KEGG   PATHWAY: cmk04010
Entry
cmk04010                    Pathway                                
Name
MAPK signaling pathway - Callorhinchus milii (elephant shark)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
cmk04010  MAPK signaling pathway
cmk04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Callorhinchus milii (elephant shark) [GN:cmk]
Gene
103171601  [KO:K03283]
103172117  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
103172174  [KO:K02308]
103172185  [KO:K04461] [EC:3.1.3.16]
103172493  [KO:K04386]
103172499  [KO:K04407] [EC:2.7.11.1]
103172589  dusp3a; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
103172733  [KO:K04410] [EC:2.7.11.1]
103172863  [KO:K04344]
103173024  [KO:K04431] [EC:2.7.12.2]
103173178  [KO:K04864]
103173202  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
103173289  nradd; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
103173461  [KO:K17386]
103174353  [KO:K04456] [EC:2.7.11.1]
103174463  crk; adapter molecule crk [KO:K04438]
103174601  [KO:K04372] [EC:2.7.11.1]
103174709  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X2 [KO:K04345] [EC:2.7.11.11]
103174789  [KO:K25415]
103174912  rras2; ras-related protein R-Ras2 [KO:K07830]
103174983  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
103175015  fgf19; fibroblast growth factor 19 [KO:K22603]
103175016  fgf4; fibroblast growth factor 4 [KO:K04358]
103175051  mapk8ip1b; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
103175102  fgf3; fibroblast growth factor 3 [KO:K04358]
103175195  [KO:K04350]
103175219  max; protein max isoform X1 [KO:K04453]
103175274  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
103175285  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103175438  grb2a; growth factor receptor-bound protein 2a [KO:K04364]
103175476  rac3a; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
103175503  [KO:K04359]
103175615  [KO:K04866]
103175616  [KO:K04869]
103175617  [KO:K04870]
103175619  [KO:K02677] [EC:2.7.11.13]
103175698  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X3 [KO:K04430] [EC:2.7.12.2]
103175734  [KO:K04433] [EC:2.7.12.2]
103175750  [KO:K04854]
103175928  map3k4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
103176110  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
103176199  [KO:K04439]
103176297  [KO:K04863]
103176334  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
103176455  map3k20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
103176469  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
103176608  zgc:171775; STKc_p38 domain-containing protein isoform X1 [KO:K04441] [EC:2.7.11.24]
103176639  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
103176715  [KO:K04444] [EC:2.7.11.1]
103176741  [KO:K04730] [EC:2.7.11.1]
103176769  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
103176814  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a [KO:K04859]
103177006  [KO:K05460]
103177010  [KO:K04858]
103177012  [KO:K04441] [EC:2.7.11.24]
103177013  [KO:K04441] [EC:2.7.11.24]
103177314  [KO:K04358]
103177513  [KO:K04373] [EC:2.7.11.1]
103177593  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
103177620  [KO:K04348] [EC:3.1.3.16]
103177625  [KO:K02580]
103177659  dusp4; dual specificity protein phosphatase 4 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103177672  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
103177684  [KO:K09784]
103177685  [KO:K09782]
103177736  [KO:K04373] [EC:2.7.11.1]
103177849  [KO:K04358]
103177870  map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
103177901  ppp3r1a; calcineurin subunit B type 1 [KO:K06268]
103177970  [KO:K04445] [EC:2.7.11.1]
103178069  tek; tyrosine-protein kinase receptor Tie-2 [KO:K05121] [EC:2.7.10.1]
103178167  pdgfra; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103178168  kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
103178186  fgf20a; fibroblast growth factor 20a [KO:K04358]
103178222  kita; mast/stem cell growth factor receptor kita [KO:K05091] [EC:2.7.10.1]
103178276  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
103178324  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
103178364  mef2cb; myocyte-specific enhancer factor 2C isoform X3 [KO:K04454]
103178407  efna5b; ephrin-A5b isoform X3 [KO:K05462]
103178584  map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
103178687  [KO:K04359]
103178707  rac1a; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103178759  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
103178838  fgf16; fibroblast growth factor 16 [KO:K04358]
103178993  angpt2a; angiopoietin-2a [KO:K05466]
103179095  [KO:K04458] [EC:3.1.3.48]
103179134  [KO:K04441] [EC:2.7.11.24]
103179136  [KO:K04441] [EC:2.7.11.24]
103179194  rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X3 [KO:K04373] [EC:2.7.11.1]
103179198  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
103179222  [KO:K03099]
103179226  map4k3b; mitogen-activated protein kinase kinase kinase kinase 3 isoform X2 [KO:K04406] [EC:2.7.11.1]
103179260  map3k21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
103179281  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
103179332  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103179355  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
103179419  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
103179538  [KO:K04373] [EC:2.7.11.1]
103179539  [KO:K03283]
103179557  [KO:K04381]
103179558  [KO:K04381]
103179638  rasa2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
103179698  stk3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
103179844  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
103179846  kitlga; kit ligand a isoform X1 [KO:K05461]
103179868  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
103179984  [KO:K16342] [EC:3.1.1.4]
103180013  [KO:K04389]
103180014  [KO:K04389]
103180016  [KO:K04389]
103180215  vegfc; vascular endothelial growth factor C [KO:K05449]
103180319  [KO:K03283]
103180320  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
103180424  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a [KO:K04849]
103180429  [KO:K07831]
103180441  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a isoform X1 [KO:K04865]
103180610  [KO:K04455]
103180778  [KO:K04390]
103180804  ppm1ba; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
103180852  mecom; histone-lysine N-methyltransferase MECOM [KO:K04462] [EC:2.1.1.367]
103180867  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103180890  egf; pro-epidermal growth factor [KO:K04357]
103180906  fgf5; fibroblast growth factor 5 [KO:K04358]
103181270  egfra; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
103181348  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
103181515  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
103181516  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
103181552  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
103181709  [KO:K04378]
103181750  [KO:K04456] [EC:2.7.11.1]
103181767  rasgrp3; LOW QUALITY PROTEIN: ras guanyl-releasing protein 3 [KO:K12362]
103181799  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
103181856  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
103181859  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103181915  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b [KO:K04372] [EC:2.7.11.1]
103181940  [KO:K05462]
103181960  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
103181967  [KO:K04527] [EC:2.7.10.1]
103181987  mef2b; myocyte-specific enhancer factor 2B [KO:K04454]
103182041  jund; transcription factor jun-D [KO:K04449]
103182076  fgf22; fibroblast growth factor 22 [KO:K04358]
103182170  taok3a; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
103182174  si:dkey-1k23.3; heat shock protein beta-1 [KO:K04455]
103182230  nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
103182258  rapgef2b; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
103182267  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
103182425  rap1a; ras-related protein Rap-1A [KO:K04353]
103182483  [KO:K04358]
103182495  [KO:K04443] [EC:2.7.11.1]
103182535  elk4; ETS domain-containing protein Elk-4 [KO:K04376]
103182663  ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
103182667  rasa1b; ras GTPase-activating protein 1 [KO:K04352]
103182680  rasgrf2b; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
103182857  [KO:K04402]
103182941  [KO:K05085] [EC:2.7.10.1]
103183006  [KO:K03173] [EC:2.3.2.27]
103183227  nfatc1; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
103183246  flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
103183275  [KO:K04358]
103183285  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
103183335  taok1a; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
103183357  nf1a; neurofibromin [KO:K08052]
103183358  nlk2; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
103183530  [KO:K04369] [EC:2.7.12.2]
103183732  [KO:K04440] [EC:2.7.11.24]
103183785  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
103183821  [KO:K02583]
103184054  mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
103184127  fgf1; fibroblast growth factor 1 [KO:K18496]
103184142  [KO:K05449]
103184512  [KO:K25414]
103184590  [KO:K05465]
103184612  [KO:K03173] [EC:2.3.2.27]
103184804  [KO:K04852]
103185022  raf1b; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
103185068  [KO:K04851]
103185113  [KO:K04377]
103185131  gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
103185143  map2k6; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
103185197  fgf9; fibroblast growth factor 4A [KO:K04358]
103185223  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103185297  jun; transcription factor AP-1 [KO:K04448]
103185322  [KO:K04458] [EC:3.1.3.48]
103185375  ppm1aa; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
103185425  [KO:K05093] [EC:2.7.10.1]
103185566  ntf3; neurotrophin-3 [KO:K04356]
103185575  [KO:K04358]
103185576  [KO:K22428]
103185595  [KO:K04439]
103185765  pdgfd; platelet-derived growth factor D isoform X2 [KO:K05450]
103185816  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
103185841  [KO:K04348] [EC:3.1.3.16]
103185857  [KO:K04440] [EC:2.7.11.24]
103185931  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
103186003  ins; insulin [KO:K04526]
103186018  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103186026  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
103186041  [KO:K13769]
103186050  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
103186117  [KO:K07836]
103186122  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
103186142  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
103186399  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103186428  map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
103186617  prkcba; protein kinase C, beta a [KO:K19662] [EC:2.7.11.13]
103186967  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103186971  fgf7; fibroblast growth factor 7 precursor [KO:K04358]
103187106  cacna1ha; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
103187266  fgf24; fibroblast growth factor 24 [KO:K04358]
103187308  angpt2b; angiopoietin-2b isoform X1 [KO:K05466]
103187330  [KO:K04426] [EC:2.7.11.25]
103187358  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a [KO:K04360] [EC:2.7.10.1]
103187405  [KO:K02187] [EC:3.4.22.56]
103187639  epha2b; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
103187711  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
103187759  [KO:K04348] [EC:3.1.3.16]
103187802  [KO:K04519]
103187819  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103187976  [KO:K04723]
103188221  [KO:K05090] [EC:2.7.10.1]
103188224  [KO:K05097] [EC:2.7.10.1]
103188232  [KO:K05089] [EC:2.7.10.1]
103188323  fgf2; fibroblast growth factor 2 [KO:K18497]
103188389  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
103188576  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103188785  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103188873  [KO:K07827]
103188937  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
103189067  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
103189080  [KO:K02833]
103189096  [KO:K04345] [EC:2.7.11.11]
103189132  [KO:K04402]
103189133  [KO:K04347]
103189271  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
103189401  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
103189452  ntf4; neurotrophin-4 precursor [KO:K12457]
103189582  map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X2 [KO:K04463] [EC:2.7.12.2]
103189665  rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
103189723  nras; GTPase NRas [KO:K07828]
103189775  [KO:K04374]
103189809  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
103189851  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
103189852  map3k22; mitogen-activated protein kinase kinase kinase 22 [KO:K04421] [EC:2.7.11.25]
103189875  [KO:K16342] [EC:3.1.1.4]
103189966  fos; proto-oncogene c-Fos [KO:K04379]
103190066  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
103190146  [KO:K07827]
103190236  [KO:K05085] [EC:2.7.10.1]
103190243  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
103190258  tgfa; protransforming growth factor alpha [KO:K08774]
103190280  [KO:K13769]
103190313  [KO:K02187] [EC:3.4.22.56]
103190331  [KO:K04350]
103190471  [KO:K04374]
103190572  si:ch211-45c16.2; mitogen-activated protein kinase kinase kinase 13 isoform X4 [KO:K04422] [EC:2.7.11.25]
103190676  map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
103190693  [KO:K04362] [EC:2.7.10.1]
103190804  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
103190808  [KO:K16859]
103190861  [KO:K04857]
103190892  [KO:K03283]
103190959  [KO:K04411]
103191021  [KO:K04392]
103191023  [KO:K04392]
103191264  [KO:K05452]
103191520  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121851675  [KO:K04431] [EC:2.7.12.2]
121852185  [KO:K07827]
121852210  [KO:K03175] [EC:2.3.2.27]
121852244  [KO:K02833]
121852520  [KO:K04457] [EC:3.1.3.16]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
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PMID:11369511
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Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
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PMID:12390245
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Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
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PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
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PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
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PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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PMID:22367796
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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PMID:23085193
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
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PMID:22296764
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
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PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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PMID:23664135
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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PMID:24892271
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Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
cmk04070  Phosphatidylinositol signaling system
cmk04110  Cell cycle
cmk04115  p53 signaling pathway
cmk04210  Apoptosis
cmk04310  Wnt signaling pathway
KO pathway
ko04010   

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