KEGG   PATHWAY: clud05160
Entry
clud05160                   Pathway                                
Name
Hepatitis C - Canis lupus dingo (dingo)
Description
Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
Pathway map
clud05160  Hepatitis C
clud05160

Organism
Canis lupus dingo (dingo) [GN:clud]
Gene
112666525  LDLR; low-density lipoprotein receptor [KO:K12473]
112676441  SCARB1; scavenger receptor class B member 1 isoform X8 [KO:K13885]
112663220  CD81; CD81 antigen isoform X1 [KO:K06508]
112674962  CLDN12; claudin-12 [KO:K06087]
112644339  CLDN20; claudin-20 [KO:K06087]
112656123  CLDN10; claudin-10 isoform X1 [KO:K06087]
112678627  CLDN23; claudin-23 [KO:K06087]
112645827  CLDN1; claudin-1 [KO:K06087]
112645828  CLDN16; claudin-16 isoform X1 [KO:K06087]
112645951  CLDN11; claudin-11 isoform X1 [KO:K06087]
112646147  CLDN4; claudin-4 [KO:K06087]
112646148  CLDN3; claudin-3 [KO:K06087]
112646201  CLDN15; claudin-15 isoform X1 [KO:K06087]
112647497  CLDN7; claudin-7 [KO:K06087]
112671532  CLDN25; putative claudin-25 [KO:K06087]
112649288  CLDN2; claudin-2 [KO:K06087]
112661115  CLDN18; claudin-18 isoform X1 [KO:K06087]
112661716  CLDN14; claudin-14 [KO:K06087]
112661731  CLDN17; claudin-17 [KO:K06087]
112661796  CLDN8; claudin-8 [KO:K06087]
112640493  CLDN6; claudin-6 isoform X2 [KO:K06087]
112640494  CLDN9; claudin-9 [KO:K06087]
112652658  CLDN34; claudin-34 [KO:K06087]
112675249  claudin-22 [KO:K06087]
112642257  CLDN19; claudin-19 isoform X2 [KO:K06087]
112676980  CLDN5; claudin-5 [KO:K06087]
112675250  CLDN24; putative claudin-24 [KO:K06087]
112660042  OCLN; occludin isoform X2 [KO:K06088]
112676583  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
112676584  OAS3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
112676585  OAS2; 2'-5'-oligoadenylate synthase 2 isoform X1 [KO:K14216] [EC:2.7.7.84]
112648464  RNASEL; 2-5A-dependent ribonuclease isoform X1 [KO:K01165]
112649835  RIGI; antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
112673652  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
112656934  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
112677914  TBK1; serine/threonine-protein kinase TBK1 isoform X2 [KO:K05410] [EC:2.7.11.10]
112643194  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X3 [KO:K07211] [EC:2.7.11.10]
112645138  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
112663568  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
112650216  interferon alpha-1/2 [KO:K05414]
112650218  interferon alpha-1/2 [KO:K05414]
112650347  interferon alpha-1/2-like [KO:K05414]
112650391  interferon alpha-1/2-like [KO:K05414]
112650394  interferon alpha-1/2-like [KO:K05414]
112650424  interferon alpha-1/2 [KO:K05414]
112662614  interferon alpha-1/2 [KO:K05414]
112662615  interferon alpha-1/2-like [KO:K05414]
112662616  interferon alpha-2-like [KO:K05414]
112650509  interferon alpha-1/2-like [KO:K05414]
118350223  interferon alpha-3 [KO:K05414]
118350179  interferon alpha-1/2 [KO:K05414]
118350228  interferon alpha-1/2 [KO:K05414]
125756056  interferon alpha-1/2 [KO:K05414]
118350222  interferon alpha-1/2 [KO:K05414]
125756057  interferon alpha-1/2 [KO:K05414]
118350183  interferon alpha-1/2 [KO:K05414]
118350181  interferon alpha-1/2-like [KO:K05414]
112650215  IFNB1; interferon beta [KO:K05415]
112677888  IFNG; interferon gamma [KO:K04687]
112675199  TLR3; toll-like receptor 3 [KO:K05401]
112666319  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
112663495  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
112659329  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
112672189  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
112656000  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
112668352  IKBKG; NF-kappa-B essential modulator isoform X6 [KO:K07210]
112657364  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
112644595  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
112659193  RELA; transcription factor p65 isoform X1 [KO:K04735]
112641287  TNF; tumor necrosis factor [KO:K03156]
112647088  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
112646324  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
112664523  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
112664364  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
112676135  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
112660808  LOW QUALITY PROTEIN: interferon-induced protein with tetratricopeptide repeats 1B-like [KO:K14217]
125754933  interferon-induced protein with tetratricopeptide repeats 1-like [KO:K14217]
112661991  EIF3E; eukaryotic translation initiation factor 3 subunit E [KO:K03250]
112658058  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
112654961  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
112672873  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
112661621  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
112661687  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
112647170  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
112666499  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
112656324  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
112678012  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
112657153  IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
112669153  MX2; interferon-induced GTP-binding protein Mx2 isoform X1 [KO:K14754]
112669154  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
112664889  RSAD2; radical S-adenosyl methionine domain-containing protein 2 [KO:K15045]
112671356  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
112643382  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
112669708  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
112660214  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
112672520  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
112653371  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X3 [KO:K04354]
112649885  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
112643039  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
112675696  PIAS1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706] [EC:2.3.2.-]
112671646  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
112661500  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
112672798  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
112657995  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
112664493  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
112663536  HRAS; GTPase HRas isoform X1 [KO:K02833]
112665533  KRAS; GTPase KRas isoform X1 [KO:K07827]
112664166  NRAS; GTPase NRas [KO:K07828]
112650991  BRAF; serine/threonine-protein kinase B-raf isoform X5 [KO:K04365] [EC:2.7.11.1]
112661394  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
112673245  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
112671427  14-3-3 protein theta-like [KO:K16197]
112661983  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
112674006  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
112664855  YWHAQ; 14-3-3 protein theta [KO:K16197]
112654641  LOW QUALITY PROTEIN: 14-3-3 protein zeta/delta-like [KO:K16197]
112661372  14-3-3 protein zeta/delta-like [KO:K16197]
112671739  14-3-3 protein theta-like [KO:K16197]
112665948  14-3-3 protein zeta/delta-like [KO:K16197]
112677584  YWHAE; 14-3-3 protein epsilon isoform X4 [KO:K06630]
112648525  LOW QUALITY PROTEIN: 14-3-3 protein epsilon-like [KO:K06630]
112646175  YWHAG; 14-3-3 protein gamma [KO:K16198]
112676845  YWHAH; 14-3-3 protein eta [KO:K16198]
112649868  14-3-3 protein gamma [KO:K16198]
112675721  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
112666294  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
112640050  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
112677029  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112669083  mitogen-activated protein kinase 3-like [KO:K04371] [EC:2.7.11.24]
112666735  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112660199  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112642563  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
112646871  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X5 [KO:K00922] [EC:2.7.1.153]
112661215  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112662621  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112658031  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112648737  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112645463  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112677588  GSK3B; glycogen synthase kinase-3 beta isoform X3 [KO:K03083] [EC:2.7.11.26]
112668716  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
112659359  BAD; bcl2-associated agonist of cell death [KO:K02158]
112641497  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
112647438  TP53; cellular tumor antigen p53 [KO:K04451]
112678040  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
112677962  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
112654545  LOW QUALITY PROTEIN: cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
112674930  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
112678896  RB1; retinoblastoma-associated protein isoform X2 [KO:K06618]
112673817  E2F1; transcription factor E2F1 isoform X2 [KO:K17454]
112660192  E2F2; transcription factor E2F2 [KO:K09389]
112657478  E2F3; transcription factor E2F3 isoform X3 [KO:K06620]
112669080  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X2 [KO:K03158]
112646480  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
112677465  TRAF2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
112648603  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
112656223  FAS; tumor necrosis factor receptor superfamily member 6 isoform X2 [KO:K04390]
112663192  FADD; FAS-associated death domain protein isoform X1 [KO:K02373]
112656364  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
112675231  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
112656294  CFLAR; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
112667429  LOW QUALITY PROTEIN: BH3-interacting domain death agonist [KO:K04726]
118352478  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
112645177  BAX; apoptosis regulator BAX [KO:K02159]
112641425  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
112670591  cytochrome c [KO:K08738]
112678206  LOW QUALITY PROTEIN: cytochrome c-like [KO:K08738]
112653556  LOW QUALITY PROTEIN: cytochrome c-like [KO:K08738]
112654697  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
112659987  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
112655651  PSME3; proteasome activator complex subunit 3 isoform X1 [KO:K06698]
112677388  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
112665976  PPARA; peroxisome proliferator-activated receptor alpha isoform X1 [KO:K07294]
112663309  NR1H3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
112663184  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
112662261  MYC; myc proto-oncogene protein [KO:K04377]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20935  2-5A
Reference
PMID:24520529
  Authors
Hassan M, Selimovic D, El-Khattouti A, Ghozlan H, Haikel Y, Abdelkader O
  Title
Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies.
  Journal
World J Exp Med 2:7-25 (2012)
DOI:10.5493/wjem.v2.i2.7
Reference
PMID:23641066
  Authors
Yamauchi Y, Helenius A
  Title
Virus entry at a glance.
  Journal
J Cell Sci 126:1289-95 (2013)
DOI:10.1242/jcs.119685
Reference
PMID:24509809
  Authors
Feneant L, Levy S, Cocquerel L
  Title
CD81 and hepatitis C virus (HCV) infection.
  Journal
Viruses 6:535-72 (2014)
DOI:10.3390/v6020535
Reference
PMID:18081727
  Authors
Dubuisson J, Helle F, Cocquerel L
  Title
Early steps of the hepatitis C virus life cycle.
  Journal
Cell Microbiol 10:821-7 (2008)
DOI:10.1111/j.1462-5822.2007.01107.x
Reference
PMID:23675659
  Authors
Liang TJ, Ghany MG
  Title
Current and future therapies for hepatitis C virus infection.
  Journal
N Engl J Med 368:1907-17 (2013)
DOI:10.1056/NEJMra1213651
Reference
PMID:23836234
  Authors
Scheel TK, Rice CM
  Title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
  Journal
Nat Med 19:837-49 (2013)
DOI:10.1038/nm.3248
Reference
PMID:26586968
  Authors
Holmes JA, Thompson AJ
  Title
Interferon-free combination therapies for the treatment of hepatitis C: current insights.
  Journal
Hepat Med 7:51-70 (2015)
DOI:10.2147/HMER.S55864
Reference
PMID:15039538
  Authors
Taguchi T, Nagano-Fujii M, Akutsu M, Kadoya H, Ohgimoto S, Ishido S, Hotta H
  Title
Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner.
  Journal
J Gen Virol 85:959-69 (2004)
DOI:10.1099/vir.0.19513-0
Reference
PMID:19708811
  Authors
Horner SM, Gale M Jr
  Title
Intracellular innate immune cascades and interferon defenses that control hepatitis C virus.
  Journal
J Interferon Cytokine Res 29:489-98 (2009)
DOI:10.1089/jir.2009.0063
Reference
PMID:20457596
  Authors
Lemon SM
  Title
Induction and evasion of innate antiviral responses by hepatitis C virus.
  Journal
J Biol Chem 285:22741-7 (2010)
DOI:10.1074/jbc.R109.099556
Reference
PMID:23836238
  Authors
Horner SM, Gale M Jr
  Title
Regulation of hepatic innate immunity by hepatitis C virus.
  Journal
Nat Med 19:879-88 (2013)
DOI:10.1038/nm.3253
Reference
PMID:28862649
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:E24 (2017)
DOI:10.3390/vaccines5030024
Reference
PMID:25852264
  Authors
Yang DR, Zhu HZ
  Title
Hepatitis C virus and antiviral innate immunity: who wins at tug-of-war?
  Journal
World J Gastroenterol 21:3786-800 (2015)
DOI:10.3748/wjg.v21.i13.3786
Reference
PMID:16107833
  Authors
Gale M Jr, Foy EM
  Title
Evasion of intracellular host defence by hepatitis C virus.
  Journal
Nature 436:939-45 (2005)
DOI:10.1038/nature04078
Reference
PMID:17467654
  Authors
Bode JG, Brenndorfer ED, Haussinger D
  Title
Subversion of innate host antiviral strategies by the hepatitis C virus.
  Journal
Arch Biochem Biophys 462:254-65 (2007)
DOI:10.1016/j.abb.2007.03.033
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:16239065
  Authors
Pang R, Tse E, Poon RT
  Title
Molecular pathways in hepatocellular carcinoma.
  Journal
Cancer Lett 240:157-69 (2006)
DOI:10.1016/j.canlet.2005.08.031
Reference
PMID:15302943
  Authors
Macdonald A, Harris M
  Title
Hepatitis C virus NS5A: tales of a promiscuous protein.
  Journal
J Gen Virol 85:2485-502 (2004)
DOI:10.1099/vir.0.80204-0
Reference
PMID:21250384
  Authors
He Y, Staschke KA, Tan SL
  Title
HCV NS5A: A Multifunctional Regulator of Cellular Pathways and Virus Replication
  Journal
Hepatitis C Viruses: Genomes and Molecular Biology (2006)
Reference
PMID:12101418
  Authors
Lan KH, Sheu ML, Hwang SJ, Yen SH, Chen SY, Wu JC, Wang YJ, Kato N, Omata M, Chang FY, Lee SD
  Title
HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis.
  Journal
Oncogene 21:4801-11 (2002)
DOI:10.1038/sj.onc.1205589
Reference
PMID:11886269
  Authors
Majumder M, Ghosh AK, Steele R, Zhou XY, Phillips NJ, Ray R, Ray RB
  Title
Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice.
  Journal
Virology 294:94-105 (2002)
DOI:10.1006/viro.2001.1309
Reference
PMID:15381253
  Authors
Hassan M, Ghozlan H, Abdel-Kader O
  Title
Activation of RB/E2F signaling pathway is required for the modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells.
  Journal
Cell Signal 16:1375-85 (2004)
DOI:10.1016/j.cellsig.2004.04.005
Reference
PMID:11514734
  Authors
Kwun HJ, Jung EY, Ahn JY, Lee MN, Jang KL
  Title
p53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3.
  Journal
J Gen Virol 82:2235-41 (2001)
DOI:10.1099/0022-1317-82-9-2235
Reference
PMID:12056797
  Authors
Yamanaka T, Uchida M, Doi T
  Title
Innate form of HCV core protein plays an important role in the localization and the function of HCV core protein.
  Journal
Biochem Biophys Res Commun 294:521-7 (2002)
DOI:10.1016/S0006-291X(02)00507-7
Reference
PMID:22611309
  Authors
Lim EJ, Chin R, Angus PW, Torresi J
  Title
Enhanced apoptosis in post-liver transplant hepatitis C: effects of virus and immunosuppressants.
  Journal
World J Gastroenterol 18:2172-9 (2012)
DOI:10.3748/wjg.v18.i18.2172
Reference
PMID:17828818
  Authors
Fischer R, Baumert T, Blum HE
  Title
Hepatitis C virus infection and apoptosis.
  Journal
World J Gastroenterol 13:4865-72 (2007)
DOI:10.3748/wjg.v13.i36.4865
Reference
PMID:16611896
  Authors
Saito K, Meyer K, Warner R, Basu A, Ray RB, Ray R
  Title
Hepatitis C virus core protein inhibits tumor necrosis factor alpha-mediated apoptosis by a protective effect involving cellular FLICE inhibitory protein.
  Journal
J Virol 80:4372-9 (2006)
DOI:10.1128/JVI.80.9.4372-4379.2006
Reference
PMID:19148799
  Authors
Koike K
  Title
Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection.
  Journal
J Gastroenterol 44 Suppl 19:82-8 (2009)
DOI:10.1007/s00535-008-2276-4
Reference
PMID:17764115
  Authors
Tanaka N, Moriya K, Kiyosawa K, Koike K, Aoyama T
  Title
Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: implications for HCV-associated hepatocarcinogenesis.
  Journal
Int J Cancer 122:124-31 (2008)
DOI:10.1002/ijc.23056
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Related
pathway
clud03320  PPAR signaling pathway
clud04010  MAPK signaling pathway
clud04144  Endocytosis
clud04210  Apoptosis
clud04514  Cell adhesion molecules
clud04620  Toll-like receptor signaling pathway
clud04622  RIG-I-like receptor signaling pathway
clud04630  JAK-STAT signaling pathway
clud04668  TNF signaling pathway
KO pathway
ko05160   
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