KEGG   PATHWAY: aml04510
Entry
aml04510                    Pathway                                
Name
Focal adhesion - Ailuropoda melanoleuca (giant panda)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
aml04510  Focal adhesion
aml04510

Other DBs
GO: 0005925
Organism
Ailuropoda melanoleuca (giant panda) [GN:aml]
Gene
100476237  COL1A1; collagen alpha-1(I) chain [KO:K06236]
100474885  COL1A2; collagen alpha-2(I) chain [KO:K06236]
100474711  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
100478914  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
100478752  COL4A1; collagen alpha-1(IV) chain isoform X4 [KO:K06237]
100479004  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
100479688  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
100480195  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
100478660  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
100483347  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
100464071  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
100465530  COL6A3; LOW QUALITY PROTEIN: collagen alpha-3(VI) chain [KO:K06238]
100463941  COL6A6; LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
100484892  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
105241345  collagen alpha-4(VI) chain [KO:K06238]
105240522  COL9A1; collagen alpha-1(IX) chain isoform X2 [KO:K08131]
100477095  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
105240457  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
100484712  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
100465830  LAMA1; laminin subunit alpha-1 [KO:K05637]
100484669  LAMA3; laminin subunit alpha-3 isoform X3 [KO:K06240]
100482780  LAMA5; laminin subunit alpha-5 [KO:K06240]
100472419  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
100472572  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
100477974  LAMB2; laminin subunit beta-2 [KO:K06243]
100465597  LAMB3; laminin subunit beta-3 isoform X2 [KO:K06244]
100477380  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
100476326  LAMC1; laminin subunit gamma-1 [KO:K05635]
100475077  LAMC2; laminin subunit gamma-2 [KO:K06246]
100477198  LAMC3; laminin subunit gamma-3 [KO:K06247]
100474986  CHAD; chondroadherin [KO:K06248]
100480458  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
100465724  THBS1; thrombospondin-1 [KO:K16857]
100479895  COMP; cartilage oligomeric matrix protein [KO:K04659]
100481026  THBS2; thrombospondin-2 isoform X2 [KO:K04659]
100475917  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
100471588  THBS4; thrombospondin-4 [KO:K04659]
100464134  FN1; fibronectin isoform X1 [KO:K05717]
100475539  SPP1; osteopontin isoform X2 [KO:K06250]
100480900  VTN; vitronectin [KO:K06251]
100478371  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
100468841  TNR; tenascin-R isoform X1 [KO:K06252]
100471963  TNN; tenascin-N [KO:K06252]
100473350  TNC; LOW QUALITY PROTEIN: tenascin [KO:K06252]
100468710  VWF; von Willebrand factor [KO:K03900]
100476112  IBSP; bone sialoprotein 2 [KO:K06253]
100476147  ITGA1; integrin alpha-1 isoform X2 [KO:K06480]
100476403  ITGA2; integrin alpha-2 [KO:K06481]
100484185  ITGA2B; integrin alpha-IIb [KO:K06476]
100479748  ITGA3; integrin alpha-3 [KO:K06482]
100464670  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
100479433  ITGA5; integrin alpha-5 [KO:K06484]
100474079  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
100475280  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
100478512  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
100480310  ITGA9; integrin alpha-9 [KO:K06585]
100483953  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
100479237  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
100483894  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
100482697  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
100476256  ITGB3; integrin beta-3 [KO:K06493]
100469928  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
100476382  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
100471721  ITGB6; integrin beta-6 isoform X3 [KO:K06589]
100474212  ITGB7; integrin beta-7 [KO:K06590]
100468149  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
100479179  EMP2; epithelial membrane protein 2 [KO:K26256]
100473486  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100475543  PDGFB; platelet-derived growth factor subunit B isoform X4 [KO:K17386]
100479872  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
100481171  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
100467733  pro-epidermal growth factor isoform X1 [KO:K04357]
100473254  IGF1; insulin-like growth factor I isoform X3 [KO:K05459]
100482983  VEGFA; vascular endothelial growth factor A [KO:K05448]
100465735  VEGFB; vascular endothelial growth factor B [KO:K16858]
100480980  PGF; placenta growth factor isoform X1 [KO:K16859]
100482213  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
100483046  VEGFC; vascular endothelial growth factor C [KO:K05449]
100463560  HGF; hepatocyte growth factor isoform X5 [KO:K05460]
100464991  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
100472005  PDGFRB; LOW QUALITY PROTEIN: platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100471374  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100484938  KDR; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
100483462  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
100478767  FLT4; vascular endothelial growth factor receptor 3 isoform X3 [KO:K05097] [EC:2.7.10.1]
100480742  MET; hepatocyte growth factor receptor isoform X2 [KO:K05099] [EC:2.7.10.1]
100480029  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
100466401  EMP1; epithelial membrane protein 1 [KO:K26255]
100474271  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100470620  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
100471100  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
100476723  RHOA; transforming protein RhoA [KO:K04513]
100478130  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
100474469  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
100466003  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
100483724  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
100480867  MYL5; myosin light chain 5 [KO:K12753]
100475493  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
100465571  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
100480951  MYL10; myosin regulatory light chain 10 [KO:K12756]
100471142  myosin regulatory light chain 12B [KO:K12757]
100472299  myosin regulatory light polypeptide 9 isoform X2 [KO:K12757]
117799888  myosin regulatory light chain 2, smooth muscle minor isoform-like isoform X1 [KO:K12757]
100480191  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
117799351  myosin regulatory light chain 2, skeletal muscle isoform-like [KO:K12758]
100464499  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100471456  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100476029  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
100483995  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
100470069  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X8 [KO:K12329]
100476917  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
100473453  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
100481263  MYLK; myosin light chain kinase, smooth muscle isoform X5 [KO:K00907] [EC:2.7.11.18]
100469244  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
100474254  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
100472550  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
100476738  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
100478325  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X5 [KO:K00889] [EC:2.7.1.68]
100466132  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100481739  actin [KO:K05692]
117800125  actin, cytoplasmic 1 [KO:K05692]
117800181  actin, cytoplasmic type 5 isoform X1 [KO:K05692]
117800361  actin, cytoplasmic 1-like [KO:K05692]
117800408  actin, cytoplasmic 1 [KO:K05692]
100479998  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X2 [KO:K04349]
100476150  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
100472341  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
100467263  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
100471856  TLN1; talin-1 [KO:K06271]
100469891  TLN2; talin-2 [KO:K06271]
100467791  FLNA; filamin-A isoform X1 [KO:K04437]
100481308  FLNB; filamin-B isoform X5 [KO:K27392]
100474505  PXN; paxillin isoform X4 [KO:K05760]
100473650  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
100479855  ZYX; zyxin [KO:K06273]
100478770  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
100476722  VCL; vinculin isoform X1 [KO:K05700]
100466429  PARVA; alpha-parvin [KO:K06275]
100475418  PARVG; gamma-parvin [KO:K06275]
100475657  PARVB; LOW QUALITY PROTEIN: beta-parvin [KO:K06275]
100473305  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
100468763  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100480414  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100465793  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100479224  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
100477834  CTNNB1; catenin beta-1 [KO:K02105]
100477326  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100478007  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100484719  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
100464496  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
100463775  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100479294  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100479580  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100475291  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100483828  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100467916  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100469483  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100480126  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
100480092  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
100476091  VAV1; proto-oncogene vav isoform X3 [KO:K05730]
100465648  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100469737  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100468971  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
100472811  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100475388  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
100481001  PAK3; serine/threonine-protein kinase PAK 3 isoform X8 [KO:K05733] [EC:2.7.11.1]
100470043  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
100481254  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
100464295  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
100465076  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
100479448  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X2 [KO:K05726]
100466609  CRKL; crk-like protein [KO:K04438]
100467322  CRK; adapter molecule crk isoform X1 [KO:K04438]
100469133  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
100478465  RAPGEF1; rap guanine nucleotide exchange factor 1 [KO:K06277]
100471801  RAP1A; ras-related protein Rap-1A [KO:K04353]
100480240  RAP1B; ras-related protein Rap-1b [KO:K07836]
100477951  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100482196  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100477600  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
100483834  JUN; transcription factor AP-1 [KO:K04448]
100469346  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
100480993  CAV1; caveolin-1 isoform X1 [KO:K06278]
100481243  CAV2; caveolin-2 [KO:K12958]
100473119  CAV3; caveolin-3 [KO:K12959]
100470931  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
100480856  SHC1; SHC-transforming protein 1 isoform X2 [KO:K06279]
100480694  SHC2; LOW QUALITY PROTEIN: SHC-transforming protein 2 [KO:K17447]
100468080  SHC3; SHC-transforming protein 3 [KO:K17448]
100475137  SHC4; SHC-transforming protein 4 isoform X2 [KO:K17449]
100468916  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
100474396  SOS2; son of sevenless homolog 2 isoform X9 [KO:K03099]
100482526  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100473836  HRAS; GTPase HRas isoform X1 [KO:K02833]
100482255  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100478039  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100470035  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100472388  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100481494  ELK1; ETS domain-containing protein Elk-1 isoform X2 [KO:K04375]
100469787  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
100471517  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100479467  CCND3; G1/S-specific cyclin-D3 isoform X4 [KO:K10152]
100477152  baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
100477406  baculoviral IAP repeat-containing protein 2 [KO:K16060]
100471203  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
100473937  BAD; bcl2-associated agonist of cell death [KO:K02158]
100484344  BCL2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
aml04010  MAPK signaling pathway
aml04060  Cytokine-cytokine receptor interaction
aml04070  Phosphatidylinositol signaling system
aml04110  Cell cycle
aml04151  PI3K-Akt signaling pathway
aml04310  Wnt signaling pathway
aml04512  ECM-receptor interaction
aml04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
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