KEGG   PATHWAY: cge05205
Entry
cge05205                    Pathway                                
Name
Proteoglycans in cancer - Cricetulus griseus (Chinese hamster)
Description
Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis and metastasis, affecting tumor progress. The four main types of proteoglycans include hyaluronan (HA), which does not occur as a PG but in free form, heparan sulfate proteoglycans (HSPGs), chondroitin sulfate proteoglycans (CSPGs), dematan sulfate proteoglycans (DSPG) and keratan sulfate proteoglycans (KSPGs) [BR:00535]. Among these proteoglycans such as HA, acting with CD44, promotes tumor cell growth and migration, whereas other proteoglycans such as syndecans (-1~-4), glypican (-1, -3) and perlecan may interact with growth factors, cytokines, morphogens and enzymes through HS chains [BR:00536], also leading to tumor growth and invasion. In contrast, some of the small leucine-rich proteolgycans, such as decorin and lumican, can function as tumor repressors, and modulate the signaling pathways by the interaction of their core proteins and multiple receptors.
Class
Human Diseases; Cancer: overview
Pathway map
cge05205  Proteoglycans in cancer
cge05205

Organism
Cricetulus griseus (Chinese hamster) [GN:cge]
Gene
100750640  Cd44; CD44 antigen isoform X1 [KO:K06256]
100757188  Src; proto-oncogene tyrosine-protein kinase Src isoform X2 [KO:K05704] [EC:2.7.10.2]
100772651  Cttn; src substrate cortactin isoform X1 [KO:K06106]
100764646  Hcls1; hematopoietic lineage cell-specific protein [KO:K06106]
100759983  Erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
100769627  Grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
100768658  Vav3; guanine nucleotide exchange factor VAV3 isoform X5 [KO:K05730]
100765426  Vav1; proto-oncogene vav isoform X1 [KO:K05730]
100759294  Vav2; guanine nucleotide exchange factor VAV2 isoform X2 [KO:K05730]
100773737  Hras; GTPase HRas isoform X2 [KO:K02833]
100763178  Kras; GTPase KRas isoform X4 [KO:K07827]
113839127  GTPase KRas-like [KO:K07827]
113837935  GTPase KRas-like isoform X2 [KO:K07827]
113837956  GTPase KRas-like [KO:K07827]
113838653  GTPase KRas-like isoform X2 [KO:K07827]
113838692  GTPase KRas-like [KO:K07827]
113838722  GTPase KRas-like isoform X1 [KO:K07827]
113838818  GTPase KRas-like [KO:K07827]
113837633  GTPase KRas-like isoform X1 [KO:K07827]
113838146  GTPase KRas-like isoform X1 [KO:K07827]
113838876  GTPase KRas-like [KO:K07827]
113838228  GTPase KRas-like isoform X1 [KO:K07827]
113839011  GTPase KRas-like [KO:K07827]
100771078  GTPase KRas-like isoform X2 [KO:K07827]
113837960  GTPase KRas-like [KO:K07827]
113838098  GTPase KRas-like [KO:K07827]
113838326  GTPase KRas-like [KO:K07827]
113838417  GTPase KRas-like isoform X1 [KO:K07827]
113838488  GTPase KRas-like [KO:K07827]
113838583  GTPase KRas-like isoform X1 [KO:K07827]
113838676  GTPase KRas-like [KO:K07827]
113838679  GTPase KRas-like isoform X1 [KO:K07827]
113838746  GTPase KRas-like [KO:K07827]
113838796  GTPase KRas-like isoform X1 [KO:K07827]
113838871  GTPase KRas-like [KO:K07827]
113838872  GTPase KRas-like [KO:K07827]
113838892  GTPase KRas-like [KO:K07827]
113838898  GTPase KRas-like [KO:K07827]
113838914  GTPase KRas-like [KO:K07827]
113838921  GTPase KRas-like [KO:K07827]
113838942  GTPase KRas-like isoform X1 [KO:K07827]
113838943  GTPase KRas-like isoform X1 [KO:K07827]
113839007  GTPase HRas-like isoform X1 [KO:K07827]
118239746  GTPase KRas-like isoform X1 [KO:K07827]
118239767  GTPase KRas-like isoform X1 [KO:K07827]
118239768  GTPase KRas-like [KO:K07827]
118239770  GTPase KRas-like [KO:K07827]
118239801  GTPase KRas-like [KO:K07827]
118239825  GTPase KRas-like isoform X1 [KO:K07827]
100757614  Nras; GTPase NRas [KO:K07828]
100766263  Rras; ras-related protein R-Ras isoform X1 [KO:K07829]
100771410  Rras2; ras-related protein R-Ras2 isoform X2 [KO:K07830]
100767950  Mras; ras-related protein M-Ras isoform X1 [KO:K07831]
100771486  Braf; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf isoform X6 [KO:K04365] [EC:2.7.11.1]
100769018  Raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
100751432  Araf; serine/threonine-protein kinase A-Raf isoform X5 [KO:K08845] [EC:2.7.11.1]
100689403  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
113835540  dual specificity mitogen-activated protein kinase kinase 1-like isoform X1 [KO:K04368] [EC:2.7.12.2]
103158537  dual specificity mitogen-activated protein kinase kinase 1-like isoform X2 [KO:K04368] [EC:2.7.12.2]
100774204  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X2 [KO:K04369] [EC:2.7.12.2]
100759514  Mapk1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
100753149  Mapk3; mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
100756792  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
113837706  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
100757264  Iqgap1; ras GTPase-activating-like protein IQGAP1 isoform X1 [KO:K16848]
100765433  Cdc42; cell division control protein 42 homolog [KO:K04393]
100763890  Elk1; ETS domain-containing protein Elk-1 [KO:K04375]
100768474  Esr1; estrogen receptor isoform X2 [KO:K08550]
100689063  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
113830633  Actg1; actin, cytoplasmic 2 isoform X2 [KO:K05692]
100689477  Actb; actin, cytoplasmic 1 [KO:K05692]
100760050  Flna; filamin-A isoform X3 [KO:K04437]
100767503  Pak1; serine/threonine-protein kinase PAK 1 isoform X4 [KO:K04409] [EC:2.7.11.1]
100756100  Tiam1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
100758784  Arhgef1; rho guanine nucleotide exchange factor 1 isoform X2 [KO:K12330]
100762797  Rhoa; transforming protein RhoA [KO:K04513]
100757042  transforming protein RhoA isoform X1 [KO:K04513]
100770074  Rock1; rho-associated protein kinase 1 isoform X3 [KO:K04514] [EC:2.7.11.1]
100767265  Rock2; rho-associated protein kinase 2 isoform X2 [KO:K17388] [EC:2.7.11.1]
100757830  Ank2; ankyrin-2 isoform X2 [KO:K09255]
100767295  Ank3; ankyrin-3 isoform X12 [KO:K09259]
118239462  ankyrin-3-like [KO:K09259]
100753832  Gab1; GRB2-associated-binding protein 1 isoform X2 [KO:K09593]
100689251  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100769225  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100689252  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100771181  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649]
100750761  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100774067  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100768351  Akt2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100752454  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100769460  Akt1; RAC-alpha serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100689320  Slc9a1; sodium/hydrogen exchanger 1 [KO:K05742]
100761524  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X2 [KO:K06269] [EC:3.1.3.16]
100760810  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100774547  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X2 [KO:K06269] [EC:3.1.3.16]
100754718  Ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X5 [KO:K06270]
100753601  Ppp1r12b; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
100765970  Ppp1r12c; protein phosphatase 1 regulatory subunit 12C isoform X2 [KO:K17457]
100765006  Arhgef12; rho guanine nucleotide exchange factor 12 isoform X3 [KO:K07532]
100754217  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
100764450  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X9 [KO:K04958]
100758965  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X2 [KO:K04959]
100751775  inositol 1,4,5-trisphosphate receptor type 3 isoform X3 [KO:K04960]
100769205  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X2 [KO:K04515] [EC:2.7.11.17]
100763272  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X2 [KO:K04515] [EC:2.7.11.17]
100752268  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X4 [KO:K04515] [EC:2.7.11.17]
100765253  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X3 [KO:K04515] [EC:2.7.11.17]
100774227  Nanog; homeobox protein NANOG isoform X2 [KO:K10164]
100768812  Ddx5; probable ATP-dependent RNA helicase DDX5 isoform X1 [KO:K12823] [EC:5.6.2.7]
100766983  Drosha; ribonuclease 3 isoform X1 [KO:K03685] [EC:3.1.26.3]
100755865  Stat3; signal transducer and activator of transcription 3 isoform X9 [KO:K04692]
103163738  Twist1; LOW QUALITY PROTEIN: twist-related protein 1 isoform X2 [KO:K09069]
113831658  twist-related protein 2 [KO:K09069]
102466106  Mir10a; cgr-miR-10a-5p [KO:K16864]
102466522  Mir10b; cgr-miR-10b-5p [KO:K17393]
100752695  Hoxd10; homeobox protein Hox-D10 [KO:K09295]
100756152  Dcn; decorin [KO:K04660]
100751642  Igf1; insulin-like growth factor I isoform X1 [KO:K05459]
100768531  Igf1r; insulin-like growth factor 1 receptor isoform X2 [KO:K05087] [EC:2.7.10.1]
100755421  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100772477  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X2 [KO:K06276] [EC:2.7.11.1]
100757513  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
100760227  Rps6kb2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
100758911  Eif4b; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
100753707  Rps6; 40S ribosomal protein S6 isoform X2 [KO:K02991]
100767070  40S ribosomal protein S6 isoform X2 [KO:K02991]
113837892  40S ribosomal protein S6-like [KO:K02991]
113837022  40S ribosomal protein S6-like [KO:K02991]
103159011  40S ribosomal protein S6-like isoform X2 [KO:K02991]
113838911  40S ribosomal protein S6-like [KO:K02991]
100774580  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100753021  Cav1; caveolin-1 isoform X3 [KO:K06278]
100751645  Cav2; caveolin-2 [KO:K12958]
100773488  Cav3; caveolin-3 [KO:K12959]
100772167  Cd63; CD63 antigen isoform X1 [KO:K06497]
103160601  Cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
100689061  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100773359  Tgfb1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375]
100771475  Tlr2; LOW QUALITY PROTEIN: toll-like receptor 2 [KO:K10159]
100689329  Tlr4; toll-like receptor 4 precursor [KO:K10160]
100766922  Pdcd4; programmed cell death protein 4 [KO:K16865]
100764780  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
100764758  Il12b; interleukin-12 subunit beta [KO:K05425]
100767681  Erbb3; receptor tyrosine-protein kinase erbB-3 isoform X2 [KO:K05084] [EC:2.7.10.1]
100760475  receptor tyrosine-protein kinase erbB-4 isoform X2 [KO:K05085] [EC:2.7.10.1]
100773301  Myc; myc proto-oncogene protein isoform X2 [KO:K04377]
100773307  Ctnnb1; catenin beta-1 [KO:K02105]
100751293  Hif1a; hypoxia-inducible factor 1-alpha isoform X3 [KO:K08268]
100751080  Tfap4; transcription factor AP-4 isoform X1 [KO:K09108]
100755957  Vegfa; LOW QUALITY PROTEIN: vascular endothelial growth factor A isoform X2 [KO:K05448]
100756294  Kdr; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
100751933  Met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
100754737  Cbl; E3 ubiquitin-protein ligase CBL isoform X2 [KO:K04707] [EC:2.3.2.27]
100760878  Thbs1; thrombospondin-1 isoform X1 [KO:K16857]
100774744  Mmp2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
100770707  Mmp9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
100755861  Lum; lumican [KO:K08122]
100773293  Faslg; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
100762537  Fas; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
100770120  Mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X3 [KO:K06643] [EC:2.3.2.27]
100682525  Tp53; cellular tumor antigen p53 [KO:K04451]
100774918  Tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
100771578  Smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
100755610  Hpse; heparanase [KO:K07964] [EC:3.2.1.166]
100762007  Hpse2; inactive heparanase-2 isoform X1 [KO:K07965] [EC:3.2.1.-]
100689057  Sdc1; syndecan-1 precursor [KO:K06257]
100759384  Plau; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
100689422  Plaur; urokinase plasminogen activator surface receptor isoform X2 [KO:K03985]
100759814  Col1a1; collagen alpha-1(I) chain [KO:K06236]
100766269  Col1a2; collagen alpha-2(I) chain isoform X2 [KO:K06236]
100774579  Itga2; integrin alpha-2 isoform X2 [KO:K06481]
100763033  Itgb1; integrin beta-1 isoform X2 [KO:K05719]
100767624  Vtn; vitronectin [KO:K06251]
100752313  Itgav; integrin alpha-V isoform X2 [KO:K06487]
100775048  Itgb3; integrin beta-3 isoform X2 [KO:K06493]
100751189  Fn1; fibronectin isoform X1 [KO:K05717]
100765378  Itgb5; integrin beta-5 isoform X3 [KO:K06588]
100764472  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
100766046  Wnt1; proto-oncogene Wnt-1 [KO:K03209]
100766658  Fzd7; frizzled-7 isoform X2 [KO:K02432]
100770917  Fzd1; frizzled-1 isoform X2 [KO:K02432]
100763109  Fzd2; frizzled-2 isoform X2 [KO:K02235]
100751712  Fzd3; frizzled-3 isoform X1 [KO:K02329]
100756296  Fzd4; frizzled-4 [KO:K02354]
100762351  Fzd5; frizzled-5 isoform X2 [KO:K02375]
113834637  frizzled-8 [KO:K02375]
100774509  Fzd6; frizzled-6 isoform X2 [KO:K02376]
100755785  Fzd10; frizzled-10 isoform X2 [KO:K02842]
100761155  Fzd9; frizzled-9 isoform X2 [KO:K02842]
100768174  Itga5; integrin alpha-5 isoform X2 [KO:K06484]
100761785  Sdc2; syndecan-2 isoform X2 [KO:K16336]
100762541  Ezr; ezrin [KO:K08007]
100752135  Rdx; radixin [KO:K05762]
100751956  Msn; moesin [KO:K05763]
100760006  Sdc4; syndecan-4 [KO:K16338]
100757429  Fgf2; fibroblast growth factor 2 isoform X2 [KO:K18497]
100773586  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
100758678  Frs2; fibroblast growth factor receptor substrate 2 [KO:K12461]
100771077  Ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform X2 [KO:K07293] [EC:3.1.3.48]
100757521  Sos1; son of sevenless homolog 1 isoform X2 [KO:K03099]
100769325  Sos2; son of sevenless homolog 2 isoform X3 [KO:K03099]
100769697  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [KO:K01116] [EC:3.1.4.11]
100752475  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
100766006  Prkca; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
100760922  Prkcb; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100762950  Prkcg; protein kinase C gamma type isoform X2 [KO:K19663] [EC:2.7.11.13]
100772569  Nudt16l1; tudor-interacting repair regulator protein isoform X1 [KO:K16867]
100760740  Pxn; paxillin isoform X1 [KO:K05760]
100759464  Ptk2; focal adhesion kinase 1 isoform X5 [KO:K05725] [EC:2.7.10.2]
100689423  Hbegf; proheparin-binding EGF-like growth factor isoform X2 [KO:K08523]
100751141  Gpc1; glypican-1 isoform X2 [KO:K08107]
100762359  Igf2; LOW QUALITY PROTEIN: insulin-like growth factor II isoform X2 [KO:K13769]
100768919  Gpc3; glypican-3 [KO:K08109]
100761413  Wnt2b; protein Wnt-2b [KO:K00182]
100752722  Wnt2; protein Wnt-2 [KO:K00182]
100764164  Wnt3a; protein Wnt-3a isoform X2 [KO:K00312]
100774849  proto-oncogene Wnt-3 isoform X2 [KO:K00312]
100769003  Wnt4; protein Wnt-4 isoform X3 [KO:K00408]
100753089  Wnt5a; protein Wnt-5a [KO:K00444]
100753017  Wnt5b; protein Wnt-5b isoform X2 [KO:K00444]
100751289  Wnt6; protein Wnt-6 isoform X2 [KO:K00445]
100772978  Wnt7a; protein Wnt-7a isoform X2 [KO:K00572]
100755799  Wnt7b; protein Wnt-7b isoform X1 [KO:K00572]
100775075  Wnt8b; protein Wnt-8b [KO:K00714]
100752907  Wnt8a; protein Wnt-8a isoform X2 [KO:K00714]
100766088  Wnt9b; protein Wnt-9b isoform X2 [KO:K01064]
100764466  Wnt9a; protein Wnt-9a isoform X2 [KO:K01064]
100770174  Wnt10a; protein Wnt-10a [KO:K01357]
100766340  Wnt10b; protein Wnt-10b [KO:K01357]
100774690  Wnt11; protein Wnt-11 isoform X1 [KO:K01384]
100764115  Wnt16; protein Wnt-16 [KO:K01558]
100773402  Shh; sonic hedgehog protein isoform X2 [KO:K11988]
100774896  Ihh; indian hedgehog protein isoform X2 [KO:K11989]
100763926  Ptch1; protein patched homolog 1 isoform X3 [KO:K06225]
100762005  Smo; smoothened homolog isoform X2 [KO:K06226]
100689041  Hspg2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X2 [KO:K06255]
100768693  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
100768997  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X2 [KO:K04345] [EC:2.7.11.11]
100767097  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
100689104  Mapk14; mitogen-activated protein kinase 14 isoform X3 [KO:K04441] [EC:2.7.11.24]
100759172  Mapk11; mitogen-activated protein kinase 11 isoform X2 [KO:K04441] [EC:2.7.11.24]
100754042  Mapk12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
100763519  Mapk13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
100772331  Hspb2; heat shock protein beta-2 isoform X1 [KO:K09543]
100758996  Ptpn6; tyrosine-protein phosphatase non-receptor type 6 [KO:K05697] [EC:3.1.3.48]
Compound
C00426  Dermatan sulfate
C00573  Keratan sulfate
C00607  Chondroitin sulfate
C00925  Heparan sulfate
G10505  Hyaluronic acid
G13063  Binding domain for FGF2 in heparin/heparan sulfate
G13064  Binding domain for HGF in heparin/heparan sulfate
Reference
PMID:18450475
  Authors
Bourguignon LY
  Title
Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression.
  Journal
Semin Cancer Biol 18:251-9 (2008)
DOI:10.1016/j.semcancer.2008.03.007
Reference
PMID:12729888
  Authors
Briggs MW, Sacks DB
  Title
IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton.
  Journal
FEBS Lett 542:7-11 (2003)
DOI:10.1016/S0014-5793(03)00333-8
Reference
PMID:12748184
  Authors
Bourguignon LY, Singleton PA, Zhu H, Diedrich F
  Title
Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression.
  Journal
J Biol Chem 278:29420-34 (2003)
DOI:10.1074/jbc.M301885200
Reference
PMID:15655247
  Authors
Bourguignon LY, Gilad E, Rothman K, Peyrollier K
  Title
Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.
  Journal
J Biol Chem 280:11961-72 (2005)
DOI:10.1074/jbc.M411985200
Reference
PMID:11717317
  Authors
Turley EA, Noble PW, Bourguignon LY
  Title
Signaling properties of hyaluronan receptors.
  Journal
J Biol Chem 277:4589-92 (2002)
DOI:10.1074/jbc.R100038200
Reference
PMID:9346940
  Authors
Bourguignon LY, Zhu H, Chu A, Iida N, Zhang L, Hung MC
  Title
Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation.
  Journal
J Biol Chem 272:27913-8 (1997)
DOI:10.1074/jbc.272.44.27913
Reference
PMID:22735579
  Authors
Neill T, Schaefer L, Iozzo RV
  Title
Decorin: a guardian from the matrix.
  Journal
Am J Pathol 181:380-7 (2012)
DOI:10.1016/j.ajpath.2012.04.029
Reference
PMID:22194599
  Authors
Neill T, Painter H, Buraschi S, Owens RT, Lisanti MP, Schaefer L, Iozzo RV
  Title
Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1alpha, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.
  Journal
J Biol Chem 287:5492-506 (2012)
DOI:10.1074/jbc.M111.283499
Reference
PMID:19433454
  Authors
Goldoni S, Humphries A, Nystrom A, Sattar S, Owens RT, McQuillan DJ, Ireton K, Iozzo RV
  Title
Decorin is a novel antagonistic ligand of the Met receptor.
  Journal
J Cell Biol 185:743-54 (2009)
DOI:10.1083/jcb.200901129
Reference
PMID:15994311
  Authors
Zhu JX, Goldoni S, Bix G, Owens RT, McQuillan DJ, Reed CC, Iozzo RV
  Title
Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis.
  Journal
J Biol Chem 280:32468-79 (2005)
DOI:10.1074/jbc.M503833200
Reference
PMID:20974860
  Authors
Buraschi S, Pal N, Tyler-Rubinstein N, Owens RT, Neill T, Iozzo RV
  Title
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.
  Journal
J Biol Chem 285:42075-85 (2010)
DOI:10.1074/jbc.M110.172841
Reference
PMID:18798267
  Authors
Goldoni S, Iozzo RV
  Title
Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs.
  Journal
Int J Cancer 123:2473-9 (2008)
DOI:10.1002/ijc.23930
Reference
PMID:23058688
  Authors
Sofeu Feugaing DD, Gotte M, Viola M
  Title
More than matrix: the multifaceted role of decorin in cancer.
  Journal
Eur J Cell Biol 92:1-11 (2013)
DOI:10.1016/j.ejcb.2012.08.004
Reference
PMID:22087031
  Authors
Merline R, Moreth K, Beckmann J, Nastase MV, Zeng-Brouwers J, Tralhao JG, Lemarchand P, Pfeilschifter J, Schaefer RM, Iozzo RV, Schaefer L
  Title
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21.
  Journal
Sci Signal 4:ra75 (2011)
DOI:10.1126/scisignal.2001868
Reference
PMID:22033227
  Authors
Teng YH, Aquino RS, Park PW
  Title
Molecular functions of syndecan-1 in disease.
  Journal
Matrix Biol 31:3-16 (2012)
DOI:10.1016/j.matbio.2011.10.001
Reference
PMID:11830493
  Authors
Derksen PW, Keehnen RM, Evers LM, van Oers MH, Spaargaren M, Pals ST
  Title
Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma.
  Journal
Blood 99:1405-10 (2002)
DOI:10.1182/blood.V99.4.1405
Reference
PMID:19733083
  Authors
Fux L, Ilan N, Sanderson RD, Vlodavsky I
  Title
Heparanase: busy at the cell surface.
  Journal
Trends Biochem Sci 34:511-9 (2009)
DOI:10.1016/j.tibs.2009.06.005
Reference
PMID:18812315
  Authors
Purushothaman A, Chen L, Yang Y, Sanderson RD
  Title
Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.
  Journal
J Biol Chem 283:32628-36 (2008)
DOI:10.1074/jbc.M806266200
Reference
PMID:19255147
  Authors
Beauvais DM, Ell BJ, McWhorter AR, Rapraeger AC
  Title
Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor.
  Journal
J Exp Med 206:691-705 (2009)
DOI:10.1084/jem.20081278
Reference
PMID:20655987
  Authors
Mahtouk K, Tjin EP, Spaargaren M, Pals ST
  Title
The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas.
  Journal
Biochim Biophys Acta 1806:208-19 (2010)
DOI:10.1016/j.bbcan.2010.07.006
Reference
PMID:11931647
  Authors
Munesue S, Kusano Y, Oguri K, Itano N, Yoshitomi Y, Nakanishi H, Yamashina I, Okayama M
  Title
The role of syndecan-2 in regulation of actin-cytoskeletal organization of Lewis lung carcinoma-derived metastatic clones.
  Journal
Biochem J 363:201-9 (2002)
DOI:10.1042/bj3630201
Reference
PMID:10687947
  Authors
Nugent MA, Iozzo RV
  Title
Fibroblast growth factor-2.
  Journal
Int J Biochem Cell Biol 32:115-20 (2000)
DOI:10.1016/S1357-2725(99)00123-5
Reference
PMID:10633082
  Authors
Baciu PC, Saoncella S, Lee SH, Denhez F, Leuthardt D, Goetinck PF
  Title
Syndesmos, a protein that interacts with the cytoplasmic domain of syndecan-4, mediates cell spreading and actin cytoskeletal organization.
  Journal
J Cell Sci 113 Pt 2:315-24 (2000)
Reference
PMID:12509413
  Authors
Thodeti CK, Albrechtsen R, Grauslund M, Asmar M, Larsson C, Takada Y, Mercurio AM, Couchman JR, Wewer UM
  Title
ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA.
  Journal
J Biol Chem 278:9576-84 (2003)
DOI:10.1074/jbc.M208937200
Reference
PMID:14711376
  Authors
Beauvais DM, Rapraeger AC
  Title
Syndecans in tumor cell adhesion and signaling.
  Journal
Reprod Biol Endocrinol 2:3 (2004)
DOI:10.1186/1477-7827-2-3
Reference
PMID:17971838
  Authors
Morgan MR, Humphries MJ, Bass MD
  Title
Synergistic control of cell adhesion by integrins and syndecans.
  Journal
Nat Rev Mol Cell Biol 8:957-69 (2007)
DOI:10.1038/nrm2289
Reference
PMID:18505598
  Authors
Filmus J, Capurro M, Rast J
  Title
Glypicans.
  Journal
Genome Biol 9:224 (2008)
DOI:10.1186/gb-2008-9-5-224
Reference
PMID:23305321
  Authors
Filmus J, Capurro M
  Title
Glypican-3: a marker and a therapeutic target in hepatocellular carcinoma.
  Journal
FEBS J 280:2471-6 (2013)
DOI:10.1111/febs.12126
Reference
PMID:22563565
  Authors
Gao W, Ho M
  Title
The role of glypican-3 in regulating Wnt in hepatocellular carcinomas.
  Journal
Cancer Rep 1:14-19 (2011)
Reference
PMID:24412155
  Authors
Filmus J, Capurro M
  Title
The role of glypicans in Hedgehog signaling.
  Journal
Matrix Biol 35:248-52 (2014)
DOI:10.1016/j.matbio.2013.12.007
Reference
PMID:18413366
  Authors
Cheng W, Tseng CJ, Lin TT, Cheng I, Pan HW, Hsu HC, Lee YM
  Title
Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathway.
  Journal
Carcinogenesis 29:1319-26 (2008)
DOI:10.1093/carcin/bgn091
Reference
PMID:21155971
  Authors
Iozzo RV, Sanderson RD
  Title
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis.
  Journal
J Cell Mol Med 15:1013-31 (2011)
DOI:10.1111/j.1582-4934.2010.01236.x
Reference
PMID:18949819
  Authors
Nikitovic D, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN
  Title
Lumican, a small leucine-rich proteoglycan.
  Journal
IUBMB Life 60:818-23 (2008)
DOI:10.1002/iub.131
Related
pathway
cge04010  MAPK signaling pathway
cge04020  Calcium signaling pathway
cge04066  HIF-1 signaling pathway
cge04150  mTOR signaling pathway
cge04151  PI3K-Akt signaling pathway
cge04210  Apoptosis
cge04310  Wnt signaling pathway
cge04340  Hedgehog signaling pathway
cge04350  TGF-beta signaling pathway
cge04370  VEGF signaling pathway
cge04510  Focal adhesion
cge04520  Adherens junction
cge04810  Regulation of actin cytoskeleton
KO pathway
ko05205   
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