KEGG   PATHWAY: mnp04810
Entry
mnp04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Mustela nigripes (black-footed ferret)
Class
Cellular Processes; Cell motility
Pathway map
mnp04810  Regulation of actin cytoskeleton
mnp04810

Other DBs
GO: 0030036
Organism
Mustela nigripes (black-footed ferret) [GN:mnp]
Gene
132024516  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
132011227  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
132007415  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
132019925  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
132016597  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
132013919  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
132008217  prothrombin [KO:K01313] [EC:3.4.21.5]
132008408  prothrombin [KO:K01313] [EC:3.4.21.5]
132028743  F2R; proteinase-activated receptor 1 [KO:K03914]
132016807  INS; insulin isoform X1 [KO:K04526]
132002212  EGF; pro-epidermal growth factor [KO:K04357]
132028621  FGF1; fibroblast growth factor 1 [KO:K18496]
132028444  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
132015368  FGF8; fibroblast growth factor 8 [KO:K04358]
132016131  FGF5; fibroblast growth factor 5 [KO:K04358]
132002632  FGF9; fibroblast growth factor 9 [KO:K04358]
132010674  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
132004528  FGF3; fibroblast growth factor 3 [KO:K04358]
132004607  FGF4; fibroblast growth factor 4 [KO:K04358]
132027828  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
131998728  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
131998918  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
132020822  FGF6; fibroblast growth factor 6 [KO:K04358]
132028292  FGF10; fibroblast growth factor 10 [KO:K04358]
132006489  FGF20; fibroblast growth factor 20 [KO:K04358]
132007507  FGF16; fibroblast growth factor 16 [KO:K04358]
132004742  FGF19; fibroblast growth factor 19 [KO:K22603]
132005252  FGF21; fibroblast growth factor 21 [KO:K22429]
132020823  FGF23; fibroblast growth factor 23 [KO:K22428]
132026405  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
132019214  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
132000852  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
132029044  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
132025840  INSRR; insulin receptor-related protein isoform X1 [KO:K05086] [EC:2.7.10.1]
132016105  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
132006317  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
132016838  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
132003670  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
132028463  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
132006175  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
132028321  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
132013520  FN1; fibronectin isoform X1 [KO:K05717]
132028298  ITGA1; integrin alpha-1 [KO:K06480]
132028299  ITGA2; integrin alpha-2 [KO:K06481]
132003633  ITGA2B; integrin alpha-IIb [KO:K06476]
132004044  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
132013879  ITGA4; integrin alpha-4 [KO:K06483]
132019757  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
132013834  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
132019766  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
132020145  ITGA8; integrin alpha-8 [KO:K06584]
132011667  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
132001411  ITGA10; LOW QUALITY PROTEIN: integrin alpha-10 [KO:K06586]
131999559  ITGA11; integrin alpha-11 [KO:K06587]
132013895  ITGAV; integrin alpha-V [KO:K06487]
132026714  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
132026679  integrin alpha-M-like isoform X1 [KO:K06461]
132026678  integrin alpha-X-like isoform X1 [KO:K06462]
132003182  ITGAE; integrin alpha-E [KO:K06524]
132020196  ITGB1; integrin beta-1 [KO:K05719]
132012472  ITGB2; integrin beta-2 [KO:K06464]
132004398  ITGB3; integrin beta-3 [KO:K06493]
132003460  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
132011872  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
132013780  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
132019724  ITGB7; integrin beta-7 [KO:K06590]
132015891  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
132011953  KNG1; kininogen-1 isoform X1 [KO:K03898]
132000240  BDKRB2; B2 bradykinin receptor isoform X1 [KO:K03916]
132019827  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
132014913  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
132015171  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
132008205  muscarinic acetylcholine receptor M4 [KO:K04132]
132008379  muscarinic acetylcholine receptor M4 [KO:K04132]
131998679  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
132024987  C5; complement C5 [KO:K03994]
132027499  C6; complement component C6 [KO:K03995]
132028273  C7; complement component C7 [KO:K03996]
132000925  C8A; complement component C8 alpha chain [KO:K03997]
132000926  C8B; complement component C8 beta chain isoform X1 [KO:K03998]
132024226  C8G; complement component C8 gamma chain [KO:K03999]
132028266  C9; complement component C9 [KO:K04000]
132026441  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
132004175  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
132000997  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
132020499  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
132006930  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
132024881  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
132014328  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
132005689  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
132023406  CRKL; crk-like protein [KO:K04438]
132004503  CRK; adapter molecule crk isoform X1 [KO:K04438]
132016872  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
132021907  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
132021307  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
131999927  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
132016391  HRAS; GTPase HRas isoform X1 [KO:K02833]
132027717  LOW QUALITY PROTEIN: ras protein let-60-like [KO:K02833]
132019561  KRAS; GTPase KRas isoform X1 [KO:K07827]
132001334  NRAS; GTPase NRas [KO:K07828]
132002077  LOW QUALITY PROTEIN: GTPase NRas-like [KO:K07828]
132005677  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
132022713  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
132011827  MRAS; ras-related protein M-Ras [KO:K07831]
132007713  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
132001008  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
132010495  PIK3CB; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
132012033  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
132000809  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
132011173  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
132028693  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
132001226  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
132024270  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
132010871  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
132012341  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
132007524  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
132015636  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
132011570  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
132014538  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
131999543  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
132010799  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
132008541  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
132023779  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
132026755  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
132000311  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
132025379  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
132005674  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
132002967  RGCC; regulator of cell cycle RGCC isoform X1 [KO:K26108]
132004999  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
132026896  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
132005749  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
132011318  RHOA; transforming protein RhoA [KO:K04513]
132026481  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
132019253  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
132004336  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
132000635  cell division control protein 42 homolog [KO:K04393]
132001733  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
132017383  cell division control protein 42 homolog [KO:K04393]
132024667  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
132011906  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
132006661  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
132004757  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
132021731  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
131999625  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
132002789  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
132004571  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
132023518  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
132021141  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
132022711  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
132018517  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
132011867  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
132006129  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
132023151  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
132017911  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
132021249  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
132019394  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
132025613  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
132005432  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
132023807  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
131998882  MYL5; myosin light chain 5 [KO:K12753]
132015131  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
132021891  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
132027152  MYL10; myosin regulatory light chain 10 [KO:K12756]
132023504  myosin regulatory light polypeptide 9 [KO:K12757]
132023505  myosin regulatory light chain 12B [KO:K12757]
132009910  myosin regulatory light chain 12B-like [KO:K12757]
132017265  myosin regulatory light chain 12B-like [KO:K12757]
132026721  MYL11; myosin regulatory light chain 11 isoform X1 [KO:K12758]
132004199  MYH10; myosin-10 isoform X1 [KO:K10352]
132019267  MYH9; myosin-9 [KO:K10352]
132005207  MYH14; myosin-14 isoform X1 [KO:K10352]
132026876  MYH11; myosin-11 isoform X1 [KO:K10352]
132028607  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
132007551  DIAPH2; protein diaphanous homolog 2 [KO:K05741]
132001864  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
132001468  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
132024834  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
132010781  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
132003800  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
132019848  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [KO:K00920] [EC:2.7.1.149]
132020101  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
132013506  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
132026631  LIMK1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
132023348  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
132002527  DIAPH3; protein diaphanous homolog 3 [KO:K05745]
132003830  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
132025524  ENAH; protein enabled homolog isoform X1 [KO:K05746]
132015748  WASL; actin nucleation-promoting factor WASL [KO:K23612]
132001878  WASF2; actin-binding protein WASF2 [KO:K05748]
131999131  CYFIP1; cytoplasmic FMR1-interacting protein 1 [KO:K05749]
132028360  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
132019758  NCKAP1L; nck-associated protein 1-like [KO:K05750]
132013888  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
132013476  ABI2; abl interactor 2 isoform X1 [KO:K05751]
132015216  probable protein BRICK1 [KO:K05752]
132011552  BRK1; protein BRICK1 [KO:K05752]
132018358  WASF1; actin-binding protein WASF1 isoform X1 [KO:K05753]
132021498  ACTR2; actin-related protein 2 [KO:K17260]
132015540  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
132013941  ACTR3; actin-related protein 3 [KO:K18584]
132026505  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
132026506  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
132013536  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
132023745  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
132011543  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
132024427  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein isoform X1 [KO:K05754]
132025452  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
132003745  ACTG1; actin, cytoplasmic 2 [KO:K05692]
132026463  ACTB; actin, cytoplasmic 1 [KO:K05692]
132003855  PFN1; profilin-1 [KO:K05759]
132012135  PFN2; profilin-2 isoform X1 [KO:K05759]
132027847  PFN3; profilin-3 [KO:K05759]
132021177  PFN4; profilin-4 [KO:K05759]
132023227  PXN; paxillin isoform X1 [KO:K05760]
132018429  EZR; ezrin isoform X1 [KO:K08007]
132028605  RDX; radixin [KO:K05762]
132006703  MSN; moesin [KO:K05763]
132005238  thymosin beta-4-like [KO:K05764]
132008041  thymosin beta-4 [KO:K05764]
132016370  thymosin beta-4-like [KO:K05764]
132005156  thymosin beta-4-like [KO:K05764]
132012202  thymosin beta-4-like [KO:K05764]
132013210  thymosin beta-4-like [KO:K05764]
132006969  TMSB4X; thymosin beta-4 [KO:K05764]
132014019  thymosin beta-4 [KO:K05764]
132018557  CFL1; cofilin-1 isoform X1 [KO:K05765]
131999879  CFL2; cofilin-2 [KO:K05765]
132023255  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
132017997  SSH3; protein phosphatase Slingshot homolog 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
132004334  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
132016526  VCL; vinculin isoform X1 [KO:K05700]
131999019  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
132025853  IQGAP3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
132028740  IQGAP2; ras GTPase-activating-like protein IQGAP2 [KO:K05767]
132015909  SCIN; scinderin [KO:K05768]
132024458  GSN; gelsolin isoform X1 [KO:K05768]
132004838  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
132000063  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
132010709  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
132028849  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
132002862  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
mnp04010  MAPK signaling pathway
mnp04510  Focal adhesion
mnp04520  Adherens junction
KO pathway
ko04810   
LinkDB

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