Entry
Name
Cytokine-cytokine receptor interaction - Bos taurus (cow)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
bta04060 Cytokine-cytokine receptor interaction
Ortholog table
Organism
Bos taurus (cow) [GN:
bta ]
Gene
281212 GRO1; growth-regulated protein homolog alpha precursor [KO:K05505 ]
281214 CXCL2; growth-regulated protein homolog gamma precursor [KO:K05505 ]
613667 CXCL3; chemokine (C-X-C motif) ligand 3 precursor [KO:K05505 ]
615107 CXCL10; C-X-C motif chemokine 10 precursor [KO:K12671 ]
516104 CXCL11; C-X-C motif chemokine 11 precursor [KO:K12672 ]
511674 CXCL13; C-X-C motif chemokine 13 precursor [KO:K10032 ]
613811 CXCL12; stromal cell-derived factor 1 precursor [KO:K10031 ]
511671 CXCL16; C-X-C motif chemokine 16 precursor [KO:K10035 ]
511771 CXCL14; C-X-C motif chemokine 14 precursor [KO:K10033 ]
788717 CXCL17; C-X-C motif chemokine 17 precursor [KO:K22627 ]
281095 CSF2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427 ]
281097 CSH2; chorionic somatomammotropin hormone 2 isoform 2 [KO:K05439 ]
281429 PRP1; placental prolactin-related protein 1 precursor [KO:K05439 ]
281430 PRP3; placental prolactin-related protein 3 precursor [KO:K05439 ]
282007 PRP14; prolactin-related protein 14 precursor [KO:K05439 ]
404081 PRP6; prolactin-related protein VI precursor [KO:K05439 ]
406200 PRP4; placental prolactin-related protein 4 precursor [KO:K05439 ]
497206 PRP-VII; prolactin-related protein VII precursor [KO:K05439 ]
519859 PRP9; prolactin-related protein IX precursor [KO:K05439 ]
613971 PRP8; prolactin-related protein VIII precursor [KO:K05439 ]
790470 PRP2; placental prolactin-related protein 2 precursor [KO:K05439 ]
281096 CSF3; granulocyte colony-stimulating factor precursor [KO:K05423 ]
281856 IL12A; interleukin-12 subunit alpha precursor [KO:K05406 ]
281857 IL12B; interleukin-12 subunit beta precursor [KO:K05425 ]
511022 IL23A; interleukin-23 subunit alpha precursor [KO:K05426 ]
614927 IL27; interleukin-27 subunit alpha precursor [KO:K22629 ]
514933 EBI3; interleukin-27 subunit beta precursor [KO:K24476 ]
100336481 CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421 ]
280840 LIF; leukemia inhibitory factor precursor [KO:K05419 ]
617556 LOW QUALITY PROTEIN: interferon alpha-1-like [KO:K05414 ]
515953 LOW QUALITY PROTEIN: interferon omega-1-like [KO:K05440 ]
281860 IL1RN; interleukin-1 receptor antagonist protein precursor [KO:K05481 ]
518514 IL36RN; interleukin-36 receptor antagonist protein [KO:K05483 ]
505800 IL32; uncharacterized protein IL32 isoform X2 [KO:K22632 ]
281094 CSF1; macrophage colony-stimulating factor 1 precursor [KO:K05453 ]
505521 TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
407111 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
514239 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
507215 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
513836 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
100551513 TNFSF12; tumor necrosis factor ligand superfamily member 12 [KO:K05474 ]
574056 TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
521748 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
539800 TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
768081 TNFSF18; tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
538567 TNFSF13; tumor necrosis factor ligand superfamily member 13 [KO:K05475 ]
504507 TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
282089 TGFB1; transforming growth factor beta-1 proprotein precursor [KO:K13375 ]
534069 TGFB2; transforming growth factor beta-2 proprotein precursor [KO:K13376 ]
538957 TGFB3; transforming growth factor beta-3 proprotein [KO:K13377 ]
618677 GDF15; growth/differentiation factor 15 precursor [KO:K05504 ]
540384 GDF2; growth/differentiation factor 2 precursor [KO:K05503 ]
538874 BMP10; bone morphogenetic protein 10 precursor [KO:K22670 ]
539527 BMP3; bone morphogenetic protein 3 precursor [KO:K05496 ]
539510 GDF10; growth/differentiation factor 10 precursor [KO:K22674 ]
281187 MSTN; growth/differentiation factor 8 precursor [KO:K05497 ]
282574 GDF9; growth/differentiation factor 9 precursor [KO:K22673 ]
280718 AMH; muellerian-inhibiting factor precursor [KO:K04665 ]
615037 BMP2; bone morphogenetic protein 2 precursor [KO:K21283 ]
407216 BMP4; bone morphogenetic protein 4 precursor [KO:K04662 ]
539559 GDF5; growth/differentiation factor 5 precursor [KO:K04664 ]
407175 GDF6; growth/differentiation factor 6 precursor [KO:K20012 ]
286859 GDF7; growth/differentiation factor 7 precursor [KO:K20013 ]
353351 BMP15; bone morphogenetic protein 15 precursor [KO:K05498 ]
507682 BMP5; bone morphogenetic protein 5 precursor [KO:K04663 ]
617566 BMP6; bone morphogenetic protein 6 isoform X1 [KO:K16620 ]
540595 BMP7; bone morphogenetic protein 7 precursor [KO:K16621 ]
788948 BMP8A; bone morphogenetic protein 8A precursor [KO:K16622 ]
510668 CCR7; C-C chemokine receptor type 7 precursor [KO:K04182 ]
281861 IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068 ]
510185 interleukin-2 receptor subunit beta isoform X2 [KO:K05069 ]
281862 IL2RG; cytokine receptor common subunit gamma precursor [KO:K05070 ]
404154 IL4R; interleukin-4 receptor subunit alpha precursor [KO:K05071 ]
521554 IL7R; interleukin-7 receptor subunit alpha precursor [KO:K05072 ]
615030 IL15RA; interleukin-15 receptor subunit alpha isoform X2 [KO:K05074 ]
529792 cytokine receptor-like factor 2 isoform X1 [KO:K05078 ]
100299249 IL3RA; interleukin-3 receptor subunit alpha isoform X3 [KO:K04737 ]
528530 CSF2RB; cytokine receptor common subunit beta precursor [KO:K04738 ]
615848 IL5RA; interleukin-5 receptor subunit alpha isoform X1 [KO:K05067 ]
407110 IL13RA1; interleukin-13 receptor subunit alpha-1 precursor [KO:K05076 ]
616008 IL13RA2; interleukin-13 receptor subunit alpha-2 precursor [KO:K05077 ]
281422 PRLR; prolactin receptor long isoform precursor [KO:K05081 ]
132344945 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
507359 IL6R; interleukin-6 receptor subunit alpha precursor [KO:K05055 ]
522155 IL6ST; interleukin-6 receptor subunit beta isoform X2 [KO:K05060 ]
508932 IL11RA; interleukin-11 receptor subunit alpha precursor [KO:K05056 ]
524299 IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063 ]
282452 IL12RB2; interleukin-12 receptor subunit beta-2 precursor [KO:K05064 ]
514529 IL27RA; interleukin-27 receptor subunit alpha precursor [KO:K19598 ]
522636 IL31RA; interleukin-31 receptor subunit alpha precursor [KO:K22630 ]
539548 CNTFR; ciliary neurotrophic factor receptor subunit alpha precursor [KO:K05059 ]
539504 LIFR; leukemia inhibitory factor receptor [KO:K05058 ]
514720 OSMR; oncostatin-M-specific receptor subunit beta precursor [KO:K05057 ]
513478 IL10RA; interleukin-10 receptor subunit alpha precursor [KO:K05134 ]
767864 IL10RB; interleukin-10 receptor subunit beta precursor [KO:K05135 ]
509038 IL20RA; interleukin-20 receptor subunit alpha precursor [KO:K05136 ]
534581 IL20RB; interleukin-20 receptor subunit beta [KO:K05137 ]
508044 IL22RA1; interleukin-22 receptor subunit alpha-1 precursor [KO:K05138 ]
616826 IFNLR1; interferon lambda receptor 1 precursor [KO:K05140 ]
282257 IFNAR1; interferon alpha/beta receptor 1 precursor [KO:K05130 ]
282258 IFNAR2; interferon alpha/beta receptor 2 precursor [KO:K05131 ]
508619 IFNGR1; interferon gamma receptor 1 precursor [KO:K05132 ]
514889 IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133 ]
515640 IL1R1; interleukin-1 receptor type 1 precursor [KO:K04386 ]
539334 IL1RAP; interleukin-1 receptor accessory protein precursor [KO:K04723 ]
515700 IL1R2; interleukin-1 receptor type 2 precursor [KO:K04387 ]
522114 IL1RL2; interleukin-1 receptor-like 2 precursor [KO:K05172 ]
407221 IL18R1; interleukin-18 receptor 1 isoform X2 [KO:K05173 ]
493716 IL18RAP; interleukin-18 receptor accessory protein [KO:K05174 ]
520709 IL1RL1; interleukin-1 receptor-like 1 precursor [KO:K05171 ]
525040 IL17RA; interleukin-17 receptor A isoform X1 [KO:K05164 ]
504855 IL17RC; interleukin-17 receptor C precursor [KO:K05166 ]
783335 IL17RE; interleukin-17 receptor E isoform X1 [KO:K05168 ]
407098 CD4; T-cell surface glycoprotein CD4 precursor [KO:K06454 ]
282527 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158 ]
338033 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B precursor [KO:K05141 ]
504653 LTBR; tumor necrosis factor receptor superfamily member 3 precursor [KO:K03159 ]
789154 TNFRSF6B; tumor necrosis factor receptor superfamily member 6B precursor [KO:K05143 ]
282488 FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390 ]
783432 TNFRSF25; tumor necrosis factor receptor superfamily member 25 precursor [KO:K05160 ]
784541 tumor necrosis factor receptor superfamily member 10A isoform X1 [KO:K04722 ]
104968444 tumor necrosis factor receptor superfamily member 10C [KO:K04722 ]
782274 TNFRSF10D; tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain [KO:K22702 ]
537922 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
613947 EDAR; tumor necrosis factor receptor superfamily member EDAR [KO:K05162 ]
100301324 EDA2R; tumor necrosis factor receptor superfamily member 27 [KO:K05163 ]
353110 NGFR; tumor necrosis factor receptor superfamily member 16 precursor [KO:K02583 ]
523822 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B precursor [KO:K05148 ]
530884 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A isoform X3 [KO:K05147 ]
617439 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A isoform 1 precursor [KO:K05149 ]
614780 TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145 ]
286849 CD40; tumor necrosis factor receptor superfamily member 5 precursor [KO:K03160 ]
520341 TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146 ]
528782 TNFRSF4; tumor necrosis factor receptor superfamily member 4 precursor [KO:K05142 ]
516256 TNFRSF18; tumor necrosis factor receptor superfamily member 18 precursor [KO:K05154 ]
101908051 TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
617948 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B isoform X1 [KO:K05150 ]
618516 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151 ]
768037 TNFRSF19; tumor necrosis factor receptor superfamily member 19 precursor [KO:K05155 ]
505716 RELT; tumor necrosis factor receptor superfamily member 19L isoform X2 [KO:K05156 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
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