KEGG ORTHOLOGY: K10900

ORTHOLOGY: K10900

Entry

K10900                      KO

Symbol

WRN, RECQL2

Name

werner syndrome ATP-dependent helicase [EC:5.6.2.4]

Disease

H00296

Defects in RecQ helicases

H01733

Werner syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins
    K10900  WRN, RECQL2; werner syndrome ATP-dependent helicase
   03400 DNA repair and recombination proteins
    K10900  WRN, RECQL2; werner syndrome ATP-dependent helicase
Enzymes [BR:ko01000]
5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.4  DNA 3'-5' helicase
     K10900  WRN, RECQL2; werner syndrome ATP-dependent helicase
DNA replication proteins [BR:ko03032]
Eukaryotic type
  DNA Replication Termination Factors
   Other termination factors
    K10900  WRN, RECQL2; werner syndrome ATP-dependent helicase
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    RecQ family DNA helicases
     K10900  WRN, RECQL2; werner syndrome ATP-dependent helicase

Genes

HSA:

7486(WRN)

PTR:	472732(WRN)

PPS:	100975088(WRN)

GGO:	101126909(WRN)

PON:	100188896(WRN)

PPYG:

129042234(WRN)

NLE:	100586959(WRN)

HMH:	116461714(WRN)

SSYN:

129491482(WRN)

MCC:	695678(WRN)

MCF:	102140708(WRN)

MTHB:

126961758

MNI:	105481956(WRN)

CSAB:

103215588(WRN)

CATY:

105579125(WRN)

PANU:

101014667(WRN)

TGE:	112630084(WRN)

MLEU:

105537992(WRN)

RRO:	104668217(WRN)

RBB:	108518678(WRN)

TFN:	117094565(WRN)

PTEH:

111544151(WRN)

CANG:

105513618(WRN)

CJC:	100396599(WRN)

SBQ:	101048471(WRN)

CIMI:

108309615(WRN)

ANAN:

105728426(WRN)

CSYR:

103253735(WRN)

MMUR:

105882042(WRN)

LCAT:

123626485(WRN)

PCOQ:

105813774(WRN)

OGA:	100948223(WRN)

MMU:	22427(Wrn)

MCAL:

110299750(Wrn)

MPAH:

110336568(Wrn)

RNO:	290805(Wrn)

MCOC:

116069123(Wrn)

ANU:	117721789(Wrn)

ASYL:

127668774(Wrn)

MUN:	110557520(Wrn)

CGE:	100753909(Wrn)

MAUA:

101829497(Wrn)

PROB:

127220417(Wrn)

PLEU:

114698502(Wrn)

MORG:

121462348(Wrn)

MFOT:

126504391

AAMP:

119811695(Wrn)

NGI:	103743580(Wrn)

HGL:	101701103 101724469(Wrn)

CPOC:

100719896(Wrn)

CCAN:

109697231(Wrn)

DORD:

105992864(Wrn)

DSP:	122127348(Wrn)

PLOP:

125339693(Wrn)

NCAR:

124982998

MMMA:

107155367(Wrn)

ITI:	101960252(Wrn)

OCU:

100341925

OPI:	101522073(WRN)

TUP:	102470583(WRN)

GVR:	103601083(WRN)

CFA:	493997(WRN)

CLUD:

112643523(WRN)

VVP:	112916106(WRN)

VLG:	121489622(WRN)

NPO:	129515949(WRN)

AML:	100474249(WRN)

UMR:	103659100(WRN)

UAH:	113262139(WRN)

UAR:	123780345(WRN)

ELK:

111144475

LLV:

125092391

MPUF:

101671340(WRN)

MNP:	132006495(WRN)

MLK:	131820694(WRN)

NVS:	122889906(WRN)

ORO:	101366610(WRN)

EJU:	114196801(WRN)

ZCA:	113924749(WRN)

MLX:	118009791(WRN)

NSU:	110584087(WRN)

LWW:	102739174(WRN)

FCA:	101095574(WRN)

PYU:	121039799(WRN)

PCOO:

112869856(WRN)

PBG:	122471846(WRN)

PVIV:

125163989(WRN)

LRUF:

124520459

LGF:	123586747(WRN)

AJU:

106966549

PTG:	102963326(WRN)

PPAD:

109277274(WRN)

PUC:

125923389

PLEZ:

122217478(WRN)

HHV:	120222863(WRN)

BTA:	505061(WRN)

BOM:	102282258(WRN)

BIU:	109553502(WRN)

BBUB:

102398997(WRN)

BBIS:

104987745(WRN)

CHX:	102182278(WRN)

OAS:	101106742(WRN)

BTAX:

128068328(WRN)

CSUM:

138078525(WRN)

ODA:	120865631(WRN)

CCAD:

122432625(WRN)

MREE:

136176405(WRN)

OVR:	110128331(WRN)

MBEZ:

129549382(WRN)

SSC:	100512139(WRN)

CFR:	102510058(WRN)

CBAI:

105067620(WRN)

CDK:	105095802(WRN)

VPC:	102526607(WRN)

BACU:

103001086(WRN)

BMUS:

118887884(WRN)

LVE:	103086411(WRN)

OOR:	101286297(WRN)

LALB:

132512692(WRN)

DLE:	111173484(WRN)

PCAD:

102988164(WRN)

PSIU:

116746827(WRN)

NASI:

112413223(WRN)

ECB:	100062021(WRN)

EPZ:	103565518(WRN)

EAI:	106824397(WRN)

MYB:	102239371(WRN)

MYD:	102771349(WRN)

MMYO:

118650260(WRN)

MLF:	102434151(WRN)

MDT:	132228663(WRN)

MYUM:

139005973(WRN)

PKL:	118730346(WRN)

EFUS:

103290280(WRN)

MNA:	107534107(WRN)

DRO:	112306651(WRN)

SHON:

118993147(WRN)

AJM:	119036803(WRN)

PDIC:

114508850(WRN)

PHAS:

123807557(WRN)

MMF:	118622552(WRN)

PPAM:

129064835(WRN)

HAI:	109382967(WRN)

RFQ:	117021697(WRN)

PALE:

102886512(WRN)

PGIG:

120589046(WRN)

PVP:	105300874(WRN)

RAY:	107505811(WRN)

MJV:	108385950(WRN)

TOD:	119257791(WRN)

SARA:

101551210(WRN)

SFUM:

130025962(WRN)

SETR:

126007236(WRN)

LAV:	100669012(WRN)

TMU:

101345229

ETF:	101644496(WRN)

DNM:	101442456(WRN)

MDO:	100019443(WRN)

GAS:	123251266(WRN)

SHR:	100921189(WRN)

AFZ:

127541885

PCW:	110222977(WRN)

TVP:	118854957(WRN)

PBRV:

138174598(WRN)

OAA:	100077021(WRN)

TACU:

119928436(WRN)

GGA:	422505(WRN)

PCOC:

116238051(WRN)

MGP:	100550079(WRN)

CJO:	107313186(WRN)

LMUT:

125691750(WRN)

NMEL:

110399141(WRN)

APLA:

101803062(WRN)

ACYG:

106035204(WRN)

CATA:

118243051(WRN)

AFUL:

116488733(WRN)

TGU:	100224252(WRN)

LSR:	110471192(WRN)

SCAN:

103823418(WRN)

PMOA:

120502706(WRN)

OTC:	121331967(WRN)

PRUF:

121349165(WRN)

ATRC:

139592008

GFR:	102042375(WRN)

OMA:	130252384(WRN)

PHI:	102112392(WRN)

PMAJ:

107203395(WRN)

CCAE:

111928991(WRN)

CCW:	104696833(WRN)

CBRC:

103618952(WRN)

ACOE:

138109291(WRN)

ETL:	114069592(WRN)

ZAB:	102068596(WRN)

ZLE:	135446900(WRN)

ACHL:

103806213(WRN)

SVG:	106858335(WRN)

MMEA:

130585852(WRN)

HRT:	120752758(WRN)

SATI:

136360779(WRN)

CCIC:

134044105

FPG:	101921016(WRN)

FCH:	102052817(WRN)

CCRI:

104158599(WRN)

NNT:	104408145(WRN)

SHAB:

115605248

ACUN:

113479626(WRN)

TALA:

104368864(WRN)

ACHC:

115344714(WRN)

HALD:

104316211(WRN)

HLE:	104836783(WRN)

AGEN:

126044940

HHAR:

128153514(WRN)

GCL:

127015585

CSTI:

104556226(WRN)

LDI:	104353778(WRN)

MNB:	103768357(WRN)

DPUB:

104296191(WRN)

PPUS:

135178680(WRN)

AVIT:

104272207(WRN)

BRHI:

104490389(WRN)

EGZ:	104134361(WRN)

NNI:	104016604(WRN)

PCRI:

104025275(WRN)

PCAO:

104050974(WRN)

PADL:

103913380(WRN)

AFOR:

103898509(WRN)

FGA:	104080748(WRN)

GSTE:

104251639(WRN)

CBOY:

140651920(WRN)

CLV:	102089359(WRN)

PGUU:

104466444(WRN)

PLET:

104619510(WRN)

EHS:	104503756(WRN)

CMAC:

104478948(WRN)

CUCA:

104063875(WRN)

OHA:	104330284(WRN)

ACAR:

104530418(WRN)

CPEA:

104390596(WRN)

CVF:	104287136(WRN)

RTD:	128909875(WRN)

CRID:

134515833(WRN)

AAM:	106494833(WRN)

AROW:

112978301(WRN)

NPD:	112953455(WRN)

TGT:	104564794(WRN)

DNE:	112993038(WRN)

SCAM:

104152078(WRN)

ASN:	102387381(WRN)

AMJ:	102565260(WRN)

CPOO:

109324390(WRN)

GGN:	109297151(WRN)

PSS:	102450023(WRN)

CMY:	102948137(WRN)

CCAY:

125636125(WRN)

DCC:	119854786(WRN)

CPIC:

101952893(WRN)

TST:	117877753(WRN)

CABI:

116818524(WRN)

MRV:	120406261(WRN)

ACS:	100561844(wrn)

ASAO:

132768147(WRN)

PVT:	110087360(WRN)

SUND:

121921385(WRN)

PBI:	103066362(WRN)

PMUR:

107285620(WRN)

CTIG:

120303860(WRN)

TSR:	106539815(WRN)

PGUT:

117661730(WRN)

APRI:

131193229(WRN)

PTEX:

113444184(WRN)

NSS:	113415467(WRN)

VKO:	123017490(WRN)

PMUA:

114587515(WRN)

PRAF:

128404655(WRN)

ZVI:	118097808(WRN)

HCG:	128343264(WRN)

GJA:	107108055(WRN)

STOW:

125436294(WRN)

EMC:	129334186(WRN)

XLA:	398079(wrn.L)

XTR:	734043(wrn)

NPR:	108798838(WRN)

RTEM:

120914930(WRN)

BBUF:

120989649(WRN)

BGAR:

122926859(WRN)

PWL:	138259627(WRN)

MUO:	115463750(WRN)

GSH:	117367806(WRN)

DRE:	569495(wrn)

SRX:

107715857

SANH:

107665470(wrn)

SGH:

107573262

CCAR:

109068098(wrn)

CAUA:

113109517(wrn)

CGIB:

127965968

PTET:

122353167

LROH:

127171951(wrn)

OMC:	131547892(wrn)

PPRM:

120482888(wrn)

RKG:	130099749(wrn)

MAMB:

125256286(wrn)

CIDE:

127521313

CERY:

137028964(wrn)

MASI:

127432325

TROS:

130550622(wrn)

TDW:	130411363(wrn)

MANU:

129445832(wrn)

PDAB:

135718351 135753700

IPU:

108276782

IFU:	128620118(wrn)

PHYP:

113543536(wrn)

SMEO:

124393279(wrn)

TFD:	113639331(wrn)

TVC:	132863577(wrn)

CGAR:

128545553(wrn)

NGRA:

132873022(wrn)

TRN:	134332589(wrn)

AMEX:

103034404(wrn)

CMAO:

118824668(wrn)

EEE:	113569995(wrn)

CHAR:

105894601(wrn)

SPIL:

134101263(wrn)

SASA:

106571354(wrn)

STRU:

115160073(wrn)

OTW:	112246751(wrn)

OMY:	110523180(wrn)

OGO:	123989483(wrn)

ONE:	115118345(wrn)

OKI:	109868293(wrn)

OKE:	118387269(wrn)

OMM:	135518348(wrn)

OCLA:

139408332

SALP:

111961934(wrn)

SNH:	120025819(wrn)

CCLU:

121581985(wrn)

ELS:	105021732(wrn)

OEP:	134039093(wrn)

SFM:	108929909(wrn)

PKI:	111835389(wrn)

AANG:

118213054(wrn)

AROT:

135238973(wrn)

CCOG:

133142468(wrn)

LOC:	102694137(wrn)

PSPA:

121301087(wrn)

ARUT:

117409515 117962576

PSEX:

120532620(wrn)

LCM:	102350127(WRN)

CMK:	103187853(wrn)

RTP:	109929150(wrn)

CPLA:

122539257(wrn)

HOC:	132833324(wrn)

LERI:

129701091(wrn)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

SKO:

PFLL:

DMO:	Dmoj_GI16195

DAZ:

DNV:

DHE:

SCAC:

LSQ:

CVJ:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:	110674056 5577399

AALB:

109400065 115254366 115259646 115259677

ASUA:

134205037

CQU:	CpipJ_CPIJ007658

CBRI:

CNS:

BCOO:

LLL:

PPAP:

TCA:

TMOL:

DPA:

ESIM:

EFOR:

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:	111518246 111518247

DVV:

NVL:

APLN:

PPYR:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:

MQU:

FOC:

TPAL:

BROR:

IEL:

HAMR:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

MNZ:

MRJ:

PORN:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

CSCU:

CVS:

PTEP:

ABRU:

UDV:	129219155 129234202

SDM:

118186278

LPOL:

106457546

CEL:	CELE_F18C5.2(wrn-1)

CBR:	CBG_02689(Cbr-wrn-1)

CRQ:	GCK72_006280

LOA:	LOAG_17704

HRO:	HELRODRAFT_189333

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:	111112348 111115333

OED:

125665171

MYI:

110463710

PMAX:

117343740

AIRR:

138307516 138314770 138330998 138331000

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

LLON:

NVE:	5501897 5504471

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

138016553 138016564 138021129 138028623 138028829 138033523 138042538 138045937 138051964 138052148 138055727 138057050 138059441

MFOO:

137967376 137982133 137991251 138007925 138009630

PDAM:

113683099

SPIS:

111336972

DGT:	114519843 114540960

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_56013

AQU:

100632682

ATH:	AT5G27680(RECQSIM)

ALY:

9310427

CRB:

17884521

CSAT:

104736747

EUS:	EUTSA_v10003644mg

BRP:

103874517

BNA:	106348681 106411451

BOE:

RSZ:

CPAP:

CIT:

CIC:	CICLE_v10000234mg

PVY:

MINC:

TCC:

GRA:

GHI:	107887642 107927308

GAB:

108470577

HSYR:

120163323

DZI:

111277315

EGR:	104429275 104429276 104448125

RARG:

GMX:

GSJ:

PVU:

VRA:

VAR:

VUN:

VUM:

CCAJ:

APRC:

MTR:

TPRA:

CAM:

PSAT:

VVO:

ADU:

AIP:

AHF:	112710812 112779241

LANG:

109354310

PCIN:

129305825

QSA:	O6P43_011098

FVE:

AANS:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:

MSYL:

PXB:

PCOX:

ZJU:

MNT:	21386406 21386438

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

MEAN:

JCU:

HBR:

MESC:

POP:

PEU:

PALZ:

PNZ:

JRE:

CILL:

CAVE:

AGLU:

QSU:

QLO:	115979176 115981723

TWL:

120009581

VVI:

100257897

VRI:	117929445 117929712

SLY:

SPEN:

SOT:

SSTN:

SDUL:

CANN:

LBB:

NTA:	107761280 107814562

NSY:

NTO:

NAU:

INI:

ITR:

SIND:

OEU:

EGT:

SSPL:

SMIL:

SHIS:

HAN:

ECAD:

LSV:

CCAV:

DCR:

CSIN:

RVL:

AEW:	130773922 130794971

DLT:

127801992

BVG:

104890300

SOE:

110794680

CQI:	110708670 110736869

MOF:

NNU:

MING:

TSS:

PSOM:

OSA:

DOSA:

OBR:

OGL:

BDI:

ATS:

TDC:	119326114 119365063

TAES:

123112731 123180518 123191338

TUA:

125550150

LPER:

127348385

LRD:	124646553 124708098

SBI:

ZMA:

MFLO:

SITA:

SVS:

PVIR:

PHAI:

PAUA:

PDA:	103718623 120107927

EGU:

105032154

MUS:

135618809

ZOF:	122041793 122046318

DCT:

110100837

PEQ:

110027647

AOF:	109819436 109851598

MSIN:

ACAK:

NCOL:

ATR:

CJF:

PPP:	112273562 112275843

OTA:	OT_ostta04g00480

BPG:	Bathy15g00660

MPP:	MICPUCDRAFT_52663

ACAN:

ACA1_331590

GTT:	GUITHDRAFT_112459

» show all

Reference

PMID:17563354

Authors

Kamath-Loeb AS, Lan L, Nakajima S, Yasui A, Loeb LA

Title

Werner syndrome protein interacts functionally with translesion DNA polymerases.

Journal

Proc Natl Acad Sci U S A 104:10394-9 (2007)
DOI:10.1073/pnas.0702513104

Sequence

[hsa:7486]

LinkDB

DBGET integrated database retrieval system