine-rich splicing factor 2 isoform X1 [KO:K12891 ]
112629273 SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893 ]
112632811 SRSF6; serine/arginine-rich splicing factor 6 isoform X1 [KO:K12893 ]
112636915 SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896 ]
112635523 SRSF9; serine/arginine-rich splicing factor 9 isoform X1 [KO:K21123 ]
112636918 FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389 ]
112631569 FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390 ]
112635096 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158 ]
112614422 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171 ]
112606473 BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158 ]
112634060 APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084 ]
Compound
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Granger SW, Rickert S
Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
Journal
Reference
Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
Journal
Reference
Authors
MacLeod IJ, Minson T
Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
Journal
Reference
Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
Journal
Reference
Authors
Gianni T, Campadelli-Fiume G
Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
Journal
Reference
Authors
Spear PG
Title
Herpes simplex virus: receptors and ligands for cell entry.
Journal
Reference
Authors
Boutell C, Everett RD
Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
Journal
Reference
Authors
Ma Y, He B
Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
Journal
Reference
Authors
Su C, Zhan G, Zheng C
Title
Evasion of host antiviral innate immunity by HSV-1, an update.
Journal
Reference
Authors
Melchjorsen J, Matikainen S, Paludan SR
Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
Journal
Reference
Authors
Morrison LA
Title
The Toll of herpes simplex virus infection.
Journal
Reference
Authors
Zheng C
Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
Journal
Reference
Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
Journal
Reference
Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
Journal
Reference
Authors
Sanchez R, Mohr I
Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
Journal
Reference
Authors
Wysocka J, Herr W
Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
Journal
Reference
Authors
Fleming SB
Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
Journal
Reference
Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
Journal
Reference
Authors
Gu H, Zheng Y, Roizman B
Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
Journal
Reference
Authors
Tavalai N, Stamminger T
Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
Journal
Reference
Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
Journal
Reference
Authors
Neumann J, Eis-Hubinger AM, Koch N
Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
Journal
Reference
Authors
Liu X, Cohen JI
Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
Journal
Reference
Authors
Vink EI, Smiley JR, Mohr I
Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
Journal
Reference
Authors
Sandri-Goldin RM
Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
Journal
Reference
Authors
Sandri-Goldin RM
Title
Viral regulation of mRNA export.
Journal
Reference
Authors
Yu X, He S
Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
Journal
Related pathway
tge04610 Complement and coagulation cascades
tge04612 Antigen processing and presentation
tge04620 Toll-like receptor signaling pathway
tge04622 RIG-I-like receptor signaling pathway
KO pathway
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