KEGG   PATHWAY: pon04015
Entry
pon04015                    Pathway                                
Name
Rap1 signaling pathway - Pongo abelii (Sumatran orangutan)
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
Pathway map
pon04015  Rap1 signaling pathway
pon04015

Other DBs
GO: 0007264
Organism
Pongo abelii (Sumatran orangutan) [GN:pon]
Gene
100137030  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
100169740  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100171540  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
100171605  RHOA; transforming protein RhoA [KO:K04513]
100171706  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
100171723  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
100171907  RAP1B; ras-related protein Rap-1b [KO:K07836]
100172156  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100172223  ITGB1; integrin beta-1 precursor [KO:K05719]
100172539  FGF7; fibroblast growth factor 7 precursor [KO:K04358]
100172679  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100172680  CALM1; calmodulin-1 [KO:K02183]
100172718  PDGFD; platelet-derived growth factor D precursor [KO:K05450]
100172734  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
100172890  CALM3; calmodulin [KO:K02183]
100173130  EVL; ena/VASP-like protein [KO:K23487]
100173214  CALM2; calmodulin-2 [KO:K02183]
100173558  PFN2; profilin-2 [KO:K05759]
100173589  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
100173732  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
100173739  CTNNB1; catenin beta-1 [KO:K02105]
100173832  ACTB; actin, cytoplasmic 1 [KO:K05692]
100173964  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
100174018  RALB; ras-related protein Ral-B [KO:K07835]
100174087  RAPGEF3; rap guanine nucleotide exchange factor 3 [KO:K08014]
100174103  FGF1; fibroblast growth factor 1 [KO:K18496]
100174126  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
100174298  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100174302  TEK; angiopoietin-1 receptor precursor [KO:K05121] [EC:2.7.10.1]
100174317  NRAS; GTPase NRas [KO:K07828]
100174439  CDH1; cadherin-1 precursor [KO:K05689]
100174545  FGFR1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
100189641  CTNND1; catenin delta-1 isoform 1 [KO:K05690]
100189803  DKFZP459H027; uncharacterized protein LOC100189803 [KO:K17700]
100189911  RAPGEF4; rap guanine nucleotide exchange factor 4 [KO:K04351]
100431221  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
100431483  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100431618  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
100431669  PARD3; partitioning defective 3 homolog isoform X3 [KO:K04237]
100431735  PDGFRA; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
100431824  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100431849  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
100431992  FGF10; fibroblast growth factor 10 [KO:K04358]
100432789  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
100432846  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100432952  PFN1; profilin-1 isoform X2 [KO:K05759]
100433126  FGFR3; fibroblast growth factor receptor 3 isoform X4 [KO:K05094] [EC:2.7.10.1]
100433386  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
100433388  PFN3; profilin-3 [KO:K05759]
100433664  SKAP1; src kinase-associated phosphoprotein 1 isoform X1 [KO:K17699]
100433743  VEGFD; vascular endothelial growth factor D [KO:K05449]
100433839  RAP1A; ras-related protein Rap-1A isoform X2 [KO:K04353]
100434285  DOCK4; dedicator of cytokinesis protein 4 isoform X5 [KO:K17697]
100434355  PRKCA; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
100434502  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100434503  ANGPT4; angiopoietin-4 [KO:K05467]
100434751  RGL4; ral-GDS-related protein [KO:K08732]
100435177  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X6 [KO:K05208]
100435995  RGS14; regulator of G-protein signaling 14 isoform X2 [KO:K17706]
100436432  CALML5; calmodulin-like protein 5 [KO:K02183]
100436498  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100436577  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
100436811  CALML3; calmodulin-like protein 3 [KO:K02183]
100436839  SIPA1L1; signal-induced proliferation-associated 1-like protein 1 isoform X3 [KO:K17701]
100436897  CNR1; cannabinoid receptor 1 [KO:K04277]
100437110  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
100437263  MAPK12; mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
100437462  PFN4; profilin-4 [KO:K05759]
100437617  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100437858  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
100437861  PDGFC; platelet-derived growth factor C isoform X2 [KO:K05450]
100437871  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
100438178  ADCY6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
100438199  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
100438207  PRKD3; serine/threonine-protein kinase D3 isoform X1 [KO:K06070] [EC:2.7.11.13]
100438358  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
100438553  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
100439010  FGF23; fibroblast growth factor 23 [KO:K22428]
100439142  ENAH; protein enabled homolog isoform X12 [KO:K05746]
100439441  SIPA1L3; signal-induced proliferation-associated 1-like protein 3 isoform X1 [KO:K17703]
100439620  APBB1IP; amyloid beta A4 precursor protein-binding family B member 1-interacting protein isoform X2 [KO:K17704]
100439660  ITGAM; integrin alpha-M [KO:K06461]
100439900  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100440212  PDGFA; platelet-derived growth factor subunit A isoform X2 [KO:K04359]
100440363  FGF3; fibroblast growth factor 3 [KO:K04358]
100440675  FYB1; FYN-binding protein 1 isoform X4 [KO:K17698]
100440732  FGF4; fibroblast growth factor 4 [KO:K04358]
100440872  PGF; placenta growth factor isoform X1 [KO:K16859]
100440912  RRAS; ras-related protein R-Ras isoform X2 [KO:K07829]
100441363  PRKD1; serine/threonine-protein kinase D1 isoform X4 [KO:K06070] [EC:2.7.11.13]
100441387  ACTG1; actin, cytoplasmic 2 isoform X2 [KO:K05692]
100441438  RALA; ras-related protein Ral-A [KO:K07834]
100441475  FGF19; fibroblast growth factor 19 [KO:K22603]
100441497  NGF; beta-nerve growth factor isoform X3 [KO:K02582]
100441699  TLN1; talin-1 [KO:K06271]
100442100  AKT1; RAC-alpha serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100442288  BRAF; serine/threonine-protein kinase B-raf isoform X6 [KO:K04365] [EC:2.7.11.1]
100442703  VAV3; guanine nucleotide exchange factor VAV3 isoform X3 [KO:K05730]
100442948  DRD2; D(2) dopamine receptor [KO:K04145]
100443271  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
100443298  CRKL; crk-like protein [KO:K04438]
100443388  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
100443653  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
100443662  FPR1; fMet-Leu-Phe receptor [KO:K04172]
100444094  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
100444145  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3 [KO:K05860] [EC:3.1.4.11]
100444153  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
100444262  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X3 [KO:K06277]
100444426  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
100444645  IGF1; insulin-like growth factor I isoform X4 [KO:K05459]
100445301  ADORA2A; adenosine receptor A2a [KO:K04266]
100445345  ITGB3; integrin beta-3 isoform X2 [KO:K06493]
100445431  ADCY2; adenylate cyclase type 2 isoform X2 [KO:K08042] [EC:4.6.1.1]
100445861  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
100446021  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100446406  PARD6A; partitioning defective 6 homolog alpha isoform X3 [KO:K06093]
100446683  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
100447155  VAV1; proto-oncogene vav [KO:K05730]
100447288  PRKD2; serine/threonine-protein kinase D2 isoform X1 [KO:K06070] [EC:2.7.11.13]
100447289  FGF21; fibroblast growth factor 21 [KO:K22429]
100447792  F2R; proteinase-activated receptor 1 isoform X2 [KO:K03914]
100447844  RASGRP2; RAS guanyl-releasing protein 2 isoform X2 [KO:K12361]
100447897  F2RL3; proteinase-activated receptor 4 [KO:K04236]
100448001  LPAR3; lysophosphatidic acid receptor 3 isoform X1 [KO:K04294]
100448114  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100448360  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
100448382  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
100448388  FGF22; fibroblast growth factor 22 [KO:K04358]
100448500  ADORA2B; adenosine receptor A2b [KO:K04267]
100448769  VEGFA; vascular endothelial growth factor A, long form isoform X1 [KO:K05448]
100448970  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
100449269  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
100449504  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100449853  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
100449916  EFNA4; ephrin-A4 isoform X2 [KO:K05462]
100450037  MAGI3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X1 [KO:K06112]
100450364  FGF17; fibroblast growth factor 17 isoform X2 [KO:K04358]
100450750  SIPA1; signal-induced proliferation-associated protein 1 [KO:K08013]
100450890  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
100450941  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X3 [KO:K01116] [EC:3.1.4.11]
100450988  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
100451193  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
100451422  INSR; insulin receptor isoform X3 [KO:K04527] [EC:2.7.10.1]
100451493  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
100451531  TLN2; talin-2 [KO:K06271]
100451563  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
100451658  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
100451664  EPHA2; ephrin type-A receptor 2 isoform X2 [KO:K05103] [EC:2.7.10.1]
100451665  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
100451938  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
100452144  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
100452263  SIPA1L2; signal-induced proliferation-associated 1-like protein 2 isoform X4 [KO:K17702]
100452410  CRK; adapter molecule crk isoform X1 [KO:K04438]
100452800  ITGA2B; integrin alpha-IIb [KO:K06476]
100453027  LAT; LOW QUALITY PROTEIN: linker for activation of T-cells family member 1 [KO:K07362]
100453191  VEGFC; vascular endothelial growth factor C [KO:K05449]
100453386  THBS1; thrombospondin-1 isoform X2 [KO:K16857]
100453779  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100454035  P2RY1; P2Y purinoceptor 1 [KO:K04270]
100454138  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
100454279  AKT2; RAC-beta serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
100454626  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
100454905  FGF16; fibroblast growth factor 16 [KO:K04358]
100455021  EGF; pro-epidermal growth factor isoform X10 [KO:K04357]
100455662  [KO:K02183]
100455766  RAPGEF5; rap guanine nucleotide exchange factor 5 isoform X1 [KO:K08019]
100456038  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
100456050  VEGFB; vascular endothelial growth factor B isoform X2 [KO:K16858]
100456061  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
100456074  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
100456827  LCP2; lymphocyte cytosolic protein 2 [KO:K07361]
100457536  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
100458137  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
100458628  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
100458686  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
100458706  GRIN2B; glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210]
100458716  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
100458931  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
100458983  FARP2; FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X2 [KO:K06082]
100459069  FGF6; fibroblast growth factor 6 [KO:K04358]
100459280  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100459427  HRAS; GTPase HRas isoform X1 [KO:K02833]
100459511  LPAR4; lysophosphatidic acid receptor 4 isoform X2 [KO:K04275]
100459533  ANGPT2; angiopoietin-2 isoform X2 [KO:K05466]
100459690  KITLG; kit ligand isoform X1 [KO:K05461]
100459751  FGF2; fibroblast growth factor 2 [KO:K18497]
100460001  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
100460020  AFDN; afadin isoform X22 [KO:K05702]
100460060  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100460243  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
100460498  FGF18; fibroblast growth factor 18 [KO:K04358]
100460806  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
100460891  FGF20; fibroblast growth factor 20 [KO:K04358]
100461105  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
100461368  KRIT1; krev interaction trapped protein 1 isoform X1 [KO:K17705]
100461383  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100461961  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X5 [KO:K05858] [EC:3.1.4.11]
100462098  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
100462115  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
100462324  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
100462446  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
100462513  KRAS; GTPase KRas isoform X1 [KO:K07827]
103888841  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
103889133  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103889518  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
103889530  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
103890710  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X7 [KO:K08020]
103892390  [KO:K02183]
112128523  [KO:K10785]
112129584  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
112129943  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
112130075  EFNA2; ephrin-A2 [KO:K05462]
129047212  [KO:K04632]
129047268  FGF9; fibroblast growth factor 9 [KO:K04358]
129052407  [KO:K04634]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:11331911
  Authors
Bos JL, de Rooij J, Reedquist KA
  Title
Rap1 signalling: adhering to new models.
  Journal
Nat Rev Mol Cell Biol 2:369-77 (2001)
DOI:10.1038/35073073
Reference
PMID:17383543
  Authors
Minato N, Kometani K, Hattori M
  Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
  Journal
Adv Immunol 93:229-64 (2007)
DOI:10.1016/S0065-2776(06)93006-5
Reference
PMID:15780587
  Authors
Bos JL
  Title
Linking Rap to cell adhesion.
  Journal
Curr Opin Cell Biol 17:123-8 (2005)
DOI:10.1016/j.ceb.2005.02.009
Reference
PMID:12508104
  Authors
Caron E
  Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
  Journal
J Cell Sci 116:435-40 (2003)
DOI:10.1242/jcs.00238
Reference
PMID:10579920
  Authors
Zwartkruis FJ, Bos JL
  Title
Ras and Rap1: two highly related small GTPases with distinct function.
  Journal
Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695
Reference
PMID:14607972
  Authors
Hattori M, Minato N
  Title
Rap1 GTPase: functions, regulation, and malignancy.
  Journal
J Biochem 134:479-84 (2003)
DOI:10.1093/jb/mvg180
Reference
PMID:19159611
  Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
  Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1788:790-6 (2009)
DOI:10.1016/j.bbamem.2008.12.010
Reference
PMID:19615876
  Authors
Boettner B, Van Aelst L
  Title
Control of cell adhesion dynamics by Rap1 signaling.
  Journal
Curr Opin Cell Biol 21:684-93 (2009)
DOI:10.1016/j.ceb.2009.06.004
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
PMID:17624948
  Authors
Mor A, Dustin ML, Philips MR
  Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
  Journal
Immunol Rev 218:114-25 (2007)
DOI:10.1111/j.1600-065X.2007.00538.x
Reference
PMID:17624944
  Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
  Title
T-cell receptor signaling to integrins.
  Journal
Immunol Rev 218:65-81 (2007)
DOI:10.1111/j.1600-065X.2007.00527.x
Reference
PMID:12765839
  Authors
Stork PJ
  Title
Does Rap1 deserve a bad Rap?
  Journal
Trends Biochem Sci 28:267-75 (2003)
DOI:10.1016/S0968-0004(03)00087-2
Reference
PMID:12351703
  Authors
Banihashemi B, Albert PR
  Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
  Journal
Mol Endocrinol 16:2393-404 (2002)
DOI:10.1210/me.2001-0220
Reference
PMID:18363565
  Authors
Banno A, Ginsberg MH
  Title
Integrin activation.
  Journal
Biochem Soc Trans 36:229-34 (2008)
DOI:10.1042/BST0360229
Reference
PMID:19710505
  Authors
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
  Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
  Journal
Blood 114:4592-600 (2009)
DOI:10.1182/blood-2009-04-217042
Reference
PMID:21402149
  Authors
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
  Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
  Journal
Cell Signal 23:1257-66 (2011)
DOI:10.1016/j.cellsig.2011.03.007
Related
pathway
pon04010  MAPK signaling pathway
pon04014  Ras signaling pathway
pon04020  Calcium signaling pathway
pon04151  PI3K-Akt signaling pathway
pon04510  Focal adhesion
pon04520  Adherens junction
pon04660  T cell receptor signaling pathway
pon04810  Regulation of actin cytoskeleton
KO pathway
ko04015   

DBGET integrated database retrieval system