KEGG   PATHWAY: pvp04062
Entry
pvp04062                    Pathway                                
Name
Chemokine signaling pathway - Pteropus vampyrus (large flying fox)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
pvp04062  Chemokine signaling pathway
pvp04062

Other DBs
GO: 0070098
Organism
Pteropus vampyrus (large flying fox) [GN:pvp]
Gene
105292342  growth-regulated protein homolog gamma-like isoform X1 [KO:K05505]
105292340  C-X-C motif chemokine 6-like [KO:K05506]
105292414  platelet basic protein [KO:K10029]
105292339  CXCL8; interleukin-8 [KO:K10030]
105292356  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
105292357  C-X-C motif chemokine 10 [KO:K12671]
105304170  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
105292372  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
105291750  CXCL16; C-X-C motif chemokine 16 [KO:K10035]
105292341  platelet factor 4-like isoform X1 [KO:K05407]
105293591  CXCL14; C-X-C motif chemokine 14 isoform X1 [KO:K10033]
105301493  lymphotactin-like [KO:K05507]
105292028  CX3CL1; fractalkine isoform X1 [KO:K05508]
105291969  CCL1; C-C motif chemokine 1 [KO:K05514]
105291966  C-C motif chemokine 2-like [KO:K14624]
105304981  C-C motif chemokine 3 [KO:K05408]
105305012  C-C motif chemokine 3-like [KO:K05408]
105304982  C-C motif chemokine 4 [KO:K12964]
105304977  CCL5; C-C motif chemokine 5 [KO:K12499]
111728743  C-C motif chemokine 8-like [KO:K16596]
105291967  LOW QUALITY PROTEIN: eotaxin-like [KO:K16597]
105291968  C-C motif chemokine 13-like [KO:K16595]
105304979  C-C motif chemokine 14-like [KO:K21092]
105304980  C-C motif chemokine 15-like isoform X1 [KO:K05511]
105304978  CCL16; C-C motif chemokine 16 [KO:K21093]
105292027  CCL17; C-C motif chemokine 17 [KO:K21083]
105306479  CCL19; C-C motif chemokine 19 [KO:K05512]
105294740  CCL20; C-C motif chemokine 20 isoform X1 [KO:K14625]
105306442  CCL21; C-C motif chemokine 21 [KO:K16062]
105292029  CCL22; C-C motif chemokine 22 [KO:K21095]
105299777  CCL24; C-C motif chemokine 24 [KO:K21097]
105307707  CCL25; C-C motif chemokine 25 [KO:K13072]
105299690  CCL26; C-C motif chemokine 26 [KO:K21096]
111732239  uncharacterized protein LOC111732239 [KO:K16598]
105306440  CCL27; C-C motif chemokine 27 [KO:K16598]
105301292  CCL28; C-C motif chemokine 28 [KO:K05513]
105291074  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
105291073  C-X-C chemokine receptor type 2 [KO:K04175]
105299597  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
105288337  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
105308846  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
105290288  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
105290287  XCR1; chemokine XC receptor 1 [KO:K04193]
105310437  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
105290341  CCR8; C-C chemokine receptor type 8 [KO:K04183]
105303703  CCR6; C-C chemokine receptor type 6 isoform X1 [KO:K04181]
105290289  CCR9; C-C chemokine receptor type 9 isoform X1 [KO:K04184]
105293598  CCR4; C-C chemokine receptor type 4 [KO:K04179]
105307527  CCR7; C-C chemokine receptor type 7 [KO:K04182]
105290283  CCR2; C-C chemokine receptor type 2 [KO:K04177]
105290282  C-C chemokine receptor type 5 [KO:K04180]
105290285  CCR1; C-C chemokine receptor type 1 [KO:K04176]
105290284  CCR3; C-C chemokine receptor type 3 [KO:K04178]
105306334  CCR10; C-C chemokine receptor type 10 [KO:K04185]
105303192  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
105296612  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
105289309  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
105302576  STAT2; signal transducer and activator of transcription 2 isoform X2 [KO:K11221]
105306294  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
105306336  signal transducer and activator of transcription 5B [KO:K11224]
105297202  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
105295155  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
105295517  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
105308299  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
105299581  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105289813  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
105309400  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
105288850  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
105297518  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
105292087  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
105301250  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
105303095  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
105289063  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105308501  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
105291403  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
105305509  HCK; tyrosine-protein kinase HCK isoform X2 [KO:K08893] [EC:2.7.10.2]
105290517  FGR; tyrosine-protein kinase Fgr [KO:K08891] [EC:2.7.10.2]
105296513  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
105296379  SHC1; SHC-transforming protein 1 isoform X3 [KO:K06279]
105302278  SHC2; SHC-transforming protein 2 [KO:K17447]
105300265  SHC3; SHC-transforming protein 3 [KO:K17448]
105288811  SHC4; SHC-transforming protein 4 [KO:K17449]
105293353  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
105292949  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
105309535  SOS2; son of sevenless homolog 2 [KO:K03099]
105305933  HRAS; GTPase HRas isoform X1 [KO:K02833]
105294059  KRAS; GTPase KRas isoform X2 [KO:K07827]
105296550  NRAS; GTPase NRas isoform X1 [KO:K07828]
105299021  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105291659  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105309827  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
105289326  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
105304566  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
105307215  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105307575  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105308956  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
105296605  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105297140  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
105299371  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
105300332  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
105291261  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
105291351  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
105303610  PRKCZ; LOW QUALITY PROTEIN: protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
105303899  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105300159  RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
105298702  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105295250  FOXO3; forkhead box protein O3 [KO:K09408]
105304619  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
105301022  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
105302532  IKBKG; NF-kappa-B essential modulator [KO:K07210]
105303182  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
105300180  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
105293029  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105297999  RELA; transcription factor p65 [KO:K04735]
105297848  BAD; bcl2-associated agonist of cell death [KO:K02158]
105307350  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
105301304  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105289957  ITK; tyrosine-protein kinase ITK/TSK [KO:K07363] [EC:2.7.10.2]
105308212  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
105298133  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
105301110  VAV1; proto-oncogene vav [KO:K05730]
105302942  rho guanine nucleotide exchange factor 25-like [KO:K05730]
105294623  RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392]
105311532  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X2 [KO:K07860]
105301137  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
105297614  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
105290433  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105310012  WAS; wiskott-Aldrich syndrome protein [KO:K05747]
105302383  RHOA; transforming protein RhoA [KO:K04513]
105292284  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
105295461  ROCK2; LOW QUALITY PROTEIN: rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
105303584  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
105299738  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
105295952  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
105307521  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
105288758  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
105309385  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
105297807  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 isoform X2 [KO:K04540]
105302718  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 isoform X1 [KO:K04541]
105289068  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
105310269  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
111744611  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
105307968  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
105294373  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
105307158  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
105295886  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
105303281  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 isoform X4 [KO:K04547]
105294383  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
105307274  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
105296076  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
105293695  ELMO1; engulfment and cell motility protein 1 [KO:K12366]
105289940  DOCK2; dedicator of cytokinesis protein 2 [KO:K12367]
105307748  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
105289271  paxillin isoform X3 [KO:K05760]
105305354  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X4 [KO:K05726]
105289311  CRKL; crk-like protein [KO:K04438]
105291866  CRK; adapter molecule crk isoform X1 [KO:K04438]
105292221  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
105302452  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
105297846  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
105288781  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
105298737  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
105299444  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
105296521  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
105289863  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
105297993  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
105296884  RAP1A; ras-related protein Rap-1A [KO:K04353]
105302160  RAP1B; ras-related protein Rap-1b [KO:K07836]
105303015  PARD3; partitioning defective 3 homolog [KO:K04237]
105301274  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
105308818  protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
105304348  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
105299667  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
105305099  GRK1; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
105290356  GRK7; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
105309917  GRK2; beta-adrenergic receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
105301826  GRK3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
105291448  GRK5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
105293506  GRK6; G protein-coupled receptor kinase 6 isoform X3 [KO:K08291] [EC:2.7.11.16]
105301218  GRK4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
105297636  ARRB1; beta-arrestin-1 isoform X2 [KO:K04439]
105291748  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
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Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
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  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
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Reference
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  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
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Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
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Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
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Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
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  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
pvp04010  MAPK signaling pathway
pvp04060  Cytokine-cytokine receptor interaction
pvp04120  Ubiquitin mediated proteolysis
pvp04630  JAK-STAT signaling pathway
pvp04670  Leukocyte transendothelial migration
pvp04810  Regulation of actin cytoskeleton
KO pathway
ko04062   
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