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ENTRY	nt06544
Name	Neuroactive ligand signaling
Category	Pathway view; Cellular process
Pathway	hsa04082 Neuroactive ligand signaling hsa04724 Glutamatergic synapse hsa04727 GABAergic synapse hsa04725 Cholinergic synapse hsa04728 Dopaminergic synapse hsa04726 Serotonergic synapse
Display	drug-target relation   disease type

N01878    Glutamate → GRM1/5 → (GNAQ,GNAS) → (PLCB,ADCY)     SCA44/SCAR13     GRM1*↗ N01879    Glutamate → GRM → (GNAI,GNAO) ⊣ ADCY     CSNB1B     GRM6*     NEDSHBA     GRM7* N00970    Glutamate → NMDAR → Ca2+     DEE101/NDHMSD/NDHMSR     GRIN1*     LKS     GRIN2A*     DEE27/MRD6     GRIN2B*     DEE46     GRIN2D*↗ N01883    Glutamate → GRIA → Na+     MRD67     GRIA1*↗     MRD76     GRIA1*     NEDLIB     GRIA2*     MRXSW     GRIA3*     NEDSGA     GRIA4* N01882    Glutamate → GRIK → Na+     MRT6/NEDLAS     GRIK2*     NEDLAS     GRIK2*↗ N01884    Glutamate(extracel.. − EAAT → Glutamate(cyto)     EA6     SLC1A3*     DEE41/EME     SLC1A2*↗     SCZD18     SLC1A1* N01885    Glutamine(extracel.. − SNAT → Glutamine(cyto) N01886            Glutamine − GLS → Glutamate(cyto) − vGLUT → Glutamate(vesicula.. N01893            Glutamine − GLS → Glutamate(cyto) − GAD → GABA(cyto) − VGAT → GABA(vesicular)     DEE102     SNAT3*     FVH2     SNAT8*     DEE71/GDPAG             GLS*     CASGID             GLS*↗     DFNA25                     vGLUT3*     DEE89                     GAD1*     DEE114/GEFSP12                             VGAT* N01881    (NCDN,TAMALIN,FRMP.. = GRM1/5 N01880        GRM1/5 = (DLG4,DLGAP1,SHANK.. = NMDAR     NEDIES NCDN*     XLID104 FRMPD4*     MRD62         DLG4*     AUST17         SHANK2*     PHMDS/SCZD15         SHANK3*     DFNA68         HOMER2*   N01888    GABA → GABBR → (GNAI,GNAO) ⊣ ADCY N01889            (GNAI,GNAO) ⌿ (GNB+GNG) → KCNJ N01899            (GNAI,GNAO) ⌿ (GNB+GNG) ⊣ CACNA1A/B     NEDLC     GABBR1*     DEE59/NDPLHS     GABBR2*     MRD42             GNB1*↗     NEDHYDF             GNB2*↗     CSNB1H             GNB3*     CMTDIF             GNB4*     LDMLS             GNB5*     KPLBS                 KCNJ6*     DEE42/EA2                 CACNA1A*     SCA6/FHM1/SHM1                 CACNA1A*↗     NEDNEH                 CACNA1B* N01887    GABA → GABR → Cl-     DEE19/EIG13     GABRA1*     DEE78/AD     GABRA2*     EPILX2     GABRA3*     DEE79     GABRA5*     DEE45     GABRB1*     DEE92     GABRB2*     DEE43/ECA5     GABRB3*     DEE74/FEB8     GABRG2* N01892    GABA(extracellular.. − GAT2/3 → GABA(cyto) − ABAT → Succinate → Glutamate − GLUL → Glutamine(cyto) − SNAT3/5 → Glutamine(extracel..     GABATD             ABAT*     CSGD                         GLUL*     DEE116                         GLUL*↗     DEE102                                 SNAT3* N01891    (GABR+(GABARAP+GAB.. → (GABR+TRAK2+PLCL1)     DEE96 NSF* N01890    NRXN = NLGN2 = GPHN = ARHGEF9     PTHSL2/SZCD17 NRXN1*     MOCODC         GPHN*     DEE8             ARHGEF9*   N01894    Acetylcholine → CHRM → (GNAQ,GNA11) → PLCB     PBS     CHRM3* N01895    Acetylcholine → CHRN → (Na+,Ca2+)     BAIPRCK     CHRNA3*     ENFL1     CHRNA4*     ENFL3     CHRNB2*↗     ENFL3     CHRNB2* N01896    Acetylcholine − ACHE → Choline(extracellu.. − SLC5A7 → Choline(cyto) − CHAT → Acetylcholine(cyto.. − SLC18A3 → Acetylcholine(vesi..     CMS20/HMND7             SLC5A7*     CMS6                     CHAT*     CMS21                             SLC18A3*   N01897    Dopamine → DRD1/5 → (GNAQ,GNAS,GNAL) → (PLCB,ADCY5)     ADHD     DRD5* N01898    Dopamine → DRD → (GNAI,GNAO) ⊣ ADCY5     ETM1     DRD3*↗     SCZD     DRD3*     ADHD     DRD4* N01790    Dopamine(outer) − DAT → Dopamine(inner)     PKDYS1     DAT* N01040    Dopamine − VMAT → Dopamine(SV)     PKDYS2     VMAT2* N01530    Tyr+BH4 − TH → L-Dopa − DDC → Dopamine − MAO → DOPAL     DYT5b     TH*     AADC             DDC*     BRNRS                     MAOA* N01918                    Dopamine − (COMT,LRTOMT) ⇉ MAO ⇉ ADH → HVA     SCZD                     COMT*     DFNB63                     LRTOMT* N01919                    Dopamine − DBH → Noradrenaline − PNMT → Adrenaline − COMT ⇉ MAO → MHPG     ORTHYP1                     DBH*   N01903    Norepinephrine → ADRA2 → (GNAI,GNAO) ⊣ ADCY     FPLD8     ADRA2A* N01904    Norepinephrine → ADRB → GNAS → ADCY N01905                ADCY → cAMP → PKA → PPP1R1B ⊣ PP1 ⊣ HCN     FNSS2     ADRB1*     DEE24/GEFSP10                                 HCN1*     FEB2/GEFSP11                                 HCN2*↗     EIG18                                 HCN4* N01920    Norepinephrine(ext.. − SLC6A2 → Norepinephrine(cyt..     OI     SLC6A2*   N01900    Serotonin → HTR2 → (GNAQ,GNA11) → (PLCB,PLA2G4)     OCD/MDD/SCZD     HTR2A* N01901    Serotonin → (HTR1,HTR5A) → (GNAI,GNAO) ⊣ ADCY     PFMCD     HTR1A* N01902    Serotonin(extracel.. − SLC6A4 → Serotonin(cyto)     OCD     SLC6A4* N01551    Trp − TPH1/2 ⇉ DDC → Serotonin − MAO → 5-HIAL     MDD/ADHD7     TPH2*   N01908    (ADP,UDP-glucose) → P2RY12/13/14 → (GNAI,GNAO) ⊣ ADCY     BDPLT8     P2Y12* N01909    ATP → P2RX → Ca2+     DFNA41     P2RX2* N01910    ATP − ENTPD1/3 → ADP − ENTPD1/2/3 → AMP − NT5E/C → Adenosine     SPG64             ENTPD1* N01911    ATP(cyto) − SLC17A9 → ATP(vesicular)     POROK8     SLC17A9*   N01912    Histidine − HDC → Histamine(cyto) − VMAT2 → Histamine(vesicula.. → Histamine(extracel.. − (SLC22A3,SLC29A4) → Histamine(cyto) − HNMT → N-Methylhistamine     TS     HDC*   N01906    Glycine(extracellu.. − SLC6A5/9 → Glycine(cyto) − SLC32A1 → Glycine(vesicular)     HKPX3     SLC6A5*     NKH     SLC6A9* N01907    Glycine → GLR → Cl-     HKPX1     GLRA1*     HKPX2     GLRB*   N01913    MSH → (MC3R,MC4R) → GNAS → ADCY N01914    AgRP ⊣ (MC3R,MC4R) → GNAS → ADCY     Obesity AGRP*     BMIQ9     MC3R*     BMIQ20     MC4R* N01916    POMC − PCSK1/2/3 → MSH,Opioids N01917    PDYN − PCSK1/2/3 → Opioids     OBAIRH POMC*     SCA23 PDYN*     PC1/3 deficiency/BMIQ12     PCSK1*   N01915    TAC → TACR → (GNAQ,GNA11) → PLCB     HH10 TAC3*     HH11     TACR3*

		Disease name	Disease category
SCA44/SCAR13	H00063	Spinocerebellar ataxia (SCA)	Neurodegenerative disease
	H01891	Autosomal recessive spinocerebellar ataxias	Neurodegenerative disease
CSNB1B	H00787	Congenital stationary night blindness	Nervous system disease
NEDSHBA	H02886	Neurodevelopmental disorder with seizures, hypotonia, and brain imaging abnormalities	Congenital malformation
DEE101/NDHMSD/NDHMSR	H00606	Early infantile epileptic encephalopathy	Nervous system disease
	H02865	Neurodevelopmental disorder with or without hyperkinetic movements and seizures	Nervous system disease
LKS	H01514	Landau-Kleffner syndrome	Nervous system disease
DEE27/MRD6	H00606	Early infantile epileptic encephalopathy	Nervous system disease
	H00773	Autosomal dominant intellectual developmental disorder	Mental and behavioural disorder
DEE46	H00606	Early infantile epileptic encephalopathy	Nervous system disease
MRD67	H00773	Autosomal dominant intellectual developmental disorder	Mental and behavioural disorder
MRD76	H00768	Autosomal recessive intellectual developmental disorder	Mental and behavioural disorder
NEDLIB	H02887	Neurodevelopmental disorder with language impairment and behavioral abnormalities	Congenital malformation
MRXSW	H00658	X-linked syndromic intellectual developmental disorder	Mental and behavioural disorder
NEDSGA	H02888	Neurodevelopmental disorder with or without seizures and gait abnormalities	Congenital malformation
MRT6/NEDLAS	H00768	Autosomal recessive intellectual developmental disorder	Mental and behavioural disorder
	H02894	Neurodevelopmental disorder with impaired language and ataxia and with or without seizures	Congenital malformation
NEDLAS	H02894	Neurodevelopmental disorder with impaired language and ataxia and with or without seizures	Congenital malformation
EA6	H00749	Episodic ataxias	Nervous system disease
DEE41/EME	H00606	Early infantile epileptic encephalopathy	Nervous system disease
	H01819	Early myoclonic encephalopathy	Nervous system disease
SCZD18	H01649	Schizophrenia	Mental and behavioural disorder
DEE102	H00606	Early infantile epileptic encephalopathy	Nervous system disease
FVH2	H01256	Foveal hypoplasia	Nervous system disease
DEE71/GDPAG	H00606	Early infantile epileptic encephalopathy	Nervous system disease
	H02846	Global developmental delay, progressive ataxia, and elevated glutamine	Inherited metabolic disorder
CASGID	H02847	CASGID syndrome	Inherited metabolic disorder
DFNA25	H00604	Deafness, autosomal dominant	Nervous system disease
DEE89	H00606	Early infantile epileptic encephalopathy	Nervous system disease
DEE114/GEFSP12	H00606	Early infantile epileptic encephalopathy	Nervous system disease
	H02564	Generalized epilepsy with febrile seizures plus	Nervous system disease
NEDIES	H02892	Neurodevelopmental disorder with infantile epileptic spasms	Congenital malformation
XLID104	H00480	X-linked intellectual developmental disorder	Mental and behavioural disorder
MRD62	H00773	Autosomal dominant intellectual developmental disorder	Mental and behavioural disorder
AUST17	H02111	Autism	Mental and behavioural disorder
PHMDS/SCZD15	H01238	Phelan-McDermid syndrome	Chromosomal abnormality
	H01649	Schizophrenia	Mental and behavioural disorder
DFNA68	H00604	Deafness, autosomal dominant	Nervous system disease
NEDLC	H02890	Neurodevelopmental disorder with language delay and variable cognitive abnormalities	Congenital malformation
DEE59/NDPLHS	H00606	Early infantile epileptic encephalopathy	Nervous system disease
	H02891	Neurodevelopmental disorder with poor language and loss of hand skills	Congenital malformation
MRD42	H00773	Autosomal dominant intellectual developmental disorder	Mental and behavioural disorder
NEDHYDF	H02885	Neurodevelopmental disorder with hypotonia and dysmorphic facies	Congenital malformation
CSNB1H	H00787	Congenital stationary night blindness	Nervous system disease
CMTDIF	H00264	Charcot-Marie-Tooth disease	Neurodegenerative disease
LDMLS	H02895	Lodder-Merla syndrome	Cardiovascular disease
KPLBS	H02236	Keppen-Lubinsky syndrome	Inherited metabolic disorder
DEE42/EA2	H00606	Early infantile epileptic encephalopathy	Nervous system disease
	H00749	Episodic ataxias	Nervous system disease
SCA6/FHM1/SHM1	H00063	Spinocerebellar ataxia (SCA)	Neurodegenerative disease
	H00775	Hemiplegic migraine	Nervous system disease
NEDNEH	H02859	Neurodevelopmental disorder with seizures and nonepileptic hyperkinetic movements	Congenital malformation
DEE19/EIG13	H00606	Early infantile epileptic encephalopathy	Nervous system disease
	H00808	Idiopathic generalized epilepsies	Nervous system disease
DEE78/AD	H00606	Early infantile epileptic encephalopathy	Nervous system disease
	H01611	Alcohol dependence	Mental and behavioural disorder
EPILX2	H02889	X-linked epilepsy-2 with or without impaired intellectual development and dysmorphic features	Congenital malformation
DEE79	H00606	Early infantile epileptic encephalopathy	Nervous system disease
DEE45	H00606	Early infantile epileptic encephalopathy	Nervous system disease
DEE92	H00606	Early infantile epileptic encephalopathy	Nervous system disease
DEE43/ECA5	H00606	Early infantile epileptic encephalopathy	Nervous system disease
	H02215	Childhood absence epilepsy	Nervous system disease
DEE74/FEB8	H00606	Early infantile epileptic encephalopathy	Nervous system disease
	H00783	Febrile seizures	Nervous system disease
GABATD	H01257	GABA-transaminase deficiency	Inherited metabolic disorder
CSGD	H00923	Congenital systemic glutamine deficiency	Inherited metabolic disorder
DEE116	H00606	Early infantile epileptic encephalopathy	Nervous system disease
DEE96	H00606	Early infantile epileptic encephalopathy	Nervous system disease
PTHSL2/SZCD17	H00756	Pitt-Hopkins syndrome	Congenital malformation
	H01649	Schizophrenia	Mental and behavioural disorder
MOCODC	H02311	Molybdenum cofactor deficiency	Inherited metabolic disorder
DEE8	H00606	Early infantile epileptic encephalopathy	Nervous system disease
PBS	H02129	Prune belly syndrome	Congenital malformation
BAIPRCK	H02796	Autonomic bladder dysfunction with impaired pupillary reflex and secondary CAKUT	Congenital malformation
ENFL1	H00807	Nocturnal frontal lobe epilepsy	Nervous system disease
ENFL3	H00807	Nocturnal frontal lobe epilepsy	Nervous system disease
CMS20/HMND7	H00770	Congenital myasthenic syndrome	Nervous system disease
	H00856	Distal hereditary motor neuropathies	Nervous system disease
CMS6	H00770	Congenital myasthenic syndrome	Nervous system disease
CMS21	H00770	Congenital myasthenic syndrome	Nervous system disease
ADHD	H01895	Attention deficit hyperactivity disorder (ADHD)	Mental and behavioural disorder
ETM1	H01577	Essential tremor	Nervous system disease
SCZD	H01649	Schizophrenia	Mental and behavioural disorder
PKDYS1	H02676	Infantile-onset parkinsonism-dystonia	Nervous system disease
PKDYS2	H02676	Infantile-onset parkinsonism-dystonia	Nervous system disease
DYT5b	H02557	Dopa-responsive dystonia	Nervous system disease
AADC	H01161	Aromatic L-amino acid decarboxylase deficiency	Nervous system disease
BRNRS	H00548	Brunner syndrome	Inherited metabolic disorder
DFNB63	H00605	Deafness, autosomal recessive	Nervous system disease
ORTHYP1	H02751	Orthostatic hypotension	Cardiovascular disease
FPLD8	H00420	Familial partial lipodystrophy	Inherited metabolic disorder
FNSS2	H02849	Familial natural short sleep	Nervous system disease
DEE24/GEFSP10	H00606	Early infantile epileptic encephalopathy	Nervous system disease
	H02564	Generalized epilepsy with febrile seizures plus	Nervous system disease
FEB2/GEFSP11	H00783	Febrile seizures	Nervous system disease
	H02564	Generalized epilepsy with febrile seizures plus	Nervous system disease
EIG18	H00808	Idiopathic generalized epilepsies	Nervous system disease
OI	H01031	Orthostatic intolerance	Cardiovascular disease
OCD/MDD/SCZD	H01450	Obsessive-compulsive disorder	Mental and behavioural disorder
	H01646	Major depressive disorder	Mental and behavioural disorder
	H01649	Schizophrenia	Mental and behavioural disorder
PFMCD	H02773	Menstrual cycle-dependent periodic fever	Endocrine and metabolic disease
OCD	H01450	Obsessive-compulsive disorder	Mental and behavioural disorder
MDD/ADHD7	H01646	Major depressive disorder	Mental and behavioural disorder
	H01895	Attention deficit hyperactivity disorder (ADHD)	Mental and behavioural disorder
BDPLT8	H01235	Bleeding disorder platelet-type	Hematologic disease
DFNA41	H00604	Deafness, autosomal dominant	Nervous system disease
SPG64	H00266	Hereditary spastic paraplegia	Nervous system disease
POROK8	H01933	Porokeratosis	Congenital malformation
TS	H00862	Tourette syndrome	Mental and behavioural disorder
HKPX3	H00769	Hyperekplexia	Nervous system disease
NKH	H02419	Glycine encephalopathy with normal serum glycine	Inherited metabolic disorder
HKPX1	H00769	Hyperekplexia	Nervous system disease
HKPX2	H00769	Hyperekplexia	Nervous system disease
Obesity	H02106	Genetic obesity	Endocrine and metabolic disease
BMIQ9	H02106	Genetic obesity	Endocrine and metabolic disease
BMIQ20	H02106	Genetic obesity	Endocrine and metabolic disease
OBAIRH	H02106	Genetic obesity	Endocrine and metabolic disease
SCA23	H00063	Spinocerebellar ataxia (SCA)	Neurodegenerative disease
PC1/3 deficiency/BMIQ12	H02105	Prohormone convertase 1/3 deficiency	Endocrine and metabolic disease
	H02106	Genetic obesity	Endocrine and metabolic disease
HH10	H00255	Hypogonadotropic hypogonadism	Endocrine and metabolic disease
HH11	H00255	Hypogonadotropic hypogonadism	Endocrine and metabolic disease