KEGG   PATHWAY: pon04024
Entry
pon04024                    Pathway                                
Name
cAMP signaling pathway - Pongo abelii (Sumatran orangutan)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
pon04024  cAMP signaling pathway
pon04024

Other DBs
GO: 0019933
Organism
Pongo abelii (Sumatran orangutan) [GN:pon]
Gene
100127093  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
100137035  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
100169740  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100171559  ADORA1; adenosine receptor A1 [KO:K04265]
100171605  RHOA; transforming protein RhoA [KO:K04513]
100171723  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
100171907  RAP1B; ras-related protein Rap-1b [KO:K07836]
100172203  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
100172212  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
100172283  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 [KO:K00232] [EC:1.3.3.6]
100172462  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
100172575  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
100172617  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
100172679  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100172680  CALM1; calmodulin-1 [KO:K02183]
100172812  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
100172890  CALM3; calmodulin [KO:K02183]
100172928  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 [KO:K04615]
100172935  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
100173011  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
100173051  RYR2; ryanodine receptor 2 [KO:K04962]
100173211  TNNI3; troponin I, cardiac muscle [KO:K12044]
100173214  CALM2; calmodulin-2 [KO:K02183]
100173410  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100173589  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
100173732  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
100173919  GRIA4; glutamate receptor 4 precursor [KO:K05200]
100174087  RAPGEF3; rap guanine nucleotide exchange factor 3 [KO:K08014]
100174298  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100174388  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
100174482  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
100174748  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform 2 [KO:K04345] [EC:2.7.11.11]
100189911  RAPGEF4; rap guanine nucleotide exchange factor 4 [KO:K04351]
100294619  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
100431221  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
100431483  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100431618  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
100431752  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
100431824  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100431906  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
100432200  CRHR1; corticotropin-releasing factor receptor 1 isoform X5 [KO:K04578]
100432215  FFAR2; free fatty acid receptor 2 [KO:K04328]
100432292  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
100432306  [KO:K16056]
100432362  GIPR; gastric inhibitory polypeptide receptor isoform X1 [KO:K04580]
100432417  PTCH1; protein patched homolog 1 isoform X2 [KO:K06225]
100432582  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
100432846  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100433305  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
100433531  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X8 [KO:K04515] [EC:2.7.11.17]
100433839  RAP1A; ras-related protein Rap-1A isoform X2 [KO:K04353]
100433948  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100434376  HHIP; hedgehog-interacting protein [KO:K06231]
100434655  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
100434842  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
100435135  GLP1R; glucagon-like peptide 1 receptor [KO:K04581]
100435177  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X6 [KO:K05208]
100435329  KCNK2; potassium channel subfamily K member 2 isoform X1 [KO:K04913]
100435791  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
100436186  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100436209  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
100436432  CALML5; calmodulin-like protein 5 [KO:K02183]
100436502  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
100436577  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
100436697  SSTR1; somatostatin receptor type 1 [KO:K04217]
100436723  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
100436726  MC2R; adrenocorticotropic hormone receptor [KO:K04200]
100436747  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X8 [KO:K04515] [EC:2.7.11.17]
100436811  CALML3; calmodulin-like protein 3 [KO:K02183]
100437035  GIP; gastric inhibitory polypeptide [KO:K05258]
100437102  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
100437424  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100437465  GCG; pro-glucagon [KO:K05259]
100437615  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
100437617  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100437871  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
100438178  ADCY6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
100438531  GLI1; zinc finger protein GLI1 [KO:K16797]
100438553  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
100438617  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X3 [KO:K05850] [EC:7.2.2.10]
100438626  GLI3; transcriptional activator GLI3 isoform X1 [KO:K06230]
100438701  OXTR; oxytocin receptor isoform X1 [KO:K04229]
100438704  PDE4C; 3',5'-cyclic-AMP phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
100438869  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100438953  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
100438964  GRIA2; glutamate receptor 2 isoform X3 [KO:K05198]
100439098  BVES; blood vessel epicardial substance [KO:K21108]
100439448  EDNRA; endothelin-1 receptor [KO:K04197]
100439466  POPDC3; popeye domain-containing protein 3 [KO:K26207]
100439470  [KO:K07830]
100439720  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X3 [KO:K09047]
100439813  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
100440050  POPDC2; popeye domain-containing protein 2 isoform X2 [KO:K26206]
100440055  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539] [EC:7.2.2.13]
100440364  GPHA2; glycoprotein hormone alpha-2 isoform X2 [KO:K25483]
100440451  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
100440902  [KO:K13293] [EC:3.1.4.53]
100440911  SST; somatostatin [KO:K05237]
100440912  RRAS; ras-related protein R-Ras isoform X2 [KO:K07829]
100440992  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
100441154  GHSR; growth hormone secretagogue receptor type 1 [KO:K04284]
100441564  VIPR2; vasoactive intestinal polypeptide receptor 2 isoform X2 [KO:K04590]
100441708  ADRB1; beta-1 adrenergic receptor [KO:K04141]
100441756  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
100441853  [KO:K08402]
100441959  ABCC4; ATP-binding cassette sub-family C member 4 isoform X1 [KO:K05673]
100442085  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X5 [KO:K04850]
100442100  AKT1; RAC-alpha serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100442224  HCAR1; LOW QUALITY PROTEIN: hydroxycarboxylic acid receptor 1 [KO:K08401]
100442288  BRAF; serine/threonine-protein kinase B-raf isoform X6 [KO:K04365] [EC:2.7.11.1]
100442459  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
100442703  VAV3; guanine nucleotide exchange factor VAV3 isoform X3 [KO:K05730]
100442948  DRD2; D(2) dopamine receptor [KO:K04145]
100443269  VIP; VIP peptides isoform X2 [KO:K05264]
100443271  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
100443520  CRHR2; corticotropin-releasing factor receptor 2 isoform X2 [KO:K04579]
100443696  TSHB; thyrotropin subunit beta [KO:K05251]
100444145  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3 [KO:K05860] [EC:3.1.4.11]
100444274  FSHB; follitropin subunit beta [KO:K05250]
100444332  DRD5; D(1B) dopamine receptor [KO:K05840]
100444426  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
100444476  NPY; pro-neuropeptide Y [KO:K05232]
100444741  CRH; corticoliberin [KO:K05256]
100444851  CNGB3; cyclic nucleotide-gated cation channel beta-3 [KO:K04953]
100445301  ADORA2A; adenosine receptor A2a [KO:K04266]
100445431  ADCY2; adenylate cyclase type 2 isoform X2 [KO:K08042] [EC:4.6.1.1]
100445634  CREBBP; CREB-binding protein isoform X2 [KO:K04498] [EC:2.3.1.48]
100445800  LIPE; hormone-sensitive lipase isoform X2 [KO:K07188] [EC:3.1.1.79]
100445940  EDN3; endothelin-3 isoform X1 [KO:K05227]
100445961  ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587]
100446010  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
100446021  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100446082  GRIA3; glutamate receptor 3 isoform X6 [KO:K05199]
100446219  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
100446316  NPY1R; neuropeptide Y receptor type 1 [KO:K04204]
100446409  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X3 [KO:K05853] [EC:7.2.2.10]
100446745  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A [KO:K19021] [EC:3.1.4.17]
100447155  VAV1; proto-oncogene vav [KO:K05730]
100447185  DRD1; D(1A) dopamine receptor [KO:K04144]
100447350  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
100447375  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X3 [KO:K04260]
100447776  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 isoform X1 [KO:K01540]
100447784  OXT; oxytocin-neurophysin 1 [KO:K05243]
100447792  F2R; proteinase-activated receptor 1 isoform X2 [KO:K03914]
100447977  CNGA4; cyclic nucleotide-gated cation channel alpha-4 isoform X1 [KO:K04951]
100448030  AMH; muellerian-inhibiting factor [KO:K04665]
100448114  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100448293  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
100448495  CNGB1; cyclic nucleotide-gated cation channel beta-1 isoform X2 [KO:K04952]
100448699  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 isoform X1 [KO:K04615]
100449041  CNGA2; cyclic nucleotide-gated olfactory channel [KO:K04949]
100449215  HCN4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [KO:K04957]
100449316  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100449474  HCN2; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform X1 [KO:K04955]
100449504  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100450045  SLC9A1; sodium/hydrogen exchanger 1 isoform X2 [KO:K05742]
100450243  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
100450292  JUN; transcription factor Jun [KO:K04448]
100450294  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
100450419  SSTR5; somatostatin receptor type 5 [KO:K04221]
100450436  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
100450656  NPPA; natriuretic peptides A [KO:K12334]
100450988  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
100451523  ATP1A4; sodium/potassium-transporting ATPase subunit alpha-4 isoform X1 [KO:K01539] [EC:7.2.2.13]
100451658  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
100451793  PPP1R1B; protein phosphatase 1 regulatory subunit 1B [KO:K15494]
100452183  SUCNR1; succinate receptor 1 [KO:K10042]
100452528  SOX9; transcription factor SOX-9 [KO:K18435]
100452667  GHRL; appetite-regulating hormone [KO:K05254]
100453755  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X2 [KO:K05853] [EC:7.2.2.10]
100453779  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100453904  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X5 [KO:K04851]
100454008  CNGA3; cyclic nucleotide-gated cation channel alpha-3 [KO:K04950]
100454097  BAD; bcl2-associated agonist of cell death isoform X2 [KO:K02158]
100454138  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
100454169  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
100454279  AKT2; RAC-beta serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
100454280  LHB; lutropin subunit beta isoform X1 [KO:K08521]
100454414  HTR4; 5-hydroxytryptamine receptor 4 isoform X2 [KO:K04160]
100455135  CNGA1; cGMP-gated cation channel alpha-1 [KO:K04948]
100455201  GPHB5; glycoprotein hormone beta-5 isoform X1 [KO:K25484]
100455260  EP300; histone acetyltransferase p300 isoform X4 [KO:K04498] [EC:2.3.1.48]
100455484  SSTR2; somatostatin receptor type 2 [KO:K04218]
100455509  ADRB2; beta-2 adrenergic receptor [KO:K04142]
100455662  [KO:K02183]
100455725  FSHR; follicle-stimulating hormone receptor [KO:K04247]
100456049  RELA; transcription factor p65 isoform X1 [KO:K04735]
100456074  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
100456679  FXYD1; phospholemman [KO:K13360]
100457163  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
100457164  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
100457204  EDN1; endothelin-1 [KO:K16366]
100457665  ADCYAP1; pituitary adenylate cyclase-activating polypeptide isoform X2 [KO:K05262]
100458137  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
100458223  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
100458401  PDE4D; 3',5'-cyclic-AMP phosphodiesterase 4D isoform X3 [KO:K13293] [EC:3.1.4.53]
100458706  GRIN2B; glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210]
100458986  GRIN3B; glutamate receptor ionotropic, NMDA 3B isoform X2 [KO:K05214]
100459133  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100459445  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100459692  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
100459701  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
100459799  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100460020  AFDN; afadin isoform X22 [KO:K05702]
100460464  POMC; pro-opiomelanocortin [KO:K05228]
100460789  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform X1 [KO:K13296] [EC:3.1.4.17]
100460806  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
100461112  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
100461304  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
100461383  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100461556  PDE4B; 3',5'-cyclic-AMP phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
100461559  EDN2; endothelin-2 [KO:K16367]
100461595  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
100461605  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
100461614  GPR119; glucose-dependent insulinotropic receptor [KO:K08424]
100461801  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
100462106  CGA; glycoprotein hormones alpha chain isoform X2 [KO:K08522]
100462290  FOS; protein c-Fos [KO:K04379]
100462386  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X2 [KO:K04515] [EC:2.7.11.17]
103888841  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
103889133  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103889530  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
103892390  [KO:K02183]
112129584  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
112133783  PLN; cardiac phospholamban [KO:K05852]
112135785  [KO:K08402]
129047212  [KO:K04632]
129047407  FXYD2; LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit gamma [KO:K01538]
129049795  [KO:K04249]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
Reference
PMID:11493633
  Authors
Fimia GM, Sassone-Corsi P
  Title
Cyclic AMP signalling.
  Journal
J Cell Sci 114:1971-2 (2001)
Reference
PMID:18323530
  Authors
Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M
  Title
Cyclic AMP: master regulator of innate immune cell function.
  Journal
Am J Respir Cell Mol Biol 39:127-32 (2008)
DOI:10.1165/rcmb.2008-0091TR
Reference
PMID:24281338
  Authors
Oldenburger A, Maarsingh H, Schmidt M
  Title
Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.
  Journal
Pharmaceuticals (Basel) 5:1291-331 (2012)
DOI:10.3390/ph5121291
Reference
PMID:24613710
  Authors
Ahuja M, Jha A, Maleth J, Park S, Muallem S
  Title
cAMP and Ca signaling in secretory epithelia: Crosstalk and synergism.
  Journal
Cell Calcium 55:385-393 (2014)
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Related
pathway
pon00071  Fatty acid degradation
pon04015  Rap1 signaling pathway
pon04020  Calcium signaling pathway
pon04151  PI3K-Akt signaling pathway
pon04210  Apoptosis
pon04260  Cardiac muscle contraction
pon04340  Hedgehog signaling pathway
pon04720  Long-term potentiation
pon04740  Olfactory transduction
pon04972  Pancreatic secretion
pon04976  Bile secretion
KO pathway
ko04024   

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