KEGG   PATHWAY: cbai05170
Entry
cbai05170                   Pathway                                
Name
Human immunodeficiency virus 1 infection - Camelus bactrianus (Bactrian camel)
Description
Human immunodeficiency virus type 1 (HIV-1) , the causative agent of AIDS (acquired immunodeficiency syndrome), is a lentivirus belonging to the Retroviridae family. The primary cell surface receptor for HIV-1, the CD4 protein, and the co-receptor for HIV-1, either CCR5 or CXCR4, are found on macrophages and T lymphocytes. At the earliest step, sequential binding of virus envelope (Env) glycoprotein gp120 to CD4 and the co-receptor CCR5 or CXCR4 facilitates HIV-1 entry and has the potential to trigger critical signaling that may favor viral replication. At advanced stages of the disease, HIV-1 infection results in dramatic induction of T-cell (CD4+ T and CD8+ T cell) apoptosis both in infected and uninfected bystander T cells, a hallmark of HIV-1 pathogenesis. On the contrary, macrophages are resistant to the cytopathic effect of HIV-1 and produce virus for longer periods of time.
Class
Human Diseases; Infectious disease: viral
Pathway map
cbai05170  Human immunodeficiency virus 1 infection
cbai05170

Organism
Camelus bactrianus (Bactrian camel) [GN:cbai]
Gene
105071091  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
105081727  BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
105082644  FBXW11; F-box/WD repeat-containing protein 11 [KO:K03362]
105082123  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
105068877  CUL1; cullin-1 [KO:K03347]
105073197  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
105083390  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
105078728  CCR5; C-C chemokine receptor type 5 [KO:K04180]
105080234  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
105062385  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
105063651  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
105078712  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha [KO:K04534]
105063312  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105071167  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105066839  PIK3CB; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105082679  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105064416  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
105065663  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
105074777  focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
105063850  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
105080562  paxillin isoform X1 [KO:K05760]
105070566  CRKL; crk-like protein [KO:K04438]
105071519  CRK; adapter molecule crk [KO:K04438]
105079975  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105083596  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105062855  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105070974  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105070333  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
105065845  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
105067913  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105070689  RELA; transcription factor p65 [KO:K04735]
105075289  FOS; proto-oncogene c-Fos [KO:K04379]
105071674  JUN; transcription factor AP-1 [KO:K04448]
105070634  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
105069943  HRAS; GTPase HRas isoform X1 [KO:K02833]
105062297  KRAS; GTPase KRas [KO:K07827]
105079555  NRAS; GTPase NRas [KO:K07828]
105067475  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105069422  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105078209  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105082839  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105069349  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105067298  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
105078179  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
105071939  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
105078942  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
105074761  ITPR1; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
105062304  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
105064212  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
105074723  calmodulin-like [KO:K02183]
105079857  CALM1; calmodulin [KO:K02183]
105079032  CALM2; calmodulin [KO:K02183]
105062547  CALM3; calmodulin [KO:K02183]
105069522  CALML4; calmodulin-like protein 4 [KO:K02183]
105071194  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
105075369  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105067906  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
105068979  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105069046  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
105071843  nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
105074856  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
105068820  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
105063941  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
105073669  PRKCB; LOW QUALITY PROTEIN: protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
105074322  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105071051  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
105067755  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
105071086  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
105063316  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
105080494  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
105070137  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
105075111  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
105069319  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4-like [KO:K04541]
105062549  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
105082939  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
105068344  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04347]
105065706  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
105082944  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
105077365  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
105073153  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
105065540  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
105083612  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
105072383  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
105075749  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
105062831  PAK4; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
105082994  PAK7; serine/threonine-protein kinase PAK 7 isoform X1 [KO:K05736] [EC:2.7.11.1]
105076891  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
105082735  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
105066098  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
105079144  CFL2; cofilin-2 [KO:K05765]
105070695  CFL1; cofilin-1 [KO:K05765]
105074074  TNF; tumor necrosis factor [KO:K03156]
105071154  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
105073585  BCL2L1; bcl-2-like protein 1 [KO:K04570]
105079727  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
105070721  TLR4; LOW QUALITY PROTEIN: toll-like receptor 4 [KO:K10160]
105061728  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
105081383  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
105076069  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
105076500  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
105073104  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
105077308  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
105064109  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
105081887  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
105071245  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
105076053  IKBKG; NF-kappa-B essential modulator [KO:K07210]
105076396  NF-kappa-B essential modulator-like [KO:K07210]
105079152  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
105061913  LOW QUALITY PROTEIN: interferon alpha-2-like [KO:K05414]
105082393  interferon alpha-1-like [KO:K05414]
105061875  interferon alpha-1-like [KO:K05414]
105061876  interferon alpha-1-like [KO:K05414]
105061880  interferon alpha-14-like [KO:K05414]
105061881  IFNB1; interferon beta [KO:K05415]
105064175  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105064176  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105070806  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
105070807  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
105075609  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105077723  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105062001  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105064893  MB21D1; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
105082187  TMEM173; stimulator of interferon genes protein isoform X1 [KO:K12654]
105081359  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
105062642  IRF3; interferon regulatory factor 3 [KO:K05411]
105073500  SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [KO:K22544] [EC:3.1.5.-]
105076717  tripartite motif-containing protein 5-like isoform X1 [KO:K10648] [EC:2.3.2.27]
105071112  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105079771  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
105074812  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
105064517  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
105068625  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
105084150  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
105063918  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
105078286  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
105070302  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
105081852  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
105070436  FADD; FAS-associated death domain protein [KO:K02373]
105082299  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
105076073  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
105062612  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
105064215  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
105073903  BCL2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
105079817  cytochrome c [KO:K08738]
105065989  cytochrome c [KO:K08738]
105070945  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
105067685  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105067821  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
105067817  CD3G; T-cell surface glycoprotein CD3 gamma chain isoform X1 [KO:K06452]
105067818  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
105068057  CD247; T-cell surface glycoprotein CD3 zeta chain isoform X1 [KO:K06453]
105064241  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
105064243  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
105064223  TAPBP; tapasin [KO:K08058]
105076963  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
105068326  CALR; calreticulin [KO:K08057]
105074080  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
105074082  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
105074083  LOW QUALITY PROTEIN: histocompatibility antigen-related [KO:K06751]
105074084  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
105074117  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
105065248  HLA class I histocompatibility antigen, Cw-8 alpha chain-like [KO:K06751]
105061640  putative HLA class I histocompatibility antigen, alpha chain H [KO:K06751]
105066059  AP1B1; AP-1 complex subunit beta-1 [KO:K12392]
105068789  AP1G2; AP-1 complex subunit gamma-like 2 [KO:K12391]
105073484  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
105082527  AP1M1; AP-1 complex subunit mu-1 isoform X1 [KO:K12393]
105068388  AP1M2; AP-1 complex subunit mu-2 isoform X1 [KO:K12393]
105079300  AP1S2; AP-1 complex subunit sigma-2 [KO:K12394]
105067243  AP1S1; AP-1 complex subunit sigma-1A isoform X1 [KO:K12394]
105064104  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
105076977  B2M; beta-2-microglobulin [KO:K08055]
105064833  TCEB2; transcription elongation factor B polypeptide 2 [KO:K03873]
105066169  TCEB1; transcription elongation factor B polypeptide 1 [KO:K03872]
105069059  CUL5; cullin-5 [KO:K10612]
105066825  RNF7; RING-box protein 2 isoform X1 [KO:K10611]
105080211  VPRBP; protein VPRBP [KO:K11789] [EC:2.7.11.1]
105070099  DDB1; DNA damage-binding protein 1 [KO:K10610]
105075949  CUL4B; cullin-4B [KO:K10609]
105066884  CUL4A; cullin-4A [KO:K10609]
105080329  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
105066817  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
105074175  CHEK1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
105082163  CDC25C; M-phase inducer phosphatase 3 [KO:K05867] [EC:3.1.3.48]
105076805  WEE1; wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
105063014  WEE2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
105064414  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
105080458  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
105076105  CCNB3; G2/mitotic-specific cyclin-B3 [KO:K21771]
105071301  CDK1; cyclin-dependent kinase 1 isoform X1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:22749173
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Evans VA, Khoury G, Saleh S, Cameron PU, Lewin SR
  Title
HIV persistence: chemokines and their signalling pathways.
  Journal
Cytokine Growth Factor Rev 23:151-7 (2012)
DOI:10.1016/j.cytogfr.2012.05.002
Reference
PMID:23806647
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Abbas W, Herbein G
  Title
Plasma membrane signaling in HIV-1 infection.
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Biochim Biophys Acta 1838:1132-42 (2014)
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PMID:20041213
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Wu Y, Yoder A
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Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.
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PLoS Pathog 5:e1000520 (2009)
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PMID:22085380
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Choi WT, Duggineni S, Xu Y, Huang Z, An J
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Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4).
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J Med Chem 55:977-94 (2012)
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Reference
PMID:21321123
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Vorster PJ, Guo J, Yoder A, Wang W, Zheng Y, Xu X, Yu D, Spear M, Wu Y
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LIM kinase 1 modulates cortical actin and CXCR4 cycling and is activated by HIV-1 to initiate viral infection.
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J Biol Chem 286:12554-64 (2011)
DOI:10.1074/jbc.M110.182238
Reference
PMID:15817946
  Authors
Das SR, Jameel S
  Title
Biology of the HIV Nef protein.
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Indian J Med Res 121:315-32 (2005)
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PMID:24822052
  Authors
Roy N, Pacini G, Berlioz-Torrent C, Janvier K
  Title
Mechanisms underlying HIV-1 Vpu-mediated viral egress.
  Journal
Front Microbiol 5:177 (2014)
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Reference
PMID:22090097
  Authors
Magadan JG, Bonifacino JS
  Title
Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu.
  Journal
J Virol 86:757-72 (2012)
DOI:10.1128/JVI.05933-11
Reference
PMID:26056579
  Authors
Kumar A, Herbein G
  Title
The macrophage: a therapeutic target in HIV-1 infection.
  Journal
Mol Cell Ther 2:10 (2014)
DOI:10.1186/2052-8426-2-10
Reference
PMID:20672047
  Authors
Yokota S, Okabayashi T, Fujii N
  Title
The battle between virus and host: modulation of Toll-like receptor signaling pathways by virus infection.
  Journal
Mediators Inflamm 2010:184328 (2010)
DOI:10.1155/2010/184328
Reference
PMID:26628325
  Authors
Sauter D, Kirchhoff F
  Title
HIV replication: a game of hide and sense.
  Journal
Curr Opin HIV AIDS 11:173-81 (2016)
DOI:10.1097/COH.0000000000000233
Reference
PMID:25988887
  Authors
Altfeld M, Gale M Jr
  Title
Innate immunity against HIV-1 infection.
  Journal
Nat Immunol 16:554-62 (2015)
DOI:10.1038/ni.3157
Reference
PMID:28358311
  Authors
Pasquereau S, Kumar A, Herbein G
  Title
Targeting TNF and TNF Receptor Pathway in HIV-1 Infection: from Immune Activation to Viral Reservoirs.
  Journal
Viruses 9:E64 (2017)
DOI:10.3390/v9040064
Reference
PMID:18178131
  Authors
Herbein G, Khan KA
  Title
Is HIV infection a TNF receptor signalling-driven disease?
  Journal
Trends Immunol 29:61-7 (2008)
DOI:10.1016/j.it.2007.10.008
Reference
PMID:24453421
  Authors
Kumar A, Abbas W, Herbein G
  Title
TNF and TNF receptor superfamily members in HIV infection: new cellular targets for therapy?
  Journal
Mediators Inflamm 2013:484378 (2013)
DOI:10.1155/2013/484378
Reference
PMID:23986795
  Authors
Abbas W, Herbein G
  Title
T-Cell Signaling in HIV-1 Infection.
  Journal
Open Virol J 7:57-71 (2013)
DOI:10.2174/1874357920130621001
Reference
PMID:21368875
  Authors
Cummins NW, Badley AD
  Title
Mechanisms of HIV-associated lymphocyte apoptosis: 2010.
  Journal
Cell Death Dis 1:e99 (2010)
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Nat Rev Immunol 3:392-404 (2003)
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  Title
CD4+ T cell depletion in human immunodeficiency virus (HIV) infection: role of apoptosis.
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Viruses 3:586-612 (2011)
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Using death to one's advantage: HIV modulation of apoptosis.
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Leukemia 15:332-41 (2001)
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Nat Struct Mol Biol 19:661-2 (2012)
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Adv Virus Res 80:103-27 (2011)
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Mol Aspects Med 31:418-33 (2010)
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Traffic 17:976-96 (2016)
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Viruses 8:67 (2016)
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Methods Mol Biol 1170:165-227 (2014)
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Curr HIV Res 3:43-51 (2005)
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PLoS Pathog 2:e127 (2006)
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HIV-1 Vif: a guardian of the virus that opens up a new era in the research field of restriction factors.
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Front Microbiol 4:34 (2013)
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Philos Trans R Soc Lond B Biol Sci 364:675-87 (2009)
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J Virol 85:11220-34 (2011)
DOI:10.1128/JVI.05238-11
Related
pathway
cbai03050  Proteasome
cbai04010  MAPK signaling pathway
cbai04020  Calcium signaling pathway
cbai04064  NF-kappa B signaling pathway
cbai04110  Cell cycle
cbai04141  Protein processing in endoplasmic reticulum
cbai04142  Lysosome
cbai04150  mTOR signaling pathway
cbai04151  PI3K-Akt signaling pathway
cbai04210  Apoptosis
cbai04612  Antigen processing and presentation
cbai04620  Toll-like receptor signaling pathway
cbai04623  Cytosolic DNA-sensing pathway
cbai04668  TNF signaling pathway
cbai04810  Regulation of actin cytoskeleton
KO pathway
ko05170   
LinkDB

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