KEGG   PATHWAY: cimi05169
Entry
cimi05169                   Pathway                                
Name
Epstein-Barr virus infection - Cebus imitator (Panamanian white-faced capuchin)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
cimi05169  Epstein-Barr virus infection
cimi05169

Organism
Cebus imitator (Panamanian white-faced capuchin) [GN:cimi]
Gene
108302100  CR2; complement receptor type 2 isoform X1 [KO:K04012]
108302212  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
108300065  HLA class II histocompatibility antigen, DP beta 1 chain isoform X1 [KO:K06752]
108300066  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
108300070  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
108300073  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
108300075  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
108300083  HLA class II histocompatibility antigen, DQ beta 1 chain isoform X1 [KO:K06752]
108300084  HLA class II histocompatibility antigen, DQ beta 1 chain-like isoform X1 [KO:K06752]
108300085  HLA class II histocompatibility antigen, DQ alpha 2 chain [KO:K06752]
108300086  HLA class II histocompatibility antigen, DQ alpha 1 chain [KO:K06752]
108300087  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
108300090  HLA class II histocompatibility antigen, DR beta 3 chain isoform X1 [KO:K06752]
108300093  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
108300091  HLA class II histocompatibility antigen, DRB1 beta chain [KO:K06752]
119470189  HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752]
108299883  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DQ beta 2 chain-like [KO:K06752]
108282777  toll-like receptor 2 [KO:K10159]
108289112  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
108305262  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
108294753  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
108305750  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
108315297  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
108287389  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
108311469  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
108306378  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
108316185  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
108298093  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
108306065  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
108289254  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
108310400  RELA; transcription factor p65 isoform X2 [KO:K04735]
108299857  TNF; tumor necrosis factor [KO:K03156]
108303199  IL6; interleukin-6 isoform X1 [KO:K05405]
108317669  DDX58; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
108286781  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
108304024  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
108288399  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
108301897  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
108288787  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
108298392  IRF3; interferon regulatory factor 3 isoform X3 [KO:K05411]
108296181  interferon alpha-8-like [KO:K05414]
108296168  interferon alpha-8-like [KO:K05414]
108296165  IFNA21; interferon alpha-21 [KO:K05414]
108296167  interferon alpha-2-like [KO:K05414]
108296180  interferon alpha-5-like [KO:K05414]
108296183  interferon alpha-1/13 [KO:K05414]
108296184  interferon alpha-8-like [KO:K05414]
108296169  IFNB1; interferon beta [KO:K05415]
108302441  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
108302508  interferon alpha/beta receptor 2 isoform X3 [KO:K05131]
108313230  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
108283688  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
108284049  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
108309779  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
108315378  IRF9; interferon regulatory factor 9 isoform X2 [KO:K04693]
108308872  EIF2AK2; LOW QUALITY PROTEIN: interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
108314219  OAS1; 2'-5'-oligoadenylate synthase 1 isoform X1 [KO:K14216] [EC:2.7.7.84]
108314231  OAS3; 2'-5'-oligoadenylate synthase 3 isoform X1 [KO:K14216] [EC:2.7.7.84]
108314247  OAS2; 2'-5'-oligoadenylate synthase 2 isoform X1 [KO:K14216] [EC:2.7.7.84]
108293435  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
108313913  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
108290337  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
108294124  FADD; FAS-associated death domain protein [KO:K02373]
108315757  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
108294856  BID; BH3-interacting domain death agonist [KO:K04726]
108318653  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
108304605  BCL2; apoptosis regulator Bcl-2 isoform X2 [KO:K02161]
108287107  apoptosis regulator BAX-like [KO:K02159]
108283911  BAX; apoptosis regulator BAX [KO:K02159]
108300037  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
108281951  cytochrome c, somatic-like [KO:K08738]
108288191  cytochrome c-like [KO:K08738]
108288636  cytochrome c-like [KO:K08738]
108299683  cytochrome c-like [KO:K08738]
108290168  cytochrome c [KO:K08738]
108290453  cytochrome c-like [KO:K08738]
108303234  cytochrome c [KO:K08738]
108305303  cytochrome c, somatic-like [KO:K08738]
108306377  cytochrome c, somatic-like [KO:K08738]
108311641  cytochrome c, testis-specific-like [KO:K08738]
108304381  cytochrome c-like [KO:K08738]
108313879  cytochrome c-like [KO:K08738]
108293847  cytochrome c [KO:K08738]
108305848  cytochrome c-like [KO:K08738]
108307291  cytochrome c-like [KO:K08738]
108290860  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
108286842  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
108288114  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
108310786  caspase-3-like [KO:K02187] [EC:3.4.22.56]
108291083  uncharacterized protein LOC108291083 [KO:K10785]
108291134  uncharacterized protein LOC108291134 [KO:K10785]
108291137  uncharacterized protein LOC108291137 [KO:K10785]
108300594  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
108300596  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
108300597  CD3D; T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
108308316  CD247; T-cell surface glycoprotein CD3 zeta chain isoform X1 [KO:K06453]
108300288  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
108298560  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 7-like [KO:K03061]
108298258  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 4-like [KO:K03062]
108301412  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
108285679  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
108291927  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
108304839  PSMC3; 26S proteasome regulatory subunit 6A isoform X1 [KO:K03065]
108318267  PSMC5; 26S proteasome regulatory subunit 8 [KO:K03066]
108311077  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
108304748  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
108281507  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
108301820  26S proteasome non-ATPase regulatory subunit 12-like [KO:K03035]
108314101  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
108313687  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
108303512  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
108311781  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
108298295  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
108282790  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 4-like [KO:K03029]
108316441  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X2 [KO:K03029]
108317417  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
108287895  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
108285952  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
108301852  SEM1; 26S proteasome complex subunit SEM1 isoform X1 [KO:K10881]
108300077  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
108300082  TAP2; antigen peptide transporter 2 isoform X1 [KO:K05654] [EC:7.4.2.14]
108300054  tapasin isoform X1 [KO:K08058]
108314972  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
108306996  protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
108282029  CALR; calreticulin [KO:K08057]
108297411  patr class I histocompatibility antigen, A-2 alpha chain isoform X2 [KO:K06751]
108298047  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
119466666  popy Class I histocompatibility antigen, A-1 alpha chain-like isoform X2 [KO:K06751]
108298050  saoe class I histocompatibility antigen, A alpha chain-like isoform X4 [KO:K06751]
108298051  HLA class I histocompatibility antigen, B alpha chain-like [KO:K06751]
108298501  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X4 [KO:K06751]
108298504  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
108298705  class I histocompatibility antigen, Gogo-C*0202 alpha chain-like isoform X1 [KO:K06751]
108298732  HLA class I histocompatibility antigen, B alpha chain-like isoform X1 [KO:K06751]
108298843  patr class I histocompatibility antigen, CH28 alpha chain-like isoform X3 [KO:K06751]
108300114  class I histocompatibility antigen, Gogo-C*0101/C*0102 alpha chain-like isoform X2 [KO:K06751]
108290625  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
108290578  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
108290635  mamu class I histocompatibility antigen, alpha chain F-like isoform X1 [KO:K06751]
119468491  patr class I histocompatibility antigen, B-1 alpha chain-like [KO:K06751]
108290580  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
108290620  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
108290621  saoe class I histocompatibility antigen, A alpha chain isoform X1 [KO:K06751]
108290623  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
108290634  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
108298999  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like [KO:K06751]
108316057  B2M; beta-2-microglobulin [KO:K08055]
108304395  SNW1; SNW domain-containing protein 1 [KO:K06063]
108317469  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
108303947  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
108306044  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
108315204  NCOR2; nuclear receptor corepressor 2 isoform X1 [KO:K06065]
108282534  SAP30; histone deacetylase complex subunit SAP30 [KO:K19202]
108312570  SAP30L; histone deacetylase complex subunit SAP30L [KO:K19202]
108311009  CIR1; corepressor interacting with RBPJ 1 [KO:K06066]
108313014  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
108286958  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
108302925  HES1; transcription factor HES-1 [KO:K06054]
108283663  FCER2; low affinity immunoglobulin epsilon Fc receptor [KO:K06468]
108308679  RUNX3; runt-related transcription factor 3 [KO:K09279]
108283896  MYC; myc proto-oncogene protein [KO:K04377]
108308030  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
108300229  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
108306559  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
108299987  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
108288511  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
108304315  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
108307085  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
108304850  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
108303724  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
108302141  TRAF5; TNF receptor-associated factor 5 isoform X4 [KO:K09849]
108287732  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108300786  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108286022  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108312772  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
108284538  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
108295514  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
108285792  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108306856  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108287186  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108318325  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
108285322  RELB; transcription factor RelB [KO:K09253]
108306313  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
108311730  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
108287871  NFKBIB; NF-kappa-B inhibitor beta isoform X4 [KO:K02581]
108317156  NFKBIE; NF-kappa-B inhibitor epsilon [KO:K05872]
108306463  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
108283651  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
108315696  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
108286678  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
108295228  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
108287258  TRAF2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
108281783  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
108290685  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
108281677  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
108300002  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
108300003  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
108286818  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
108286819  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
108314896  JUN; transcription factor AP-1 [KO:K04448]
108312804  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
108295720  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
108287232  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X1 [KO:K01510] [EC:3.6.1.5]
108313050  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
108305762  CD44; CD44 antigen isoform X2 [KO:K06256]
108293872  ITGAL; LOW QUALITY PROTEIN: integrin alpha-L [KO:K05718]
108301137  CD58; lymphocyte function-associated antigen 3 isoform X1 [KO:K06492]
108283590  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
108305230  VIM; vimentin [KO:K07606]
108305702  TNFAIP3; tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
108284528  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
108289826  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
108306729  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
108304303  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
108314471  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
108303482  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
108307873  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
108287438  BTK; tyrosine-protein kinase BTK isoform X1 [KO:K07370] [EC:2.7.10.2]
108285533  BLNK; B-cell linker protein isoform X2 [KO:K07371]
108313460  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
108317630  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
108304025  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
108294139  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
108316314  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
108317085  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
108309741  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
108304334  LOW QUALITY PROTEIN: cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
108313247  cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
108309877  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
108310820  CCNA1; cyclin-A1 [KO:K06627]
108281889  CCNA2; cyclin-A2 [KO:K06627]
108310921  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
108301073  G1/S-specific cyclin-E1-like [KO:K06626]
108283527  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
108296806  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
108309540  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
108292968  E2F1; transcription factor E2F1 [KO:K17454]
108308638  E2F2; transcription factor E2F2 [KO:K09389]
108314944  E2F3; transcription factor E2F3 isoform X3 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
  Journal
F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
Reference
PMID:12740915
  Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
  Journal
Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
  Journal
MBio 6:e00441-15 (2015)
DOI:10.1128/mBio.00441-15
Reference
PMID:11905817
  Authors
Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
  Journal
Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
  Journal
Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
  Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
  Journal
J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
Reference
PMID:25403939
  Authors
Kang H, Kiess A, Chung CH
  Title
Emerging biomarkers in head and neck cancer in the era of genomics.
  Journal
Nat Rev Clin Oncol 12:11-26 (2015)
DOI:10.1038/nrclinonc.2014.192
Reference
PMID:29932446
  Authors
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
  Title
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
  Journal
Cancers (Basel) 10:E213 (2018)
DOI:10.3390/cancers10070213
Reference
PMID:19649319
  Authors
Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
  Title
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
  Journal
PLoS Pathog 5:e1000530 (2009)
DOI:10.1371/journal.ppat.1000530
Reference
PMID:19244339
  Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
  Journal
J Virol 83:4652-69 (2009)
DOI:10.1128/JVI.02408-08
Reference
PMID:19394062
  Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
  Journal
Virology 388:236-47 (2009)
DOI:10.1016/j.virol.2009.03.027
Reference
PMID:25635182
  Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
  Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
  Journal
Future Virol 4:79-91 (2009)
DOI:10.2217/17460794.4.1.79
Reference
PMID:10818681
  Authors
Longnecker R
  Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
  Journal
Adv Cancer Res 79:175-200 (2000)
DOI:10.1016/s0065-230x(00)79006-3
Reference
PMID:30116721
  Authors
El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
  Journal
Front Oncol 8:265 (2018)
DOI:10.3389/fonc.2018.00265
Reference
PMID:12811813
  Authors
Dolcetti R, Masucci MG
  Title
Epstein-Barr virus: induction and control of cell transformation.
  Journal
J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
Reference
PMID:21347341
  Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
  Journal
PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Related
pathway
cimi03050  Proteasome
cimi04010  MAPK signaling pathway
cimi04020  Calcium signaling pathway
cimi04064  NF-kappa B signaling pathway
cimi04110  Cell cycle
cimi04115  p53 signaling pathway
cimi04210  Apoptosis
cimi04612  Antigen processing and presentation
cimi04620  Toll-like receptor signaling pathway
cimi04622  RIG-I-like receptor signaling pathway
cimi04630  JAK-STAT signaling pathway
cimi04662  B cell receptor signaling pathway
KO pathway
ko05169   
LinkDB

DBGET integrated database retrieval system