KEGG   PATHWAY: cbai04151
Entry
cbai04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Camelus bactrianus (Bactrian camel)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
cbai04151  PI3K-Akt signaling pathway
cbai04151

Other DBs
GO: 0043491
Organism
Camelus bactrianus (Bactrian camel) [GN:cbai]
Gene
105061821  ITGA9; integrin alpha-9 [KO:K06585]
105061875  [KO:K05414]
105061876  [KO:K05414]
105061880  [KO:K05414]
105061881  IFNB1; interferon beta [KO:K05415]
105061888  RPS6; 40S ribosomal protein S6 [KO:K02991]
105061913  [KO:K05414]
105061970  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
105061971  COL4A6; LOW QUALITY PROTEIN: collagen alpha-6(IV) chain [KO:K06237]
105061997  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
105062044  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
105062090  EIF4E1B; LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E type 1B [KO:K03259]
105062140  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
105062235  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
105062281  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
105062297  KRAS; GTPase KRas [KO:K07827]
105062379  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
105062387  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
105062407  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
105062421  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
105062549  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
105062602  FGF21; fibroblast growth factor 21 [KO:K22429]
105062615  NTF4; neurotrophin-4 [KO:K12457]
105062634  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
105062760  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
105062855  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105062994  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
105063003  LAMB1; laminin subunit beta-1 [KO:K05636]
105063046  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
105063049  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
105063149  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
105063244  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
105063312  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105063316  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
105063452  YWHAH; 14-3-3 protein eta [KO:K16198]
105063558  COL6A3; LOW QUALITY PROTEIN: collagen alpha-3(VI) chain [KO:K06238]
105063584  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
105063662  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
105063763  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
105063941  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
105064075  IRS1; insulin receptor substrate 1 [KO:K16172]
105064077  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
105064107  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
105064166  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
105064228  COL1A1; LOW QUALITY PROTEIN: collagen alpha-1(I) chain [KO:K06236]
105064290  ITGA3; integrin alpha-3 [KO:K06482]
105064344  THBS4; thrombospondin-4 [KO:K04659]
105064378  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
105064416  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
105064448  F2R; proteinase-activated receptor 1 [KO:K03914]
105064508  LAMB3; laminin subunit beta-3 [KO:K06244]
105064526  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
105064612  CHAD; chondroadherin [KO:K06248]
105064618  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
105064838  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
105064848  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
105064853  TSC2; tuberin [KO:K07207]
105064984  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
105065277  [KO:K06584]
105065479  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
105065502  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
105065517  FGF16; fibroblast growth factor 16 [KO:K04358]
105065574  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
105065643  ITGB4; LOW QUALITY PROTEIN: integrin beta-4 [KO:K06525]
105065653  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105065663  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
105065706  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
105065845  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
105065997  PKN3; LOW QUALITY PROTEIN: serine/threonine-protein kinase N3 [KO:K23692]
105066072  OSM; oncostatin-M [KO:K05418]
105066144  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
105066246  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
105066272  FGF9; fibroblast growth factor 9 isoform X1 [KO:K04358]
105066278  IL7; interleukin-7 isoform X1 [KO:K05431]
105066317  FLT1; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
105066577  MAGI1; LOW QUALITY PROTEIN: membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
105066839  PIK3CB; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105066896  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
105066898  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
105067006  KITLG; kit ligand [KO:K05461]
105067010  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
105067026  RHEB; GTP-binding protein Rheb [KO:K07208]
105067112  FGF2; fibroblast growth factor 2 [KO:K18497]
105067115  IL2; interleukin-2 [KO:K05429]
105067189  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
105067333  CREB3; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3 [KO:K09048]
105067475  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105067589  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
105067621  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
105067674  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
105067716  ANGPT2; angiopoietin-2 [KO:K05466]
105067732  FGF20; LOW QUALITY PROTEIN: fibroblast growth factor 20 [KO:K04358]
105067742  VEGFC; vascular endothelial growth factor C [KO:K05449]
105067755  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
105067758  EPO; erythropoietin [KO:K05437]
105067888  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
105067913  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105067960  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
105068159  THBS3; LOW QUALITY PROTEIN: thrombospondin-3 [KO:K04659]
105068164  EFNA1; ephrin-A1 [KO:K05462]
105068196  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
105068230  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
105068244  EFNA3; ephrin-A3 [KO:K05462]
105068246  EFNA4; ephrin-A4 [KO:K05462]
105068250  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
105068252  CRTC2; CREB-regulated transcription coactivator 2 [KO:K16333]
105068296  PKN1; serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
105068344  [KO:K04347]
105068382  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
105068475  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
105068501  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
105068579  [KO:K08524]
105068615  [KO:K08524]
105068796  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
105068905  TNR; tenascin-R [KO:K06252]
105068949  LAMC1; laminin subunit gamma-1 [KO:K05635]
105068993  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
105069012  TNN; tenascin-N [KO:K06252]
105069029  LAMC2; laminin subunit gamma-2 [KO:K06246]
105069319  [KO:K04541]
105069349  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105069374  PDGFC; platelet-derived growth factor C [KO:K05450]
105069416  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
105069420  PRLR; prolactin receptor isoform X1 [KO:K05081]
105069422  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105069622  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
105069653  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
105069700  LAMC3; laminin subunit gamma-3 [KO:K06247]
105069721  TSC1; hamartin [KO:K07206]
105069779  [KO:K05438]
105069802  ITGB3; integrin beta-3 [KO:K06493]
105069943  HRAS; GTPase HRas isoform X1 [KO:K02833]
105070137  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
105070152  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
105070234  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
105070236  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
105070302  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
105070333  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
105070367  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
105070386  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
105070434  FGF19; fibroblast growth factor 19 [KO:K22603]
105070615  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
105070629  VEGFB; vascular endothelial growth factor B [KO:K16858]
105070634  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
105070655  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
105070663  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
105070689  RELA; transcription factor p65 [KO:K04735]
105070721  TLR4; LOW QUALITY PROTEIN: toll-like receptor 4 [KO:K10160]
105070726  TNC; LOW QUALITY PROTEIN: tenascin [KO:K06252]
105070805  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
105070877  GHR; growth hormone receptor [KO:K05080]
105070931  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
105070945  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
105070974  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105071051  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
105071086  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
105071114  VWF; LOW QUALITY PROTEIN: von Willebrand factor [KO:K03900]
105071116  NTF3; neurotrophin-3 [KO:K04356]
105071167  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105071210  LPAR5; LOW QUALITY PROTEIN: lysophosphatidic acid receptor 5 [KO:K08390]
105071245  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
105071266  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
105071376  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
105071441  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
105071469  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
105071521  YWHAE; 14-3-3 protein epsilon [KO:K06630]
105071575  VTN; LOW QUALITY PROTEIN: vitronectin [KO:K06251]
105071667  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
105071682  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
105071701  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
105071745  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
105071815  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
105071914  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
105071932  SGK2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
105072152  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
105072182  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
105072468  ITGB1; integrin beta-1 [KO:K05719]
105072547  ITGA2B; integrin alpha-IIb [KO:K06476]
105072558  G6PC3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
105072609  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
105072689  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
105072759  COL9A2; LOW QUALITY PROTEIN: collagen alpha-2(IX) chain [KO:K08131]
105072803  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
105072910  ITGAV; integrin alpha-V [KO:K06487]
105072931  FN1; LOW QUALITY PROTEIN: fibronectin [KO:K05717]
105072941  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
105072963  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
105072984  ITGA4; integrin alpha-4 [KO:K06483]
105073101  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105073106  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
105073156  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
105073250  CSF3; granulocyte colony-stimulating factor [KO:K05423]
105073259  ERBB2; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
105073436  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
105073454  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
105073511  PHLPP2; LOW QUALITY PROTEIN: PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
105073585  BCL2L1; bcl-2-like protein 1 [KO:K04570]
105073643  ANGPT4; LOW QUALITY PROTEIN: angiopoietin-4 [KO:K05467]
105073657  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
105073864  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
105073865  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
105073877  [KO:K06238]
105073903  BCL2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
105073986  PHLPP1; LOW QUALITY PROTEIN: PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
105074031  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
105074122  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
105074263  ITGA11; integrin alpha-11 [KO:K06587]
105074289  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
105074292  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
105074656  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
105074697  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
105074777  [KO:K05725] [EC:2.7.10.2]
105075052  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
105075111  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
105075161  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
105075181  PGF; placenta growth factor isoform X1 [KO:K16859]
105075390  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
105075464  PKN2; serine/threonine-protein kinase N2 [KO:K23691]
105075487  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
105075725  RBL2; retinoblastoma-like protein 2 [KO:K16332]
105075786  TGFA; protransforming growth factor alpha [KO:K08774]
105075904  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
105075910  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
105076035  YWHAQ; 14-3-3 protein theta [KO:K16197]
105076053  IKBKG; NF-kappa-B essential modulator [KO:K07210]
105076173  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
105076251  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
105076373  EIF4B; LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4B [KO:K03258]
105076376  ITGB7; integrin beta-7 [KO:K06590]
105076384  ITGA5; integrin alpha-5 [KO:K06484]
105076396  [KO:K07210]
105076506  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
105076521  FGF6; fibroblast growth factor 6 [KO:K04358]
105076551  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
105076770  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
105076884  THBS1; LOW QUALITY PROTEIN: thrombospondin-1 [KO:K16857]
105077011  FGF7; fibroblast growth factor 7 [KO:K04358]
105077103  FOXO3; forkhead box protein O3 [KO:K09408]
105077138  LAMA4; laminin subunit alpha-4 [KO:K06241]
105077247  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
105077254  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
105077284  [KO:K02991]
105077365  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
105077423  LAMA2; laminin subunit alpha-2 [KO:K05637]
105077515  TP53; cellular tumor antigen p53 [KO:K04451]
105077550  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
105077591  PIK3R5; LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
105077645  THBS2; thrombospondin-2 [KO:K04659]
105077672  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105077673  KIT; LOW QUALITY PROTEIN: mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
105077707  SPP1; osteopontin [KO:K06250]
105077708  IBSP; bone sialoprotein 2 [KO:K06253]
105077731  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
105077813  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
105077825  ITGA2; integrin alpha-2 [KO:K06481]
105077827  ITGA1; integrin alpha-1 [KO:K06480]
105077831  FGF10; fibroblast growth factor 10 [KO:K04358]
105077992  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
105077993  COL6A1; LOW QUALITY PROTEIN: collagen alpha-1(VI) chain [KO:K06238]
105078127  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
105078209  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105078244  NRTN; neurturin [KO:K25414]
105078270  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
105078321  EPOR; erythropoietin receptor [KO:K05079]
105078345  FGF22; fibroblast growth factor 22 [KO:K04358]
105078356  EFNA2; ephrin-A2 [KO:K05462]
105078379  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
105078393  PSPN; persephin [KO:K25416]
105078489  SOS2; son of sevenless homolog 2 [KO:K03099]
105078528  MTCP1; protein p13 MTCP-1 [KO:K16837]
105078601  ITGB8; integrin beta-8 [KO:K06591]
105078857  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
105078927  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
105078987  SOS1; son of sevenless homolog 1 [KO:K03099]
105079146  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
105079173  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
105079294  FIGF; vascular endothelial growth factor D [KO:K05449]
105079478  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
105079513  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
105079555  NRAS; GTPase NRas [KO:K07828]
105079607  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
105079727  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
105079801  IL6; interleukin-6 [KO:K05405]
105079939  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
105079942  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
105079965  NGF; beta-nerve growth factor [KO:K02582]
105079975  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105080005  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
105080007  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
105080043  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
105080080  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
105080088  G6PC; LOW QUALITY PROTEIN: glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
105080269  LAMB2; laminin subunit beta-2 [KO:K06243]
105080377  AREG; amphiregulin isoform X1 [KO:K09782]
105080429  EREG; proepiregulin [KO:K09784]
105080494  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
105080508  [KO:K05855] [EC:2.7.10.2]
105080789  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
105080960  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
105081297  HSP90B1; endoplasmin [KO:K09487]
105081337  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
105081451  [KO:K13304] [EC:2.7.11.1]
105081598  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105081644  ITGB5; integrin beta-5 [KO:K06588]
105081722  FGF8; fibroblast growth factor 8 [KO:K04358]
105081861  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105081887  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
105081892  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
105081942  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
105081978  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
105082019  EFNA5; ephrin-A5 [KO:K05462]
105082021  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
105082107  IL4; interleukin-4 [KO:K05430]
105082124  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
105082393  [KO:K05414]
105082560  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
105082587  COMP; cartilage oligomeric matrix protein [KO:K04659]
105082616  LPAR2; lysophosphatidic acid receptor 2 isoform X1 [KO:K04291]
105082679  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105082696  FGF18; fibroblast growth factor 18 [KO:K04358]
105082704  YWHAG; 14-3-3 protein gamma [KO:K16198]
105082839  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105082852  CD19; B-lymphocyte antigen CD19 [KO:K06465]
105082901  COL1A2; collagen alpha-2(I) chain [KO:K06236]
105082939  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
105082940  MYC; myc proto-oncogene protein [KO:K04377]
105082944  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
105083000  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
105083253  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
105083596  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105083690  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
105083774  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
105083790  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
105083818  VEGFA; vascular endothelial growth factor A [KO:K05448]
105083823  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
105084000  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
105084199  PRL; prolactin [KO:K05439]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
cbai00010  Glycolysis / Gluconeogenesis
cbai04010  MAPK signaling pathway
cbai04012  ErbB signaling pathway
cbai04062  Chemokine signaling pathway
cbai04064  NF-kappa B signaling pathway
cbai04068  FoxO signaling pathway
cbai04110  Cell cycle
cbai04115  p53 signaling pathway
cbai04150  mTOR signaling pathway
cbai04210  Apoptosis
cbai04370  VEGF signaling pathway
cbai04510  Focal adhesion
cbai04620  Toll-like receptor signaling pathway
cbai04630  JAK-STAT signaling pathway
cbai04662  B cell receptor signaling pathway
cbai04910  Insulin signaling pathway
KO pathway
ko04151   

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