KEGG   PATHWAY: ppad04810
Entry
ppad04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Panthera pardus (leopard)
Class
Cellular Processes; Cell motility
Pathway map
ppad04810  Regulation of actin cytoskeleton
ppad04810

Other DBs
GO: 0030036
Organism
Panthera pardus (leopard) [GN:ppad]
Gene
109245090  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
109245108  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
109245373  EZR; ezrin isoform X1 [KO:K08007]
109245694  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
109245884  MYH10; myosin-10 isoform X1 [KO:K10352]
109246017  PFN1; profilin-1 [KO:K05759]
109246616  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
109246691  FGF2; fibroblast growth factor 2 [KO:K18497]
109246760  CFL1; cofilin-1 isoform X1 [KO:K05765]
109246777  [KO:K23612]
109246833  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
109246846  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
109246904  FGF19; fibroblast growth factor 19 [KO:K22603]
109247037  FGF4; fibroblast growth factor 4 [KO:K04358]
109247038  FGF3; fibroblast growth factor 3 [KO:K04358]
109247149  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
109247309  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
109247399  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
109247606  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
109247675  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
109247805  RHOA; transforming protein RhoA [KO:K04513]
109248153  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
109248156  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
109248295  TMSB4X; thymosin beta-4 [KO:K05764]
109248559  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
109248585  [KO:K12757]
109248586  [KO:K12757]
109248733  ITGA9; integrin alpha-9 [KO:K06585]
109248850  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
109249190  ITGB7; integrin beta-7 [KO:K06590]
109249251  ITGA5; integrin alpha-5 [KO:K06484]
109249258  NCKAP1L; nck-associated protein 1-like isoform X1 [KO:K05750]
109249481  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
109249680  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
109250166  ENAH; protein enabled homolog [KO:K05746]
109250175  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
109250228  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
109250462  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
109250506  MYL10; myosin regulatory light chain 10 [KO:K12756]
109250510  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
109251089  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
109251142  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
109251167  ACTB; actin, cytoplasmic 1 [KO:K05692]
109251192  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
109251231  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
109251233  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
109251379  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109252200  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
109252228  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
109252245  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
109252409  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
109252867  RRAS; LOW QUALITY PROTEIN: ras-related protein R-Ras [KO:K07829]
109253020  MYH14; LOW QUALITY PROTEIN: myosin-14 [KO:K10352]
109253108  FGF21; fibroblast growth factor 21 [KO:K22429]
109253182  ARHGAP35; rho GTPase-activating protein 35 isoform X1 [KO:K05732]
109253332  CFL2; cofilin-2 [KO:K05765]
109253418  [KO:K23612]
109253609  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
109253672  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
109253886  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
109254045  [KO:K04347]
109254372  BRK1; protein BRICK1 isoform X1 [KO:K05752]
109254390  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
109255104  ITGAE; LOW QUALITY PROTEIN: integrin alpha-E [KO:K06524]
109255155  CRK; adapter molecule crk isoform X1 [KO:K04438]
109255194  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
109255204  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
109255916  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
109255967  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
109256337  IQGAP3; ras GTPase-activating-like protein IQGAP3 isoform X1 [KO:K05767]
109256352  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
109256388  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
109256570  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109256593  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
109256627  [KO:K05734] [EC:2.7.11.1]
109256761  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
109256776  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
109256994  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
109257492  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
109257520  PDGFD; platelet-derived growth factor D [KO:K05450]
109257669  FGF22; fibroblast growth factor 22 [KO:K04358]
109257701  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
109257810  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109257905  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
109257994  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
109258109  ITGB2; integrin beta-2 [KO:K06464]
109258195  ITGA2B; integrin alpha-IIb [KO:K06476]
109258267  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
109258453  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
109258479  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
109258782  C8G; complement component C8 gamma chain isoform X1 [KO:K03999]
109258958  FGF16; fibroblast growth factor 16 [KO:K04358]
109258960  [KO:K12758]
109258998  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
109259024  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
109259037  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
109259168  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
109259216  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 isoform X1 [KO:K05720]
109259322  MYL5; myosin light chain 5 isoform X1 [KO:K12753]
109259395  INS; insulin [KO:K04526]
109259695  CRKL; crk-like protein [KO:K04438]
109259699  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109259759  [KO:K02833]
109259803  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
109259902  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
109259912  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
109260054  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
109260136  CYFIP1; cytoplasmic FMR1-interacting protein 1 [KO:K05749]
109260287  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
109260871  MSN; moesin [KO:K05763]
109260946  PFN2; profilin-2 isoform X1 [KO:K05759]
109261011  [KO:K06594]
109261030  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
109261343  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
109262303  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
109262483  PDGFC; platelet-derived growth factor C [KO:K05450]
109262786  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
109262816  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
109263014  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
109263168  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
109263534  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
109263760  SCIN; adseverin [KO:K05768]
109263803  ITGB8; integrin beta-8 [KO:K06591]
109264057  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
109264429  VCL; vinculin isoform X1 [KO:K05700]
109264599  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
109265076  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
109265107  FN1; fibronectin isoform X1 [KO:K05717]
109265143  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
109265196  ABI2; abl interactor 2 isoform X1 [KO:K05751]
109265228  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
109265500  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
109265504  MYH9; myosin-9 isoform X1 [KO:K10352]
109265580  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
109265876  RGCC; regulator of cell cycle RGCC isoform X1 [KO:K26108]
109266159  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
109266172  FGF9; fibroblast growth factor 9 [KO:K04358]
109266491  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
109266499  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
109266512  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
109266552  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
109266704  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
109266793  C8A; complement component C8 alpha chain [KO:K03997]
109266794  C8B; complement component C8 beta chain isoform X1 [KO:K03998]
109266953  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
109267249  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
109267492  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
109267570  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
109267585  PFN3; profilin-3 [KO:K05759]
109267599  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
109267673  PFN4; profilin-4 isoform X1 [KO:K05759]
109267914  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
109267979  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
109268253  FAM49A; protein FAM49A isoform X1 [KO:K27976]
109268265  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
109268495  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
109268505  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
109268563  [KO:K23612]
109268745  KRAS; GTPase KRas isoform X1 [KO:K07827]
109268919  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
109269060  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
109269114  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
109269781  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
109269874  GSN; gelsolin isoform X1 [KO:K05768]
109269880  [KO:K03994]
109269885  [KO:K03994]
109269943  ACTR3; actin-related protein 3 [KO:K18584]
109269980  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
109270291  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
109270372  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
109270379  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
109270552  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
109270987  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
109271166  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
109271789  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
109271959  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
109272105  NRAS; GTPase NRas [KO:K07828]
109272472  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
109272490  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
109272550  [KO:K05765]
109272590  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
109272992  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
109273006  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
109273012  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
109273067  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
109273122  FAM49B; protein FAM49B isoform X1 [KO:K27976]
109273484  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
109273645  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
109273690  ITGA8; integrin alpha-8 [KO:K06584]
109273952  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
109274075  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
109274111  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
109274234  ITGAV; integrin alpha-V [KO:K06487]
109274276  CDC42; cell division control protein 42 homolog [KO:K04393]
109274530  BDKRB2; B2 bradykinin receptor isoform X1 [KO:K03916]
109274718  PAK5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
109274968  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
109274975  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
109275060  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
109275159  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
109275271  [KO:K03898]
109275437  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
109275834  C9; complement component C9 [KO:K04000]
109275846  C7; complement component C7 isoform X1 [KO:K03996]
109275850  C6; complement component C6 [KO:K03995]
109275883  FGF10; fibroblast growth factor 10 [KO:K04358]
109275894  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
109275896  ITGA2; integrin alpha-2 [KO:K06481]
109275948  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
109276018  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
109276125  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
109276197  FGF23; fibroblast growth factor 23 [KO:K22428]
109276308  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
109276373  FGF6; fibroblast growth factor 6 [KO:K04358]
109276785  ACTG1; actin, cytoplasmic 2 [KO:K05692]
109276796  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
109276923  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
109277040  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
109277047  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
109277132  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
109277365  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
109277393  FGF20; fibroblast growth factor 20 [KO:K04358]
109277487  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
109277539  PXN; paxillin isoform X1 [KO:K05760]
109277655  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
109277658  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
109277667  ARPC3; actin-related protein 2/3 complex subunit 3 isoform X1 [KO:K05756]
109278371  MYH11; myosin-11 isoform X1 [KO:K10352]
109278500  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
109278687  RDX; radixin isoform X1 [KO:K05762]
109278821  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
109278988  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
ppad04010  MAPK signaling pathway
ppad04510  Focal adhesion
ppad04520  Adherens junction
KO pathway
ko04810   

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